Putative endo/exonuclease Mre11

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

endo/exonuclease Mre11, putative

Species:

Leishmania mexicana

UniProt:

E9AZ91_LEIMU

TriTrypDb:

LmxM.27.1890

Length:

858

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	5
GO:0043226	organelle	2	5
GO:0043227	membrane-bounded organelle	3	5
GO:0043229	intracellular organelle	3	5
GO:0043231	intracellular membrane-bounded organelle	4	5
GO:0110165	cellular anatomical entity	1	6
GO:0030870	Mre11 complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0035861	site of double-strand break	3	1
GO:0090734	site of DNA damage	2	1
GO:0140513	nuclear protein-containing complex	2	2

Expansion

Sequence features

E9AZ91

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZ91

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006259	DNA metabolic process	4	7
GO:0006281	DNA repair	5	7
GO:0006302	double-strand break repair	6	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0006950	response to stress	2	7
GO:0006974	DNA damage response	4	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0033554	cellular response to stress	3	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044260	obsolete cellular macromolecule metabolic process	3	7
GO:0046483	heterocycle metabolic process	3	7
GO:0050896	response to stimulus	1	7
GO:0051716	cellular response to stimulus	2	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:0000075	cell cycle checkpoint signaling	4	1
GO:0000077	DNA damage checkpoint signaling	5	1
GO:0000723	telomere maintenance	5	1
GO:0000724	double-strand break repair via homologous recombination	7	1
GO:0000725	recombinational repair	6	1
GO:0006303	double-strand break repair via nonhomologous end joining	7	1
GO:0006310	DNA recombination	5	1
GO:0006996	organelle organization	4	1
GO:0007093	mitotic cell cycle checkpoint signaling	4	1
GO:0007095	mitotic G2 DNA damage checkpoint signaling	6	1
GO:0007165	signal transduction	2	1
GO:0007346	regulation of mitotic cell cycle	5	1
GO:0010389	regulation of G2/M transition of mitotic cell cycle	7	1
GO:0010564	regulation of cell cycle process	5	1
GO:0010948	negative regulation of cell cycle process	6	1
GO:0010972	negative regulation of G2/M transition of mitotic cell cycle	8	1
GO:0016043	cellular component organization	3	1
GO:0022402	cell cycle process	2	1
GO:0022414	reproductive process	1	2
GO:0031570	DNA integrity checkpoint signaling	5	1
GO:0032200	telomere organization	6	1
GO:0035556	intracellular signal transduction	3	1
GO:0042138	meiotic DNA double-strand break formation	4	1
GO:0042770	signal transduction in response to DNA damage	4	1
GO:0044773	mitotic DNA damage checkpoint signaling	6	1
GO:0044774	mitotic DNA integrity checkpoint signaling	5	1
GO:0044818	mitotic G2/M transition checkpoint	5	1
GO:0045786	negative regulation of cell cycle	5	1
GO:0045930	negative regulation of mitotic cell cycle	6	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051276	chromosome organization	5	1
GO:0051726	regulation of cell cycle	4	1
GO:0061982	meiosis I cell cycle process	3	1
