Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZ79_LEIMU

TriTrypDb:

LmxM.27.1790

Length:

841

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZ79

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZ79

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	755	759	PF00656	0.618
CLV_MEL_PAP_1	701	707	PF00089	0.368
CLV_NRD_NRD_1	300	302	PF00675	0.575
CLV_NRD_NRD_1	348	350	PF00675	0.560
CLV_NRD_NRD_1	363	365	PF00675	0.613
CLV_NRD_NRD_1	444	446	PF00675	0.602
CLV_NRD_NRD_1	462	464	PF00675	0.563
CLV_NRD_NRD_1	478	480	PF00675	0.508
CLV_NRD_NRD_1	508	510	PF00675	0.698
CLV_NRD_NRD_1	614	616	PF00675	0.515
CLV_NRD_NRD_1	623	625	PF00675	0.395
CLV_NRD_NRD_1	724	726	PF00675	0.646
CLV_NRD_NRD_1	87	89	PF00675	0.475
CLV_PCSK_FUR_1	506	510	PF00082	0.707
CLV_PCSK_KEX2_1	300	302	PF00082	0.575
CLV_PCSK_KEX2_1	348	350	PF00082	0.553
CLV_PCSK_KEX2_1	444	446	PF00082	0.602
CLV_PCSK_KEX2_1	462	464	PF00082	0.563
CLV_PCSK_KEX2_1	478	480	PF00082	0.508
CLV_PCSK_KEX2_1	508	510	PF00082	0.698
CLV_PCSK_KEX2_1	614	616	PF00082	0.495
CLV_PCSK_KEX2_1	623	625	PF00082	0.405
CLV_PCSK_KEX2_1	724	726	PF00082	0.601
CLV_PCSK_SKI1_1	195	199	PF00082	0.432
CLV_PCSK_SKI1_1	614	618	PF00082	0.522
CLV_PCSK_SKI1_1	624	628	PF00082	0.408
CLV_PCSK_SKI1_1	685	689	PF00082	0.416
CLV_PCSK_SKI1_1	698	702	PF00082	0.416
CLV_PCSK_SKI1_1	724	728	PF00082	0.586
CLV_PCSK_SKI1_1	80	84	PF00082	0.416
DEG_APCC_DBOX_1	134	142	PF00400	0.534
DEG_APCC_DBOX_1	660	668	PF00400	0.442
DEG_Nend_UBRbox_4	1	3	PF02207	0.567
DEG_SPOP_SBC_1	241	245	PF00917	0.617
DEG_SPOP_SBC_1	408	412	PF00917	0.663
DOC_CYCLIN_RxL_1	682	692	PF00134	0.414
DOC_MAPK_FxFP_2	826	829	PF00069	0.661
DOC_MAPK_gen_1	702	709	PF00069	0.360
DOC_MAPK_gen_1	77	85	PF00069	0.400
DOC_MAPK_JIP1_4	835	841	PF00069	0.578
DOC_MAPK_MEF2A_6	24	33	PF00069	0.408
DOC_MAPK_MEF2A_6	535	544	PF00069	0.500
DOC_MAPK_MEF2A_6	698	705	PF00069	0.354
DOC_MAPK_MEF2A_6	77	85	PF00069	0.397
DOC_PP1_RVXF_1	683	690	PF00149	0.414
DOC_PP1_RVXF_1	700	706	PF00149	0.426
DOC_PP4_FxxP_1	826	829	PF00568	0.661
DOC_SPAK_OSR1_1	704	708	PF12202	0.475
DOC_USP7_MATH_1	137	141	PF00917	0.428
DOC_USP7_MATH_1	330	334	PF00917	0.530
DOC_USP7_MATH_1	733	737	PF00917	0.695
DOC_USP7_MATH_1	780	784	PF00917	0.737
DOC_USP7_MATH_2	482	488	PF00917	0.664
DOC_WW_Pin1_4	139	144	PF00397	0.395
DOC_WW_Pin1_4	179	184	PF00397	0.576
DOC_WW_Pin1_4	226	231	PF00397	0.587
DOC_WW_Pin1_4	242	247	PF00397	0.472
DOC_WW_Pin1_4	260	265	PF00397	0.593
DOC_WW_Pin1_4	270	275	PF00397	0.598
DOC_WW_Pin1_4	277	282	PF00397	0.596
DOC_WW_Pin1_4	336	341	PF00397	0.620
DOC_WW_Pin1_4	342	347	PF00397	0.625
DOC_WW_Pin1_4	35	40	PF00397	0.334
DOC_WW_Pin1_4	399	404	PF00397	0.621
