C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mRNA export factor MEX67

Species:

Leishmania mexicana

UniProt:

E9AZ72_LEIMU

TriTrypDb:

LmxM.27.1690

Length:

616

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	20
GO:0042995	cell projection	2	20
GO:0043226	organelle	2	20
GO:0043227	membrane-bounded organelle	3	20
GO:0110165	cellular anatomical entity	1	20
GO:0120025	plasma membrane bounded cell projection	3	20
GO:0005634	nucleus	5	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0005643	nuclear pore	3	1
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

E9AZ72

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZ72

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	3
GO:0015931	nucleobase-containing compound transport	5	3
GO:0050657	nucleic acid transport	6	3
GO:0050658	RNA transport	4	3
GO:0051028	mRNA transport	5	3
GO:0051179	localization	1	3
GO:0051234	establishment of localization	2	3
GO:0051236	establishment of RNA localization	3	3
GO:0071702	organic substance transport	4	3
GO:0071705	nitrogen compound transport	4	3
GO:0006405	RNA export from nucleus	5	2
GO:0006406	mRNA export from nucleus	6	2
GO:0006913	nucleocytoplasmic transport	5	2
GO:0009987	cellular process	1	2
GO:0016973	poly(A)+ mRNA export from nucleus	7	2
GO:0046907	intracellular transport	3	2
GO:0051168	nuclear export	6	2
GO:0051169	nuclear transport	4	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	283	287	PF00656	0.534
CLV_NRD_NRD_1	528	530	PF00675	0.438
CLV_PCSK_KEX2_1	441	443	PF00082	0.393
CLV_PCSK_KEX2_1	521	523	PF00082	0.493
CLV_PCSK_KEX2_1	528	530	PF00082	0.452
CLV_PCSK_PC1ET2_1	441	443	PF00082	0.491
CLV_PCSK_PC1ET2_1	521	523	PF00082	0.449
CLV_PCSK_SKI1_1	22	26	PF00082	0.524
CLV_PCSK_SKI1_1	259	263	PF00082	0.423
CLV_PCSK_SKI1_1	446	450	PF00082	0.395
CLV_PCSK_SKI1_1	70	74	PF00082	0.411
DEG_SCF_FBW7_1	309	315	PF00400	0.546
DOC_CDC14_PxL_1	275	283	PF14671	0.420
DOC_CKS1_1	17	22	PF01111	0.436
DOC_CKS1_1	309	314	PF01111	0.548
DOC_CKS1_1	496	501	PF01111	0.535
DOC_CYCLIN_RxL_1	256	263	PF00134	0.316
DOC_MAPK_gen_1	257	264	PF00069	0.303
DOC_MAPK_MEF2A_6	531	539	PF00069	0.372
DOC_PP1_RVXF_1	198	204	PF00149	0.553
DOC_PP1_RVXF_1	68	74	PF00149	0.372
DOC_PP2B_LxvP_1	223	226	PF13499	0.574
DOC_PP4_FxxP_1	230	233	PF00568	0.637
DOC_USP7_MATH_1	307	311	PF00917	0.484
DOC_USP7_MATH_1	490	494	PF00917	0.737
DOC_USP7_MATH_1	576	580	PF00917	0.466
DOC_USP7_UBL2_3	200	204	PF12436	0.551
DOC_WW_Pin1_4	123	128	PF00397	0.530
DOC_WW_Pin1_4	16	21	PF00397	0.460
DOC_WW_Pin1_4	308	313	PF00397	0.501
DOC_WW_Pin1_4	318	323	PF00397	0.614
DOC_WW_Pin1_4	380	385	PF00397	0.530
DOC_WW_Pin1_4	495	500	PF00397	0.642
DOC_WW_Pin1_4	512	517	PF00397	0.518
LIG_14-3-3_CanoR_1	159	164	PF00244	0.358
LIG_14-3-3_CanoR_1	335	345	PF00244	0.455
LIG_14-3-3_CanoR_1	358	362	PF00244	0.411
LIG_14-3-3_CanoR_1	40	45	PF00244	0.695
LIG_14-3-3_CanoR_1	446	451	PF00244	0.377
