Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZ95_LEIMU

TriTrypDb:

LmxM.27.1920

Length:

650

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9AZ95

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZ95

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	485	489	PF00656	0.380
CLV_NRD_NRD_1	153	155	PF00675	0.569
CLV_NRD_NRD_1	248	250	PF00675	0.381
CLV_NRD_NRD_1	319	321	PF00675	0.403
CLV_NRD_NRD_1	349	351	PF00675	0.597
CLV_NRD_NRD_1	372	374	PF00675	0.560
CLV_NRD_NRD_1	420	422	PF00675	0.647
CLV_NRD_NRD_1	494	496	PF00675	0.563
CLV_NRD_NRD_1	540	542	PF00675	0.378
CLV_NRD_NRD_1	570	572	PF00675	0.597
CLV_NRD_NRD_1	574	576	PF00675	0.509
CLV_NRD_NRD_1	582	584	PF00675	0.522
CLV_NRD_NRD_1	601	603	PF00675	0.414
CLV_PCSK_FUR_1	567	571	PF00082	0.471
CLV_PCSK_FUR_1	580	584	PF00082	0.415
CLV_PCSK_KEX2_1	153	155	PF00082	0.569
CLV_PCSK_KEX2_1	248	250	PF00082	0.381
CLV_PCSK_KEX2_1	319	321	PF00082	0.403
CLV_PCSK_KEX2_1	420	422	PF00082	0.647
CLV_PCSK_KEX2_1	494	496	PF00082	0.563
CLV_PCSK_KEX2_1	540	542	PF00082	0.378
CLV_PCSK_KEX2_1	567	569	PF00082	0.549
CLV_PCSK_KEX2_1	570	572	PF00082	0.594
CLV_PCSK_KEX2_1	574	576	PF00082	0.506
CLV_PCSK_KEX2_1	582	584	PF00082	0.503
CLV_PCSK_KEX2_1	601	603	PF00082	0.414
CLV_PCSK_PC7_1	570	576	PF00082	0.517
CLV_PCSK_SKI1_1	298	302	PF00082	0.500
DEG_APCC_DBOX_1	262	270	PF00400	0.570
DEG_APCC_DBOX_1	372	380	PF00400	0.354
DEG_APCC_DBOX_1	530	538	PF00400	0.339
DOC_CDC14_PxL_1	312	320	PF14671	0.339
DOC_CYCLIN_yCln2_LP_2	35	41	PF00134	0.623
DOC_MAPK_gen_1	123	132	PF00069	0.548
DOC_MAPK_gen_1	261	268	PF00069	0.579
DOC_MAPK_gen_1	350	358	PF00069	0.328
DOC_MAPK_gen_1	425	433	PF00069	0.402
DOC_MAPK_MEF2A_6	126	134	PF00069	0.500
DOC_MAPK_MEF2A_6	169	177	PF00069	0.368
DOC_MAPK_MEF2A_6	36	45	PF00069	0.603
DOC_MAPK_MEF2A_6	425	433	PF00069	0.402
DOC_MAPK_MEF2A_6	513	522	PF00069	0.300
DOC_PP1_RVXF_1	141	148	PF00149	0.256
DOC_PP2B_LxvP_1	433	436	PF13499	0.446
DOC_PP4_FxxP_1	167	170	PF00568	0.451
DOC_PP4_FxxP_1	313	316	PF00568	0.339
DOC_USP7_MATH_1	11	15	PF00917	0.644
DOC_USP7_MATH_1	179	183	PF00917	0.415
DOC_USP7_MATH_1	193	197	PF00917	0.398
DOC_USP7_MATH_1	226	230	PF00917	0.239
DOC_USP7_MATH_1	393	397	PF00917	0.440
DOC_USP7_MATH_1	441	445	PF00917	0.428
DOC_USP7_MATH_1	590	594	PF00917	0.653
DOC_WW_Pin1_4	162	167	PF00397	0.451
DOC_WW_Pin1_4	20	25	PF00397	0.636
DOC_WW_Pin1_4	235	240	PF00397	0.413
DOC_WW_Pin1_4	358	363	PF00397	0.400
DOC_WW_Pin1_4	431	436	PF00397	0.473
