Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZ92_LEIMU

TriTrypDb:

LmxM.27.1895

Length:

1177

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AZ92

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZ92

PDB structure(s): 7ane_ab

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1013	1017	PF00656	0.462
CLV_C14_Caspase3-7	109	113	PF00656	0.347
CLV_C14_Caspase3-7	202	206	PF00656	0.567
CLV_C14_Caspase3-7	322	326	PF00656	0.474
CLV_C14_Caspase3-7	333	337	PF00656	0.605
CLV_C14_Caspase3-7	828	832	PF00656	0.363
CLV_C14_Caspase3-7	849	853	PF00656	0.385
CLV_NRD_NRD_1	1026	1028	PF00675	0.376
CLV_NRD_NRD_1	1149	1151	PF00675	0.355
CLV_NRD_NRD_1	331	333	PF00675	0.590
CLV_NRD_NRD_1	341	343	PF00675	0.454
CLV_NRD_NRD_1	362	364	PF00675	0.593
CLV_NRD_NRD_1	386	388	PF00675	0.425
CLV_NRD_NRD_1	399	401	PF00675	0.523
CLV_NRD_NRD_1	418	420	PF00675	0.390
CLV_NRD_NRD_1	511	513	PF00675	0.328
CLV_NRD_NRD_1	534	536	PF00675	0.394
CLV_NRD_NRD_1	690	692	PF00675	0.350
CLV_NRD_NRD_1	864	866	PF00675	0.447
CLV_NRD_NRD_1	926	928	PF00675	0.364
CLV_NRD_NRD_1	940	942	PF00675	0.389
CLV_NRD_NRD_1	948	950	PF00675	0.392
CLV_NRD_NRD_1	95	97	PF00675	0.454
CLV_PCSK_FUR_1	688	692	PF00082	0.423
CLV_PCSK_FUR_1	861	865	PF00082	0.362
CLV_PCSK_KEX2_1	1026	1028	PF00082	0.377
CLV_PCSK_KEX2_1	330	332	PF00082	0.605
CLV_PCSK_KEX2_1	362	364	PF00082	0.453
CLV_PCSK_KEX2_1	386	388	PF00082	0.545
CLV_PCSK_KEX2_1	399	401	PF00082	0.536
CLV_PCSK_KEX2_1	418	420	PF00082	0.390
CLV_PCSK_KEX2_1	511	513	PF00082	0.322
CLV_PCSK_KEX2_1	534	536	PF00082	0.393
CLV_PCSK_KEX2_1	690	692	PF00082	0.355
CLV_PCSK_KEX2_1	863	865	PF00082	0.431
CLV_PCSK_KEX2_1	926	928	PF00082	0.369
CLV_PCSK_KEX2_1	940	942	PF00082	0.402
CLV_PCSK_KEX2_1	948	950	PF00082	0.383
CLV_PCSK_KEX2_1	95	97	PF00082	0.453
CLV_PCSK_SKI1_1	1093	1097	PF00082	0.382
CLV_PCSK_SKI1_1	1156	1160	PF00082	0.437
CLV_PCSK_SKI1_1	126	130	PF00082	0.579
CLV_PCSK_SKI1_1	140	144	PF00082	0.624
CLV_PCSK_SKI1_1	363	367	PF00082	0.472
CLV_PCSK_SKI1_1	387	391	PF00082	0.533
CLV_PCSK_SKI1_1	534	538	PF00082	0.454
CLV_PCSK_SKI1_1	620	624	PF00082	0.328
CLV_PCSK_SKI1_1	633	637	PF00082	0.352
CLV_PCSK_SKI1_1	773	777	PF00082	0.428
CLV_PCSK_SKI1_1	901	905	PF00082	0.377
CLV_PCSK_SKI1_1	999	1003	PF00082	0.375