LIG_14-3-3_CanoR_1	46	53	PF00244	0.714
LIG_APCC_ABBA_1	69	74	PF00400	0.502
LIG_BRCT_BRCA1_1	104	108	PF00533	0.380
LIG_CaM_NSCaTE_8	209	216	PF13499	0.343
LIG_deltaCOP1_diTrp_1	224	231	PF00928	0.680
LIG_EH1_1	458	466	PF00400	0.381
LIG_FHA_1	110	116	PF00498	0.365
LIG_FHA_1	297	303	PF00498	0.461
LIG_FHA_1	351	357	PF00498	0.533
LIG_FHA_1	492	498	PF00498	0.691
LIG_FHA_1	59	65	PF00498	0.462
LIG_FHA_1	75	81	PF00498	0.320
LIG_FHA_1	83	89	PF00498	0.437
LIG_FHA_2	167	173	PF00498	0.497
LIG_FHA_2	281	287	PF00498	0.551
LIG_FHA_2	568	574	PF00498	0.493
LIG_FHA_2	92	98	PF00498	0.532
LIG_LIR_Gen_1	297	308	PF02991	0.552
LIG_LIR_Gen_1	606	614	PF02991	0.354
LIG_LIR_Gen_1	94	103	PF02991	0.443
LIG_LIR_Nem_3	224	230	PF02991	0.580
LIG_LIR_Nem_3	297	303	PF02991	0.511
LIG_LIR_Nem_3	606	610	PF02991	0.530
LIG_LIR_Nem_3	94	99	PF02991	0.422
LIG_PCNA_PIPBox_1	65	74	PF02747	0.392
LIG_PCNA_yPIPBox_3	252	265	PF02747	0.551
LIG_PCNA_yPIPBox_3	372	380	PF02747	0.442
LIG_Pex14_1	227	231	PF04695	0.673
LIG_PTB_Apo_2	388	395	PF02174	0.638
LIG_REV1ctd_RIR_1	21	30	PF16727	0.536
LIG_REV1ctd_RIR_1	70	79	PF16727	0.524
LIG_SH2_CRK	17	21	PF00017	0.490
LIG_SH2_CRK	510	514	PF00017	0.624
LIG_SH2_CRK	530	534	PF00017	0.209
LIG_SH2_SRC	36	39	PF00017	0.535
LIG_SH2_STAP1	510	514	PF00017	0.624
LIG_SH2_STAP1	565	569	PF00017	0.436
LIG_SH2_STAT5	36	39	PF00017	0.535
LIG_SH2_STAT5	379	382	PF00017	0.486
LIG_SH3_3	122	128	PF00018	0.435
LIG_SH3_3	186	192	PF00018	0.467
LIG_SH3_3	266	272	PF00018	0.494
LIG_SH3_3	288	294	PF00018	0.413
LIG_SH3_3	306	312	PF00018	0.483
LIG_SH3_3	365	371	PF00018	0.477
LIG_SH3_3	493	499	PF00018	0.724
LIG_SH3_3	529	535	PF00018	0.570
LIG_SUMO_SIM_anti_2	385	390	PF11976	0.576
LIG_SUMO_SIM_anti_2	595	602	PF11976	0.417
LIG_SUMO_SIM_par_1	404	410	PF11976	0.416
LIG_SUMO_SIM_par_1	445	454	PF11976	0.496
LIG_SUMO_SIM_par_1	558	566	PF11976	0.479
LIG_TRAF2_1	148	151	PF00917	0.464
LIG_UBA3_1	346	350	PF00899	0.645
LIG_UBA3_1	68	75	PF00899	0.406
LIG_WRC_WIRS_1	261	266	PF05994	0.233
LIG_WRC_WIRS_1	540	545	PF05994	0.386
LIG_WRC_WIRS_1	93	98	PF05994	0.473
MOD_CDK_SPxK_1	16	22	PF00069	0.442
MOD_CDK_SPxK_1	308	314	PF00069	0.491
MOD_CDK_SPxxK_3	318	325	PF00069	0.556
MOD_CK1_1	301	307	PF00069	0.469
MOD_CK1_1	310	316	PF00069	0.520
MOD_CK1_1	407	413	PF00069	0.460
MOD_CK1_1	515	521	PF00069	0.557
MOD_CK1_1	91	97	PF00069	0.485
MOD_CK2_1	46	52	PF00069	0.532
MOD_CK2_1	471	477	PF00069	0.486
MOD_CK2_1	543	549	PF00069	0.543
MOD_CK2_1	567	573	PF00069	0.484
MOD_GlcNHglycan	195	198	PF01048	0.286
MOD_GlcNHglycan	248	251	PF01048	0.676
MOD_GlcNHglycan	266	269	PF01048	0.451
MOD_GlcNHglycan	473	476	PF01048	0.556
MOD_GlcNHglycan	486	489	PF01048	0.670
MOD_GlcNHglycan	606	610	PF01048	0.497
MOD_GSK3_1	123	130	PF00069	0.415
MOD_GSK3_1	260	267	PF00069	0.372
MOD_GSK3_1	294	301	PF00069	0.353
MOD_GSK3_1	308	315	PF00069	0.436
MOD_GSK3_1	40	47	PF00069	0.655
MOD_GSK3_1	442	449	PF00069	0.339
MOD_GSK3_1	491	498	PF00069	0.518
