C-CAP/cofactor C-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tubulin cofactor C domain-containing protein 1, putative

Species:

Leishmania mexicana

UniProt:

E9AZ76_LEIMU

TriTrypDb:

LmxM.27.1760

Length:

566

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000922	spindle pole	2	1
GO:0005737	cytoplasm	2	1
GO:0005815	microtubule organizing center	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AZ76

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZ76

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	21	25	PF00656	0.544
CLV_C14_Caspase3-7	211	215	PF00656	0.449
CLV_NRD_NRD_1	172	174	PF00675	0.557
CLV_NRD_NRD_1	3	5	PF00675	0.698
CLV_NRD_NRD_1	500	502	PF00675	0.428
CLV_PCSK_KEX2_1	174	176	PF00082	0.607
CLV_PCSK_KEX2_1	3	5	PF00082	0.698
CLV_PCSK_KEX2_1	500	502	PF00082	0.428
CLV_PCSK_PC1ET2_1	174	176	PF00082	0.589
CLV_PCSK_SKI1_1	132	136	PF00082	0.460
DEG_APCC_DBOX_1	131	139	PF00400	0.460
DEG_SCF_FBW7_1	109	116	PF00400	0.527
DEG_SPOP_SBC_1	25	29	PF00917	0.578
DOC_CKS1_1	110	115	PF01111	0.572
DOC_CKS1_1	384	389	PF01111	0.410
DOC_MAPK_DCC_7	154	163	PF00069	0.378
DOC_MAPK_gen_1	78	86	PF00069	0.473
DOC_MAPK_MEF2A_6	154	163	PF00069	0.378
DOC_MAPK_RevD_3	161	175	PF00069	0.526
DOC_PP2B_LxvP_1	490	493	PF13499	0.541
DOC_PP2B_LxvP_1	50	53	PF13499	0.520
DOC_USP7_MATH_1	148	152	PF00917	0.471
DOC_USP7_MATH_1	25	29	PF00917	0.684
DOC_USP7_MATH_1	392	396	PF00917	0.370
DOC_USP7_MATH_1	400	404	PF00917	0.662
DOC_USP7_MATH_1	426	430	PF00917	0.363
DOC_USP7_MATH_1	5	9	PF00917	0.705
DOC_USP7_MATH_2	463	469	PF00917	0.541
DOC_WW_Pin1_4	109	114	PF00397	0.554
DOC_WW_Pin1_4	295	300	PF00397	0.509
DOC_WW_Pin1_4	383	388	PF00397	0.279
DOC_WW_Pin1_4	441	446	PF00397	0.490
LIG_14-3-3_CanoR_1	120	124	PF00244	0.652
LIG_14-3-3_CanoR_1	154	159	PF00244	0.407
LIG_14-3-3_CanoR_1	209	213	PF00244	0.480
LIG_14-3-3_CanoR_1	309	317	PF00244	0.410
LIG_14-3-3_CanoR_1	534	539	PF00244	0.486
LIG_Actin_WH2_2	505	522	PF00022	0.552
LIG_Actin_WH2_2	528	546	PF00022	0.442
LIG_BIR_II_1	1	5	PF00653	0.589
LIG_BRCT_BRCA1_1	235	239	PF00533	0.469
LIG_BRCT_BRCA1_1	467	471	PF00533	0.548
LIG_BRCT_BRCA1_1	5	9	PF00533	0.702
LIG_EVH1_2	462	466	PF00568	0.402
LIG_FHA_1	245	251	PF00498	0.454
LIG_FHA_1	272	278	PF00498	0.668
LIG_FHA_1	292	298	PF00498	0.316
LIG_FHA_1	341	347	PF00498	0.389
LIG_FHA_1	377	383	PF00498	0.288
LIG_FHA_1	384	390	PF00498	0.294
LIG_FHA_1	514	520	PF00498	0.489
LIG_FHA_1	56	62	PF00498	0.426
LIG_FHA_2	209	215	PF00498	0.464
LIG_FHA_2	544	550	PF00498	0.550
LIG_IRF3_LxIS_1	311	318	PF10401	0.424
LIG_LIR_Gen_1	254	263	PF02991	0.612
LIG_LIR_Gen_1	298	307	PF02991	0.577