DEG_APCC_DBOX_1	1092	1100	PF00400	0.476
DEG_APCC_DBOX_1	510	518	PF00400	0.393
DEG_APCC_DBOX_1	534	542	PF00400	0.344
DEG_SPOP_SBC_1	12	16	PF00917	0.601
DEG_SPOP_SBC_1	181	185	PF00917	0.733
DEG_SPOP_SBC_1	961	965	PF00917	0.401
DOC_CYCLIN_RxL_1	531	540	PF00134	0.505
DOC_CYCLIN_RxL_1	616	625	PF00134	0.360
DOC_CYCLIN_yCln2_LP_2	36	42	PF00134	0.530
DOC_CYCLIN_yCln2_LP_2	800	806	PF00134	0.494
DOC_MAPK_MEF2A_6	773	782	PF00069	0.375
DOC_PP1_RVXF_1	618	625	PF00149	0.474
DOC_PP2B_LxvP_1	800	803	PF13499	0.486
DOC_PP4_FxxP_1	1126	1129	PF00568	0.428
DOC_PP4_FxxP_1	895	898	PF00568	0.365
DOC_USP7_MATH_1	107	111	PF00917	0.429
DOC_USP7_MATH_1	12	16	PF00917	0.722
DOC_USP7_MATH_1	179	183	PF00917	0.610
DOC_USP7_MATH_1	188	192	PF00917	0.494
DOC_USP7_MATH_1	546	550	PF00917	0.346
DOC_USP7_MATH_1	753	757	PF00917	0.430
DOC_USP7_MATH_1	85	89	PF00917	0.550
DOC_USP7_UBL2_3	1106	1110	PF12436	0.388
DOC_USP7_UBL2_3	728	732	PF12436	0.531
DOC_WW_Pin1_4	1036	1041	PF00397	0.343
DOC_WW_Pin1_4	1100	1105	PF00397	0.398
DOC_WW_Pin1_4	177	182	PF00397	0.343
DOC_WW_Pin1_4	35	40	PF00397	0.613
DOC_WW_Pin1_4	542	547	PF00397	0.349
DOC_WW_Pin1_4	574	579	PF00397	0.299
DOC_WW_Pin1_4	749	754	PF00397	0.498
DOC_WW_Pin1_4	773	778	PF00397	0.425
DOC_WW_Pin1_4	843	848	PF00397	0.376
LIG_14-3-3_CanoR_1	1135	1142	PF00244	0.400
LIG_14-3-3_CanoR_1	114	120	PF00244	0.509
LIG_14-3-3_CanoR_1	362	366	PF00244	0.510
LIG_14-3-3_CanoR_1	386	396	PF00244	0.496
LIG_14-3-3_CanoR_1	399	406	PF00244	0.403
LIG_14-3-3_CanoR_1	433	437	PF00244	0.531
LIG_14-3-3_CanoR_1	534	539	PF00244	0.474
LIG_14-3-3_CanoR_1	901	906	PF00244	0.444
LIG_14-3-3_CanoR_1	994	1001	PF00244	0.383
LIG_ActinCP_TwfCPI_2	1126	1135	PF01115	0.428
LIG_APCC_ABBA_1	465	470	PF00400	0.428
LIG_APCC_ABBA_1	477	482	PF00400	0.405
LIG_BIR_II_1	1	5	PF00653	0.556
LIG_BRCT_BRCA1_1	104	108	PF00533	0.431
LIG_BRCT_BRCA1_1	1065	1069	PF00533	0.406
LIG_Clathr_ClatBox_1	621	625	PF01394	0.368
LIG_deltaCOP1_diTrp_1	1005	1010	PF00928	0.427
LIG_deltaCOP1_diTrp_1	497	501	PF00928	0.306
LIG_eIF4E_1	617	623	PF01652	0.354
LIG_FHA_1	1058	1064	PF00498	0.553
LIG_FHA_1	1150	1156	PF00498	0.511
LIG_FHA_1	241	247	PF00498	0.468
LIG_FHA_1	318	324	PF00498	0.416
LIG_FHA_1	634	640	PF00498	0.460