MOD_GSK3_1	539	546	PF00069	0.444
MOD_GSK3_1	88	95	PF00069	0.428
MOD_GSK3_1	97	104	PF00069	0.411
MOD_LATS_1	165	171	PF00433	0.341
MOD_LATS_1	38	44	PF00433	0.638
MOD_N-GLC_1	294	299	PF02516	0.519
MOD_N-GLC_1	40	45	PF02516	0.660
MOD_N-GLC_1	442	447	PF02516	0.412
MOD_N-GLC_1	58	63	PF02516	0.561
MOD_N-GLC_1	88	93	PF02516	0.418
MOD_NEK2_1	154	159	PF00069	0.398
MOD_NEK2_1	25	30	PF00069	0.584
MOD_NEK2_1	264	269	PF00069	0.422
MOD_NEK2_1	298	303	PF00069	0.400
MOD_NEK2_1	349	354	PF00069	0.556
MOD_NEK2_1	605	610	PF00069	0.352
MOD_NEK2_1	88	93	PF00069	0.438
MOD_NEK2_2	576	581	PF00069	0.480
MOD_NEK2_2	58	63	PF00069	0.503
MOD_OFUCOSY	114	120	PF10250	0.465
MOD_PIKK_1	74	80	PF00454	0.575
MOD_PIKK_1	88	94	PF00454	0.414
MOD_PK_1	167	173	PF00069	0.346
MOD_PKA_2	25	31	PF00069	0.543
MOD_PKA_2	336	342	PF00069	0.502
MOD_PKA_2	357	363	PF00069	0.516
MOD_Plk_1	294	300	PF00069	0.514
MOD_Plk_1	40	46	PF00069	0.681
MOD_Plk_1	442	448	PF00069	0.413
MOD_Plk_1	605	611	PF00069	0.352
MOD_Plk_1	88	94	PF00069	0.398
MOD_Plk_1	97	103	PF00069	0.408
MOD_Plk_4	127	133	PF00069	0.404
MOD_Plk_4	260	266	PF00069	0.426
MOD_Plk_4	40	46	PF00069	0.676
MOD_Plk_4	404	410	PF00069	0.492
MOD_Plk_4	429	435	PF00069	0.655
MOD_Plk_4	463	469	PF00069	0.393
MOD_Plk_4	539	545	PF00069	0.509
MOD_Plk_4	567	573	PF00069	0.420
MOD_Plk_4	576	582	PF00069	0.344
MOD_Plk_4	64	70	PF00069	0.420
MOD_ProDKin_1	123	129	PF00069	0.526
MOD_ProDKin_1	16	22	PF00069	0.456
MOD_ProDKin_1	308	314	PF00069	0.505
MOD_ProDKin_1	318	324	PF00069	0.604
MOD_ProDKin_1	380	386	PF00069	0.525
MOD_ProDKin_1	495	501	PF00069	0.640
MOD_ProDKin_1	512	518	PF00069	0.521
MOD_SUMO_for_1	363	366	PF00179	0.498
MOD_SUMO_rev_2	135	142	PF00179	0.523
MOD_SUMO_rev_2	195	201	PF00179	0.503
MOD_SUMO_rev_2	385	394	PF00179	0.613
MOD_SUMO_rev_2	515	523	PF00179	0.488
TRG_DiLeu_BaEn_1	595	600	PF01217	0.402
TRG_ENDOCYTIC_2	36	39	PF00928	0.535
TRG_ENDOCYTIC_2	510	513	PF00928	0.623
TRG_ER_diArg_1	334	337	PF00400	0.507
TRG_ER_diArg_1	528	530	PF00400	0.477
TRG_NLS_MonoExtC_3	5	11	PF00514	0.557
TRG_NLS_MonoExtN_4	3	10	PF00514	0.679
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.481

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8E9	Leptomonas seymouri	70%	98%
A0A0N0P8S6	Leptomonas seymouri	25%	100%
A0A0S4IW66	Bodo saltans	30%	100%
A0A1X0P4A3	Trypanosomatidae	28%	100%
A0A1X0P4L1	Trypanosomatidae	44%	100%
A0A3R7NID6	Trypanosoma rangeli	44%	100%
A0A3S7X0T0	Leishmania donovani	25%	100%
A0A3S7X0T8	Leishmania donovani	95%	100%
A4HFU4	Leishmania braziliensis	85%	100%
A4I2W0	Leishmania infantum	25%	100%
A4I2W1	Leishmania infantum	95%	100%
D0A641	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D0A644	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9ADE7	Leishmania major	24%	100%
E9ADE8	Leishmania major	94%	100%
E9AZ71	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
V5B0W6	Trypanosoma cruzi	45%	100%
V5BQG4	Trypanosoma cruzi	27%	100%