Paraflagellar rod protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

paraflagellar rod protein 5, putative

Species:

Leishmania mexicana

UniProt:

E9AZ87_LEIMU

TriTrypDb:

LmxM.27.1850

Length:

780

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 8
Forrest at al. (procyclic)	no	yes: 8
Silverman et al.	no	yes: 2
Pissara et al.	no	yes: 24

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 8

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 29
NetGPI	no	yes: 0, no: 29

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	30
GO:0031514	motile cilium	5	30
GO:0042995	cell projection	2	30
GO:0043226	organelle	2	30
GO:0043227	membrane-bounded organelle	3	30
GO:0110165	cellular anatomical entity	1	30
GO:0120025	plasma membrane bounded cell projection	3	30
GO:0005930	axoneme	2	1
GO:0005737	cytoplasm	2	3
GO:0031974	membrane-enclosed lumen	2	3
GO:0031981	nuclear lumen	5	3
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	3
GO:0043233	organelle lumen	3	3
GO:0070013	intracellular organelle lumen	4	3
GO:0097014	ciliary plasm	5	3
GO:0099568	cytoplasmic region	3	3

Expansion

Sequence features

E9AZ87

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZ87

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	30
GO:0005515	protein binding	2	30
GO:0005516	calmodulin binding	3	30