LIG_FHA_1	717	723	PF00498	0.423
LIG_FHA_1	762	768	PF00498	0.305
LIG_FHA_1	789	795	PF00498	0.426
LIG_FHA_1	996	1002	PF00498	0.379
LIG_FHA_2	1000	1006	PF00498	0.395
LIG_FHA_2	1037	1043	PF00498	0.346
LIG_FHA_2	107	113	PF00498	0.522
LIG_FHA_2	1111	1117	PF00498	0.404
LIG_FHA_2	306	312	PF00498	0.474
LIG_FHA_2	367	373	PF00498	0.452
LIG_FHA_2	386	392	PF00498	0.301
LIG_FHA_2	525	531	PF00498	0.376
LIG_FHA_2	535	541	PF00498	0.354
LIG_FHA_2	543	549	PF00498	0.462
LIG_FHA_2	577	583	PF00498	0.342
LIG_FHA_2	847	853	PF00498	0.385
LIG_FHA_2	932	938	PF00498	0.379
LIG_LIR_Apic_2	435	441	PF02991	0.490
LIG_LIR_Apic_2	463	467	PF02991	0.350
LIG_LIR_Apic_2	50	55	PF02991	0.381
LIG_LIR_Gen_1	1005	1015	PF02991	0.413
LIG_LIR_Gen_1	1039	1049	PF02991	0.396
LIG_LIR_Gen_1	411	421	PF02991	0.291
LIG_LIR_Gen_1	484	493	PF02991	0.375
LIG_LIR_Gen_1	497	506	PF02991	0.301
LIG_LIR_Nem_3	1005	1010	PF02991	0.401
LIG_LIR_Nem_3	1016	1021	PF02991	0.341
LIG_LIR_Nem_3	1039	1044	PF02991	0.366
LIG_LIR_Nem_3	1066	1071	PF02991	0.420
LIG_LIR_Nem_3	1113	1117	PF02991	0.484
LIG_LIR_Nem_3	411	417	PF02991	0.418
LIG_LIR_Nem_3	463	468	PF02991	0.371
LIG_LIR_Nem_3	484	489	PF02991	0.440
LIG_LIR_Nem_3	497	501	PF02991	0.249
LIG_LIR_Nem_3	681	686	PF02991	0.504
LIG_LIR_Nem_3	697	702	PF02991	0.530
LIG_LIR_Nem_3	764	768	PF02991	0.374
LIG_LIR_Nem_3	792	798	PF02991	0.415
LIG_LYPXL_yS_3	76	79	PF13949	0.532
LIG_MAD2	886	894	PF02301	0.507
LIG_MLH1_MIPbox_1	1065	1069	PF16413	0.406
LIG_PAM2_1	292	304	PF00658	0.321
LIG_PCNA_yPIPBox_3	443	457	PF02747	0.352
LIG_PDZ_Class_2	1172	1177	PF00595	0.410
LIG_Pex14_1	569	573	PF04695	0.317
LIG_Pex14_1	631	635	PF04695	0.476
LIG_Pex14_1	924	928	PF04695	0.375
LIG_Pex14_2	627	631	PF04695	0.439
LIG_RPA_C_Fungi	326	338	PF08784	0.332
LIG_RPA_C_Fungi	611	623	PF08784	0.265
LIG_SH2_CRK	1018	1022	PF00017	0.268
LIG_SH2_CRK	438	442	PF00017	0.479
LIG_SH2_CRK	707	711	PF00017	0.410
LIG_SH2_CRK	891	895	PF00017	0.403
LIG_SH2_GRB2like	1088	1091	PF00017	0.428
LIG_SH2_NCK_1	192	196	PF00017	0.489
LIG_SH2_NCK_1	650	654	PF00017	0.435
LIG_SH2_NCK_1	89	93	PF00017	0.396
LIG_SH2_NCK_1	942	946	PF00017	0.476
LIG_SH2_PTP2	573	576	PF00017	0.439
LIG_SH2_PTP2	950	953	PF00017	0.393
LIG_SH2_SRC	950	953	PF00017	0.378
LIG_SH2_STAP1	1088	1092	PF00017	0.504