GO:0065007	biological regulation	1	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1
GO:0097551	mitochondrial double-strand break repair	7	1
GO:0097552	mitochondrial double-strand break repair via homologous recombination	7	1
GO:1901987	regulation of cell cycle phase transition	6	1
GO:1901988	negative regulation of cell cycle phase transition	7	1
GO:1901990	regulation of mitotic cell cycle phase transition	6	1
GO:1901991	negative regulation of mitotic cell cycle phase transition	7	1
GO:1902749	regulation of cell cycle G2/M phase transition	7	1
GO:1902750	negative regulation of cell cycle G2/M phase transition	8	1
GO:1903046	meiotic cell cycle process	2	1
GO:1903047	mitotic cell cycle process	3	1
GO:0007049	cell cycle	2	1
GO:0051321	meiotic cell cycle	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004518	nuclease activity	4	7
GO:0004519	endonuclease activity	5	7
GO:0004527	exonuclease activity	5	7
GO:0005488	binding	1	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0030145	manganese ion binding	6	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0046914	transition metal ion binding	5	7
GO:0000014	single-stranded DNA endodeoxyribonuclease activity	6	1
GO:0004520	DNA endonuclease activity	5	2
GO:0004536	DNA nuclease activity	4	2
GO:0140097	catalytic activity, acting on DNA	3	2
GO:0140640	catalytic activity, acting on a nucleic acid	2	2
GO:0004529	DNA exonuclease activity	5	1
GO:0008296	3'-5'-DNA exonuclease activity	7	1
GO:0008408	3'-5' exonuclease activity	6	1
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	1
GO:0016895	DNA exonuclease activity, producing 5'-phosphomonoesters	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	311	315	PF00656	0.475
CLV_C14_Caspase3-7	751	755	PF00656	0.533
CLV_NRD_NRD_1	161	163	PF00675	0.326
CLV_NRD_NRD_1	200	202	PF00675	0.286
CLV_NRD_NRD_1	24	26	PF00675	0.312
CLV_NRD_NRD_1	303	305	PF00675	0.275
CLV_NRD_NRD_1	405	407	PF00675	0.286
CLV_NRD_NRD_1	496	498	PF00675	0.467
CLV_NRD_NRD_1	574	576	PF00675	0.593
CLV_NRD_NRD_1	642	644	PF00675	0.653
CLV_NRD_NRD_1	73	75	PF00675	0.313
CLV_NRD_NRD_1	772	774	PF00675	0.762
CLV_PCSK_FUR_1	640	644	PF00082	0.651
CLV_PCSK_KEX2_1	24	26	PF00082	0.312
CLV_PCSK_KEX2_1	303	305	PF00082	0.275
CLV_PCSK_KEX2_1	405	407	PF00082	0.286
CLV_PCSK_KEX2_1	496	498	PF00082	0.474
CLV_PCSK_KEX2_1	520	522	PF00082	0.470
CLV_PCSK_KEX2_1	574	576	PF00082	0.590
CLV_PCSK_KEX2_1	642	644	PF00082	0.653
CLV_PCSK_KEX2_1	691	693	PF00082	0.650
CLV_PCSK_KEX2_1	772	774	PF00082	0.762
CLV_PCSK_PC1ET2_1	520	522	PF00082	0.470
CLV_PCSK_PC1ET2_1	691	693	PF00082	0.650
CLV_PCSK_PC7_1	299	305	PF00082	0.275
CLV_PCSK_SKI1_1	397	401	PF00082	0.277
CLV_PCSK_SKI1_1	7	11	PF00082	0.315
CLV_PCSK_SKI1_1	75	79	PF00082	0.342
CLV_PCSK_SKI1_1	826	830	PF00082	0.664
CLV_Separin_Metazoa	35	39	PF03568	0.312
CLV_Separin_Metazoa	394	398	PF03568	0.475
CLV_Separin_Metazoa	581	585	PF03568	0.589
DEG_SCF_TRCP1_1	596	601	PF00400	0.611
DOC_CYCLIN_RxL_1	4	13	PF00134	0.312
DOC_CYCLIN_yCln2_LP_2	395	401	PF00134	0.529
DOC_MAPK_FxFP_2	192	195	PF00069	0.291
