Protein kinase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cdc2-related kinase 9

Species:

Leishmania mexicana

UniProt:

E9AZ98_LEIMU

TriTrypDb:

LmxM.27.1940

Length:

959

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0016592	mediator complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

E9AZ98

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZ98

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	9
GO:0006793	phosphorus metabolic process	3	9
GO:0006796	phosphate-containing compound metabolic process	4	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0009987	cellular process	1	9
GO:0016310	phosphorylation	5	9
GO:0019538	protein metabolic process	3	9
GO:0036211	protein modification process	4	9
GO:0043170	macromolecule metabolic process	3	9
GO:0043412	macromolecule modification	4	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0071704	organic substance metabolic process	2	9
GO:1901564	organonitrogen compound metabolic process	3	9
GO:0000086	G2/M transition of mitotic cell cycle	5	1
GO:0000365	mRNA trans splicing, via spliceosome	9	1
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	1
GO:0000398	mRNA splicing, via spliceosome	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0008380	RNA splicing	7	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0022402	cell cycle process	2	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0044770	cell cycle phase transition	3	1
GO:0044772	mitotic cell cycle phase transition	4	1
GO:0044839	cell cycle G2/M phase transition	4	1
GO:0045291	mRNA trans splicing, SL addition	10	1
GO:0046483	heterocycle metabolic process	3	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1903047	mitotic cell cycle process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0003824	catalytic activity	1	9
GO:0004672	protein kinase activity	3	9
GO:0005488	binding	1	9
GO:0005524	ATP binding	5	9
GO:0016301	kinase activity	4	9
GO:0016740	transferase activity	2	9
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	9
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	9
GO:0017076	purine nucleotide binding	4	9
GO:0030554	adenyl nucleotide binding	5	9
GO:0032553	ribonucleotide binding	3	9
GO:0032555	purine ribonucleotide binding	4	9
GO:0032559	adenyl ribonucleotide binding	5	9
GO:0035639	purine ribonucleoside triphosphate binding	4	9
GO:0036094	small molecule binding	2	9
GO:0043167	ion binding	2	9
GO:0043168	anion binding	3	9
GO:0097159	organic cyclic compound binding	2	9
GO:0097367	carbohydrate derivative binding	2	9
GO:0140096	catalytic activity, acting on a protein	2	9
GO:1901265	nucleoside phosphate binding	3	9
GO:1901363	heterocyclic compound binding	2	9