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	379	383	PF00656	0.346
CLV_C14_Caspase3-7	550	554	PF00656	0.418
CLV_NRD_NRD_1	129	131	PF00675	0.450
CLV_NRD_NRD_1	245	247	PF00675	0.446
CLV_NRD_NRD_1	292	294	PF00675	0.283
CLV_NRD_NRD_1	348	350	PF00675	0.344
CLV_NRD_NRD_1	359	361	PF00675	0.333
CLV_NRD_NRD_1	443	445	PF00675	0.274
CLV_NRD_NRD_1	447	449	PF00675	0.270
CLV_NRD_NRD_1	592	594	PF00675	0.502
CLV_NRD_NRD_1	88	90	PF00675	0.586
CLV_NRD_NRD_1	92	94	PF00675	0.630
CLV_PCSK_FUR_1	10	14	PF00082	0.479
CLV_PCSK_FUR_1	243	247	PF00082	0.474
CLV_PCSK_KEX2_1	12	14	PF00082	0.478
CLV_PCSK_KEX2_1	129	131	PF00082	0.438
CLV_PCSK_KEX2_1	211	213	PF00082	0.389
CLV_PCSK_KEX2_1	243	245	PF00082	0.505
CLV_PCSK_KEX2_1	294	296	PF00082	0.336
CLV_PCSK_KEX2_1	348	350	PF00082	0.339
CLV_PCSK_KEX2_1	359	361	PF00082	0.322
CLV_PCSK_KEX2_1	429	431	PF00082	0.288
CLV_PCSK_KEX2_1	447	449	PF00082	0.399
CLV_PCSK_KEX2_1	88	90	PF00082	0.469
CLV_PCSK_KEX2_1	92	94	PF00082	0.513
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.478
CLV_PCSK_PC1ET2_1	211	213	PF00082	0.483
CLV_PCSK_PC1ET2_1	294	296	PF00082	0.333
CLV_PCSK_PC1ET2_1	429	431	PF00082	0.274
CLV_PCSK_PC7_1	239	245	PF00082	0.444
CLV_PCSK_PC7_1	355	361	PF00082	0.401
CLV_PCSK_PC7_1	88	94	PF00082	0.606
CLV_PCSK_SKI1_1	222	226	PF00082	0.360
CLV_PCSK_SKI1_1	255	259	PF00082	0.328
CLV_PCSK_SKI1_1	320	324	PF00082	0.396
CLV_PCSK_SKI1_1	463	467	PF00082	0.226
CLV_PCSK_SKI1_1	483	487	PF00082	0.162
CLV_PCSK_SKI1_1	507	511	PF00082	0.391
CLV_PCSK_SKI1_1	68	72	PF00082	0.647
CLV_Separin_Metazoa	418	422	PF03568	0.258
CLV_Separin_Metazoa	494	498	PF03568	0.222
DEG_APCC_DBOX_1	760	768	PF00400	0.258
DEG_SPOP_SBC_1	678	682	PF00917	0.512
DOC_CKS1_1	123	128	PF01111	0.520
DOC_MAPK_gen_1	727	736	PF00069	0.240
DOC_MAPK_gen_1	88	97	PF00069	0.437
DOC_PP1_RVXF_1	138	145	PF00149	0.431
DOC_PP1_RVXF_1	512	519	PF00149	0.274
DOC_PP2B_PxIxI_1	525	531	PF00149	0.204
DOC_PP4_FxxP_1	123	126	PF00568	0.458
DOC_USP7_MATH_1	24	28	PF00917	0.670
DOC_USP7_MATH_1	3	7	PF00917	0.667
DOC_USP7_MATH_1	671	675	PF00917	0.645
DOC_USP7_MATH_1	684	688	PF00917	0.569
DOC_USP7_MATH_1	701	705	PF00917	0.758
DOC_WW_Pin1_4	122	127	PF00397	0.470
DOC_WW_Pin1_4	181	186	PF00397	0.375
DOC_WW_Pin1_4	507	512	PF00397	0.403
DOC_WW_Pin1_4	667	672	PF00397	0.523
DOC_WW_Pin1_4	773	778	PF00397	0.563
LIG_14-3-3_CanoR_1	222	231	PF00244	0.377
LIG_14-3-3_CanoR_1	239	247	PF00244	0.541
LIG_14-3-3_CanoR_1	320	325	PF00244	0.415
LIG_14-3-3_CanoR_1	33	39	PF00244	0.400
LIG_14-3-3_CanoR_1	430	436	PF00244	0.289
LIG_14-3-3_CanoR_1	537	544	PF00244	0.274
LIG_APCC_ABBA_1	322	327	PF00400	0.297
LIG_BRCT_BRCA1_1	119	123	PF00533	0.587
LIG_BRCT_BRCA1_1	140	144	PF00533	0.502
LIG_BRCT_BRCA1_1	302	306	PF00533	0.222
LIG_BRCT_BRCA1_1	466	470	PF00533	0.169
LIG_BRCT_BRCA1_1	514	518	PF00533	0.274
LIG_FHA_1	151	157	PF00498	0.521
LIG_FHA_1	164	170	PF00498	0.459
LIG_FHA_1	2	8	PF00498	0.652
LIG_FHA_1	256	262	PF00498	0.324
LIG_FHA_1	508	514	PF00498	0.398
LIG_FHA_1	560	566	PF00498	0.635
LIG_FHA_1	621	627	PF00498	0.698
LIG_FHA_1	680	686	PF00498	0.512
LIG_FHA_2	176	182	PF00498	0.421
LIG_FHA_2	538	544	PF00498	0.324
LIG_FHA_2	711	717	PF00498	0.722
LIG_LIR_Apic_2	120	126	PF02991	0.581
LIG_LIR_Gen_1	215	224	PF02991	0.392
LIG_LIR_Gen_1	536	544	PF02991	0.404
LIG_LIR_Gen_1	718	728	PF02991	0.393
LIG_LIR_Nem_3	215	220	PF02991	0.382
LIG_LIR_Nem_3	225	231	PF02991	0.386
LIG_LIR_Nem_3	323	328	PF02991	0.328
LIG_LIR_Nem_3	515	521	PF02991	0.258
LIG_LIR_Nem_3	536	541	PF02991	0.275
LIG_LIR_Nem_3	543	547	PF02991	0.288
LIG_LIR_Nem_3	718	723	PF02991	0.509
LIG_LIR_Nem_3	751	757	PF02991	0.282
LIG_LYPXL_yS_3	228	231	PF13949	0.377
LIG_PCNA_yPIPBox_3	408	420	PF02747	0.274
LIG_Pex14_1	318	322	PF04695	0.258
LIG_Pex14_2	31	35	PF04695	0.448
LIG_Pex14_2	720	724	PF04695	0.391
LIG_PTB_Apo_2	316	323	PF02174	0.274
LIG_SH2_CRK	544	548	PF00017	0.208
LIG_SH2_PTP2	523	526	PF00017	0.258
LIG_SH2_PTP2	769	772	PF00017	0.212
LIG_SH2_SRC	217	220	PF00017	0.421
LIG_SH2_SRC	235	238	PF00017	0.383
LIG_SH2_SRC	477	480	PF00017	0.297
LIG_SH2_SRC	523	526	PF00017	0.258
LIG_SH2_STAP1	217	221	PF00017	0.317
LIG_SH2_STAT3	409	412	PF00017	0.274
LIG_SH2_STAT5	15	18	PF00017	0.456
LIG_SH2_STAT5	435	438	PF00017	0.319
LIG_SH2_STAT5	441	444	PF00017	0.316
