Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AZ96_LEIMU

TriTrypDb:

LmxM.27.1930

Length:

354

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9AZ96

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZ96

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	202	204	PF00675	0.389
CLV_NRD_NRD_1	61	63	PF00675	0.392
CLV_NRD_NRD_1	94	96	PF00675	0.594
CLV_PCSK_FUR_1	200	204	PF00082	0.402
CLV_PCSK_KEX2_1	202	204	PF00082	0.389
CLV_PCSK_KEX2_1	61	63	PF00082	0.390
CLV_PCSK_KEX2_1	93	95	PF00082	0.605
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.605
CLV_PCSK_SKI1_1	157	161	PF00082	0.442
CLV_PCSK_SKI1_1	61	65	PF00082	0.428
DEG_APCC_DBOX_1	60	68	PF00400	0.626
DEG_SCF_FBW7_1	84	90	PF00400	0.417
DOC_CDC14_PxL_1	52	60	PF14671	0.618
DOC_CKS1_1	84	89	PF01111	0.471
DOC_MAPK_gen_1	61	69	PF00069	0.480
DOC_MAPK_MEF2A_6	31	40	PF00069	0.648
DOC_MAPK_MEF2A_6	62	71	PF00069	0.480
DOC_MAPK_RevD_3	80	95	PF00069	0.430
DOC_PP2B_PxIxI_1	86	92	PF00149	0.361
DOC_USP7_MATH_1	238	242	PF00917	0.420
DOC_USP7_MATH_1	292	296	PF00917	0.647
DOC_USP7_MATH_1	307	311	PF00917	0.676
DOC_WW_Pin1_4	83	88	PF00397	0.470
LIG_14-3-3_CanoR_1	172	180	PF00244	0.635
LIG_14-3-3_CanoR_1	208	216	PF00244	0.227
LIG_14-3-3_CanoR_1	22	27	PF00244	0.691
LIG_14-3-3_CanoR_1	61	71	PF00244	0.420
LIG_BIR_II_1	1	5	PF00653	0.740
LIG_Clathr_ClatBox_1	69	73	PF01394	0.368
LIG_deltaCOP1_diTrp_1	185	195	PF00928	0.638
LIG_EH1_1	119	127	PF00400	0.227
LIG_FHA_1	216	222	PF00498	0.334
LIG_FHA_1	319	325	PF00498	0.638
LIG_FHA_1	4	10	PF00498	0.695
LIG_FHA_1	49	55	PF00498	0.608
LIG_FHA_1	84	90	PF00498	0.507
LIG_FHA_2	301	307	PF00498	0.679
LIG_LIR_Gen_1	207	217	PF02991	0.425
LIG_LIR_Gen_1	253	263	PF02991	0.360
LIG_LIR_Gen_1	43	52	PF02991	0.627
LIG_LIR_Gen_1	86	96	PF02991	0.277
LIG_LIR_LC3C_4	43	48	PF02991	0.626
LIG_LIR_Nem_3	207	212	PF02991	0.425
LIG_LIR_Nem_3	253	259	PF02991	0.360
LIG_LIR_Nem_3	43	48	PF02991	0.626
LIG_LIR_Nem_3	86	91	PF02991	0.280
LIG_NRBOX	67	73	PF00104	0.423
LIG_Pex14_2	77	81	PF04695	0.227
LIG_RPA_C_Fungi	289	301	PF08784	0.428
LIG_RPA_C_Fungi	57	69	PF08784	0.324
LIG_SH2_CRK	120	124	PF00017	0.227
LIG_SH2_NCK_1	329	333	PF00017	0.523
LIG_SH2_NCK_1	52	56	PF00017	0.515
LIG_SH2_STAP1	120	124	PF00017	0.247
LIG_SH2_STAT3	163	166	PF00017	0.488
LIG_SH2_STAT5	277	280	PF00017	0.574