GO:0004674	protein serine/threonine kinase activity	4	1
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	5	1
GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	5	1
GO:0097472	cyclin-dependent protein kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	150	154	PF00656	0.615
CLV_C14_Caspase3-7	158	162	PF00656	0.587
CLV_C14_Caspase3-7	446	450	PF00656	0.504
CLV_C14_Caspase3-7	475	479	PF00656	0.615
CLV_C14_Caspase3-7	52	56	PF00656	0.647
CLV_C14_Caspase3-7	904	908	PF00656	0.731
CLV_C14_Caspase3-7	92	96	PF00656	0.594
CLV_C14_Caspase3-7	936	940	PF00656	0.640
CLV_NRD_NRD_1	10	12	PF00675	0.496
CLV_NRD_NRD_1	383	385	PF00675	0.684
CLV_NRD_NRD_1	428	430	PF00675	0.674
CLV_NRD_NRD_1	513	515	PF00675	0.489
CLV_NRD_NRD_1	653	655	PF00675	0.385
CLV_NRD_NRD_1	751	753	PF00675	0.400
CLV_NRD_NRD_1	803	805	PF00675	0.693
CLV_NRD_NRD_1	925	927	PF00675	0.737
CLV_PCSK_KEX2_1	383	385	PF00082	0.724
CLV_PCSK_KEX2_1	428	430	PF00082	0.674
CLV_PCSK_KEX2_1	513	515	PF00082	0.546
CLV_PCSK_KEX2_1	653	655	PF00082	0.385
CLV_PCSK_KEX2_1	750	752	PF00082	0.385
CLV_PCSK_KEX2_1	803	805	PF00082	0.693
CLV_PCSK_KEX2_1	925	927	PF00082	0.737
CLV_PCSK_SKI1_1	200	204	PF00082	0.568
CLV_PCSK_SKI1_1	292	296	PF00082	0.440
CLV_PCSK_SKI1_1	334	338	PF00082	0.419
CLV_PCSK_SKI1_1	462	466	PF00082	0.535
CLV_PCSK_SKI1_1	495	499	PF00082	0.450
CLV_PCSK_SKI1_1	514	518	PF00082	0.384
CLV_PCSK_SKI1_1	581	585	PF00082	0.291
CLV_PCSK_SKI1_1	654	658	PF00082	0.385
DEG_Nend_UBRbox_3	1	3	PF02207	0.622
DEG_SPOP_SBC_1	165	169	PF00917	0.503
DEG_SPOP_SBC_1	220	224	PF00917	0.516
DEG_SPOP_SBC_1	402	406	PF00917	0.640
DEG_SPOP_SBC_1	467	471	PF00917	0.518
DEG_SPOP_SBC_1	65	69	PF00917	0.695
DOC_CDC14_PxL_1	621	629	PF14671	0.291
DOC_CYCLIN_RxL_1	651	661	PF00134	0.385
DOC_CYCLIN_yCln2_LP_2	652	658	PF00134	0.385
DOC_MAPK_gen_1	581	590	PF00069	0.291
DOC_MAPK_MEF2A_6	354	362	PF00069	0.397
DOC_MAPK_MEF2A_6	493	501	PF00069	0.485
DOC_MAPK_MEF2A_6	98	105	PF00069	0.512
DOC_MAPK_RevD_3	638	654	PF00069	0.385
DOC_PP1_RVXF_1	566	573	PF00149	0.385
DOC_PP2B_LxvP_1	673	676	PF13499	0.367
DOC_PP4_FxxP_1	83	86	PF00568	0.588
DOC_USP7_MATH_1	134	138	PF00917	0.687
DOC_USP7_MATH_1	151	155	PF00917	0.751
DOC_USP7_MATH_1	220	224	PF00917	0.806
DOC_USP7_MATH_1	231	235	PF00917	0.631
DOC_USP7_MATH_1	317	321	PF00917	0.651
DOC_USP7_MATH_1	403	407	PF00917	0.751
DOC_USP7_MATH_1	49	53	PF00917	0.704
DOC_USP7_MATH_1	551	555	PF00917	0.372
DOC_USP7_MATH_1	84	88	PF00917	0.679
DOC_USP7_MATH_1	855	859	PF00917	0.756
DOC_USP7_MATH_1	868	872	PF00917	0.589
DOC_USP7_MATH_1	878	882	PF00917	0.694
DOC_USP7_UBL2_3	334	338	PF12436	0.421
DOC_WW_Pin1_4	122	127	PF00397	0.632
DOC_WW_Pin1_4	376	381	PF00397	0.621
DOC_WW_Pin1_4	384	389	PF00397	0.701
DOC_WW_Pin1_4	398	403	PF00397	0.551
