BAR domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Flabarin, putative

Species:

Leishmania mexicana

UniProt:

E9AZ74_LEIMU

TriTrypDb:

LmxM.27.1730

Length:

340

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 6
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 24

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	1
GO:0031090	organelle membrane	3	1
GO:0031253	cell projection membrane	4	1
GO:0060170	ciliary membrane	5	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098590	plasma membrane region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AZ74

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZ74

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	286	290	PF00656	0.547
CLV_C14_Caspase3-7	314	318	PF00656	0.566
CLV_C14_Caspase3-7	74	78	PF00656	0.483
CLV_NRD_NRD_1	246	248	PF00675	0.638
CLV_NRD_NRD_1	250	252	PF00675	0.652
CLV_NRD_NRD_1	68	70	PF00675	0.619
CLV_PCSK_KEX2_1	160	162	PF00082	0.619
CLV_PCSK_KEX2_1	246	248	PF00082	0.638
CLV_PCSK_KEX2_1	250	252	PF00082	0.652
CLV_PCSK_KEX2_1	283	285	PF00082	0.544
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.562
CLV_PCSK_PC1ET2_1	283	285	PF00082	0.544
CLV_PCSK_PC7_1	246	252	PF00082	0.435
CLV_PCSK_SKI1_1	111	115	PF00082	0.476
CLV_PCSK_SKI1_1	172	176	PF00082	0.579
CLV_PCSK_SKI1_1	187	191	PF00082	0.552
CLV_PCSK_SKI1_1	27	31	PF00082	0.524
CLV_PCSK_SKI1_1	80	84	PF00082	0.531
DEG_SPOP_SBC_1	149	153	PF00917	0.436
DOC_MAPK_gen_1	111	122	PF00069	0.423
DOC_USP7_MATH_1	113	117	PF00917	0.461
DOC_USP7_MATH_1	142	146	PF00917	0.541
DOC_USP7_MATH_1	149	153	PF00917	0.656
DOC_USP7_MATH_1	164	168	PF00917	0.539
DOC_USP7_MATH_1	245	249	PF00917	0.570
DOC_USP7_UBL2_3	107	111	PF12436	0.499
DOC_USP7_UBL2_3	139	143	PF12436	0.627
DOC_USP7_UBL2_3	156	160	PF12436	0.519
DOC_USP7_UBL2_3	234	238	PF12436	0.499
LIG_14-3-3_CanoR_1	69	73	PF00244	0.351
LIG_Actin_WH2_2	96	113	PF00022	0.489
LIG_BRCT_BRCA1_1	223	227	PF00533	0.566
LIG_BRCT_BRCA1_1	254	258	PF00533	0.698
LIG_CaM_IQ_9	179	194	PF13499	0.419
LIG_FHA_1	15	21	PF00498	0.571
LIG_FHA_1	184	190	PF00498	0.582
LIG_FHA_1	97	103	PF00498	0.548
LIG_FHA_2	215	221	PF00498	0.602
LIG_FHA_2	312	318	PF00498	0.643
LIG_FHA_2	46	52	PF00498	0.515
LIG_LIR_Gen_1	126	134	PF02991	0.494
LIG_LIR_Gen_1	48	57	PF02991	0.461
LIG_LIR_Nem_3	126	130	PF02991	0.547
LIG_LIR_Nem_3	48	53	PF02991	0.453
LIG_SH2_CRK	127	131	PF00017	0.499
LIG_SH2_CRK	43	47	PF00017	0.428
LIG_SH2_CRK	57	61	PF00017	0.439
LIG_SH2_GRB2like	319	322	PF00017	0.642
LIG_SH2_GRB2like	43	46	PF00017	0.404
