Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AZ88_LEIMU

TriTrypDb:

LmxM.27.1860

Length:

858

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZ88

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZ88

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	232	236	PF00656	0.669
CLV_C14_Caspase3-7	381	385	PF00656	0.646
CLV_C14_Caspase3-7	464	468	PF00656	0.664
CLV_C14_Caspase3-7	543	547	PF00656	0.525
CLV_NRD_NRD_1	103	105	PF00675	0.744
CLV_NRD_NRD_1	144	146	PF00675	0.766
CLV_NRD_NRD_1	16	18	PF00675	0.771
CLV_NRD_NRD_1	216	218	PF00675	0.579
CLV_NRD_NRD_1	25	27	PF00675	0.707
CLV_NRD_NRD_1	287	289	PF00675	0.617
CLV_NRD_NRD_1	394	396	PF00675	0.702
CLV_NRD_NRD_1	501	503	PF00675	0.668
CLV_NRD_NRD_1	810	812	PF00675	0.666
CLV_PCSK_FUR_1	142	146	PF00082	0.773
CLV_PCSK_FUR_1	499	503	PF00082	0.568
CLV_PCSK_KEX2_1	103	105	PF00082	0.669
CLV_PCSK_KEX2_1	144	146	PF00082	0.766
CLV_PCSK_KEX2_1	16	18	PF00082	0.771
CLV_PCSK_KEX2_1	237	239	PF00082	0.543
CLV_PCSK_KEX2_1	24	26	PF00082	0.723
CLV_PCSK_KEX2_1	274	276	PF00082	0.510
CLV_PCSK_KEX2_1	280	282	PF00082	0.559
CLV_PCSK_KEX2_1	287	289	PF00082	0.609
CLV_PCSK_KEX2_1	501	503	PF00082	0.668
CLV_PCSK_KEX2_1	810	812	PF00082	0.695
CLV_PCSK_PC1ET2_1	237	239	PF00082	0.543
CLV_PCSK_PC1ET2_1	274	276	PF00082	0.510
CLV_PCSK_PC1ET2_1	280	282	PF00082	0.576
CLV_PCSK_PC7_1	806	812	PF00082	0.572
CLV_PCSK_SKI1_1	103	107	PF00082	0.843
CLV_PCSK_SKI1_1	17	21	PF00082	0.693
CLV_PCSK_SKI1_1	516	520	PF00082	0.552
CLV_Separin_Metazoa	584	588	PF03568	0.815
DEG_SCF_FBW7_1	326	333	PF00400	0.834
DEG_SCF_FBW7_1	36	43	PF00400	0.717
DEG_SCF_FBW7_1	664	671	PF00400	0.742
DEG_SPOP_SBC_1	202	206	PF00917	0.520
DEG_SPOP_SBC_1	734	738	PF00917	0.732
DOC_CKS1_1	482	487	PF01111	0.726
DOC_CKS1_1	665	670	PF01111	0.747
DOC_CKS1_1	92	97	PF01111	0.750
DOC_MAPK_gen_1	237	243	PF00069	0.514
DOC_MAPK_gen_1	284	294	PF00069	0.638
DOC_MAPK_MEF2A_6	184	192	PF00069	0.537
DOC_MAPK_MEF2A_6	287	294	PF00069	0.554
DOC_PP2B_LxvP_1	179	182	PF13499	0.676
DOC_PP2B_LxvP_1	185	188	PF13499	0.590
DOC_PP2B_LxvP_1	90	93	PF13499	0.744
DOC_USP7_MATH_1	120	124	PF00917	0.862
DOC_USP7_MATH_1	140	144	PF00917	0.528
DOC_USP7_MATH_1	197	201	PF00917	0.819
DOC_USP7_MATH_1	202	206	PF00917	0.726
DOC_USP7_MATH_1	223	227	PF00917	0.455