DOC_WW_Pin1_4	444	449	PF00397	0.424
DOC_WW_Pin1_4	596	601	PF00397	0.706
DOC_WW_Pin1_4	611	616	PF00397	0.626
LIG_14-3-3_CanoR_1	157	166	PF00244	0.434
LIG_14-3-3_CanoR_1	263	269	PF00244	0.568
LIG_14-3-3_CanoR_1	354	359	PF00244	0.414
LIG_14-3-3_CanoR_1	411	416	PF00244	0.422
LIG_14-3-3_CanoR_1	531	535	PF00244	0.318
LIG_14-3-3_CanoR_1	602	611	PF00244	0.717
LIG_Actin_RPEL_3	315	334	PF02755	0.311
LIG_ActinCP_TwfCPI_2	167	176	PF01115	0.450
LIG_APCC_ABBA_1	385	390	PF00400	0.360
LIG_BRCT_BRCA1_1	163	167	PF00533	0.456
LIG_CtBP_PxDLS_1	97	101	PF00389	0.290
LIG_DLG_GKlike_1	411	419	PF00625	0.384
LIG_EH1_1	514	522	PF00400	0.300
LIG_eIF4E_1	515	521	PF01652	0.339
LIG_eIF4E_1	55	61	PF01652	0.339
LIG_EVH1_1	25	29	PF00568	0.675
LIG_FHA_1	14	20	PF00498	0.614
LIG_FHA_1	223	229	PF00498	0.244
LIG_FHA_1	285	291	PF00498	0.339
LIG_FHA_1	297	303	PF00498	0.239
LIG_FHA_1	305	311	PF00498	0.199
LIG_FHA_1	367	373	PF00498	0.357
LIG_FHA_1	477	483	PF00498	0.377
LIG_FHA_1	512	518	PF00498	0.300
LIG_FHA_1	60	66	PF00498	0.339
LIG_FHA_1	635	641	PF00498	0.559
LIG_LIR_Apic_2	164	170	PF02991	0.454
LIG_LIR_Gen_1	185	194	PF02991	0.382
LIG_LIR_Gen_1	258	266	PF02991	0.510
LIG_LIR_Gen_1	338	349	PF02991	0.416
LIG_LIR_Gen_1	403	410	PF02991	0.431
LIG_LIR_Gen_1	514	523	PF02991	0.300
LIG_LIR_Gen_1	99	109	PF02991	0.339
LIG_LIR_Nem_3	185	190	PF02991	0.378
LIG_LIR_Nem_3	244	250	PF02991	0.568
LIG_LIR_Nem_3	258	262	PF02991	0.528
LIG_LIR_Nem_3	321	327	PF02991	0.585
LIG_LIR_Nem_3	338	344	PF02991	0.220
LIG_LIR_Nem_3	403	407	PF02991	0.433
LIG_LIR_Nem_3	463	467	PF02991	0.386
LIG_LIR_Nem_3	469	473	PF02991	0.307
LIG_LIR_Nem_3	510	515	PF02991	0.351
LIG_LIR_Nem_3	99	105	PF02991	0.339
LIG_PTB_Apo_2	107	114	PF02174	0.339
LIG_REV1ctd_RIR_1	488	499	PF16727	0.364
LIG_RPA_C_Fungi	416	428	PF08784	0.478
LIG_SH2_CRK	341	345	PF00017	0.339
LIG_SH2_CRK	515	519	PF00017	0.339
LIG_SH2_PTP2	50	53	PF00017	0.332
LIG_SH2_PTP2	55	58	PF00017	0.311
LIG_SH2_SRC	377	380	PF00017	0.427
LIG_SH2_STAP1	117	121	PF00017	0.381
LIG_SH2_STAP1	341	345	PF00017	0.339
LIG_SH2_STAP1	364	368	PF00017	0.415
LIG_SH2_STAP1	377	381	PF00017	0.357
LIG_SH2_STAP1	515	519	PF00017	0.339
LIG_SH2_STAT5	146	149	PF00017	0.339
LIG_SH2_STAT5	284	287	PF00017	0.339
LIG_SH2_STAT5	312	315	PF00017	0.339
LIG_SH2_STAT5	368	371	PF00017	0.432
LIG_SH2_STAT5	460	463	PF00017	0.447
LIG_SH2_STAT5	470	473	PF00017	0.323
LIG_SH2_STAT5	50	53	PF00017	0.332
LIG_SH2_STAT5	55	58	PF00017	0.311