DOC_WW_Pin1_4	407	412	PF00397	0.537
DOC_WW_Pin1_4	540	545	PF00397	0.536
DOC_WW_Pin1_4	611	616	PF00397	0.385
DOC_WW_Pin1_4	82	87	PF00397	0.590
DOC_WW_Pin1_4	870	875	PF00397	0.644
LIG_14-3-3_CanoR_1	281	289	PF00244	0.487
LIG_14-3-3_CanoR_1	292	299	PF00244	0.347
LIG_14-3-3_CanoR_1	513	519	PF00244	0.570
LIG_14-3-3_CanoR_1	699	709	PF00244	0.418
LIG_14-3-3_CanoR_1	829	837	PF00244	0.759
LIG_Clathr_ClatBox_1	373	377	PF01394	0.533
LIG_deltaCOP1_diTrp_1	639	647	PF00928	0.367
LIG_EVH1_2	79	83	PF00568	0.682
LIG_FHA_1	30	36	PF00498	0.684
LIG_FHA_1	328	334	PF00498	0.408
LIG_FHA_1	480	486	PF00498	0.687
LIG_FHA_1	583	589	PF00498	0.303
LIG_FHA_1	612	618	PF00498	0.291
LIG_FHA_1	701	707	PF00498	0.367
LIG_FHA_2	156	162	PF00498	0.663
LIG_FHA_2	213	219	PF00498	0.577
LIG_FHA_2	293	299	PF00498	0.460
LIG_FHA_2	431	437	PF00498	0.681
LIG_FHA_2	467	473	PF00498	0.760
LIG_FHA_2	515	521	PF00498	0.571
LIG_LIR_Apic_2	619	625	PF02991	0.291
LIG_LIR_Gen_1	496	506	PF02991	0.356
LIG_LIR_Gen_1	561	572	PF02991	0.385
LIG_LIR_Gen_1	592	603	PF02991	0.385
LIG_LIR_Nem_3	502	506	PF02991	0.334
LIG_LIR_Nem_3	561	567	PF02991	0.385
LIG_LIR_Nem_3	592	598	PF02991	0.385
LIG_LIR_Nem_3	626	632	PF02991	0.367
LIG_LIR_Nem_3	678	684	PF02991	0.315
LIG_NRBOX	113	119	PF00104	0.566
LIG_Pex14_2	647	651	PF04695	0.367
LIG_REV1ctd_RIR_1	761	767	PF16727	0.319
LIG_SH2_CRK	276	280	PF00017	0.419
LIG_SH2_CRK	287	291	PF00017	0.336
LIG_SH2_CRK	515	519	PF00017	0.388
LIG_SH2_CRK	564	568	PF00017	0.367
LIG_SH2_CRK	685	689	PF00017	0.385
LIG_SH2_NCK_1	276	280	PF00017	0.474
LIG_SH2_NCK_1	515	519	PF00017	0.509
LIG_SH2_NCK_1	532	536	PF00017	0.431
LIG_SH2_PTP2	595	598	PF00017	0.385
LIG_SH2_STAP1	515	519	PF00017	0.619
LIG_SH2_STAP1	634	638	PF00017	0.291
LIG_SH2_STAT3	299	302	PF00017	0.528
LIG_SH2_STAT5	276	279	PF00017	0.379
LIG_SH2_STAT5	351	354	PF00017	0.416
LIG_SH2_STAT5	503	506	PF00017	0.414
LIG_SH2_STAT5	539	542	PF00017	0.460
LIG_SH2_STAT5	555	558	PF00017	0.382
LIG_SH2_STAT5	595	598	PF00017	0.357
LIG_SH3_2	209	214	PF14604	0.644
LIG_SH3_3	206	212	PF00018	0.619
LIG_SH3_3	343	349	PF00018	0.446
LIG_SH3_3	478	484	PF00018	0.489
LIG_SH3_3	71	77	PF00018	0.681
LIG_SH3_3	767	773	PF00018	0.428
LIG_SH3_CIN85_PxpxPR_1	378	383	PF14604	0.666
LIG_SUMO_SIM_anti_2	355	360	PF11976	0.468
LIG_SUMO_SIM_anti_2	372	377	PF11976	0.346
LIG_SUMO_SIM_anti_2	616	622	PF11976	0.385
LIG_SUMO_SIM_anti_2	735	743	PF11976	0.388
LIG_SUMO_SIM_par_1	372	377	PF11976	0.437
LIG_SUMO_SIM_par_1	665	671	PF11976	0.385
LIG_TRAF2_1	676	679	PF00917	0.363
LIG_TYR_ITIM	537	542	PF00017	0.522
LIG_TYR_ITIM	562	567	PF00017	0.367
LIG_UBA3_1	6	12	PF00899	0.588
LIG_WW_3	322	326	PF00397	0.433
MOD_CDC14_SPxK_1	387	390	PF00782	0.632
MOD_CDK_SPK_2	540	545	PF00069	0.536
MOD_CDK_SPxK_1	384	390	PF00069	0.627