DOC_USP7_MATH_1	269	273	PF00917	0.580
DOC_USP7_MATH_1	40	44	PF00917	0.723
DOC_USP7_MATH_1	45	49	PF00917	0.672
DOC_USP7_MATH_1	53	57	PF00917	0.808
DOC_USP7_MATH_1	578	582	PF00917	0.722
DOC_USP7_MATH_1	652	656	PF00917	0.545
DOC_USP7_MATH_1	657	661	PF00917	0.654
DOC_USP7_MATH_1	668	672	PF00917	0.794
DOC_USP7_MATH_1	674	678	PF00917	0.657
DOC_USP7_MATH_1	684	688	PF00917	0.571
DOC_USP7_MATH_1	7	11	PF00917	0.782
DOC_WW_Pin1_4	169	174	PF00397	0.801
DOC_WW_Pin1_4	18	23	PF00397	0.796
DOC_WW_Pin1_4	32	37	PF00397	0.610
DOC_WW_Pin1_4	326	331	PF00397	0.672
DOC_WW_Pin1_4	352	357	PF00397	0.749
DOC_WW_Pin1_4	469	474	PF00397	0.574
DOC_WW_Pin1_4	481	486	PF00397	0.792
DOC_WW_Pin1_4	528	533	PF00397	0.748
DOC_WW_Pin1_4	556	561	PF00397	0.707
DOC_WW_Pin1_4	612	617	PF00397	0.677
DOC_WW_Pin1_4	653	658	PF00397	0.612
DOC_WW_Pin1_4	664	669	PF00397	0.772
DOC_WW_Pin1_4	695	700	PF00397	0.766
DOC_WW_Pin1_4	735	740	PF00397	0.762
DOC_WW_Pin1_4	76	81	PF00397	0.780
DOC_WW_Pin1_4	794	799	PF00397	0.848
DOC_WW_Pin1_4	91	96	PF00397	0.616
LIG_14-3-3_CanoR_1	201	208	PF00244	0.516
LIG_14-3-3_CanoR_1	225	231	PF00244	0.686
LIG_14-3-3_CanoR_1	238	242	PF00244	0.455
LIG_14-3-3_CanoR_1	287	291	PF00244	0.629
LIG_14-3-3_CanoR_1	516	521	PF00244	0.612
LIG_14-3-3_CanoR_1	636	646	PF00244	0.594
LIG_14-3-3_CanoR_1	653	657	PF00244	0.645
LIG_14-3-3_CanoR_1	783	787	PF00244	0.577
LIG_14-3-3_CanoR_1	789	798	PF00244	0.551
LIG_AP2alpha_1	786	790	PF02296	0.738
LIG_BIR_III_2	50	54	PF00653	0.670
LIG_BRCT_BRCA1_1	532	536	PF00533	0.519
LIG_BRCT_BRCA1_1	654	658	PF00533	0.526
LIG_CSL_BTD_1	353	356	PF09270	0.603
LIG_deltaCOP1_diTrp_1	431	439	PF00928	0.741
LIG_deltaCOP1_diTrp_1	777	781	PF00928	0.712
LIG_FHA_1	187	193	PF00498	0.818
LIG_FHA_1	238	244	PF00498	0.583
LIG_FHA_1	503	509	PF00498	0.660
LIG_FHA_1	549	555	PF00498	0.700
LIG_FHA_1	594	600	PF00498	0.754
LIG_FHA_1	613	619	PF00498	0.499
LIG_FHA_1	797	803	PF00498	0.686
LIG_FHA_1	84	90	PF00498	0.760
LIG_FHA_2	227	233	PF00498	0.695
LIG_FHA_2	317	323	PF00498	0.836
LIG_FHA_2	450	456	PF00498	0.544
LIG_FHA_2	517	523	PF00498	0.536
LIG_FHA_2	541	547	PF00498	0.521
LIG_FHA_2	557	563	PF00498	0.643
LIG_FHA_2	628	634	PF00498	0.710
LIG_FHA_2	819	825	PF00498	0.757
LIG_FHA_2	842	848	PF00498	0.640
LIG_Integrin_RGD_1	465	467	PF01839	0.671