LIG_SH2_STAP1	211	215	PF00017	0.469
LIG_SH2_STAP1	89	93	PF00017	0.444
LIG_SH2_STAT3	1029	1032	PF00017	0.482
LIG_SH2_STAT3	59	62	PF00017	0.381
LIG_SH2_STAT3	671	674	PF00017	0.462
LIG_SH2_STAT3	890	893	PF00017	0.364
LIG_SH2_STAT5	1029	1032	PF00017	0.388
LIG_SH2_STAT5	1034	1037	PF00017	0.341
LIG_SH2_STAT5	1038	1041	PF00017	0.339
LIG_SH2_STAT5	1067	1070	PF00017	0.402
LIG_SH2_STAT5	1084	1087	PF00017	0.352
LIG_SH2_STAT5	192	195	PF00017	0.624
LIG_SH2_STAT5	464	467	PF00017	0.350
LIG_SH2_STAT5	573	576	PF00017	0.387
LIG_SH2_STAT5	659	662	PF00017	0.439
LIG_SH2_STAT5	671	674	PF00017	0.326
LIG_SH2_STAT5	692	695	PF00017	0.439
LIG_SH2_STAT5	765	768	PF00017	0.512
LIG_SH2_STAT5	826	829	PF00017	0.317
LIG_SH2_STAT5	950	953	PF00017	0.378
LIG_SH3_2	856	861	PF14604	0.506
LIG_SH3_3	1166	1172	PF00018	0.346
LIG_SH3_3	18	24	PF00018	0.749
LIG_SH3_3	269	275	PF00018	0.564
LIG_SH3_3	36	42	PF00018	0.440
LIG_SH3_3	6	12	PF00018	0.612
LIG_SH3_3	853	859	PF00018	0.437
LIG_SH3_3	950	956	PF00018	0.393
LIG_SUMO_SIM_anti_2	513	518	PF11976	0.490
LIG_SUMO_SIM_par_1	1019	1024	PF11976	0.356
LIG_SUMO_SIM_par_1	721	726	PF11976	0.473
LIG_TRAF2_1	1045	1048	PF00917	0.358
LIG_TRAF2_1	278	281	PF00917	0.474
LIG_TRAF2_1	309	312	PF00917	0.511
LIG_TRAF2_1	839	842	PF00917	0.475
LIG_TRAF2_2	247	252	PF00917	0.405
LIG_WRPW_2	465	468	PF00400	0.378
MOD_CDK_SPxK_1	1100	1106	PF00069	0.413
MOD_CK1_1	182	188	PF00069	0.726
MOD_CK1_1	3	9	PF00069	0.774
MOD_CK1_1	749	755	PF00069	0.604
MOD_CK1_1	771	777	PF00069	0.539
MOD_CK1_1	784	790	PF00069	0.492
MOD_CK1_1	846	852	PF00069	0.387
MOD_CK1_1	962	968	PF00069	0.672
MOD_CK2_1	1036	1042	PF00069	0.359
MOD_CK2_1	1110	1116	PF00069	0.401
MOD_CK2_1	119	125	PF00069	0.498
MOD_CK2_1	196	202	PF00069	0.572
MOD_CK2_1	274	280	PF00069	0.457
MOD_CK2_1	305	311	PF00069	0.505
MOD_CK2_1	366	372	PF00069	0.483
MOD_CK2_1	442	448	PF00069	0.413
MOD_CK2_1	524	530	PF00069	0.377
MOD_CK2_1	534	540	PF00069	0.331
MOD_CK2_1	576	582	PF00069	0.330
MOD_CK2_1	931	937	PF00069	0.316
MOD_Cter_Amidation	688	691	PF01082	0.457
MOD_GlcNHglycan	1136	1139	PF01048	0.543
MOD_GlcNHglycan	140	143	PF01048	0.595
MOD_GlcNHglycan	157	160	PF01048	0.348
MOD_GlcNHglycan	184	187	PF01048	0.629
MOD_GlcNHglycan	198	201	PF01048	0.582