DOC_WW_Pin1_4	536	541	PF00397	0.533
DOC_WW_Pin1_4	552	557	PF00397	0.634
DOC_WW_Pin1_4	573	578	PF00397	0.576
DOC_WW_Pin1_4	59	64	PF00397	0.468
DOC_WW_Pin1_4	709	714	PF00397	0.591
DOC_WW_Pin1_4	725	730	PF00397	0.481
DOC_WW_Pin1_4	803	808	PF00397	0.721
DOC_WW_Pin1_4	812	817	PF00397	0.615
LIG_14-3-3_CanoR_1	123	127	PF00244	0.553
LIG_14-3-3_CanoR_1	135	145	PF00244	0.454
LIG_14-3-3_CanoR_1	207	213	PF00244	0.460
LIG_14-3-3_CanoR_1	276	280	PF00244	0.653
LIG_14-3-3_CanoR_1	377	385	PF00244	0.512
LIG_14-3-3_CanoR_1	535	540	PF00244	0.470
LIG_14-3-3_CanoR_1	655	661	PF00244	0.462
LIG_14-3-3_CanoR_1	66	73	PF00244	0.432
LIG_14-3-3_CanoR_1	724	729	PF00244	0.596
LIG_14-3-3_CanoR_1	835	840	PF00244	0.616
LIG_Actin_WH2_2	529	545	PF00022	0.448
LIG_APCC_ABBA_1	127	132	PF00400	0.436
LIG_APCC_ABBAyCdc20_2	685	691	PF00400	0.414
LIG_BIR_III_2	27	31	PF00653	0.406
LIG_BRCT_BRCA1_1	685	689	PF00533	0.416
LIG_BRCT_BRCA1_1	822	826	PF00533	0.813
LIG_CSL_BTD_1	710	713	PF09270	0.590
LIG_CtBP_PxDLS_1	340	344	PF00389	0.683
LIG_CtBP_PxDLS_1	836	840	PF00389	0.631
LIG_EH_1	127	131	PF12763	0.444
LIG_FHA_1	392	398	PF00498	0.634
LIG_FHA_1	537	543	PF00498	0.615
LIG_FHA_1	60	66	PF00498	0.477
LIG_FHA_1	607	613	PF00498	0.495
LIG_FHA_1	651	657	PF00498	0.463
LIG_FHA_1	796	802	PF00498	0.542
LIG_FHA_2	11	17	PF00498	0.564
LIG_FHA_2	585	591	PF00498	0.620
LIG_FHA_2	641	647	PF00498	0.502
LIG_FHA_2	733	739	PF00498	0.601
LIG_FHA_2	753	759	PF00498	0.644
LIG_FHA_2	782	788	PF00498	0.693
LIG_LIR_Apic_2	125	129	PF02991	0.570
LIG_LIR_Apic_2	335	341	PF02991	0.529
LIG_LIR_Apic_2	475	480	PF02991	0.632
LIG_LIR_Apic_2	823	829	PF02991	0.666
LIG_LIR_Nem_3	471	477	PF02991	0.510
LIG_LIR_Nem_3	78	82	PF02991	0.418
LIG_NRBOX	149	155	PF00104	0.406
LIG_NRBOX	156	162	PF00104	0.404
LIG_PCNA_yPIPBox_3	580	593	PF02747	0.515
LIG_PDZ_Class_2	836	841	PF00595	0.598
LIG_REV1ctd_RIR_1	19	28	PF16727	0.535
LIG_RPA_C_Fungi	650	662	PF08784	0.523
LIG_SH2_CRK	239	243	PF00017	0.575
LIG_SH2_CRK	477	481	PF00017	0.651
LIG_SH2_CRK	79	83	PF00017	0.398
LIG_SH2_GRB2like	126	129	PF00017	0.529
LIG_SH2_GRB2like	72	75	PF00017	0.380
LIG_SH2_NCK_1	239	243	PF00017	0.575
LIG_SH2_SRC	126	129	PF00017	0.599
LIG_SH2_SRC	72	75	PF00017	0.380
LIG_SH2_SRC	730	733	PF00017	0.672
LIG_SH2_STAT5	126	129	PF00017	0.599
LIG_SH2_STAT5	531	534	PF00017	0.509
LIG_SH2_STAT5	72	75	PF00017	0.380
LIG_SH2_STAT5	730	733	PF00017	0.728
LIG_SH3_3	12	18	PF00018	0.573
LIG_SH3_3	186	192	PF00018	0.457
LIG_SH3_3	217	223	PF00018	0.562
LIG_SH3_3	258	264	PF00018	0.594
LIG_SH3_3	293	299	PF00018	0.610
LIG_SH3_3	394	400	PF00018	0.629
LIG_SH3_3	571	577	PF00018	0.624
LIG_SUMO_SIM_anti_2	379	387	PF11976	0.513
LIG_SUMO_SIM_par_1	29	35	PF11976	0.513
