Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZ90_LEIMU

TriTrypDb:

LmxM.27.1880

Length:

524

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AZ90

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZ90

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.688
CLV_C14_Caspase3-7	506	510	PF00656	0.596
CLV_NRD_NRD_1	125	127	PF00675	0.710
CLV_NRD_NRD_1	134	136	PF00675	0.533
CLV_NRD_NRD_1	191	193	PF00675	0.555
CLV_NRD_NRD_1	292	294	PF00675	0.614
CLV_NRD_NRD_1	320	322	PF00675	0.448
CLV_NRD_NRD_1	464	466	PF00675	0.628
CLV_NRD_NRD_1	68	70	PF00675	0.535
CLV_PCSK_FUR_1	83	87	PF00082	0.483
CLV_PCSK_KEX2_1	125	127	PF00082	0.700
CLV_PCSK_KEX2_1	134	136	PF00082	0.533
CLV_PCSK_KEX2_1	191	193	PF00082	0.449
CLV_PCSK_KEX2_1	292	294	PF00082	0.624
CLV_PCSK_KEX2_1	320	322	PF00082	0.448
CLV_PCSK_KEX2_1	411	413	PF00082	0.477
CLV_PCSK_KEX2_1	85	87	PF00082	0.589
CLV_PCSK_PC1ET2_1	411	413	PF00082	0.493
CLV_PCSK_PC1ET2_1	85	87	PF00082	0.556
CLV_PCSK_SKI1_1	266	270	PF00082	0.324
CLV_PCSK_SKI1_1	320	324	PF00082	0.460
CLV_PCSK_SKI1_1	346	350	PF00082	0.348
CLV_PCSK_SKI1_1	353	357	PF00082	0.320
CLV_PCSK_SKI1_1	371	375	PF00082	0.313
CLV_PCSK_SKI1_1	389	393	PF00082	0.642
CLV_PCSK_SKI1_1	400	404	PF00082	0.521
CLV_PCSK_SKI1_1	424	428	PF00082	0.631
CLV_PCSK_SKI1_1	442	446	PF00082	0.489
DEG_APCC_DBOX_1	319	327	PF00400	0.526
DEG_APCC_DBOX_1	441	449	PF00400	0.549
DEG_SCF_FBW7_1	499	506	PF00400	0.491
DEG_SPOP_SBC_1	216	220	PF00917	0.414
DOC_CKS1_1	500	505	PF01111	0.492
DOC_CYCLIN_RxL_1	397	406	PF00134	0.488
DOC_CYCLIN_RxL_1	421	430	PF00134	0.472
DOC_CYCLIN_yCln2_LP_2	31	37	PF00134	0.405
DOC_CYCLIN_yCln2_LP_2	374	380	PF00134	0.526
DOC_CYCLIN_yCln2_LP_2	472	478	PF00134	0.636
DOC_MAPK_DCC_7	99	107	PF00069	0.560
DOC_MAPK_FxFP_2	184	187	PF00069	0.266
DOC_MAPK_gen_1	134	140	PF00069	0.360
DOC_MAPK_gen_1	83	93	PF00069	0.370
DOC_MAPK_MEF2A_6	353	361	PF00069	0.437
DOC_PP2B_LxvP_1	213	216	PF13499	0.474
DOC_PP2B_LxvP_1	31	34	PF13499	0.280
DOC_PP2B_LxvP_1	396	399	PF13499	0.497
DOC_PP2B_LxvP_1	472	475	PF13499	0.637
DOC_PP4_FxxP_1	107	110	PF00568	0.575
DOC_PP4_FxxP_1	140	143	PF00568	0.650
DOC_PP4_FxxP_1	184	187	PF00568	0.306
DOC_PP4_FxxP_1	3	6	PF00568	0.585
DOC_USP7_MATH_1	15	19	PF00917	0.476
DOC_USP7_MATH_1	278	282	PF00917	0.505
DOC_USP7_MATH_1	287	291	PF00917	0.549
DOC_USP7_MATH_1	48	52	PF00917	0.482
DOC_USP7_MATH_1	493	497	PF00917	0.770
DOC_USP7_MATH_1	503	507	PF00917	0.578
DOC_USP7_MATH_1	519	523	PF00917	0.558
DOC_WW_Pin1_4	106	111	PF00397	0.559
DOC_WW_Pin1_4	499	504	PF00397	0.625
LIG_14-3-3_CanoR_1	125	132	PF00244	0.666