LIG_SH2_STAT5	477	480	PF00017	0.391
LIG_SH2_STAT5	523	526	PF00017	0.258
LIG_SH2_STAT5	769	772	PF00017	0.279
LIG_SH3_1	774	780	PF00018	0.460
LIG_SH3_3	140	146	PF00018	0.544
LIG_SH3_3	61	67	PF00018	0.602
LIG_SH3_3	665	671	PF00018	0.474
LIG_SH3_3	704	710	PF00018	0.696
LIG_SH3_3	774	780	PF00018	0.463
LIG_SUMO_SIM_par_1	2	9	PF11976	0.437
LIG_TRAF2_1	179	182	PF00917	0.500
LIG_TRAF2_1	270	273	PF00917	0.289
LIG_TRAF2_1	748	751	PF00917	0.259
LIG_TYR_ITIM	542	547	PF00017	0.208
LIG_ULM_U2AF65_1	243	248	PF00076	0.457
LIG_WRC_WIRS_1	32	37	PF05994	0.547
MOD_CDK_SPK_2	122	127	PF00069	0.470
MOD_CDK_SPxxK_3	122	129	PF00069	0.463
MOD_CDK_SPxxK_3	507	514	PF00069	0.391
MOD_CK1_1	238	244	PF00069	0.455
MOD_CK1_1	536	542	PF00069	0.380
MOD_CK1_1	600	606	PF00069	0.714
MOD_CK1_1	625	631	PF00069	0.558
MOD_CK1_1	645	651	PF00069	0.693
MOD_CK1_1	657	663	PF00069	0.732
MOD_CK1_1	670	676	PF00069	0.497
MOD_CK1_1	687	693	PF00069	0.627
MOD_CK1_1	695	701	PF00069	0.621
MOD_CK2_1	175	181	PF00069	0.434
MOD_CK2_1	3	9	PF00069	0.628
MOD_CK2_1	358	364	PF00069	0.274
MOD_CK2_1	567	573	PF00069	0.658
MOD_CK2_1	710	716	PF00069	0.574
MOD_Cter_Amidation	357	360	PF01082	0.258
MOD_DYRK1A_RPxSP_1	507	511	PF00069	0.391
MOD_GlcNHglycan	26	29	PF01048	0.373
MOD_GlcNHglycan	360	363	PF01048	0.258
MOD_GlcNHglycan	413	416	PF01048	0.327
MOD_GlcNHglycan	628	631	PF01048	0.663
MOD_GlcNHglycan	647	650	PF01048	0.740
MOD_GlcNHglycan	651	654	PF01048	0.699
MOD_GlcNHglycan	664	667	PF01048	0.632
MOD_GlcNHglycan	694	697	PF01048	0.723
MOD_GlcNHglycan	703	706	PF01048	0.642
MOD_GSK3_1	111	118	PF00069	0.499
MOD_GSK3_1	171	178	PF00069	0.331
MOD_GSK3_1	330	337	PF00069	0.394
MOD_GSK3_1	358	365	PF00069	0.297
MOD_GSK3_1	533	540	PF00069	0.348
MOD_GSK3_1	543	550	PF00069	0.259
MOD_GSK3_1	596	603	PF00069	0.643
MOD_GSK3_1	616	623	PF00069	0.648
MOD_GSK3_1	645	652	PF00069	0.640
MOD_GSK3_1	662	669	PF00069	0.531
MOD_GSK3_1	687	694	PF00069	0.598
MOD_LATS_1	427	433	PF00433	0.240
MOD_N-GLC_1	533	538	PF02516	0.322
MOD_N-GLC_1	649	654	PF02516	0.705
MOD_NEK2_1	1	6	PF00069	0.641
MOD_NEK2_1	111	116	PF00069	0.430
MOD_NEK2_1	194	199	PF00069	0.373
MOD_NEK2_1	31	36	PF00069	0.436
MOD_NEK2_1	39	44	PF00069	0.403
MOD_NEK2_1	533	538	PF00069	0.407
MOD_NEK2_1	598	603	PF00069	0.758
MOD_NEK2_1	71	76	PF00069	0.528
MOD_NEK2_1	715	720	PF00069	0.421
MOD_NEK2_2	171	176	PF00069	0.628
MOD_NEK2_2	3	8	PF00069	0.510
MOD_NEK2_2	622	627	PF00069	0.455
MOD_PIKK_1	41	47	PF00454	0.540
MOD_PKA_1	429	435	PF00069	0.242
MOD_PKA_2	238	244	PF00069	0.448
MOD_PKA_2	358	364	PF00069	0.267
MOD_PKA_2	429	435	PF00069	0.266
MOD_PKA_2	536	542	PF00069	0.329
MOD_PKA_2	559	565	PF00069	0.523
MOD_PKA_2	603	609	PF00069	0.803
MOD_Plk_1	171	177	PF00069	0.501
MOD_Plk_1	194	200	PF00069	0.371
MOD_Plk_1	255	261	PF00069	0.297
MOD_Plk_1	39	45	PF00069	0.469
MOD_Plk_1	533	539	PF00069	0.464
MOD_Plk_1	732	738	PF00069	0.258
MOD_Plk_2-3	732	738	PF00069	0.258
MOD_Plk_4	138	144	PF00069	0.497
MOD_Plk_4	171	177	PF00069	0.506
MOD_Plk_4	3	9	PF00069	0.477
MOD_Plk_4	34	40	PF00069	0.394
MOD_Plk_4	362	368	PF00069	0.316
MOD_Plk_4	537	543	PF00069	0.258
MOD_Plk_4	554	560	PF00069	0.498
MOD_Plk_4	687	693	PF00069	0.497
MOD_ProDKin_1	122	128	PF00069	0.467
MOD_ProDKin_1	181	187	PF00069	0.367
MOD_ProDKin_1	507	513	PF00069	0.403
MOD_ProDKin_1	667	673	PF00069	0.522
MOD_ProDKin_1	773	779	PF00069	0.567
MOD_SUMO_rev_2	133	142	PF00179	0.427
MOD_SUMO_rev_2	17	22	PF00179	0.459
MOD_SUMO_rev_2	612	619	PF00179	0.463
TRG_DiLeu_BaEn_1	145	150	PF01217	0.460
TRG_DiLeu_BaEn_2	301	307	PF01217	0.391
TRG_DiLeu_BaEn_4	17	23	PF01217	0.547
TRG_DiLeu_BaLyEn_6	219	224	PF01217	0.490
TRG_ENDOCYTIC_2	217	220	PF00928	0.325
TRG_ENDOCYTIC_2	228	231	PF00928	0.393
TRG_ENDOCYTIC_2	544	547	PF00928	0.315
TRG_ER_diArg_1	129	131	PF00400	0.451
TRG_ER_diArg_1	243	246	PF00400	0.455
TRG_ER_diArg_1	293	296	PF00400	0.287
TRG_ER_diArg_1	348	350	PF00400	0.325
TRG_ER_diArg_1	447	449	PF00400	0.267
TRG_ER_diArg_1	496	499	PF00400	0.253
TRG_ER_diArg_1	726	729	PF00400	0.369
TRG_ER_diArg_1	88	90	PF00400	0.586
TRG_ER_diArg_1	91	93	PF00400	0.610
TRG_NLS_MonoExtC_3	565	571	PF00514	0.338
TRG_Pf-PMV_PEXEL_1	130	134	PF00026	0.406
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.412
TRG_Pf-PMV_PEXEL_1	348	353	PF00026	0.325
TRG_Pf-PMV_PEXEL_1	527	531	PF00026	0.274

