Intraflagellar transport protein 43

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Intraflagellar transport protein 43, putative

Species:

Leishmania mexicana

UniProt:

E9AZA0_LEIMU

TriTrypDb:

LmxM.27.1960

Length:

430

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005815	microtubule organizing center	2	1
GO:0005929	cilium	4	2
GO:0036064	ciliary basal body	3	1
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2
GO:0031514	motile cilium	5	1

Expansion

Sequence features

E9AZA0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZA0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	165	169	PF00656	0.720
CLV_C14_Caspase3-7	256	260	PF00656	0.697
CLV_C14_Caspase3-7	4	8	PF00656	0.547
CLV_C14_Caspase3-7	75	79	PF00656	0.566
CLV_NRD_NRD_1	128	130	PF00675	0.673
CLV_NRD_NRD_1	131	133	PF00675	0.678
CLV_NRD_NRD_1	288	290	PF00675	0.671
CLV_NRD_NRD_1	341	343	PF00675	0.773
CLV_PCSK_FUR_1	129	133	PF00082	0.758
CLV_PCSK_KEX2_1	128	130	PF00082	0.665
CLV_PCSK_KEX2_1	131	133	PF00082	0.669
CLV_PCSK_KEX2_1	290	292	PF00082	0.671
CLV_PCSK_KEX2_1	294	296	PF00082	0.679
CLV_PCSK_KEX2_1	378	380	PF00082	0.762
CLV_PCSK_KEX2_1	421	423	PF00082	0.537
CLV_PCSK_KEX2_1	65	67	PF00082	0.572
CLV_PCSK_PC1ET2_1	290	292	PF00082	0.809
CLV_PCSK_PC1ET2_1	294	296	PF00082	0.789
CLV_PCSK_PC1ET2_1	378	380	PF00082	0.762
CLV_PCSK_PC1ET2_1	421	423	PF00082	0.522
CLV_PCSK_PC1ET2_1	65	67	PF00082	0.572
DEG_SCF_FBW7_1	24	30	PF00400	0.551
DEG_SPOP_SBC_1	14	18	PF00917	0.556
DEG_SPOP_SBC_1	71	75	PF00917	0.569
DOC_CKS1_1	24	29	PF01111	0.550
DOC_USP7_MATH_1	13	17	PF00917	0.776
DOC_USP7_MATH_1	27	31	PF00917	0.629
DOC_USP7_MATH_1	335	339	PF00917	0.669
DOC_USP7_MATH_1	352	356	PF00917	0.594
DOC_USP7_MATH_1	381	385	PF00917	0.657
DOC_USP7_MATH_1	70	74	PF00917	0.666
DOC_USP7_MATH_1	82	86	PF00917	0.840
DOC_USP7_MATH_1	90	94	PF00917	0.720
DOC_USP7_UBL2_3	290	294	PF12436	0.730
DOC_USP7_UBL2_3	319	323	PF12436	0.854
DOC_USP7_UBL2_3	339	343	PF12436	0.840
DOC_USP7_UBL2_3	426	430	PF12436	0.802
DOC_WW_Pin1_4	15	20	PF00397	0.842
DOC_WW_Pin1_4	191	196	PF00397	0.682
DOC_WW_Pin1_4	23	28	PF00397	0.672
DOC_WW_Pin1_4	325	330	PF00397	0.683
DOC_WW_Pin1_4	37	42	PF00397	0.685
DOC_WW_Pin1_4	397	402	PF00397	0.545
LIG_14-3-3_CanoR_1	204	210	PF00244	0.667
LIG_14-3-3_CanoR_1	219	227	PF00244	0.671
LIG_14-3-3_CanoR_1	295	300	PF00244	0.767
LIG_14-3-3_CanoR_1	342	349	PF00244	0.765
LIG_14-3-3_CanoR_1	91	95	PF00244	0.860
LIG_14-3-3_CanoR_1	98	107	PF00244	0.735
LIG_BIR_II_1	1	5	PF00653	0.766
LIG_BRCT_BRCA1_1	135	139	PF00533	0.820
LIG_BRCT_BRCA1_1	424	428	PF00533	0.728
LIG_BRCT_BRCA1_2	424	430	PF00533	0.727