LIG_LIR_Gen_1	379	389	PF02991	0.410
LIG_LIR_Gen_1	464	474	PF02991	0.562
LIG_LIR_Gen_1	92	103	PF02991	0.412
LIG_LIR_Nem_3	254	259	PF02991	0.603
LIG_LIR_Nem_3	298	303	PF02991	0.577
LIG_LIR_Nem_3	379	384	PF02991	0.386
LIG_LIR_Nem_3	92	98	PF02991	0.408
LIG_LIR_Nem_3	99	104	PF02991	0.400
LIG_LYPXL_S_1	430	434	PF13949	0.500
LIG_LYPXL_yS_3	431	434	PF13949	0.493
LIG_MYND_1	388	392	PF01753	0.306
LIG_MYND_2	387	391	PF01753	0.306
LIG_NRBOX	161	167	PF00104	0.500
LIG_NRBOX	217	223	PF00104	0.465
LIG_Pex14_2	239	243	PF04695	0.581
LIG_Pex14_2	98	102	PF04695	0.516
LIG_PTB_Apo_2	36	43	PF02174	0.486
LIG_SH2_CRK	300	304	PF00017	0.621
LIG_SH2_PTP2	381	384	PF00017	0.355
LIG_SH2_SRC	326	329	PF00017	0.410
LIG_SH2_STAT3	190	193	PF00017	0.519
LIG_SH2_STAT5	190	193	PF00017	0.511
LIG_SH2_STAT5	220	223	PF00017	0.610
LIG_SH2_STAT5	256	259	PF00017	0.602
LIG_SH2_STAT5	381	384	PF00017	0.410
LIG_SH3_3	153	159	PF00018	0.413
LIG_SH3_3	226	232	PF00018	0.505
LIG_SH3_3	381	387	PF00018	0.410
LIG_SH3_3	449	455	PF00018	0.411
LIG_SUMO_SIM_anti_2	249	254	PF11976	0.456
LIG_SUMO_SIM_par_1	386	396	PF11976	0.222
LIG_TRAF2_1	546	549	PF00917	0.514
LIG_TRFH_1	300	304	PF08558	0.616
LIG_TYR_ITSM	377	384	PF00017	0.410
LIG_UBA3_1	165	174	PF00899	0.509
LIG_WRC_WIRS_1	427	432	PF05994	0.487
MOD_CK1_1	14	20	PF00069	0.732
MOD_CK1_1	208	214	PF00069	0.571
MOD_CK1_1	27	33	PF00069	0.414
MOD_CK1_1	272	278	PF00069	0.526
MOD_CK1_1	313	319	PF00069	0.285
MOD_CK1_1	337	343	PF00069	0.440
MOD_CK1_1	373	379	PF00069	0.386
MOD_CK1_1	393	399	PF00069	0.445
MOD_CK1_1	403	409	PF00069	0.725
MOD_CK1_1	415	421	PF00069	0.575
MOD_CK1_1	441	447	PF00069	0.473
MOD_CK1_1	480	486	PF00069	0.607
MOD_CK1_1	54	60	PF00069	0.462
MOD_CK2_1	113	119	PF00069	0.671
MOD_CK2_1	543	549	PF00069	0.501
MOD_GlcNHglycan	104	107	PF01048	0.542
MOD_GlcNHglycan	115	118	PF01048	0.584
MOD_GlcNHglycan	13	16	PF01048	0.626
MOD_GlcNHglycan	199	202	PF01048	0.573
MOD_GlcNHglycan	20	23	PF01048	0.581
MOD_GlcNHglycan	271	274	PF01048	0.620
MOD_GlcNHglycan	363	366	PF01048	0.232
MOD_GlcNHglycan	402	405	PF01048	0.714
MOD_GlcNHglycan	417	420	PF01048	0.564
MOD_GlcNHglycan	440	443	PF01048	0.407
MOD_GlcNHglycan	475	478	PF01048	0.550
MOD_GlcNHglycan	5	8	PF01048	0.622
MOD_GlcNHglycan	513	516	PF01048	0.481
MOD_GlcNHglycan	53	56	PF01048	0.465
MOD_GSK3_1	109	116	PF00069	0.645
MOD_GSK3_1	13	20	PF00069	0.606
MOD_GSK3_1	269	276	PF00069	0.582
MOD_GSK3_1	291	298	PF00069	0.509
MOD_GSK3_1	305	312	PF00069	0.450
MOD_GSK3_1	331	338	PF00069	0.322
MOD_GSK3_1	400	407	PF00069	0.716
MOD_GSK3_1	411	418	PF00069	0.459
MOD_GSK3_1	437	444	PF00069	0.509
MOD_GSK3_1	461	468	PF00069	0.507
MOD_GSK3_1	473	480	PF00069	0.557