MOD_GlcNHglycan	2	5	PF01048	0.767
MOD_GlcNHglycan	256	259	PF01048	0.383
MOD_GlcNHglycan	332	335	PF01048	0.541
MOD_GlcNHglycan	725	728	PF01048	0.478
MOD_GlcNHglycan	732	735	PF01048	0.562
MOD_GlcNHglycan	783	786	PF01048	0.434
MOD_GlcNHglycan	795	798	PF01048	0.360
MOD_GlcNHglycan	804	807	PF01048	0.532
MOD_GlcNHglycan	81	84	PF01048	0.552
MOD_GlcNHglycan	965	968	PF01048	0.626
MOD_GSK3_1	102	109	PF00069	0.567
MOD_GSK3_1	1063	1070	PF00069	0.390
MOD_GSK3_1	1145	1152	PF00069	0.402
MOD_GSK3_1	155	162	PF00069	0.514
MOD_GSK3_1	177	184	PF00069	0.602
MOD_GSK3_1	23	30	PF00069	0.458
MOD_GSK3_1	428	435	PF00069	0.463
MOD_GSK3_1	542	549	PF00069	0.325
MOD_GSK3_1	576	583	PF00069	0.541
MOD_GSK3_1	612	619	PF00069	0.295
MOD_GSK3_1	747	754	PF00069	0.613
MOD_GSK3_1	784	791	PF00069	0.531
MOD_GSK3_1	81	88	PF00069	0.629
MOD_GSK3_1	959	966	PF00069	0.625
MOD_GSK3_1	995	1002	PF00069	0.387
MOD_LATS_1	328	334	PF00433	0.501
MOD_N-GLC_1	1071	1076	PF02516	0.499
MOD_N-GLC_1	145	150	PF02516	0.478
MOD_N-GLC_1	306	311	PF02516	0.540
MOD_N-GLC_1	524	529	PF02516	0.396
MOD_NEK2_1	1010	1015	PF00069	0.406
MOD_NEK2_1	1021	1026	PF00069	0.343
MOD_NEK2_1	106	111	PF00069	0.313
MOD_NEK2_1	1071	1076	PF00069	0.499
MOD_NEK2_1	155	160	PF00069	0.486
MOD_NEK2_1	240	245	PF00069	0.463
MOD_NEK2_1	449	454	PF00069	0.511
MOD_NEK2_1	547	552	PF00069	0.423
MOD_NEK2_1	723	728	PF00069	0.461
MOD_NEK2_1	730	735	PF00069	0.525
MOD_NEK2_1	79	84	PF00069	0.535
MOD_PIKK_1	127	133	PF00454	0.428
MOD_PIKK_1	826	832	PF00454	0.323
MOD_PK_1	1019	1025	PF00069	0.360
MOD_PKA_1	330	336	PF00069	0.506
MOD_PKA_1	366	372	PF00069	0.439
MOD_PKA_1	399	405	PF00069	0.461
MOD_PKA_1	534	540	PF00069	0.286
MOD_PKA_2	113	119	PF00069	0.470
MOD_PKA_2	1134	1140	PF00069	0.411
MOD_PKA_2	1149	1155	PF00069	0.439
MOD_PKA_2	155	161	PF00069	0.549
MOD_PKA_2	241	247	PF00069	0.456
MOD_PKA_2	254	260	PF00069	0.456
MOD_PKA_2	330	336	PF00069	0.467
MOD_PKA_2	361	367	PF00069	0.516
MOD_PKA_2	385	391	PF00069	0.473
MOD_PKA_2	399	405	PF00069	0.386
MOD_PKA_2	432	438	PF00069	0.468
MOD_PKA_2	534	540	PF00069	0.474
MOD_PKA_2	984	990	PF00069	0.505
MOD_PKA_2	995	1001	PF00069	0.381
MOD_Plk_1	1071	1077	PF00069	0.500
MOD_Plk_1	145	151	PF00069	0.472
MOD_Plk_1	771	777	PF00069	0.456