LIG_SH2_STAP1	319	323	PF00017	0.611
LIG_SH2_STAT3	141	144	PF00017	0.395
LIG_SH2_STAT5	197	200	PF00017	0.471
LIG_SH2_STAT5	21	24	PF00017	0.437
LIG_SH3_3	99	105	PF00018	0.447
LIG_SUMO_SIM_anti_2	99	104	PF11976	0.415
LIG_SUMO_SIM_par_1	98	104	PF11976	0.412
LIG_WRC_WIRS_1	88	93	PF05994	0.512
MOD_CK1_1	222	228	PF00069	0.602
MOD_CK1_1	266	272	PF00069	0.673
MOD_CK1_1	35	41	PF00069	0.608
MOD_CK2_1	68	74	PF00069	0.365
MOD_GlcNHglycan	220	224	PF01048	0.635
MOD_GlcNHglycan	291	294	PF01048	0.830
MOD_GSK3_1	150	157	PF00069	0.610
MOD_GSK3_1	164	171	PF00069	0.559
MOD_GSK3_1	178	185	PF00069	0.433
MOD_GSK3_1	219	226	PF00069	0.556
MOD_GSK3_1	262	269	PF00069	0.817
MOD_GSK3_1	3	10	PF00069	0.621
MOD_GSK3_1	31	38	PF00069	0.550
MOD_GSK3_1	311	318	PF00069	0.712
MOD_N-GLC_1	266	271	PF02516	0.646
MOD_N-GLC_1	289	294	PF02516	0.601
MOD_N-GLC_1	311	316	PF02516	0.617
MOD_N-GLC_1	32	37	PF02516	0.487
MOD_NEK2_1	148	153	PF00069	0.554
MOD_NEK2_1	182	187	PF00069	0.552
MOD_NEK2_1	190	195	PF00069	0.467
MOD_NEK2_1	198	203	PF00069	0.494
MOD_NEK2_1	3	8	PF00069	0.653
MOD_NEK2_1	32	37	PF00069	0.470
MOD_NEK2_2	113	118	PF00069	0.411
MOD_PIKK_1	245	251	PF00454	0.515
MOD_PKA_1	283	289	PF00069	0.650
MOD_PKA_2	245	251	PF00069	0.524
MOD_PKA_2	283	289	PF00069	0.596
MOD_PKA_2	315	321	PF00069	0.569
MOD_PKA_2	68	74	PF00069	0.355
MOD_Plk_1	137	143	PF00069	0.491
MOD_Plk_1	208	214	PF00069	0.601
MOD_Plk_1	311	317	PF00069	0.669
MOD_Plk_1	32	38	PF00069	0.433
MOD_Plk_2-3	311	317	PF00069	0.643
MOD_Plk_4	185	191	PF00069	0.534
MOD_Plk_4	283	289	PF00069	0.622
MOD_SUMO_rev_2	104	113	PF00179	0.571
TRG_DiLeu_BaEn_4	177	183	PF01217	0.405
TRG_ENDOCYTIC_2	127	130	PF00928	0.548
TRG_ENDOCYTIC_2	43	46	PF00928	0.454
TRG_ENDOCYTIC_2	57	60	PF00928	0.512
TRG_Pf-PMV_PEXEL_1	18	23	PF00026	0.431
TRG_Pf-PMV_PEXEL_1	80	84	PF00026	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3S1	Leptomonas seymouri	25%	74%
A0A0N1PG41	Leptomonas seymouri	59%	100%
A0A3Q8IKU7	Leishmania donovani	26%	100%
A0A3S5H792	Leishmania donovani	24%	100%
A0A3S5H7I1	Leishmania donovani	90%	100%
A4HBK0	Leishmania braziliensis	22%	100%
A4HFU7	Leishmania braziliensis	72%	100%
A4HZL5	Leishmania infantum	24%	100%
A4HZL6	Leishmania infantum	26%	100%
A4I2W4	Leishmania infantum	90%	100%
E9ADF0	Leishmania major	87%	100%
E9AUW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AUW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
Q4QCL3	Leishmania major	21%	100%
Q4QCL4	Leishmania major	26%	100%
V5BQF9	Trypanosoma cruzi	30%	100%