LIG_LIR_Apic_2	43	47	PF02991	0.663
LIG_LIR_Apic_2	431	437	PF02991	0.741
LIG_LIR_Gen_1	242	252	PF02991	0.653
LIG_LIR_Gen_1	533	542	PF02991	0.519
LIG_LIR_Gen_1	775	786	PF02991	0.797
LIG_LIR_Nem_3	242	247	PF02991	0.658
LIG_LIR_Nem_3	39	44	PF02991	0.811
LIG_LIR_Nem_3	533	539	PF02991	0.592
LIG_LIR_Nem_3	775	781	PF02991	0.793
LIG_MYND_1	177	181	PF01753	0.678
LIG_MYND_1	664	668	PF01753	0.809
LIG_MYND_1	693	697	PF01753	0.778
LIG_NRBOX	211	217	PF00104	0.661
LIG_NRBOX	581	587	PF00104	0.814
LIG_Pex14_2	14	18	PF04695	0.743
LIG_Pex14_2	786	790	PF04695	0.738
LIG_PTB_Apo_2	621	628	PF02174	0.526
LIG_PTB_Phospho_1	621	627	PF10480	0.523
LIG_REV1ctd_RIR_1	778	787	PF16727	0.513
LIG_SH2_CRK	244	248	PF00017	0.656
LIG_SH2_CRK	44	48	PF00017	0.764
LIG_SH2_NCK_1	44	48	PF00017	0.764
LIG_SH2_NCK_1	486	490	PF00017	0.545
LIG_SH2_STAP1	454	458	PF00017	0.732
LIG_SH2_STAP1	627	631	PF00017	0.542
LIG_SH2_STAT5	114	117	PF00017	0.565
LIG_SH2_STAT5	296	299	PF00017	0.641
LIG_SH2_STAT5	839	842	PF00017	0.663
LIG_SH3_3	350	356	PF00018	0.794
LIG_SH3_3	662	668	PF00018	0.633
LIG_SH3_3	683	689	PF00018	0.683
LIG_SH3_3	696	702	PF00018	0.653
LIG_SH3_3	86	92	PF00018	0.753
LIG_SUMO_SIM_anti_2	189	194	PF11976	0.529
LIG_SUMO_SIM_anti_2	289	294	PF11976	0.635
LIG_SUMO_SIM_anti_2	581	588	PF11976	0.813
LIG_SUMO_SIM_anti_2	86	91	PF11976	0.755
LIG_SUMO_SIM_par_1	343	351	PF11976	0.752
LIG_SUMO_SIM_par_1	726	732	PF11976	0.743
LIG_SxIP_EBH_1	666	675	PF03271	0.760
LIG_TRFH_1	18	22	PF08558	0.734
MOD_CDC14_SPxK_1	21	24	PF00782	0.730
MOD_CDC14_SPxK_1	35	38	PF00782	0.584
MOD_CDC14_SPxK_1	79	82	PF00782	0.753
MOD_CDC14_SPxK_1	797	800	PF00782	0.850
MOD_CDK_SPK_2	469	474	PF00069	0.566
MOD_CDK_SPxK_1	18	24	PF00069	0.734
MOD_CDK_SPxK_1	32	38	PF00069	0.592
MOD_CDK_SPxK_1	76	82	PF00069	0.757
MOD_CDK_SPxK_1	794	800	PF00069	0.850
MOD_CDK_SPxxK_3	18	25	PF00069	0.797
MOD_CDK_SPxxK_3	481	488	PF00069	0.759
MOD_CK1_1	169	175	PF00069	0.708
MOD_CK1_1	226	232	PF00069	0.488
MOD_CK1_1	355	361	PF00069	0.709
MOD_CK1_1	504	510	PF00069	0.803
MOD_CK1_1	56	62	PF00069	0.780
MOD_CK1_1	607	613	PF00069	0.539
MOD_CK1_1	637	643	PF00069	0.811
MOD_CK1_1	669	675	PF00069	0.601
MOD_CK1_1	677	683	PF00069	0.681
MOD_CK1_1	691	697	PF00069	0.829
MOD_CK1_1	710	716	PF00069	0.793
MOD_CK1_1	743	749	PF00069	0.635