LIG_TRAF2_1	119	122	PF00917	0.593
LIG_TRAF2_1	144	147	PF00917	0.506
LIG_TRAF2_2	577	582	PF00917	0.624
LIG_UBA3_1	81	89	PF00899	0.422
MOD_CDC14_SPxK_1	273	276	PF00782	0.621
MOD_CDC14_SPxK_1	345	348	PF00782	0.620
MOD_CDC14_SPxK_1	806	809	PF00782	0.652
MOD_CDK_SPK_2	226	231	PF00069	0.610
MOD_CDK_SPK_2	260	265	PF00069	0.593
MOD_CDK_SPK_2	573	578	PF00069	0.607
MOD_CDK_SPK_2	709	714	PF00069	0.591
MOD_CDK_SPxK_1	270	276	PF00069	0.620
MOD_CDK_SPxK_1	342	348	PF00069	0.625
MOD_CDK_SPxK_1	803	809	PF00069	0.661
MOD_CDK_SPxxK_3	277	284	PF00069	0.608
MOD_CDK_SPxxK_3	342	349	PF00069	0.536
MOD_CDK_SPxxK_3	399	406	PF00069	0.679
MOD_CDK_SPxxK_3	536	543	PF00069	0.453
MOD_CDK_SPxxK_3	573	580	PF00069	0.610
MOD_CDK_SPxxK_3	59	66	PF00069	0.469
MOD_CK1_1	211	217	PF00069	0.516
MOD_CK1_1	218	224	PF00069	0.605
MOD_CK1_1	229	235	PF00069	0.493
MOD_CK1_1	263	269	PF00069	0.753
MOD_CK1_1	32	38	PF00069	0.423
MOD_CK1_1	555	561	PF00069	0.812
MOD_CK1_1	581	587	PF00069	0.533
MOD_CK1_1	606	612	PF00069	0.523
MOD_CK1_1	712	718	PF00069	0.606
MOD_CK1_1	760	766	PF00069	0.642
MOD_CK1_1	802	808	PF00069	0.834
MOD_CK1_1	815	821	PF00069	0.552
MOD_CK1_1	827	833	PF00069	0.760
MOD_CK1_1	99	105	PF00069	0.474
MOD_CK2_1	10	16	PF00069	0.567
MOD_CK2_1	141	147	PF00069	0.494
MOD_CK2_1	229	235	PF00069	0.594
MOD_CK2_1	336	342	PF00069	0.685
MOD_CK2_1	426	432	PF00069	0.537
MOD_CK2_1	584	590	PF00069	0.627
MOD_CK2_1	733	739	PF00069	0.639
MOD_CK2_1	781	787	PF00069	0.690
MOD_CK2_1	802	808	PF00069	0.702
MOD_Cter_Amidation	362	365	PF01082	0.637
MOD_Cter_Amidation	460	463	PF01082	0.556
MOD_Cter_Amidation	722	725	PF01082	0.577
MOD_GlcNHglycan	214	217	PF01048	0.469
MOD_GlcNHglycan	281	284	PF01048	0.532
MOD_GlcNHglycan	411	414	PF01048	0.698
MOD_GlcNHglycan	420	423	PF01048	0.618
MOD_GlcNHglycan	426	431	PF01048	0.515
MOD_GlcNHglycan	465	468	PF01048	0.422
MOD_GlcNHglycan	494	497	PF01048	0.669
MOD_GSK3_1	137	144	PF00069	0.492
MOD_GSK3_1	208	215	PF00069	0.469
MOD_GSK3_1	240	247	PF00069	0.762
MOD_GSK3_1	275	282	PF00069	0.573
MOD_GSK3_1	332	339	PF00069	0.658
MOD_GSK3_1	367	374	PF00069	0.637
MOD_GSK3_1	45	52	PF00069	0.469
MOD_GSK3_1	484	491	PF00069	0.649
MOD_GSK3_1	551	558	PF00069	0.678
MOD_GSK3_1	578	585	PF00069	0.689
MOD_GSK3_1	602	609	PF00069	0.575
MOD_GSK3_1	795	802	PF00069	0.639
MOD_GSK3_1	815	822	PF00069	0.726
MOD_GSK3_1	96	103	PF00069	0.516
MOD_LATS_1	407	413	PF00433	0.545
MOD_N-GLC_2	680	682	PF02516	0.409
MOD_NEK2_1	275	280	PF00069	0.500
MOD_NEK2_1	640	645	PF00069	0.490
MOD_NEK2_1	647	652	PF00069	0.573
MOD_NEK2_1	656	661	PF00069	0.373
MOD_NEK2_1	683	688	PF00069	0.415
MOD_NEK2_1	781	786	PF00069	0.746
MOD_NEK2_1	824	829	PF00069	0.623
MOD_NEK2_2	367	372	PF00069	0.528