LIG_14-3-3_CanoR_1	209	214	PF00244	0.427
LIG_14-3-3_CanoR_1	293	303	PF00244	0.609
LIG_14-3-3_CanoR_1	353	358	PF00244	0.413
LIG_14-3-3_CanoR_1	465	472	PF00244	0.559
LIG_Actin_WH2_1	412	430	PF00022	0.533
LIG_BIR_III_2	497	501	PF00653	0.538
LIG_BIR_III_4	177	181	PF00653	0.395
LIG_BRCT_BRCA1_1	12	16	PF00533	0.385
LIG_Clathr_ClatBox_1	90	94	PF01394	0.308
LIG_CtBP_PxDLS_1	95	99	PF00389	0.469
LIG_eIF4E_1	360	366	PF01652	0.355
LIG_FHA_1	198	204	PF00498	0.426
LIG_FHA_1	210	216	PF00498	0.505
LIG_FHA_1	354	360	PF00498	0.428
LIG_FHA_2	117	123	PF00498	0.575
LIG_FHA_2	465	471	PF00498	0.546
LIG_LIR_Apic_2	137	143	PF02991	0.583
LIG_LIR_Apic_2	2	6	PF02991	0.591
LIG_LIR_Apic_2	358	363	PF02991	0.351
LIG_LIR_Apic_2	375	381	PF02991	0.568
LIG_LIR_Gen_1	117	124	PF02991	0.520
LIG_LIR_Gen_1	87	96	PF02991	0.506
LIG_LIR_Nem_3	263	268	PF02991	0.350
LIG_LIR_Nem_3	29	35	PF02991	0.516
LIG_LIR_Nem_3	390	396	PF02991	0.567
LIG_LIR_Nem_3	479	483	PF02991	0.701
LIG_LIR_Nem_3	87	91	PF02991	0.452
LIG_LYPXL_S_1	392	396	PF13949	0.532
LIG_LYPXL_yS_3	393	396	PF13949	0.533
LIG_MYND_1	394	398	PF01753	0.522
LIG_Pex14_2	12	16	PF04695	0.487
LIG_Pex14_2	369	373	PF04695	0.409
LIG_PTB_Apo_2	264	271	PF02174	0.304
LIG_PTB_Apo_2	349	356	PF02174	0.320
LIG_PTB_Phospho_1	264	270	PF10480	0.304
LIG_SH2_CRK	265	269	PF00017	0.301
LIG_SH2_CRK	480	484	PF00017	0.693
LIG_SH2_NCK_1	32	36	PF00017	0.381
LIG_SH2_PTP2	360	363	PF00017	0.321
LIG_SH2_SRC	32	35	PF00017	0.370
LIG_SH2_SRC	360	363	PF00017	0.350
LIG_SH2_SRC	507	510	PF00017	0.567
LIG_SH2_STAT5	360	363	PF00017	0.344
LIG_SH3_3	142	148	PF00018	0.512
LIG_SH3_3	224	230	PF00018	0.505
LIG_SH3_3	305	311	PF00018	0.328
LIG_SH3_3	472	478	PF00018	0.625
LIG_SH3_3	497	503	PF00018	0.770
LIG_SH3_3	89	95	PF00018	0.386
LIG_SH3_3	98	104	PF00018	0.417
LIG_SUMO_SIM_anti_2	36	41	PF11976	0.440
LIG_SUMO_SIM_par_1	211	221	PF11976	0.341
LIG_SUMO_SIM_par_1	33	38	PF11976	0.537
LIG_SUMO_SIM_par_1	89	94	PF11976	0.315
LIG_TRAF2_1	453	456	PF00917	0.640
LIG_WW_3	397	401	PF00397	0.480
MOD_CK1_1	214	220	PF00069	0.626
MOD_CK1_1	280	286	PF00069	0.656
MOD_CK1_1	38	44	PF00069	0.494
MOD_CK2_1	116	122	PF00069	0.657
MOD_CK2_1	398	404	PF00069	0.565
MOD_CK2_1	464	470	PF00069	0.532
MOD_CK2_1	515	521	PF00069	0.623
MOD_Cter_Amidation	318	321	PF01082	0.444
MOD_Cter_Amidation	409	412	PF01082	0.484
MOD_GlcNHglycan	12	15	PF01048	0.545
MOD_GlcNHglycan	177	181	PF01048	0.439
MOD_GlcNHglycan	187	190	PF01048	0.361
MOD_GlcNHglycan	203	206	PF01048	0.394
MOD_GlcNHglycan	262	265	PF01048	0.423
MOD_GlcNHglycan	280	283	PF01048	0.590
MOD_GlcNHglycan	285	288	PF01048	0.722
MOD_GlcNHglycan	50	53	PF01048	0.367