MOD_Plk_1	931	937	PF00069	0.396
MOD_Plk_4	1063	1069	PF00069	0.410
MOD_Plk_4	576	582	PF00069	0.326
MOD_Plk_4	753	759	PF00069	0.566
MOD_Plk_4	761	767	PF00069	0.455
MOD_ProDKin_1	1036	1042	PF00069	0.344
MOD_ProDKin_1	1100	1106	PF00069	0.398
MOD_ProDKin_1	177	183	PF00069	0.359
MOD_ProDKin_1	35	41	PF00069	0.613
MOD_ProDKin_1	542	548	PF00069	0.351
MOD_ProDKin_1	574	580	PF00069	0.299
MOD_ProDKin_1	749	755	PF00069	0.487
MOD_ProDKin_1	773	779	PF00069	0.428
MOD_ProDKin_1	843	849	PF00069	0.380
MOD_SUMO_rev_2	1143	1152	PF00179	0.445
MOD_SUMO_rev_2	158	166	PF00179	0.552
MOD_SUMO_rev_2	233	240	PF00179	0.539
MOD_SUMO_rev_2	310	315	PF00179	0.598
MOD_SUMO_rev_2	556	561	PF00179	0.485
TRG_DiLeu_BaEn_1	484	489	PF01217	0.327
TRG_DiLeu_BaLyEn_6	370	375	PF01217	0.515
TRG_DiLeu_BaLyEn_6	617	622	PF01217	0.371
TRG_ENDOCYTIC_2	1018	1021	PF00928	0.260
TRG_ENDOCYTIC_2	1114	1117	PF00928	0.400
TRG_ENDOCYTIC_2	480	483	PF00928	0.356
TRG_ENDOCYTIC_2	699	702	PF00928	0.360
TRG_ENDOCYTIC_2	76	79	PF00928	0.532
TRG_ENDOCYTIC_2	765	768	PF00928	0.461
TRG_ENDOCYTIC_2	950	953	PF00928	0.400
TRG_ER_diArg_1	330	332	PF00400	0.464
TRG_ER_diArg_1	385	387	PF00400	0.556
TRG_ER_diArg_1	398	400	PF00400	0.546
TRG_ER_diArg_1	417	419	PF00400	0.304
TRG_ER_diArg_1	534	536	PF00400	0.452
TRG_ER_diArg_1	688	691	PF00400	0.368
TRG_ER_diArg_1	860	863	PF00400	0.351
TRG_ER_diArg_1	864	866	PF00400	0.398
TRG_ER_diArg_1	884	887	PF00400	0.484
TRG_ER_diArg_1	926	928	PF00400	0.369
TRG_ER_diArg_1	940	942	PF00400	0.402
TRG_ER_diArg_1	947	949	PF00400	0.370
TRG_NLS_Bipartite_1	330	346	PF00514	0.496
TRG_Pf-PMV_PEXEL_1	118	123	PF00026	0.600
TRG_Pf-PMV_PEXEL_1	387	391	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	534	539	PF00026	0.443
TRG_Pf-PMV_PEXEL_1	620	625	PF00026	0.369
TRG_Pf-PMV_PEXEL_1	691	695	PF00026	0.413

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3K9	Leptomonas seymouri	76%	94%
A0A0S4JLH0	Bodo saltans	46%	100%
A0A1X0NRH4	Trypanosomatidae	59%	98%
A0A3S7X0V6	Leishmania donovani	95%	100%
A0A422NJT2	Trypanosoma rangeli	61%	100%
A4HFW4	Leishmania braziliensis	88%	100%
A4I2Z6	Leishmania infantum	95%	89%
C9ZJE4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9ADG8	Leishmania major	94%	100%
V5BN80	Trypanosoma cruzi	61%	100%