MOD_GSK3_1	5	12	PF00069	0.653
MOD_GSK3_1	51	58	PF00069	0.455
MOD_GSK3_1	555	562	PF00069	0.587
MOD_GSK3_1	65	72	PF00069	0.462
MOD_LATS_1	532	538	PF00433	0.547
MOD_N-GLC_1	284	289	PF02516	0.497
MOD_N-GLC_1	313	318	PF02516	0.336
MOD_N-GLC_1	340	345	PF02516	0.279
MOD_N-GLC_1	373	378	PF02516	0.344
MOD_N-GLC_1	477	482	PF02516	0.656
MOD_N-GLC_1	69	74	PF02516	0.400
MOD_NEK2_1	102	107	PF00069	0.381
MOD_NEK2_1	291	296	PF00069	0.403
MOD_NEK2_1	310	315	PF00069	0.403
MOD_NEK2_1	335	340	PF00069	0.379
MOD_NEK2_1	473	478	PF00069	0.627
MOD_NEK2_1	543	548	PF00069	0.496
MOD_NEK2_1	555	560	PF00069	0.600
MOD_NEK2_1	56	61	PF00069	0.383
MOD_NEK2_1	65	70	PF00069	0.444
MOD_NEK2_1	89	94	PF00069	0.436
MOD_NEK2_1	9	14	PF00069	0.712
MOD_NEK2_2	426	431	PF00069	0.479
MOD_PIKK_1	121	127	PF00454	0.391
MOD_PIKK_1	14	20	PF00454	0.598
MOD_PIKK_1	251	257	PF00454	0.446
MOD_PIKK_1	318	324	PF00454	0.293
MOD_PKA_1	3	9	PF00069	0.706
MOD_PKA_2	119	125	PF00069	0.655
MOD_PKA_2	205	211	PF00069	0.450
MOD_PKA_2	3	9	PF00069	0.706
MOD_PKA_2	400	406	PF00069	0.602
MOD_PKA_2	533	539	PF00069	0.520
MOD_PKA_2	89	95	PF00069	0.425
MOD_Plk_1	118	124	PF00069	0.635
MOD_Plk_1	244	250	PF00069	0.429
MOD_Plk_1	284	290	PF00069	0.556
MOD_Plk_1	313	319	PF00069	0.357
MOD_Plk_1	340	346	PF00069	0.279
MOD_Plk_1	376	382	PF00069	0.391
MOD_Plk_1	69	75	PF00069	0.396
MOD_Plk_1	90	96	PF00069	0.543
MOD_Plk_4	326	332	PF00069	0.322
MOD_Plk_4	376	382	PF00069	0.322
MOD_Plk_4	426	432	PF00069	0.531
MOD_Plk_4	456	462	PF00069	0.501
MOD_Plk_4	534	540	PF00069	0.419
MOD_Plk_4	57	63	PF00069	0.547
MOD_Plk_4	82	88	PF00069	0.419
MOD_ProDKin_1	109	115	PF00069	0.557
MOD_ProDKin_1	295	301	PF00069	0.521
MOD_ProDKin_1	383	389	PF00069	0.279
MOD_ProDKin_1	441	447	PF00069	0.493
TRG_DiLeu_BaEn_1	217	222	PF01217	0.457
TRG_DiLeu_BaLyEn_6	306	311	PF01217	0.578
TRG_DiLeu_BaLyEn_6	442	447	PF01217	0.539
TRG_ENDOCYTIC_2	256	259	PF00928	0.602
TRG_ENDOCYTIC_2	300	303	PF00928	0.566
TRG_ENDOCYTIC_2	381	384	PF00928	0.386
TRG_ENDOCYTIC_2	427	430	PF00928	0.367
TRG_ENDOCYTIC_2	431	434	PF00928	0.347
TRG_ENDOCYTIC_2	95	98	PF00928	0.405
TRG_ER_diArg_1	257	260	PF00400	0.476
TRG_ER_diArg_1	3	5	PF00400	0.642
TRG_ER_diArg_1	500	502	PF00400	0.428
TRG_Pf-PMV_PEXEL_1	132	136	PF00026	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8E5	Leptomonas seymouri	75%	100%
A0A1X0P3V6	Trypanosomatidae	47%	100%
A0A3Q8IEG6	Leishmania donovani	92%	99%
A0A3R7M8R7	Trypanosoma rangeli	48%	100%
A4HFU9	Leishmania braziliensis	86%	100%
A4I2W6	Leishmania infantum	92%	99%
D0A651	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9ADF3	Leishmania major	92%	100%
V5BYH8	Trypanosoma cruzi	48%	100%