MOD_PIKK_1	148	154	PF00454	0.559
MOD_PIKK_1	484	490	PF00454	0.626
MOD_PIKK_1	49	55	PF00454	0.509
MOD_PIKK_1	582	588	PF00454	0.677
MOD_PIKK_1	712	718	PF00454	0.571
MOD_PK_1	96	102	PF00069	0.474
MOD_PKA_1	724	730	PF00069	0.570
MOD_PKA_2	122	128	PF00069	0.462
MOD_PKA_2	212	218	PF00069	0.525
MOD_PKA_2	275	281	PF00069	0.653
MOD_PKA_2	322	328	PF00069	0.728
MOD_PKA_2	347	353	PF00069	0.586
MOD_PKA_2	356	362	PF00069	0.602
MOD_PKA_2	376	382	PF00069	0.520
MOD_PKA_2	408	414	PF00069	0.657
MOD_PKA_2	434	440	PF00069	0.638
MOD_PKA_2	461	467	PF00069	0.520
MOD_PKA_2	521	527	PF00069	0.559
MOD_PKA_2	534	540	PF00069	0.494
MOD_PKA_2	551	557	PF00069	0.523
MOD_PKA_2	672	678	PF00069	0.579
MOD_PKA_2	724	730	PF00069	0.644
MOD_PKA_2	781	787	PF00069	0.671
MOD_PKA_2	795	801	PF00069	0.673
MOD_Plk_1	367	373	PF00069	0.637
MOD_Plk_1	431	437	PF00069	0.538
MOD_Plk_1	691	697	PF00069	0.465
MOD_Plk_2-3	603	609	PF00069	0.543
MOD_Plk_4	122	128	PF00069	0.495
MOD_Plk_4	29	35	PF00069	0.576
MOD_Plk_4	367	373	PF00069	0.525
MOD_Plk_4	647	653	PF00069	0.451
MOD_Plk_4	683	689	PF00069	0.415
MOD_Plk_4	691	697	PF00069	0.403
MOD_ProDKin_1	139	145	PF00069	0.388
MOD_ProDKin_1	179	185	PF00069	0.576
MOD_ProDKin_1	226	232	PF00069	0.585
MOD_ProDKin_1	242	248	PF00069	0.473
MOD_ProDKin_1	260	266	PF00069	0.591
MOD_ProDKin_1	270	276	PF00069	0.600
MOD_ProDKin_1	277	283	PF00069	0.591
MOD_ProDKin_1	336	342	PF00069	0.622
MOD_ProDKin_1	35	41	PF00069	0.337
MOD_ProDKin_1	399	405	PF00069	0.621
MOD_ProDKin_1	536	542	PF00069	0.537
MOD_ProDKin_1	552	558	PF00069	0.635
MOD_ProDKin_1	573	579	PF00069	0.576
MOD_ProDKin_1	59	65	PF00069	0.463
MOD_ProDKin_1	709	715	PF00069	0.592
MOD_ProDKin_1	725	731	PF00069	0.482
MOD_ProDKin_1	803	809	PF00069	0.721
MOD_ProDKin_1	812	818	PF00069	0.614
MOD_SUMO_for_1	224	227	PF00179	0.493
MOD_SUMO_rev_2	619	629	PF00179	0.499
TRG_DiLeu_BaEn_1	194	199	PF01217	0.501
TRG_DiLeu_BaEn_1	78	83	PF01217	0.411
TRG_ENDOCYTIC_2	79	82	PF00928	0.399
TRG_ER_diArg_1	299	301	PF00400	0.570
TRG_ER_diArg_1	348	351	PF00400	0.595
TRG_ER_diArg_1	477	479	PF00400	0.639
TRG_ER_diArg_1	506	509	PF00400	0.686
TRG_ER_diArg_1	577	580	PF00400	0.639
TRG_ER_diArg_1	614	616	PF00400	0.495
TRG_ER_diArg_1	622	624	PF00400	0.408
TRG_ER_diArg_1	701	704	PF00400	0.442
TRG_ER_diArg_1	724	726	PF00400	0.493
TRG_Pf-PMV_PEXEL_1	231	235	PF00026	0.638
TRG_Pf-PMV_PEXEL_1	236	240	PF00026	0.619
TRG_Pf-PMV_PEXEL_1	615	619	PF00026	0.489
TRG_Pf-PMV_PEXEL_1	80	84	PF00026	0.416

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P552	Leptomonas seymouri	38%	87%
A0A3Q8IED4	Leishmania donovani	86%	100%
A4HFV2	Leishmania braziliensis	67%	99%
A4I2Y5	Leishmania infantum	86%	100%
E9ADF6	Leishmania major	82%	100%