Casein kinase I-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

casein kinase I-like protein

Species:

Leishmania mexicana

UniProt:

E9AZ78_LEIMU

TriTrypDb:

LmxM.27.1780

Length:

568

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AZ78

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZ78

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	14
GO:0006793	phosphorus metabolic process	3	14
GO:0006796	phosphate-containing compound metabolic process	4	14
GO:0006807	nitrogen compound metabolic process	2	14
GO:0008152	metabolic process	1	14
GO:0009987	cellular process	1	14
GO:0016310	phosphorylation	5	14
GO:0019538	protein metabolic process	3	14
GO:0036211	protein modification process	4	14
GO:0043170	macromolecule metabolic process	3	14
GO:0043412	macromolecule modification	4	14
GO:0044237	cellular metabolic process	2	14
GO:0044238	primary metabolic process	2	14
GO:0071704	organic substance metabolic process	2	14
GO:1901564	organonitrogen compound metabolic process	3	14
GO:0007165	signal transduction	2	2
GO:0018105	peptidyl-serine phosphorylation	6	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018209	peptidyl-serine modification	6	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0065007	biological regulation	1	2
GO:0006810	transport	3	1
GO:0006897	endocytosis	5	1
GO:0016192	vesicle-mediated transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	14
GO:0003824	catalytic activity	1	14
GO:0004672	protein kinase activity	3	14
GO:0005488	binding	1	14
GO:0005524	ATP binding	5	14
GO:0016301	kinase activity	4	14
GO:0016740	transferase activity	2	14
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	14
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	14
GO:0017076	purine nucleotide binding	4	14
GO:0030554	adenyl nucleotide binding	5	14
GO:0032553	ribonucleotide binding	3	14
GO:0032555	purine ribonucleotide binding	4	14
GO:0032559	adenyl ribonucleotide binding	5	14
GO:0035639	purine ribonucleoside triphosphate binding	4	14
GO:0036094	small molecule binding	2	14
GO:0043167	ion binding	2	14
GO:0043168	anion binding	3	14
GO:0097159	organic cyclic compound binding	2	14
GO:0097367	carbohydrate derivative binding	2	14
GO:0140096	catalytic activity, acting on a protein	2	14
GO:1901265	nucleoside phosphate binding	3	14
GO:1901363	heterocyclic compound binding	2	14
GO:0004674	protein serine/threonine kinase activity	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	362	366	PF00656	0.346
CLV_C14_Caspase3-7	418	422	PF00656	0.335
CLV_C14_Caspase3-7	476	480	PF00656	0.458
CLV_C14_Caspase3-7	494	498	PF00656	0.607
CLV_NRD_NRD_1	191	193	PF00675	0.515
CLV_NRD_NRD_1	302	304	PF00675	0.239
CLV_NRD_NRD_1	335	337	PF00675	0.313
CLV_PCSK_KEX2_1	191	193	PF00082	0.488
CLV_PCSK_KEX2_1	335	337	PF00082	0.313
CLV_PCSK_KEX2_1	369	371	PF00082	0.463
CLV_PCSK_PC1ET2_1	369	371	PF00082	0.412
CLV_PCSK_SKI1_1	392	396	PF00082	0.297