MOD_CDK_SPxxK_3	376	383	PF00069	0.640
MOD_CK1_1	125	131	PF00069	0.649
MOD_CK1_1	154	160	PF00069	0.657
MOD_CK1_1	169	175	PF00069	0.692
MOD_CK1_1	219	225	PF00069	0.693
MOD_CK1_1	234	240	PF00069	0.525
MOD_CK1_1	241	247	PF00069	0.496
MOD_CK1_1	316	322	PF00069	0.691
MOD_CK1_1	391	397	PF00069	0.770
MOD_CK1_1	398	404	PF00069	0.814
MOD_CK1_1	405	411	PF00069	0.556
MOD_CK1_1	531	537	PF00069	0.529
MOD_CK1_1	660	666	PF00069	0.385
MOD_CK1_1	69	75	PF00069	0.619
MOD_CK1_1	809	815	PF00069	0.681
MOD_CK1_1	831	837	PF00069	0.590
MOD_CK1_1	85	91	PF00069	0.518
MOD_CK1_1	873	879	PF00069	0.513
MOD_CK2_1	180	186	PF00069	0.715
MOD_CK2_1	2	8	PF00069	0.607
MOD_CK2_1	212	218	PF00069	0.603
MOD_CK2_1	394	400	PF00069	0.701
MOD_CK2_1	403	409	PF00069	0.665
MOD_CK2_1	429	435	PF00069	0.717
MOD_CK2_1	466	472	PF00069	0.593
MOD_CK2_1	514	520	PF00069	0.563
MOD_CK2_1	751	757	PF00069	0.325
MOD_CK2_1	844	850	PF00069	0.622
MOD_CK2_1	855	861	PF00069	0.622
MOD_CK2_1	935	941	PF00069	0.602
MOD_GlcNHglycan	169	172	PF01048	0.693
MOD_GlcNHglycan	181	185	PF01048	0.618
MOD_GlcNHglycan	218	221	PF01048	0.662
MOD_GlcNHglycan	241	244	PF01048	0.593
MOD_GlcNHglycan	261	265	PF01048	0.373
MOD_GlcNHglycan	315	318	PF01048	0.644
MOD_GlcNHglycan	319	322	PF01048	0.648
MOD_GlcNHglycan	38	41	PF01048	0.588
MOD_GlcNHglycan	533	536	PF01048	0.654
MOD_GlcNHglycan	60	63	PF01048	0.692
MOD_GlcNHglycan	735	738	PF01048	0.340
MOD_GlcNHglycan	753	756	PF01048	0.206
MOD_GlcNHglycan	795	798	PF01048	0.800
MOD_GlcNHglycan	831	834	PF01048	0.740
MOD_GlcNHglycan	846	849	PF01048	0.725
MOD_GlcNHglycan	857	860	PF01048	0.776
MOD_GlcNHglycan	87	90	PF01048	0.680
MOD_GlcNHglycan	870	873	PF01048	0.648
MOD_GlcNHglycan	902	906	PF01048	0.687
MOD_GSK3_1	151	158	PF00069	0.625
MOD_GSK3_1	165	172	PF00069	0.570
MOD_GSK3_1	180	187	PF00069	0.531
MOD_GSK3_1	212	219	PF00069	0.768
MOD_GSK3_1	220	227	PF00069	0.699
MOD_GSK3_1	234	241	PF00069	0.634
MOD_GSK3_1	29	36	PF00069	0.510
MOD_GSK3_1	309	316	PF00069	0.671
MOD_GSK3_1	384	391	PF00069	0.659
MOD_GSK3_1	392	399	PF00069	0.679
MOD_GSK3_1	401	408	PF00069	0.719
MOD_GSK3_1	410	417	PF00069	0.492
MOD_GSK3_1	430	437	PF00069	0.635
MOD_GSK3_1	462	469	PF00069	0.689
MOD_GSK3_1	527	534	PF00069	0.689
MOD_GSK3_1	65	72	PF00069	0.693
MOD_GSK3_1	689	696	PF00069	0.338
MOD_GSK3_1	701	708	PF00069	0.408
MOD_GSK3_1	824	831	PF00069	0.797
MOD_GSK3_1	873	880	PF00069	0.695
MOD_GSK3_1	897	904	PF00069	0.625
MOD_GSK3_1	921	928	PF00069	0.696
MOD_LATS_1	923	929	PF00433	0.692
MOD_N-GLC_1	165	170	PF02516	0.541
MOD_N-GLC_1	700	705	PF02516	0.454
MOD_NEK2_1	101	106	PF00069	0.441
MOD_NEK2_1	341	346	PF00069	0.514
MOD_NEK2_1	573	578	PF00069	0.412
MOD_NEK2_1	583	588	PF00069	0.281
MOD_NEK2_1	693	698	PF00069	0.319
MOD_NEK2_1	740	745	PF00069	0.367