LIG_SH2_STAT5	628	631	PF00017	0.670
LIG_SH3_3	167	173	PF00018	0.546
LIG_SH3_3	209	215	PF00018	0.428
LIG_SH3_3	21	27	PF00018	0.518
LIG_SH3_3	233	239	PF00018	0.339
LIG_SH3_3	4	10	PF00018	0.547
LIG_SH3_3	92	98	PF00018	0.442
LIG_SUMO_SIM_anti_2	299	304	PF11976	0.256
LIG_SUMO_SIM_anti_2	64	69	PF11976	0.337
LIG_SUMO_SIM_par_1	298	304	PF11976	0.339
LIG_SUMO_SIM_par_1	332	338	PF11976	0.334
LIG_SUMO_SIM_par_1	354	361	PF11976	0.385
LIG_SUMO_SIM_par_1	37	42	PF11976	0.502
LIG_SUMO_SIM_par_1	521	528	PF11976	0.339
LIG_SUMO_SIM_par_1	57	62	PF11976	0.199
LIG_SUMO_SIM_par_1	63	69	PF11976	0.298
LIG_TRAF2_1	483	486	PF00917	0.457
LIG_TRFH_1	312	316	PF08558	0.339
LIG_TYR_ITIM	310	315	PF00017	0.339
LIG_TYR_ITIM	402	407	PF00017	0.526
LIG_TYR_ITIM	53	58	PF00017	0.339
LIG_Vh1_VBS_1	134	152	PF01044	0.256
LIG_WRC_WIRS_1	242	247	PF05994	0.429
LIG_WRC_WIRS_1	305	310	PF05994	0.339
LIG_WW_2	26	29	PF00397	0.581
MOD_CDC14_SPxK_1	599	602	PF00782	0.622
MOD_CDK_SPK_2	596	601	PF00069	0.628
MOD_CDK_SPxK_1	596	602	PF00069	0.630
MOD_CDK_SPxxK_3	162	169	PF00069	0.528
MOD_CDK_SPxxK_3	444	451	PF00069	0.488
MOD_CK1_1	159	165	PF00069	0.513
MOD_CK1_1	182	188	PF00069	0.508
MOD_CK1_1	235	241	PF00069	0.356
MOD_CK1_1	357	363	PF00069	0.484
MOD_CK1_1	443	449	PF00069	0.530
MOD_CK1_1	454	460	PF00069	0.377
MOD_CK2_1	640	646	PF00069	0.438
MOD_CMANNOS	539	542	PF00535	0.453
MOD_GlcNHglycan	12	16	PF01048	0.561
MOD_GlcNHglycan	20	23	PF01048	0.492
MOD_GlcNHglycan	337	340	PF01048	0.339
MOD_GlcNHglycan	378	382	PF01048	0.445
MOD_GlcNHglycan	390	394	PF01048	0.415
MOD_GlcNHglycan	527	530	PF01048	0.339
MOD_GlcNHglycan	611	614	PF01048	0.653
MOD_GSK3_1	1	8	PF00069	0.598
MOD_GSK3_1	157	164	PF00069	0.516
MOD_GSK3_1	182	189	PF00069	0.557
MOD_GSK3_1	222	229	PF00069	0.328
MOD_GSK3_1	264	271	PF00069	0.425
MOD_GSK3_1	27	34	PF00069	0.477
MOD_GSK3_1	329	336	PF00069	0.227
MOD_GSK3_1	354	361	PF00069	0.497
MOD_GSK3_1	362	369	PF00069	0.371
MOD_GSK3_1	389	396	PF00069	0.506
MOD_GSK3_1	440	447	PF00069	0.526
MOD_GSK3_1	456	463	PF00069	0.437
MOD_GSK3_1	590	597	PF00069	0.608
MOD_GSK3_1	603	610	PF00069	0.564
MOD_GSK3_1	611	618	PF00069	0.568
MOD_GSK3_1	634	641	PF00069	0.529
MOD_GSK3_1	69	76	PF00069	0.446
MOD_N-GLC_1	454	459	PF02516	0.512
MOD_N-GLC_1	476	481	PF02516	0.432
MOD_NEK2_1	100	105	PF00069	0.339
MOD_NEK2_1	217	222	PF00069	0.339
MOD_NEK2_1	232	237	PF00069	0.235
MOD_NEK2_1	290	295	PF00069	0.428
MOD_NEK2_1	301	306	PF00069	0.263
MOD_NEK2_1	318	323	PF00069	0.358