LIG_SH2_STAT5	323	326	PF00017	0.551
LIG_SH2_STAT5	45	48	PF00017	0.579
LIG_SH2_STAT5	96	99	PF00017	0.436
LIG_SH3_3	13	19	PF00018	0.571
LIG_SH3_3	44	50	PF00018	0.509
LIG_SUMO_SIM_anti_2	121	127	PF11976	0.368
LIG_SUMO_SIM_anti_2	158	163	PF11976	0.341
LIG_SUMO_SIM_anti_2	218	223	PF11976	0.281
LIG_SUMO_SIM_anti_2	65	71	PF11976	0.279
LIG_SUMO_SIM_par_1	215	220	PF11976	0.261
LIG_SUMO_SIM_par_1	67	73	PF11976	0.461
LIG_TRFH_1	52	56	PF08558	0.571
LIG_TYR_ITIM	118	123	PF00017	0.227
LIG_Vh1_VBS_1	118	136	PF01044	0.227
MOD_CK1_1	201	207	PF00069	0.479
MOD_CK1_1	24	30	PF00069	0.458
MOD_CK1_1	241	247	PF00069	0.477
MOD_CK1_1	346	352	PF00069	0.711
MOD_CK2_1	300	306	PF00069	0.653
MOD_GlcNHglycan	174	177	PF01048	0.567
MOD_GlcNHglycan	179	183	PF01048	0.557
MOD_GlcNHglycan	224	227	PF01048	0.227
MOD_GlcNHglycan	240	243	PF01048	0.497
MOD_GlcNHglycan	309	312	PF01048	0.667
MOD_GlcNHglycan	318	321	PF01048	0.551
MOD_GlcNHglycan	329	332	PF01048	0.495
MOD_GlcNHglycan	40	43	PF01048	0.381
MOD_GlcNHglycan	64	67	PF01048	0.227
MOD_GSK3_1	128	135	PF00069	0.338
MOD_GSK3_1	174	181	PF00069	0.483
MOD_GSK3_1	318	325	PF00069	0.733
MOD_GSK3_1	345	352	PF00069	0.688
MOD_GSK3_1	83	90	PF00069	0.497
MOD_N-GLC_1	113	118	PF02516	0.426
MOD_N-GLC_2	351	353	PF02516	0.562
MOD_NEK2_1	128	133	PF00069	0.421
MOD_NEK2_1	215	220	PF00069	0.308
MOD_NEK2_1	251	256	PF00069	0.492
MOD_NEK2_2	87	92	PF00069	0.415
MOD_PIKK_1	300	306	PF00454	0.505
MOD_PIKK_1	343	349	PF00454	0.548
MOD_PKA_2	201	207	PF00069	0.468
MOD_PKA_2	21	27	PF00069	0.520
MOD_PKA_2	327	333	PF00069	0.611
MOD_Plk_4	113	119	PF00069	0.382
MOD_Plk_4	132	138	PF00069	0.280
MOD_Plk_4	217	223	PF00069	0.339
MOD_Plk_4	224	230	PF00069	0.342
MOD_Plk_4	251	257	PF00069	0.368
MOD_ProDKin_1	83	89	PF00069	0.468
MOD_SUMO_for_1	183	186	PF00179	0.623
TRG_DiLeu_BaEn_2	72	78	PF01217	0.423
TRG_ENDOCYTIC_2	120	123	PF00928	0.262
TRG_ENDOCYTIC_2	268	271	PF00928	0.487
TRG_ENDOCYTIC_2	45	48	PF00928	0.593
TRG_ENDOCYTIC_2	96	99	PF00928	0.436
TRG_ER_diArg_1	147	150	PF00400	0.462
TRG_ER_diArg_1	200	203	PF00400	0.483
TRG_ER_diArg_1	61	63	PF00400	0.463
TRG_ER_diArg_1	94	96	PF00400	0.386

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IQ36	Leishmania donovani	80%	100%
A4HFW7	Leishmania braziliensis	49%	100%
A4I300	Leishmania infantum	80%	100%
E9ADH2	Leishmania major	71%	100%