Nuclear RNA export factor 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZ71_LEIMU

TriTrypDb:

LmxM.27.1680

Length:

550

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	21
GO:0042995	cell projection	2	21
GO:0043226	organelle	2	21
GO:0043227	membrane-bounded organelle	3	21
GO:0110165	cellular anatomical entity	1	21
GO:0120025	plasma membrane bounded cell projection	3	21
GO:0005634	nucleus	5	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0005643	nuclear pore	3	1
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

E9AZ71

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZ71

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	3
GO:0015931	nucleobase-containing compound transport	5	3
GO:0050657	nucleic acid transport	6	3
GO:0050658	RNA transport	4	3
GO:0051028	mRNA transport	5	3
GO:0051179	localization	1	3
GO:0051234	establishment of localization	2	3
GO:0051236	establishment of RNA localization	3	3
GO:0071702	organic substance transport	4	3
GO:0071705	nitrogen compound transport	4	3
GO:0006405	RNA export from nucleus	5	2
GO:0006406	mRNA export from nucleus	6	2
GO:0006913	nucleocytoplasmic transport	5	2
GO:0009987	cellular process	1	2
GO:0016973	poly(A)+ mRNA export from nucleus	7	2
GO:0046907	intracellular transport	3	2
GO:0051168	nuclear export	6	2
GO:0051169	nuclear transport	4	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	495	497	PF00675	0.532
CLV_PCSK_KEX2_1	130	132	PF00082	0.622
CLV_PCSK_KEX2_1	204	206	PF00082	0.523
CLV_PCSK_KEX2_1	494	496	PF00082	0.545
CLV_PCSK_KEX2_1	545	547	PF00082	0.499
CLV_PCSK_PC1ET2_1	130	132	PF00082	0.622
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.564
CLV_PCSK_PC1ET2_1	545	547	PF00082	0.499
CLV_PCSK_SKI1_1	166	170	PF00082	0.493
CLV_PCSK_SKI1_1	182	186	PF00082	0.483
CLV_PCSK_SKI1_1	246	250	PF00082	0.628
CLV_PCSK_SKI1_1	442	446	PF00082	0.445
CLV_PCSK_SKI1_1	545	549	PF00082	0.610
CLV_PCSK_SKI1_1	92	96	PF00082	0.487
CLV_Separin_Metazoa	145	149	PF03568	0.552
DOC_CYCLIN_RxL_1	153	164	PF00134	0.560
DOC_CYCLIN_RxL_1	89	96	PF00134	0.588
DOC_CYCLIN_yClb1_LxF_4	194	200	PF00134	0.553
DOC_CYCLIN_yCln2_LP_2	415	421	PF00134	0.474
DOC_CYCLIN_yCln2_LP_2	528	531	PF00134	0.345
DOC_MAPK_DCC_7	228	238	PF00069	0.629
DOC_MAPK_MEF2A_6	231	238	PF00069	0.521
DOC_MAPK_MEF2A_6	376	384	PF00069	0.587
DOC_MAPK_MEF2A_6	520	528	PF00069	0.631
DOC_MAPK_MEF2A_6	92	99	PF00069	0.569
DOC_MAPK_NFAT4_5	92	100	PF00069	0.575
DOC_PP2B_LxvP_1	249	252	PF13499	0.612
DOC_PP2B_LxvP_1	527	530	PF13499	0.614
DOC_USP7_MATH_1	254	258	PF00917	0.628
DOC_USP7_MATH_1	332	336	PF00917	0.661
DOC_USP7_MATH_1	347	351	PF00917	0.659
DOC_USP7_MATH_1	512	516	PF00917	0.596
DOC_USP7_MATH_1	536	540	PF00917	0.624
DOC_USP7_MATH_2	361	367	PF00917	0.462
DOC_WW_Pin1_4	119	124	PF00397	0.565
DOC_WW_Pin1_4	14	19	PF00397	0.607
DOC_WW_Pin1_4	473	478	PF00397	0.588
DOC_WW_Pin1_4	483	488	PF00397	0.621
LIG_14-3-3_CanoR_1	338	346	PF00244	0.568
LIG_14-3-3_CanoR_1	442	447	PF00244	0.431