DOC_CKS1_1	317	322	PF01111	0.240
DOC_MAPK_DCC_7	126	134	PF00069	0.372
DOC_MAPK_MEF2A_6	126	134	PF00069	0.384
DOC_PP4_FxxP_1	548	551	PF00568	0.543
DOC_USP7_MATH_1	146	150	PF00917	0.406
DOC_USP7_MATH_1	28	32	PF00917	0.554
DOC_USP7_MATH_1	435	439	PF00917	0.527
DOC_USP7_MATH_1	47	51	PF00917	0.566
DOC_WW_Pin1_4	316	321	PF00397	0.240
DOC_WW_Pin1_4	534	539	PF00397	0.545
DOC_WW_Pin1_4	558	563	PF00397	0.560
LIG_14-3-3_CanoR_1	105	109	PF00244	0.343
LIG_14-3-3_CanoR_1	138	146	PF00244	0.475
LIG_14-3-3_CanoR_1	244	248	PF00244	0.287
LIG_14-3-3_CanoR_1	321	326	PF00244	0.320
LIG_14-3-3_CanoR_1	360	364	PF00244	0.239
LIG_Actin_WH2_2	347	362	PF00022	0.242
LIG_Actin_WH2_2	407	422	PF00022	0.296
LIG_BIR_III_2	532	536	PF00653	0.565
LIG_BIR_III_4	519	523	PF00653	0.551
LIG_BRCT_BRCA1_1	113	117	PF00533	0.388
LIG_BRCT_BRCA1_1	148	152	PF00533	0.350
LIG_BRCT_BRCA1_1	296	300	PF00533	0.263
LIG_eIF4E_1	344	350	PF01652	0.240
LIG_FHA_1	248	254	PF00498	0.250
LIG_FHA_1	445	451	PF00498	0.385
LIG_FHA_2	105	111	PF00498	0.348
LIG_FHA_2	202	208	PF00498	0.448
LIG_FHA_2	474	480	PF00498	0.528
LIG_Integrin_isoDGR_2	189	191	PF01839	0.508
LIG_IRF3_LxIS_1	355	362	PF10401	0.239
LIG_LIR_Gen_1	246	254	PF02991	0.240
LIG_LIR_Gen_1	319	329	PF02991	0.240
LIG_LIR_Gen_1	406	416	PF02991	0.326
LIG_LIR_Nem_3	114	120	PF02991	0.453
LIG_LIR_Nem_3	246	251	PF02991	0.274
LIG_LIR_Nem_3	319	325	PF02991	0.290
LIG_LIR_Nem_3	389	394	PF02991	0.368
LIG_LIR_Nem_3	406	412	PF02991	0.337
LIG_LYPXL_S_1	26	30	PF13949	0.565
LIG_LYPXL_yS_3	27	30	PF13949	0.564
LIG_MYND_1	24	28	PF01753	0.556
LIG_NRBOX	411	417	PF00104	0.289
LIG_NRP_CendR_1	565	568	PF00754	0.560
LIG_PCNA_yPIPBox_3	213	226	PF02747	0.263
LIG_Pex14_2	102	106	PF04695	0.422
LIG_PTB_Apo_2	310	317	PF02174	0.263
LIG_SH2_CRK	322	326	PF00017	0.240
LIG_SH2_CRK	409	413	PF00017	0.375
LIG_SH2_PTP2	344	347	PF00017	0.263
LIG_SH2_PTP2	413	416	PF00017	0.222
LIG_SH2_SRC	269	272	PF00017	0.277
LIG_SH2_STAP1	397	401	PF00017	0.354
LIG_SH2_STAT3	216	219	PF00017	0.263
LIG_SH2_STAT3	48	51	PF00017	0.600
LIG_SH2_STAT5	269	272	PF00017	0.296
LIG_SH2_STAT5	290	293	PF00017	0.313
LIG_SH2_STAT5	344	347	PF00017	0.391
LIG_SH2_STAT5	348	351	PF00017	0.443
LIG_SH2_STAT5	413	416	PF00017	0.230
LIG_SH3_3	19	25	PF00018	0.546
LIG_SH3_3	314	320	PF00018	0.239
LIG_SH3_3	41	47	PF00018	0.549
LIG_SH3_3	49	55	PF00018	0.513
LIG_SH3_3	532	538	PF00018	0.544
LIG_SH3_3	544	550	PF00018	0.496
LIG_SH3_3	68	74	PF00018	0.518
LIG_SH3_3	80	86	PF00018	0.632
LIG_SUMO_SIM_anti_2	223	229	PF11976	0.336
LIG_SUMO_SIM_par_1	249	255	PF11976	0.289
LIG_TRAF2_1	204	207	PF00917	0.476
LIG_TYR_ITIM	342	347	PF00017	0.240
LIG_UBA3_1	177	184	PF00899	0.444
LIG_WW_1	24	27	PF00397	0.543
MOD_CDK_SPK_2	316	321	PF00069	0.240
MOD_CDK_SPK_2	534	539	PF00069	0.539
MOD_CDK_SPK_2	558	563	PF00069	0.490
MOD_CDK_SPxxK_3	558	565	PF00069	0.580
MOD_CK1_1	324	330	PF00069	0.290
MOD_CK1_1	428	434	PF00069	0.482
MOD_CK1_1	508	514	PF00069	0.608
MOD_CK2_1	201	207	PF00069	0.460
