Phosphoenolpyruvate carboxykinase (ATP)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Phosphoenolpyruvate carboxykinase [ATP], glycosomal

Species:

Leishmania mexicana

UniProt:

E9AZ82_LEIMU

TriTrypDb:

LmxM.27.1807

Length:

342

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZ82

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZ82

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	3
GO:0005996	monosaccharide metabolic process	3	3
GO:0006006	glucose metabolic process	5	3
GO:0006094	gluconeogenesis	6	3
GO:0008152	metabolic process	1	3
GO:0009058	biosynthetic process	2	3
GO:0016051	carbohydrate biosynthetic process	4	3
GO:0019318	hexose metabolic process	4	3
GO:0019319	hexose biosynthetic process	5	3
GO:0044238	primary metabolic process	2	3
GO:0044281	small molecule metabolic process	2	3
GO:0044283	small molecule biosynthetic process	3	3
GO:0046364	monosaccharide biosynthetic process	4	3
GO:0071704	organic substance metabolic process	2	3
GO:1901576	organic substance biosynthetic process	3	3
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0016310	phosphorylation	5	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	3
GO:0003824	catalytic activity	1	3
GO:0004611	phosphoenolpyruvate carboxykinase activity	5	3
GO:0004612	phosphoenolpyruvate carboxykinase (ATP) activity	6	3
GO:0005488	binding	1	3
GO:0005524	ATP binding	5	3
GO:0016829	lyase activity	2	3
GO:0016830	carbon-carbon lyase activity	3	3
GO:0016831	carboxy-lyase activity	4	3
GO:0017076	purine nucleotide binding	4	3
GO:0030554	adenyl nucleotide binding	5	3
GO:0032553	ribonucleotide binding	3	3
GO:0032555	purine ribonucleotide binding	4	3
GO:0032559	adenyl ribonucleotide binding	5	3
GO:0035639	purine ribonucleoside triphosphate binding	4	3
GO:0036094	small molecule binding	2	3
GO:0043167	ion binding	2	3
GO:0043168	anion binding	3	3
GO:0097159	organic cyclic compound binding	2	3
GO:0097367	carbohydrate derivative binding	2	3
GO:1901265	nucleoside phosphate binding	3	3
GO:1901363	heterocyclic compound binding	2	3
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	292	294	PF00675	0.421
CLV_PCSK_KEX2_1	244	246	PF00082	0.295
CLV_PCSK_KEX2_1	280	282	PF00082	0.420
CLV_PCSK_KEX2_1	29	31	PF00082	0.295
CLV_PCSK_KEX2_1	319	321	PF00082	0.591
CLV_PCSK_KEX2_1	52	54	PF00082	0.420
CLV_PCSK_PC1ET2_1	244	246	PF00082	0.295
CLV_PCSK_PC1ET2_1	280	282	PF00082	0.420
CLV_PCSK_PC1ET2_1	29	31	PF00082	0.295
CLV_PCSK_PC1ET2_1	319	321	PF00082	0.591
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.420
CLV_PCSK_SKI1_1	193	197	PF00082	0.305
CLV_PCSK_SKI1_1	207	211	PF00082	0.336
CLV_PCSK_SKI1_1	218	222	PF00082	0.295
CLV_PCSK_SKI1_1	241	245	PF00082	0.295
CLV_PCSK_SKI1_1	297	301	PF00082	0.456
CLV_PCSK_SKI1_1	3	7	PF00082	0.295
CLV_PCSK_SKI1_1	52	56	PF00082	0.362
CLV_PCSK_SKI1_1	66	70	PF00082	0.227
DEG_Nend_UBRbox_1	1	4	PF02207	0.620
DOC_MAPK_gen_1	107	114	PF00069	0.620
DOC_MAPK_gen_1	2	10	PF00069	0.495
DOC_MAPK_gen_1	238	248	PF00069	0.495
DOC_MAPK_gen_1	29	37	PF00069	0.495
DOC_MAPK_MEF2A_6	2	10	PF00069	0.495