MOD_CK1_1	793	799	PF00069	0.793
MOD_CK1_1	814	820	PF00069	0.768
MOD_CK2_1	316	322	PF00069	0.747
MOD_CK2_1	337	343	PF00069	0.526
MOD_CK2_1	449	455	PF00069	0.542
MOD_CK2_1	516	522	PF00069	0.538
MOD_CK2_1	578	584	PF00069	0.806
MOD_CK2_1	627	633	PF00069	0.704
MOD_CK2_1	677	683	PF00069	0.574
MOD_CK2_1	684	690	PF00069	0.545
MOD_CK2_1	841	847	PF00069	0.644
MOD_Cter_Amidation	235	238	PF01082	0.571
MOD_DYRK1A_RPxSP_1	653	657	PF00069	0.524
MOD_GlcNHglycan	117	120	PF01048	0.846
MOD_GlcNHglycan	121	125	PF01048	0.808
MOD_GlcNHglycan	225	228	PF01048	0.471
MOD_GlcNHglycan	271	274	PF01048	0.576
MOD_GlcNHglycan	339	342	PF01048	0.685
MOD_GlcNHglycan	359	362	PF01048	0.723
MOD_GlcNHglycan	380	383	PF01048	0.813
MOD_GlcNHglycan	455	459	PF01048	0.671
MOD_GlcNHglycan	576	579	PF01048	0.722
MOD_GlcNHglycan	659	662	PF01048	0.763
MOD_GlcNHglycan	677	680	PF01048	0.540
MOD_GlcNHglycan	709	712	PF01048	0.871
MOD_GlcNHglycan	814	817	PF01048	0.567
MOD_GlcNHglycan	855	858	PF01048	0.791
MOD_GSK3_1	115	122	PF00069	0.597
MOD_GSK3_1	169	176	PF00069	0.793
MOD_GSK3_1	197	204	PF00069	0.613
MOD_GSK3_1	308	315	PF00069	0.753
MOD_GSK3_1	32	39	PF00069	0.824
MOD_GSK3_1	326	333	PF00069	0.541
MOD_GSK3_1	348	355	PF00069	0.621
MOD_GSK3_1	366	373	PF00069	0.573
MOD_GSK3_1	378	385	PF00069	0.619
MOD_GSK3_1	445	452	PF00069	0.591
MOD_GSK3_1	530	537	PF00069	0.667
MOD_GSK3_1	548	555	PF00069	0.801
MOD_GSK3_1	574	581	PF00069	0.804
MOD_GSK3_1	585	592	PF00069	0.638
MOD_GSK3_1	603	610	PF00069	0.515
MOD_GSK3_1	632	639	PF00069	0.829
MOD_GSK3_1	653	660	PF00069	0.663
MOD_GSK3_1	664	671	PF00069	0.671
MOD_GSK3_1	675	682	PF00069	0.746
MOD_GSK3_1	684	691	PF00069	0.586
MOD_GSK3_1	69	76	PF00069	0.765
MOD_GSK3_1	789	796	PF00069	0.763
MOD_GSK3_1	811	818	PF00069	0.772
MOD_GSK3_1	833	840	PF00069	0.649
MOD_LATS_1	757	763	PF00433	0.839
MOD_LATS_1	809	815	PF00433	0.756
MOD_NEK2_1	195	200	PF00069	0.633
MOD_NEK2_1	203	208	PF00069	0.552
MOD_NEK2_1	337	342	PF00069	0.632
MOD_NEK2_1	370	375	PF00069	0.766
MOD_NEK2_1	603	608	PF00069	0.731
MOD_NEK2_1	733	738	PF00069	0.733
MOD_NEK2_1	753	758	PF00069	0.677
MOD_NEK2_1	790	795	PF00069	0.732
MOD_NEK2_1	812	817	PF00069	0.623
MOD_PIKK_1	108	114	PF00454	0.553
MOD_PIKK_1	166	172	PF00454	0.605
MOD_PIKK_1	316	322	PF00454	0.829