DOC_MAPK_gen_1	162	170	PF00069	0.350
DOC_MAPK_gen_1	183	192	PF00069	0.313
DOC_MAPK_gen_1	201	209	PF00069	0.312
DOC_MAPK_MEF2A_6	355	363	PF00069	0.475
DOC_PP1_RVXF_1	186	193	PF00149	0.291
DOC_PP1_SILK_1	504	509	PF00149	0.585
DOC_PP2B_LxvP_1	246	249	PF13499	0.397
DOC_PP2B_LxvP_1	429	432	PF13499	0.510
DOC_PP2B_PxIxI_1	107	113	PF00149	0.285
DOC_PP4_FxxP_1	105	108	PF00568	0.312
DOC_PP4_FxxP_1	192	195	PF00568	0.330
DOC_USP7_MATH_1	415	419	PF00917	0.424
DOC_USP7_MATH_1	502	506	PF00917	0.507
DOC_USP7_MATH_1	564	568	PF00917	0.688
DOC_USP7_MATH_1	610	614	PF00917	0.668
DOC_USP7_MATH_1	674	678	PF00917	0.691
DOC_USP7_MATH_1	836	840	PF00917	0.565
DOC_WW_Pin1_4	288	293	PF00397	0.492
DOC_WW_Pin1_4	562	567	PF00397	0.646
DOC_WW_Pin1_4	755	760	PF00397	0.533
LIG_14-3-3_CanoR_1	162	168	PF00244	0.312
LIG_14-3-3_CanoR_1	284	289	PF00244	0.447
LIG_14-3-3_CanoR_1	303	307	PF00244	0.503
LIG_14-3-3_CanoR_1	38	46	PF00244	0.317
LIG_14-3-3_CanoR_1	68	73	PF00244	0.312
LIG_14-3-3_CanoR_1	692	701	PF00244	0.639
LIG_14-3-3_CanoR_1	826	831	PF00244	0.604
LIG_Actin_WH2_2	147	164	PF00022	0.388
LIG_Actin_WH2_2	382	399	PF00022	0.475
LIG_BIR_II_1	1	5	PF00653	0.525
LIG_EH1_1	43	51	PF00400	0.312
LIG_FHA_1	128	134	PF00498	0.312
LIG_FHA_1	3	9	PF00498	0.291
LIG_FHA_1	303	309	PF00498	0.537
LIG_FHA_1	434	440	PF00498	0.475
LIG_FHA_1	528	534	PF00498	0.409
LIG_FHA_1	723	729	PF00498	0.813
LIG_FHA_1	95	101	PF00498	0.414
LIG_FHA_2	147	153	PF00498	0.319
LIG_FHA_2	29	35	PF00498	0.312
LIG_FHA_2	40	46	PF00498	0.312
LIG_Integrin_RGD_1	25	27	PF01839	0.312
LIG_LIR_Apic_2	370	376	PF02991	0.475
LIG_LIR_Gen_1	165	173	PF02991	0.354
LIG_LIR_Gen_1	253	260	PF02991	0.399
LIG_LIR_Gen_1	27	37	PF02991	0.312
LIG_LIR_Gen_1	364	373	PF02991	0.475
LIG_LIR_Gen_1	578	588	PF02991	0.590
LIG_LIR_Nem_3	138	144	PF02991	0.312
LIG_LIR_Nem_3	165	170	PF02991	0.354
LIG_LIR_Nem_3	253	258	PF02991	0.411
LIG_LIR_Nem_3	27	33	PF02991	0.312
LIG_LIR_Nem_3	3	9	PF02991	0.312
LIG_LIR_Nem_3	364	368	PF02991	0.483
LIG_LIR_Nem_3	493	498	PF02991	0.452
LIG_LIR_Nem_3	71	76	PF02991	0.312
LIG_LYPXL_yS_3	356	359	PF13949	0.475
LIG_NRBOX	482	488	PF00104	0.451
LIG_PALB2_WD40_1	199	207	PF16756	0.312
LIG_PCNA_yPIPBox_3	216	229	PF02747	0.291
LIG_Pex14_2	605	609	PF04695	0.708
LIG_SH2_GRB2like	141	144	PF00017	0.312
LIG_SH2_STAP1	527	531	PF00017	0.505
LIG_SH2_STAT5	141	144	PF00017	0.312
LIG_SH2_STAT5	293	296	PF00017	0.475
LIG_SH2_STAT5	76	79	PF00017	0.312
LIG_SH3_3	109	115	PF00018	0.312
LIG_SH3_3	245	251	PF00018	0.437
LIG_SH3_3	254	260	PF00018	0.404
LIG_SH3_3	386	392	PF00018	0.475
LIG_SH3_3	395	401	PF00018	0.475
LIG_SH3_3	683	689	PF00018	0.683
LIG_SH3_3	817	823	PF00018	0.692
LIG_SUMO_SIM_anti_2	130	138	PF11976	0.314
LIG_TRAF2_1	269	272	PF00917	0.423
LIG_TRAF2_1	32	35	PF00917	0.312
LIG_TRFH_1	288	292	PF08558	0.475
LIG_TYR_ITIM	354	359	PF00017	0.488
LIG_UBA3_1	483	492	PF00899	0.448
LIG_WRC_WIRS_1	30	35	PF05994	0.312
LIG_WRC_WIRS_1	321	326	PF05994	0.475
MOD_CK1_1	2	8	PF00069	0.470
MOD_CK1_1	29	35	PF00069	0.312
MOD_CK1_1	327	333	PF00069	0.478
MOD_CK1_1	490	496	PF00069	0.446
MOD_CK1_1	848	854	PF00069	0.578