DOC_MAPK_MEF2A_6	241	250	PF00069	0.495
DOC_MAPK_MEF2A_6	29	37	PF00069	0.495
DOC_MAPK_MEF2A_6	304	313	PF00069	0.574
DOC_PP2B_LxvP_1	276	279	PF13499	0.495
DOC_PP4_FxxP_1	200	203	PF00568	0.495
DOC_USP7_MATH_1	323	327	PF00917	0.465
DOC_USP7_MATH_1	328	332	PF00917	0.435
DOC_USP7_UBL2_3	300	304	PF12436	0.594
DOC_WW_Pin1_4	162	167	PF00397	0.620
DOC_WW_Pin1_4	186	191	PF00397	0.620
LIG_14-3-3_CanoR_1	207	212	PF00244	0.495
LIG_BIR_III_4	153	157	PF00653	0.495
LIG_BRCT_BRCA1_1	196	200	PF00533	0.495
LIG_deltaCOP1_diTrp_1	58	69	PF00928	0.495
LIG_FHA_1	135	141	PF00498	0.620
LIG_FHA_1	176	182	PF00498	0.495
LIG_FHA_1	249	255	PF00498	0.495
LIG_FHA_1	304	310	PF00498	0.554
LIG_FHA_2	303	309	PF00498	0.397
LIG_FHA_2	84	90	PF00498	0.495
LIG_Integrin_RGD_1	30	32	PF01839	0.295
LIG_LIR_Apic_2	197	203	PF02991	0.495
LIG_LIR_Gen_1	7	14	PF02991	0.495
LIG_LIR_Gen_1	88	99	PF02991	0.498
LIG_LIR_Nem_3	266	271	PF02991	0.498
LIG_LIR_Nem_3	34	39	PF02991	0.495
LIG_LIR_Nem_3	88	94	PF02991	0.498
LIG_OCRL_FandH_1	203	215	PF00620	0.495
LIG_Pex14_2	196	200	PF04695	0.495
LIG_Pex14_2	313	317	PF04695	0.394
LIG_PTB_Apo_2	149	156	PF02174	0.495
LIG_PTB_Apo_2	228	235	PF02174	0.495
LIG_PTB_Phospho_1	228	234	PF10480	0.495
LIG_SH2_CRK	91	95	PF00017	0.495
LIG_SH2_STAP1	177	181	PF00017	0.495
LIG_SH2_STAP1	76	80	PF00017	0.495
LIG_SH2_STAT3	212	215	PF00017	0.495
LIG_SH2_STAT5	177	180	PF00017	0.495
LIG_SH2_STAT5	336	339	PF00017	0.433
LIG_SH3_3	122	128	PF00018	0.495
LIG_SH3_3	154	160	PF00018	0.495
LIG_SH3_3	188	194	PF00018	0.620
LIG_SUMO_SIM_anti_2	305	313	PF11976	0.568
LIG_TRAF2_1	305	308	PF00917	0.571
LIG_TRAF2_1	86	89	PF00917	0.620
LIG_TRAF2_2	286	291	PF00917	0.680
LIG_TRFH_1	10	14	PF08558	0.495
MOD_CDK_SPxxK_3	186	193	PF00069	0.620
MOD_CK1_1	120	126	PF00069	0.620
MOD_CK2_1	302	308	PF00069	0.399
MOD_CK2_1	83	89	PF00069	0.495
MOD_CK2_1	95	101	PF00069	0.495
MOD_Cter_Amidation	27	30	PF01082	0.295
MOD_GlcNHglycan	23	26	PF01048	0.295
MOD_GlcNHglycan	330	333	PF01048	0.430
MOD_GlcNHglycan	39	42	PF01048	0.295
MOD_GlcNHglycan	47	50	PF01048	0.295
MOD_GSK3_1	39	46	PF00069	0.495
MOD_N-GLC_1	101	106	PF02516	0.420
MOD_N-GLC_1	259	264	PF02516	0.420
MOD_N-GLC_1	302	307	PF02516	0.396
MOD_NEK2_1	175	180	PF00069	0.620
MOD_NEK2_1	21	26	PF00069	0.495
MOD_NEK2_1	229	234	PF00069	0.495
MOD_NEK2_1	248	253	PF00069	0.495
MOD_NEK2_1	313	318	PF00069	0.469
MOD_NEK2_1	37	42	PF00069	0.495
MOD_NEK2_2	31	36	PF00069	0.495
MOD_PK_1	95	101	PF00069	0.620
MOD_PKA_1	218	224	PF00069	0.620
MOD_Plk_1	101	107	PF00069	0.562
MOD_Plk_1	115	121	PF00069	0.427
MOD_Plk_1	31	37	PF00069	0.495
MOD_Plk_2-3	101	107	PF00069	0.620
MOD_Plk_4	207	213	PF00069	0.495
MOD_Plk_4	31	37	PF00069	0.495
MOD_Plk_4	4	10	PF00069	0.495
MOD_ProDKin_1	162	168	PF00069	0.620
MOD_ProDKin_1	186	192	PF00069	0.620
MOD_SUMO_for_1	108	111	PF00179	0.620
MOD_SUMO_for_1	84	87	PF00179	0.495
MOD_SUMO_rev_2	48	54	PF00179	0.620
TRG_DiLeu_BaEn_1	307	312	PF01217	0.579
TRG_ENDOCYTIC_2	91	94	PF00928	0.495
TRG_Pf-PMV_PEXEL_1	53	58	PF00026	0.295
TRG_PTS1	339	342	PF00515	0.479