LIG_Actin_WH2_2	135	150	PF00022	0.414
LIG_Actin_WH2_2	323	340	PF00022	0.522
LIG_APCC_ABBAyCdc20_2	468	474	PF00400	0.700
LIG_BIR_II_1	1	5	PF00653	0.644
LIG_BRCT_BRCA1_1	103	107	PF00533	0.519
LIG_BRCT_BRCA1_1	135	139	PF00533	0.495
LIG_BRCT_BRCA1_1	339	343	PF00533	0.504
LIG_BRCT_BRCA1_1	436	440	PF00533	0.498
LIG_BRCT_BRCA1_1	478	482	PF00533	0.632
LIG_BRCT_BRCA1_1	95	99	PF00533	0.530
LIG_BRCT_BRCA1_2	135	141	PF00533	0.490
LIG_BRCT_BRCA1_2	95	101	PF00533	0.573
LIG_FHA_1	317	323	PF00498	0.551
LIG_FHA_1	441	447	PF00498	0.404
LIG_FHA_1	500	506	PF00498	0.566
LIG_FHA_2	148	154	PF00498	0.304
LIG_FHA_2	436	442	PF00498	0.529
LIG_FHA_2	511	517	PF00498	0.590
LIG_IRF3_LxIS_1	295	301	PF10401	0.573
LIG_LIR_Gen_1	100	110	PF02991	0.582
LIG_LIR_Gen_1	133	142	PF02991	0.453
LIG_LIR_Gen_1	274	284	PF02991	0.544
LIG_LIR_Gen_1	293	300	PF02991	0.585
LIG_LIR_Nem_3	100	106	PF02991	0.576
LIG_LIR_Nem_3	133	137	PF02991	0.461
LIG_LIR_Nem_3	281	287	PF02991	0.532
LIG_LIR_Nem_3	293	298	PF02991	0.572
LIG_LIR_Nem_3	340	346	PF02991	0.563
LIG_LRP6_Inhibitor_1	160	166	PF00058	0.451
LIG_MLH1_MIPbox_1	436	440	PF16413	0.524
LIG_MYND_1	123	127	PF01753	0.529
LIG_NRBOX	208	214	PF00104	0.454
LIG_NRBOX	93	99	PF00104	0.472
LIG_PCNA_PIPBox_1	264	273	PF02747	0.553
LIG_Pex14_2	384	388	PF04695	0.621
LIG_PTB_Apo_2	382	389	PF02174	0.612
LIG_REV1ctd_RIR_1	437	446	PF16727	0.457
LIG_SH2_CRK	103	107	PF00017	0.567
LIG_SH2_CRK	134	138	PF00017	0.568
LIG_SH2_CRK	206	210	PF00017	0.555
LIG_SH2_CRK	284	288	PF00017	0.521
LIG_SH2_NCK_1	103	107	PF00017	0.548
LIG_SH2_NCK_1	134	138	PF00017	0.568
LIG_SH2_NCK_1	284	288	PF00017	0.433
LIG_SH2_SRC	289	292	PF00017	0.434
LIG_SH2_STAP1	103	107	PF00017	0.564
LIG_SH2_STAP1	225	229	PF00017	0.477
LIG_SH2_STAT3	270	273	PF00017	0.588
LIG_SH2_STAT3	291	294	PF00017	0.595
LIG_SH2_STAT5	270	273	PF00017	0.530
LIG_SH2_STAT5	289	292	PF00017	0.496
LIG_SH2_STAT5	414	417	PF00017	0.599
LIG_SH3_3	415	421	PF00018	0.474
LIG_SH3_3	423	429	PF00018	0.643
LIG_SH3_3	474	480	PF00018	0.698
LIG_SUMO_SIM_anti_2	211	216	PF11976	0.513
LIG_SUMO_SIM_par_1	441	447	PF11976	0.529
LIG_TRAF2_1	515	518	PF00917	0.701
LIG_TYR_ITIM	132	137	PF00017	0.564
LIG_UBA3_1	94	101	PF00899	0.469
LIG_WRC_WIRS_1	436	441	PF05994	0.564
MOD_CDK_SPxK_1	483	489	PF00069	0.673
MOD_CK1_1	198	204	PF00069	0.515
MOD_CK1_1	278	284	PF00069	0.553
MOD_CK1_1	293	299	PF00069	0.537
MOD_CK1_1	350	356	PF00069	0.643
MOD_CK1_1	82	88	PF00069	0.651
MOD_CK2_1	485	491	PF00069	0.503
MOD_CK2_1	511	517	PF00069	0.621
MOD_CK2_1	536	542	PF00069	0.582
MOD_Cter_Amidation	5	8	PF01082	0.682
MOD_GlcNHglycan	187	190	PF01048	0.425
MOD_GlcNHglycan	200	203	PF01048	0.432
MOD_GlcNHglycan	256	259	PF01048	0.670
MOD_GlcNHglycan	295	298	PF01048	0.539
MOD_GlcNHglycan	313	316	PF01048	0.485
MOD_GlcNHglycan	349	352	PF01048	0.681
MOD_GlcNHglycan	41	44	PF01048	0.794
MOD_GlcNHglycan	52	55	PF01048	0.718
MOD_GlcNHglycan	81	84	PF01048	0.712
MOD_GSK3_1	223	230	PF00069	0.639