MOD_CK1_1	86	92	PF00069	0.315
MOD_CK2_1	146	152	PF00069	0.300
MOD_CK2_1	266	272	PF00069	0.418
MOD_CK2_1	28	34	PF00069	0.312
MOD_CK2_1	331	337	PF00069	0.529
MOD_CK2_1	456	462	PF00069	0.475
MOD_CK2_1	552	558	PF00069	0.609
MOD_CK2_1	596	602	PF00069	0.671
MOD_Cter_Amidation	199	202	PF01082	0.285
MOD_GlcNHglycan	268	271	PF01048	0.552
MOD_GlcNHglycan	369	372	PF01048	0.302
MOD_GlcNHglycan	417	420	PF01048	0.272
MOD_GlcNHglycan	462	466	PF01048	0.275
MOD_GlcNHglycan	596	599	PF01048	0.727
MOD_GlcNHglycan	694	697	PF01048	0.686
MOD_GlcNHglycan	778	781	PF01048	0.595
MOD_GlcNHglycan	787	790	PF01048	0.521
MOD_GlcNHglycan	798	801	PF01048	0.606
MOD_GlcNHglycan	817	820	PF01048	0.539
MOD_GlcNHglycan	832	835	PF01048	0.773
MOD_GSK3_1	259	266	PF00069	0.391
MOD_GSK3_1	284	291	PF00069	0.425
MOD_GSK3_1	320	327	PF00069	0.511
MOD_GSK3_1	363	370	PF00069	0.499
MOD_GSK3_1	411	418	PF00069	0.400
MOD_GSK3_1	486	493	PF00069	0.478
MOD_GSK3_1	560	567	PF00069	0.549
MOD_GSK3_1	594	601	PF00069	0.630
MOD_GSK3_1	605	612	PF00069	0.640
MOD_GSK3_1	783	790	PF00069	0.505
MOD_GSK3_1	822	829	PF00069	0.615
MOD_GSK3_1	86	93	PF00069	0.371
MOD_N-GLC_1	502	507	PF02516	0.588
MOD_N-GLC_2	453	455	PF02516	0.329
MOD_NEK2_1	1	6	PF00069	0.416
MOD_NEK2_1	135	140	PF00069	0.312
MOD_NEK2_1	324	329	PF00069	0.478
MOD_NEK2_1	486	491	PF00069	0.439
MOD_NEK2_1	605	610	PF00069	0.635
MOD_NEK2_1	787	792	PF00069	0.507
MOD_PIKK_1	487	493	PF00454	0.481
MOD_PIKK_1	851	857	PF00454	0.570
MOD_PKA_1	162	168	PF00069	0.388
MOD_PKA_2	283	289	PF00069	0.439
MOD_PKA_2	302	308	PF00069	0.503
MOD_PKA_2	594	600	PF00069	0.543
MOD_Plk_1	2	8	PF00069	0.394
MOD_Plk_1	26	32	PF00069	0.312
MOD_Plk_1	502	508	PF00069	0.587
MOD_Plk_1	721	727	PF00069	0.654
MOD_Plk_1	734	740	PF00069	0.514
MOD_Plk_2-3	314	320	PF00069	0.475
MOD_Plk_2-3	331	337	PF00069	0.475
MOD_Plk_2-3	659	665	PF00069	0.679
MOD_Plk_4	163	169	PF00069	0.312
MOD_Plk_4	260	266	PF00069	0.409
MOD_Plk_4	320	326	PF00069	0.476
MOD_Plk_4	453	459	PF00069	0.475
MOD_Plk_4	490	496	PF00069	0.486
MOD_Plk_4	502	508	PF00069	0.551
MOD_Plk_4	564	570	PF00069	0.509
MOD_Plk_4	674	680	PF00069	0.585
MOD_Plk_4	68	74	PF00069	0.312
MOD_Plk_4	807	813	PF00069	0.603
MOD_ProDKin_1	288	294	PF00069	0.492
MOD_ProDKin_1	562	568	PF00069	0.645
MOD_ProDKin_1	755	761	PF00069	0.529
MOD_SUMO_for_1	401	404	PF00179	0.529
MOD_SUMO_rev_2	54	62	PF00179	0.312
TRG_DiLeu_BaEn_1	242	247	PF01217	0.371
TRG_DiLeu_BaLyEn_6	354	359	PF01217	0.529
TRG_ENDOCYTIC_2	278	281	PF00928	0.356
TRG_ENDOCYTIC_2	356	359	PF00928	0.497
TRG_ENDOCYTIC_2	385	388	PF00928	0.475
TRG_ER_diArg_1	23	25	PF00400	0.312
TRG_ER_diArg_1	302	304	PF00400	0.475
TRG_ER_diArg_1	405	407	PF00400	0.584
TRG_ER_diArg_1	495	497	PF00400	0.482
TRG_ER_diArg_1	640	643	PF00400	0.693
TRG_NES_CRM1_1	226	242	PF08389	0.312
TRG_NES_CRM1_1	433	445	PF08389	0.475
TRG_NLS_MonoExtN_4	688	695	PF00514	0.707

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB75	Leptomonas seymouri	64%	99%
A0A3Q8IDJ4	Leishmania donovani	93%	100%
A4HFW3	Leishmania braziliensis	84%	100%
A4I2Z5	Leishmania infantum	93%	100%
E9ADG7	Leishmania major	92%	100%