MOD_NEK2_1	356	361	PF00069	0.391
MOD_NEK2_1	440	445	PF00069	0.487
MOD_NEK2_1	524	529	PF00069	0.339
MOD_NEK2_1	61	66	PF00069	0.338
MOD_NEK2_1	71	76	PF00069	0.379
MOD_NEK2_2	226	231	PF00069	0.256
MOD_NEK2_2	284	289	PF00069	0.339
MOD_NEK2_2	476	481	PF00069	0.432
MOD_PIKK_1	594	600	PF00454	0.621
MOD_PIKK_1	615	621	PF00454	0.635
MOD_PK_1	354	360	PF00069	0.503
MOD_PKA_2	156	162	PF00069	0.498
MOD_PKA_2	179	185	PF00069	0.562
MOD_PKA_2	264	270	PF00069	0.431
MOD_PKA_2	318	324	PF00069	0.474
MOD_PKA_2	530	536	PF00069	0.227
MOD_Plk_1	389	395	PF00069	0.499
MOD_Plk_1	476	482	PF00069	0.437
MOD_Plk_1	607	613	PF00069	0.625
MOD_Plk_1	98	104	PF00069	0.227
MOD_Plk_4	182	188	PF00069	0.555
MOD_Plk_4	208	214	PF00069	0.482
MOD_Plk_4	226	232	PF00069	0.230
MOD_Plk_4	264	270	PF00069	0.431
MOD_Plk_4	284	290	PF00069	0.199
MOD_Plk_4	329	335	PF00069	0.227
MOD_Plk_4	411	417	PF00069	0.456
MOD_Plk_4	456	462	PF00069	0.466
MOD_Plk_4	530	536	PF00069	0.227
MOD_Plk_4	61	67	PF00069	0.339
MOD_ProDKin_1	162	168	PF00069	0.554
MOD_ProDKin_1	20	26	PF00069	0.529
MOD_ProDKin_1	235	241	PF00069	0.407
MOD_ProDKin_1	358	364	PF00069	0.480
MOD_ProDKin_1	431	437	PF00069	0.583
MOD_ProDKin_1	444	450	PF00069	0.512
MOD_ProDKin_1	596	602	PF00069	0.630
MOD_ProDKin_1	611	617	PF00069	0.516
TRG_DiLeu_BaLyEn_6	323	328	PF01217	0.454
TRG_DiLeu_BaLyEn_6	35	40	PF01217	0.513
TRG_DiLeu_BaLyEn_6	351	356	PF01217	0.369
TRG_ENDOCYTIC_2	146	149	PF00928	0.339
TRG_ENDOCYTIC_2	242	245	PF00928	0.414
TRG_ENDOCYTIC_2	312	315	PF00928	0.339
TRG_ENDOCYTIC_2	341	344	PF00928	0.339
TRG_ENDOCYTIC_2	404	407	PF00928	0.530
TRG_ENDOCYTIC_2	470	473	PF00928	0.393
TRG_ENDOCYTIC_2	50	53	PF00928	0.339
TRG_ENDOCYTIC_2	515	518	PF00928	0.339
TRG_ENDOCYTIC_2	55	58	PF00928	0.305
TRG_ER_diArg_1	247	249	PF00400	0.447
TRG_ER_diArg_1	262	265	PF00400	0.351
TRG_ER_diArg_1	318	320	PF00400	0.475
TRG_ER_diArg_1	419	421	PF00400	0.530
TRG_ER_diArg_1	494	496	PF00400	0.429
TRG_ER_diArg_1	539	541	PF00400	0.457
TRG_ER_diArg_1	566	569	PF00400	0.629
TRG_ER_diArg_1	570	572	PF00400	0.672
TRG_ER_diArg_1	573	575	PF00400	0.597
TRG_ER_diArg_1	580	583	PF00400	0.528
TRG_ER_diArg_1	600	602	PF00400	0.619
TRG_ER_diArg_1	75	78	PF00400	0.437
TRG_NES_CRM1_1	264	276	PF08389	0.406
TRG_NES_CRM1_1	42	54	PF08389	0.382
TRG_Pf-PMV_PEXEL_1	374	378	PF00026	0.395

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X0W2	Leishmania donovani	84%	97%
A4I2Z9	Leishmania infantum	84%	97%
E9ADH1	Leishmania major	81%	100%