MOD_CK2_1	419	425	PF00069	0.328
MOD_Cter_Amidation	189	192	PF01082	0.518
MOD_GlcNHglycan	113	116	PF01048	0.411
MOD_GlcNHglycan	34	37	PF01048	0.589
MOD_GlcNHglycan	356	359	PF01048	0.240
MOD_GlcNHglycan	437	440	PF01048	0.505
MOD_GlcNHglycan	489	492	PF01048	0.546
MOD_GlcNHglycan	526	529	PF01048	0.571
MOD_GSK3_1	243	250	PF00069	0.252
MOD_GSK3_1	28	35	PF00069	0.552
MOD_GSK3_1	312	319	PF00069	0.381
MOD_GSK3_1	415	422	PF00069	0.360
MOD_GSK3_1	424	431	PF00069	0.469
MOD_GSK3_1	483	490	PF00069	0.619
MOD_GSK3_1	504	511	PF00069	0.592
MOD_GSK3_1	524	531	PF00069	0.563
MOD_N-GLC_1	28	33	PF02516	0.500
MOD_N-GLC_1	312	317	PF02516	0.263
MOD_N-GLC_1	435	440	PF02516	0.505
MOD_N-GLC_1	450	455	PF02516	0.476
MOD_N-GLC_1	528	533	PF02516	0.545
MOD_NEK2_1	1	6	PF00069	0.584
MOD_NEK2_1	226	231	PF00069	0.240
MOD_NEK2_1	247	252	PF00069	0.240
MOD_NEK2_1	294	299	PF00069	0.252
MOD_NEK2_1	329	334	PF00069	0.278
MOD_NEK2_1	415	420	PF00069	0.345
MOD_NEK2_1	504	509	PF00069	0.648
MOD_NEK2_2	243	248	PF00069	0.225
MOD_OFUCOSY	417	423	PF10250	0.311
MOD_PIKK_1	168	174	PF00454	0.373
MOD_PIKK_1	47	53	PF00454	0.581
MOD_PKA_1	303	309	PF00069	0.239
MOD_PKA_2	104	110	PF00069	0.349
MOD_PKA_2	137	143	PF00069	0.424
MOD_PKA_2	243	249	PF00069	0.274
MOD_PKA_2	359	365	PF00069	0.262
MOD_PKA_2	419	425	PF00069	0.354
MOD_PKA_2	508	514	PF00069	0.565
MOD_PKB_1	301	309	PF00069	0.173
MOD_Plk_1	146	152	PF00069	0.373
MOD_Plk_1	28	34	PF00069	0.521
MOD_Plk_1	312	318	PF00069	0.263
MOD_Plk_1	376	382	PF00069	0.352
MOD_Plk_1	428	434	PF00069	0.423
MOD_Plk_4	146	152	PF00069	0.383
MOD_Plk_4	243	249	PF00069	0.271
MOD_Plk_4	312	318	PF00069	0.280
MOD_Plk_4	97	103	PF00069	0.460
MOD_ProDKin_1	316	322	PF00069	0.240
MOD_ProDKin_1	534	540	PF00069	0.542
MOD_ProDKin_1	558	564	PF00069	0.561
MOD_SUMO_for_1	134	137	PF00179	0.430
MOD_SUMO_for_1	374	377	PF00179	0.315
MOD_SUMO_rev_2	149	158	PF00179	0.353
MOD_SUMO_rev_2	297	306	PF00179	0.173
TRG_DiLeu_BaEn_1	287	292	PF01217	0.240
TRG_DiLeu_BaLyEn_6	306	311	PF01217	0.233
TRG_ENDOCYTIC_2	27	30	PF00928	0.564
TRG_ENDOCYTIC_2	322	325	PF00928	0.290
TRG_ENDOCYTIC_2	344	347	PF00928	0.240
TRG_ENDOCYTIC_2	409	412	PF00928	0.342
TRG_ENDOCYTIC_2	413	416	PF00928	0.339
TRG_ER_diArg_1	350	353	PF00400	0.247
TRG_ER_diArg_1	562	565	PF00400	0.493
TRG_NES_CRM1_1	220	233	PF08389	0.239
TRG_NES_CRM1_1	287	302	PF08389	0.240

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKB0	Leptomonas seymouri	57%	100%
A0A0S4IVY6	Bodo saltans	29%	100%
A0A3Q8ISA0	Leishmania donovani	33%	100%
A0A3S7WZA2	Leishmania donovani	32%	100%
A0A3S7X0V1	Leishmania donovani	93%	100%
A4HFV0	Leishmania braziliensis	75%	98%
A4HIT6	Leishmania braziliensis	33%	100%
A4I1K4	Leishmania infantum	32%	100%
A4I2Y4	Leishmania infantum	93%	100%
A4I638	Leishmania infantum	33%	100%
E9ADF5	Leishmania major	92%	99%
E9B1C3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
Q4Q6U1	Leishmania major	32%	100%
Q8LPI7	Arabidopsis thaliana	30%	100%