MOD_NEK2_1	759	764	PF00069	0.175
MOD_OFUCOSY	102	107	PF10250	0.543
MOD_PIKK_1	280	286	PF00454	0.510
MOD_PIKK_1	341	347	PF00454	0.503
MOD_PIKK_1	462	468	PF00454	0.694
MOD_PIKK_1	809	815	PF00454	0.713
MOD_PIKK_1	951	957	PF00454	0.448
MOD_PK_1	558	564	PF00069	0.385
MOD_PKA_1	751	757	PF00069	0.385
MOD_PKA_1	925	931	PF00069	0.693
MOD_PKA_2	179	185	PF00069	0.648
MOD_PKA_2	280	286	PF00069	0.492
MOD_PKA_2	309	315	PF00069	0.757
MOD_PKA_2	430	436	PF00069	0.660
MOD_PKA_2	701	707	PF00069	0.385
MOD_PKA_2	751	757	PF00069	0.291
MOD_PKA_2	809	815	PF00069	0.664
MOD_PKA_2	828	834	PF00069	0.503
MOD_PKA_2	924	930	PF00069	0.713
MOD_Plk_1	341	347	PF00069	0.562
MOD_Plk_1	677	683	PF00069	0.291
MOD_Plk_1	849	855	PF00069	0.623
MOD_Plk_2-3	414	420	PF00069	0.591
MOD_Plk_2-3	935	941	PF00069	0.602
MOD_Plk_4	113	119	PF00069	0.483
MOD_Plk_4	2	8	PF00069	0.607
MOD_Plk_4	241	247	PF00069	0.484
MOD_Plk_4	507	513	PF00069	0.399
MOD_Plk_4	551	557	PF00069	0.484
MOD_Plk_4	558	564	PF00069	0.405
MOD_Plk_4	613	619	PF00069	0.300
MOD_Plk_4	66	72	PF00069	0.610
MOD_Plk_4	689	695	PF00069	0.328
MOD_Plk_4	705	711	PF00069	0.341
MOD_Plk_4	740	746	PF00069	0.447
MOD_Plk_4	759	765	PF00069	0.172
MOD_ProDKin_1	122	128	PF00069	0.631
MOD_ProDKin_1	376	382	PF00069	0.630
MOD_ProDKin_1	384	390	PF00069	0.705
MOD_ProDKin_1	398	404	PF00069	0.551
MOD_ProDKin_1	407	413	PF00069	0.623
MOD_ProDKin_1	540	546	PF00069	0.534
MOD_ProDKin_1	611	617	PF00069	0.385
MOD_ProDKin_1	82	88	PF00069	0.591
MOD_ProDKin_1	870	876	PF00069	0.645
MOD_SUMO_for_1	443	446	PF00179	0.511
MOD_SUMO_for_1	764	767	PF00179	0.437
MOD_SUMO_rev_2	524	531	PF00179	0.605
MOD_SUMO_rev_2	576	586	PF00179	0.468
TRG_DiLeu_BaEn_1	355	360	PF01217	0.396
TRG_DiLeu_BaLyEn_6	947	952	PF01217	0.491
TRG_ENDOCYTIC_2	276	279	PF00928	0.396
TRG_ENDOCYTIC_2	287	290	PF00928	0.357
TRG_ENDOCYTIC_2	515	518	PF00928	0.597
TRG_ENDOCYTIC_2	539	542	PF00928	0.455
TRG_ENDOCYTIC_2	564	567	PF00928	0.385
TRG_ENDOCYTIC_2	595	598	PF00928	0.385
TRG_ER_diArg_1	197	200	PF00400	0.689
TRG_ER_diArg_1	308	311	PF00400	0.629
TRG_ER_diArg_1	382	384	PF00400	0.767
TRG_ER_diArg_1	427	429	PF00400	0.673
TRG_ER_diArg_1	512	514	PF00400	0.522
TRG_ER_diArg_1	652	654	PF00400	0.385
TRG_ER_diArg_1	749	752	PF00400	0.385
TRG_NLS_MonoExtC_3	10	16	PF00514	0.572
TRG_NLS_MonoExtN_4	9	15	PF00514	0.578
TRG_Pf-PMV_PEXEL_1	577	582	PF00026	0.291
TRG_Pf-PMV_PEXEL_1	950	955	PF00026	0.738

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6G8	Leptomonas seymouri	46%	100%
A0A3R7KFZ3	Trypanosoma rangeli	33%	100%
A0A3S5H7I2	Leishmania donovani	88%	100%
A4HFW9	Leishmania braziliensis	76%	100%
A4I302	Leishmania infantum	88%	100%
C9ZJF3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9ADH4	Leishmania major	88%	100%