MOD_PIKK_1	841	847	PF00454	0.644
MOD_PKA_1	237	243	PF00069	0.411
MOD_PKA_1	501	507	PF00069	0.645
MOD_PKA_2	115	121	PF00069	0.564
MOD_PKA_2	237	243	PF00069	0.514
MOD_PKA_2	286	292	PF00069	0.597
MOD_PKA_2	308	314	PF00069	0.665
MOD_PKA_2	366	372	PF00069	0.679
MOD_PKA_2	494	500	PF00069	0.795
MOD_PKA_2	501	507	PF00069	0.801
MOD_PKA_2	510	516	PF00069	0.642
MOD_PKA_2	555	561	PF00069	0.539
MOD_PKA_2	593	599	PF00069	0.763
MOD_PKA_2	652	658	PF00069	0.615
MOD_PKA_2	674	680	PF00069	0.844
MOD_PKA_2	782	788	PF00069	0.517
MOD_PKB_1	164	172	PF00069	0.551
MOD_PKB_1	499	507	PF00069	0.566
MOD_PKB_1	587	595	PF00069	0.823
MOD_Plk_1	604	610	PF00069	0.624
MOD_Plk_1	627	633	PF00069	0.647
MOD_Plk_1	83	89	PF00069	0.656
MOD_Plk_2-3	435	441	PF00069	0.741
MOD_Plk_2-3	782	788	PF00069	0.575
MOD_Plk_2-3	824	830	PF00069	0.666
MOD_Plk_4	516	522	PF00069	0.579
MOD_Plk_4	578	584	PF00069	0.790
MOD_Plk_4	607	613	PF00069	0.525
MOD_Plk_4	85	91	PF00069	0.662
MOD_ProDKin_1	169	175	PF00069	0.803
MOD_ProDKin_1	18	24	PF00069	0.796
MOD_ProDKin_1	32	38	PF00069	0.610
MOD_ProDKin_1	326	332	PF00069	0.674
MOD_ProDKin_1	352	358	PF00069	0.747
MOD_ProDKin_1	469	475	PF00069	0.574
MOD_ProDKin_1	481	487	PF00069	0.791
MOD_ProDKin_1	528	534	PF00069	0.742
MOD_ProDKin_1	556	562	PF00069	0.710
MOD_ProDKin_1	612	618	PF00069	0.678
MOD_ProDKin_1	653	659	PF00069	0.615
MOD_ProDKin_1	664	670	PF00069	0.778
MOD_ProDKin_1	695	701	PF00069	0.764
MOD_ProDKin_1	735	741	PF00069	0.763
MOD_ProDKin_1	76	82	PF00069	0.779
MOD_ProDKin_1	794	800	PF00069	0.850
MOD_ProDKin_1	91	97	PF00069	0.619
MOD_SUMO_for_1	273	276	PF00179	0.668
MOD_SUMO_for_1	81	84	PF00179	0.659
TRG_DiLeu_BaLyEn_6	174	179	PF01217	0.763
TRG_ENDOCYTIC_2	244	247	PF00928	0.655
TRG_ER_diArg_1	103	105	PF00400	0.740
TRG_ER_diArg_1	141	144	PF00400	0.783
TRG_ER_diArg_1	16	18	PF00400	0.706
TRG_ER_diArg_1	24	26	PF00400	0.617
TRG_ER_diArg_1	286	288	PF00400	0.593
TRG_ER_diArg_1	499	502	PF00400	0.590
TRG_ER_diArg_1	586	589	PF00400	0.821
TRG_ER_diArg_1	810	812	PF00400	0.666
TRG_Pf-PMV_PEXEL_1	217	222	PF00026	0.628
TRG_Pf-PMV_PEXEL_1	800	804	PF00026	0.861

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IDF6	Leishmania donovani	79%	99%
A4HFW0	Leishmania braziliensis	54%	99%
A4I2Z2	Leishmania infantum	79%	99%
E9ADG4	Leishmania major	78%	99%