MOD_GlcNHglycan	503	506	PF01048	0.809
MOD_GlcNHglycan	517	520	PF01048	0.502
MOD_GlcNHglycan	521	524	PF01048	0.464
MOD_GSK3_1	149	156	PF00069	0.667
MOD_GSK3_1	197	204	PF00069	0.471
MOD_GSK3_1	211	218	PF00069	0.477
MOD_GSK3_1	225	232	PF00069	0.515
MOD_GSK3_1	276	283	PF00069	0.558
MOD_GSK3_1	287	294	PF00069	0.709
MOD_GSK3_1	418	425	PF00069	0.488
MOD_GSK3_1	499	506	PF00069	0.640
MOD_GSK3_1	515	522	PF00069	0.587
MOD_N-GLC_1	351	356	PF02516	0.465
MOD_NEK2_1	277	282	PF00069	0.617
MOD_NEK2_1	291	296	PF00069	0.631
MOD_NEK2_1	351	356	PF00069	0.457
MOD_NEK2_1	427	432	PF00069	0.474
MOD_NEK2_2	287	292	PF00069	0.544
MOD_PIKK_1	126	132	PF00454	0.521
MOD_PIKK_1	23	29	PF00454	0.446
MOD_PIKK_1	294	300	PF00454	0.560
MOD_PIKK_1	418	424	PF00454	0.568
MOD_PKA_1	125	131	PF00069	0.473
MOD_PKA_1	134	140	PF00069	0.445
MOD_PKA_2	124	130	PF00069	0.666
MOD_PKA_2	134	140	PF00069	0.481
MOD_PKA_2	208	214	PF00069	0.434
MOD_PKA_2	291	297	PF00069	0.663
MOD_PKA_2	339	345	PF00069	0.381
MOD_PKA_2	427	433	PF00069	0.466
MOD_PKA_2	464	470	PF00069	0.554
MOD_PKA_2	8	14	PF00069	0.525
MOD_Plk_1	116	122	PF00069	0.409
MOD_Plk_1	198	204	PF00069	0.405
MOD_Plk_1	35	41	PF00069	0.511
MOD_Plk_1	351	357	PF00069	0.453
MOD_Plk_2-3	117	123	PF00069	0.614
MOD_Plk_4	198	204	PF00069	0.407
MOD_Plk_4	35	41	PF00069	0.511
MOD_Plk_4	422	428	PF00069	0.638
MOD_ProDKin_1	106	112	PF00069	0.557
MOD_ProDKin_1	499	505	PF00069	0.626
MOD_SUMO_rev_2	342	348	PF00179	0.376
MOD_SUMO_rev_2	462	468	PF00179	0.570
TRG_DiLeu_BaEn_3	455	461	PF01217	0.620
TRG_DiLeu_BaEn_4	440	446	PF01217	0.567
TRG_DiLeu_BaLyEn_6	434	439	PF01217	0.544
TRG_ENDOCYTIC_2	265	268	PF00928	0.306
TRG_ENDOCYTIC_2	270	273	PF00928	0.305
TRG_ENDOCYTIC_2	32	35	PF00928	0.516
TRG_ENDOCYTIC_2	393	396	PF00928	0.533
TRG_ENDOCYTIC_2	480	483	PF00928	0.687
TRG_ER_diArg_1	134	136	PF00400	0.432
TRG_ER_diArg_1	19	22	PF00400	0.360
TRG_ER_diArg_1	291	293	PF00400	0.654
TRG_ER_diArg_1	320	322	PF00400	0.555
TRG_ER_diArg_1	6	9	PF00400	0.576
TRG_NES_CRM1_1	231	246	PF08389	0.351
TRG_Pf-PMV_PEXEL_1	192	196	PF00026	0.460
TRG_Pf-PMV_PEXEL_1	321	325	PF00026	0.395
TRG_Pf-PMV_PEXEL_1	400	404	PF00026	0.535
TRG_Pf-PMV_PEXEL_1	437	441	PF00026	0.607

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5J3	Leptomonas seymouri	65%	86%
A0A1X0NRT0	Trypanosomatidae	40%	100%
A0A3S7X0V2	Leishmania donovani	90%	98%
A0A422NJS3	Trypanosoma rangeli	37%	100%
A4HFW2	Leishmania braziliensis	82%	99%
A4I2Z4	Leishmania infantum	90%	98%
C9ZJE2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9ADG6	Leishmania major	89%	100%
V5DEY5	Trypanosoma cruzi	45%	100%