Hereditary spastic paraplegia protein strumpellin family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Hereditary spastic paraplegia protein strumpellin, putative

Species:

Leishmania mexicana

UniProt:

E9AZ69_LEIMU

TriTrypDb:

LmxM.27.1660

Length:

1294

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

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Cellular components
Term	Name	Level	Count
GO:0005768	endosome	7	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0032991	protein-containing complex	1	10
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0071203	WASH complex	2	10
GO:0097708	intracellular vesicle	5	1

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Expansion

Sequence features

E9AZ69

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

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Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0007015	actin filament organization	5	1
GO:0007032	endosome organization	6	1
GO:0008154	actin polymerization or depolymerization	6	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016050	vesicle organization	5	1
GO:0022607	cellular component assembly	4	1
GO:0030041	actin filament polymerization	7	1
GO:0032956	regulation of actin cytoskeleton organization	5	1

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1041	1045	PF00656	0.496
CLV_C14_Caspase3-7	1112	1116	PF00656	0.496
CLV_C14_Caspase3-7	127	131	PF00656	0.454
CLV_C14_Caspase3-7	143	147	PF00656	0.472
CLV_MEL_PAP_1	1019	1025	PF00089	0.154
CLV_NRD_NRD_1	345	347	PF00675	0.181
CLV_NRD_NRD_1	541	543	PF00675	0.218
CLV_NRD_NRD_1	588	590	PF00675	0.319
CLV_NRD_NRD_1	622	624	PF00675	0.258
CLV_NRD_NRD_1	773	775	PF00675	0.202

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD82	Leptomonas seymouri	67%	100%
A0A1X0P497	Trypanosomatidae	45%	100%
A0A3Q8IHP0	Leishmania donovani	94%	100%
A0A422NCQ2	Trypanosoma rangeli	44%	100%
A4I2V8	Leishmania infantum	94%	100%
D0A639	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9ADE5	Leishmania major	93%	100%
Q12768	Homo sapiens	34%	100%
Q54IR8	Dictyostelium discoideum	31%	100%
Q5R5P0	Pongo abelii	34%	100%

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