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3R7K1T3	Trypanosoma rangeli	82%	95%
A0KRH2	Shewanella sp. (strain ANA-3)	46%	67%
A1RPC2	Shewanella sp. (strain W3-18-1)	47%	67%
A1S1X0	Shewanella amazonensis (strain ATCC BAA-1098 / SB2B)	47%	67%
A1U754	Marinobacter nauticus (strain ATCC 700491 / DSM 11845 / VT8)	46%	67%
A3DAB2	Shewanella baltica (strain OS155 / ATCC BAA-1091)	47%	67%
A3QJ41	Shewanella loihica (strain ATCC BAA-1088 / PV-4)	47%	67%
A4XP75	Pseudomonas mendocina (strain ymp)	45%	67%
A4YBE7	Shewanella putrefaciens (strain CN-32 / ATCC BAA-453)	47%	67%
A5VX32	Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1)	45%	67%
A6VDW7	Pseudomonas aeruginosa (strain PA7)	44%	67%
A6WHM7	Shewanella baltica (strain OS185)	47%	67%
A8G1J1	Shewanella sediminis (strain HAW-EB3)	45%	67%
A8GYT2	Shewanella pealeana (strain ATCC 700345 / ANG-SQ1)	46%	67%
A9KDE5	Coxiella burnetii (strain Dugway 5J108-111)	45%	66%
A9KVC7	Shewanella baltica (strain OS195)	47%	67%
A9NBT9	Coxiella burnetii (strain RSA 331 / Henzerling II)	45%	66%
B0KI05	Pseudomonas putida (strain GB-1)	45%	67%
B0TMY0	Shewanella halifaxensis (strain HAW-EB4)	45%	67%
B1JET1	Pseudomonas putida (strain W619)	44%	67%
B1KN33	Shewanella woodyi (strain ATCC 51908 / MS32)	46%	67%
B6J3V5	Coxiella burnetii (strain CbuG_Q212)	44%	66%
B6J6M2	Coxiella burnetii (strain CbuK_Q154)	45%	66%
B7V3T9	Pseudomonas aeruginosa (strain LESB58)	44%	67%
B8CH32	Shewanella piezotolerans (strain WP3 / JCM 13877)	45%	67%
B8E3X7	Shewanella baltica (strain OS223)	47%	67%
C3K4J5	Pseudomonas fluorescens (strain SBW25)	44%	67%
P13735	Trypanosoma brucei brucei	81%	72%
P51058	Trypanosoma cruzi	84%	72%
Q02EH2	Pseudomonas aeruginosa (strain UCBPP-PA14)	44%	67%
Q089V1	Shewanella frigidimarina (strain NCIMB 400)	47%	67%
Q0HNY4	Shewanella sp. (strain MR-4)	46%	67%
Q0I0F2	Shewanella sp. (strain MR-7)	46%	67%
Q12T12	Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013)	47%	67%
Q1IGK1	Pseudomonas entomophila (strain L48)	44%	67%
Q2SPF9	Hahella chejuensis (strain KCTC 2396)	46%	67%
Q3ILP3	Pseudoalteromonas translucida (strain TAC 125)	47%	67%
Q3KJP4	Pseudomonas fluorescens (strain Pf0-1)	44%	67%
Q48BY7	Pseudomonas savastanoi pv. phaseolicola (strain 1448A / Race 6)	44%	67%
Q4KK03	Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)	44%	67%
Q500D1	Pseudomonas syringae pv. syringae (strain B728a)	44%	67%
Q83A19	Coxiella burnetii (strain RSA 493 / Nine Mile phase I)	45%	66%
Q88AZ4	Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)	44%	67%
Q8EKD3	Shewanella oneidensis (strain MR-1)	47%	67%
Q9HTZ7	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	44%	67%
Q9RVP6	Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)	55%	73%
Q9YG68	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	30%	70%