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5J5	Leptomonas seymouri	70%	98%
A0A0N1IFZ5	Leptomonas seymouri	26%	100%
A0A0S4IZY8	Bodo saltans	25%	100%
A0A0S4JS20	Bodo saltans	25%	100%
A0A1X0NR57	Trypanosomatidae	56%	99%
A0A1X0NYU4	Trypanosomatidae	26%	100%
A0A381MH18	Leishmania infantum	25%	100%
A0A381MN58	Leishmania infantum	25%	100%
A0A3Q8IAP5	Leishmania donovani	25%	100%
A0A3Q8IEH2	Leishmania donovani	25%	100%
A0A3R7KDB9	Trypanosoma rangeli	26%	100%
A0A3S7X0V5	Leishmania donovani	92%	100%
A0A3S7X2K1	Leishmania donovani	25%	100%
A0A422NJR9	Trypanosoma rangeli	57%	100%
A4H8S1	Leishmania braziliensis	25%	100%
A4HFV9	Leishmania braziliensis	82%	99%
A4HIY0	Leishmania braziliensis	25%	100%
A4I2Z1	Leishmania infantum	92%	100%
C9ZJD8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
C9ZVV0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9ADG3	Leishmania major	92%	100%
E9AE36	Leishmania major	25%	100%
E9AE37	Leishmania major	25%	100%
E9AHJ2	Leishmania infantum	25%	100%
E9ALP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9ALP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
P22225	Trypanosoma brucei brucei	24%	100%
Q4QEM2	Leishmania major	25%	100%
V5BIN9	Trypanosoma cruzi	56%	100%