MOD_GSK3_1	254	261	PF00069	0.633
MOD_GSK3_1	271	278	PF00069	0.480
MOD_GSK3_1	332	339	PF00069	0.580
MOD_GSK3_1	420	427	PF00069	0.644
MOD_GSK3_1	440	447	PF00069	0.456
MOD_GSK3_1	449	456	PF00069	0.461
MOD_GSK3_1	72	79	PF00069	0.769
MOD_N-GLC_1	114	119	PF02516	0.514
MOD_N-GLC_1	13	18	PF02516	0.614
MOD_N-GLC_1	190	195	PF02516	0.607
MOD_N-GLC_1	29	34	PF02516	0.535
MOD_N-GLC_1	449	454	PF02516	0.444
MOD_N-GLC_1	510	515	PF02516	0.617
MOD_N-GLC_1	72	77	PF02516	0.791
MOD_N-GLC_1	79	84	PF02516	0.739
MOD_NEK2_1	114	119	PF00069	0.534
MOD_NEK2_1	147	152	PF00069	0.297
MOD_NEK2_1	271	276	PF00069	0.529
MOD_NEK2_1	290	295	PF00069	0.515
MOD_NEK2_1	298	303	PF00069	0.464
MOD_NEK2_1	393	398	PF00069	0.538
MOD_NEK2_1	435	440	PF00069	0.443
MOD_NEK2_1	99	104	PF00069	0.476
MOD_NEK2_2	404	409	PF00069	0.426
MOD_PIKK_1	101	107	PF00454	0.622
MOD_PIKK_1	258	264	PF00454	0.557
MOD_PIKK_1	290	296	PF00454	0.615
MOD_PIKK_1	337	343	PF00454	0.593
MOD_PIKK_1	420	426	PF00454	0.484
MOD_PK_1	190	196	PF00069	0.413
MOD_PK_1	376	382	PF00069	0.421
MOD_PKA_2	147	153	PF00069	0.292
MOD_PKA_2	227	233	PF00069	0.575
MOD_PKA_2	337	343	PF00069	0.594
MOD_Plk_1	161	167	PF00069	0.487
MOD_Plk_1	190	196	PF00069	0.538
MOD_Plk_1	271	277	PF00069	0.575
MOD_Plk_1	374	380	PF00069	0.602
MOD_Plk_1	393	399	PF00069	0.495
MOD_Plk_1	440	446	PF00069	0.462
MOD_Plk_1	99	105	PF00069	0.556
MOD_Plk_4	195	201	PF00069	0.527
MOD_Plk_4	263	269	PF00069	0.546
MOD_Plk_4	271	277	PF00069	0.446
MOD_Plk_4	435	441	PF00069	0.507
MOD_Plk_4	519	525	PF00069	0.593
MOD_Plk_4	93	99	PF00069	0.474
MOD_ProDKin_1	119	125	PF00069	0.559
MOD_ProDKin_1	14	20	PF00069	0.608
MOD_ProDKin_1	473	479	PF00069	0.586
MOD_ProDKin_1	483	489	PF00069	0.615
MOD_SUMO_rev_2	515	522	PF00179	0.626
TRG_DiLeu_BaEn_1	109	114	PF01217	0.429
TRG_ENDOCYTIC_2	103	106	PF00928	0.594
TRG_ENDOCYTIC_2	134	137	PF00928	0.562
TRG_ENDOCYTIC_2	206	209	PF00928	0.478
TRG_ENDOCYTIC_2	284	287	PF00928	0.525
TRG_ER_diArg_1	154	157	PF00400	0.571
TRG_ER_diArg_1	493	496	PF00400	0.548
TRG_Pf-PMV_PEXEL_1	141	145	PF00026	0.543
TRG_Pf-PMV_PEXEL_1	156	161	PF00026	0.545
TRG_Pf-PMV_PEXEL_1	344	349	PF00026	0.592

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8E9	Leptomonas seymouri	24%	88%
A0A0N0P8S6	Leptomonas seymouri	74%	100%
A0A0S4IW66	Bodo saltans	28%	100%
A0A1X0P4A3	Trypanosomatidae	41%	100%
A0A1X0P4L1	Trypanosomatidae	26%	94%
A0A3R7NID6	Trypanosoma rangeli	27%	95%
A0A3S7X0T0	Leishmania donovani	92%	100%
A0A3S7X0T8	Leishmania donovani	25%	89%
A4HFU3	Leishmania braziliensis	86%	99%
A4HFU4	Leishmania braziliensis	27%	100%
A4I2W0	Leishmania infantum	92%	100%
A4I2W1	Leishmania infantum	25%	89%
D0A641	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
D0A644	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9ADE7	Leishmania major	94%	98%
E9ADE8	Leishmania major	25%	100%
E9AZ72	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	89%
V5B0W6	Trypanosoma cruzi	27%	95%
V5BQG4	Trypanosoma cruzi	41%	100%