LIG_FHA_1	229	235	PF00498	0.718
LIG_FHA_2	2	8	PF00498	0.616
LIG_FHA_2	281	287	PF00498	0.815
LIG_FHA_2	343	349	PF00498	0.764
LIG_LIR_Gen_1	211	221	PF02991	0.692
LIG_LIR_Nem_3	211	217	PF02991	0.702
LIG_LIR_Nem_3	269	274	PF02991	0.778
LIG_SH2_PTP2	271	274	PF00017	0.778
LIG_SH2_SRC	271	274	PF00017	0.778
LIG_SH2_STAT5	271	274	PF00017	0.778
LIG_SH3_1	57	63	PF00018	0.675
LIG_SH3_2	60	65	PF14604	0.827
LIG_SH3_3	57	63	PF00018	0.735
MOD_CDC14_SPxK_1	18	21	PF00782	0.768
MOD_CDK_SPxK_1	15	21	PF00069	0.766
MOD_CK1_1	103	109	PF00069	0.659
MOD_CK1_1	228	234	PF00069	0.715
MOD_CK1_1	371	377	PF00069	0.788
MOD_CK1_1	400	406	PF00069	0.758
MOD_CK1_1	46	52	PF00069	0.709
MOD_CK1_1	93	99	PF00069	0.855
MOD_CK2_1	280	286	PF00069	0.707
MOD_CK2_1	70	76	PF00069	0.642
MOD_Cter_Amidation	126	129	PF01082	0.787
MOD_GlcNHglycan	102	105	PF01048	0.577
MOD_GlcNHglycan	266	269	PF01048	0.551
MOD_GlcNHglycan	29	32	PF01048	0.730
MOD_GlcNHglycan	379	382	PF01048	0.754
MOD_GlcNHglycan	385	388	PF01048	0.625
MOD_GSK3_1	113	120	PF00069	0.708
MOD_GSK3_1	15	22	PF00069	0.630
MOD_GSK3_1	189	196	PF00069	0.678
MOD_GSK3_1	225	232	PF00069	0.715
MOD_GSK3_1	23	30	PF00069	0.677
MOD_GSK3_1	364	371	PF00069	0.808
MOD_GSK3_1	373	380	PF00069	0.727
MOD_GSK3_1	39	46	PF00069	0.712
MOD_GSK3_1	405	412	PF00069	0.688
MOD_GSK3_1	422	429	PF00069	0.533
MOD_GSK3_1	49	56	PF00069	0.641
MOD_GSK3_1	66	73	PF00069	0.676
MOD_GSK3_1	99	106	PF00069	0.745
MOD_N-GLC_1	371	376	PF02516	0.813
MOD_N-GLC_1	394	399	PF02516	0.815
MOD_NEK2_1	1	6	PF00069	0.845
MOD_NEK2_1	198	203	PF00069	0.625
MOD_NEK2_1	208	213	PF00069	0.639
MOD_NEK2_1	225	230	PF00069	0.434
MOD_PIKK_1	373	379	PF00454	0.549
MOD_PKA_1	294	300	PF00069	0.678
MOD_PKA_1	342	348	PF00069	0.768
MOD_PKA_2	203	209	PF00069	0.593
MOD_PKA_2	294	300	PF00069	0.678
MOD_PKA_2	359	365	PF00069	0.758
MOD_PKA_2	90	96	PF00069	0.856
MOD_Plk_1	225	231	PF00069	0.716
MOD_Plk_2-3	134	140	PF00069	0.744
MOD_Plk_4	134	140	PF00069	0.744
MOD_Plk_4	49	55	PF00069	0.562
MOD_ProDKin_1	15	21	PF00069	0.844
MOD_ProDKin_1	191	197	PF00069	0.685
MOD_ProDKin_1	23	29	PF00069	0.672
MOD_ProDKin_1	325	331	PF00069	0.679
MOD_ProDKin_1	37	43	PF00069	0.686
MOD_ProDKin_1	397	403	PF00069	0.544
MOD_SUMO_rev_2	407	415	PF00179	0.754
TRG_ENDOCYTIC_2	271	274	PF00928	0.778
TRG_ER_diArg_1	128	131	PF00400	0.657
TRG_NLS_Bipartite_1	342	361	PF00514	0.666
TRG_NLS_MonoExtN_4	354	361	PF00514	0.663
TRG_Pf-PMV_PEXEL_1	236	240	PF00026	0.747

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IE97	Leishmania donovani	87%	100%
A4HFX1	Leishmania braziliensis	60%	100%
A4I303	Leishmania infantum	87%	100%
E9ADH6	Leishmania major	84%	100%