BRO1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

BRO1-like domain/ALIX V-shaped domain binding to HIV, putative

Species:

Leishmania mexicana

UniProt:

E9AZ67_LEIMU

TriTrypDb:

LmxM.27.1640

Length:

900

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005768	endosome	7	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AZ67

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZ67

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0016192	vesicle-mediated transport	4	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0071985	multivesicular body sorting pathway	5	11
GO:0006886	intracellular protein transport	4	1
GO:0007034	vacuolar transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016197	endosomal transport	4	1
GO:0032509	endosome transport via multivesicular body sorting pathway	5	1
GO:0032511	late endosome to vacuole transport via multivesicular body sorting pathway	6	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0043328	protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	5	1
GO:0045184	establishment of protein localization	3	1
GO:0045324	late endosome to vacuole transport	5	1
GO:0046907	intracellular transport	3	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072665	protein localization to vacuole	6	1
GO:0072666	establishment of protein localization to vacuole	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	728	732	PF00656	0.407
CLV_NRD_NRD_1	297	299	PF00675	0.433
CLV_NRD_NRD_1	413	415	PF00675	0.530
CLV_NRD_NRD_1	505	507	PF00675	0.315
CLV_NRD_NRD_1	778	780	PF00675	0.521
CLV_PCSK_KEX2_1	193	195	PF00082	0.415
CLV_PCSK_KEX2_1	505	507	PF00082	0.344
CLV_PCSK_KEX2_1	71	73	PF00082	0.418
CLV_PCSK_KEX2_1	777	779	PF00082	0.517
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.436
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.418
CLV_PCSK_PC7_1	501	507	PF00082	0.195
CLV_PCSK_SKI1_1	106	110	PF00082	0.447
CLV_PCSK_SKI1_1	12	16	PF00082	0.487
CLV_PCSK_SKI1_1	253	257	PF00082	0.291
CLV_PCSK_SKI1_1	298	302	PF00082	0.498
CLV_PCSK_SKI1_1	735	739	PF00082	0.331
CLV_Separin_Metazoa	445	449	PF03568	0.560
DEG_APCC_DBOX_1	193	201	PF00400	0.365
DOC_CKS1_1	359	364	PF01111	0.201
DOC_CYCLIN_RxL_1	100	114	PF00134	0.381
DOC_CYCLIN_yCln2_LP_2	807	813	PF00134	0.491
DOC_CYCLIN_yCln2_LP_2	883	889	PF00134	0.508
DOC_MAPK_gen_1	273	282	PF00069	0.433
DOC_MAPK_gen_1	298	307	PF00069	0.365
DOC_MAPK_gen_1	332	342	PF00069	0.433
DOC_MAPK_gen_1	396	405	PF00069	0.324
DOC_MAPK_MEF2A_6	273	282	PF00069	0.382
DOC_MAPK_NFAT4_5	275	283	PF00069	0.378
DOC_PP1_RVXF_1	104	111	PF00149	0.378
DOC_PP1_RVXF_1	565	571	PF00149	0.465
DOC_PP1_SILK_1	449	454	PF00149	0.487
DOC_PP2B_LxvP_1	547	550	PF13499	0.395
DOC_USP7_MATH_1	285	289	PF00917	0.201
DOC_USP7_MATH_1	311	315	PF00917	0.201
DOC_USP7_MATH_1	336	340	PF00917	0.325
DOC_USP7_MATH_1	413	417	PF00917	0.439
DOC_USP7_MATH_1	446	450	PF00917	0.611
DOC_USP7_MATH_1	50	54	PF00917	0.433
DOC_USP7_MATH_1	74	78	PF00917	0.343
DOC_USP7_MATH_1	887	891	PF00917	0.643
DOC_USP7_MATH_1	98	102	PF00917	0.433
DOC_USP7_MATH_2	362	368	PF00917	0.201
DOC_USP7_UBL2_3	159	163	PF12436	0.300
DOC_USP7_UBL2_3	189	193	PF12436	0.433
DOC_USP7_UBL2_3	660	664	PF12436	0.595
DOC_WW_Pin1_4	358	363	PF00397	0.203
DOC_WW_Pin1_4	523	528	PF00397	0.560
DOC_WW_Pin1_4	6	11	PF00397	0.513
DOC_WW_Pin1_4	70	75	PF00397	0.405
DOC_WW_Pin1_4	802	807	PF00397	0.544
DOC_WW_Pin1_4	885	890	PF00397	0.510
LIG_14-3-3_CanoR_1	33	39	PF00244	0.414
LIG_14-3-3_CanoR_1	414	421	PF00244	0.538
LIG_14-3-3_CanoR_1	501	508	PF00244	0.438
LIG_14-3-3_CanoR_1	735	741	PF00244	0.528
LIG_Actin_WH2_2	478	493	PF00022	0.487
LIG_AP2alpha_2	378	380	PF02296	0.318
LIG_APCC_ABBA_1	548	553	PF00400	0.512
LIG_APCC_ABBA_1	578	583	PF00400	0.496
LIG_BIR_II_1	1	5	PF00653	0.525
LIG_BRCT_BRCA1_1	338	342	PF00533	0.321
LIG_BRCT_BRCA1_1	433	437	PF00533	0.555
LIG_Dynein_DLC8_1	413	419	PF01221	0.481
LIG_EH1_1	465	473	PF00400	0.487
LIG_FHA_1	174	180	PF00498	0.490
LIG_FHA_1	310	316	PF00498	0.378
LIG_FHA_1	42	48	PF00498	0.317
LIG_FHA_1	421	427	PF00498	0.488
LIG_FHA_1	463	469	PF00498	0.492
LIG_FHA_1	62	68	PF00498	0.418
LIG_FHA_1	686	692	PF00498	0.560
LIG_FHA_2	118	124	PF00498	0.422
LIG_FHA_2	186	192	PF00498	0.459
LIG_FHA_2	359	365	PF00498	0.411
LIG_FHA_2	372	378	PF00498	0.408
LIG_FHA_2	43	49	PF00498	0.433
LIG_FHA_2	476	482	PF00498	0.507
LIG_FHA_2	555	561	PF00498	0.511
LIG_FHA_2	639	645	PF00498	0.470
LIG_FHA_2	64	70	PF00498	0.398
LIG_FHA_2	71	77	PF00498	0.313
LIG_LIR_Apic_2	873	879	PF02991	0.679
LIG_LIR_Apic_2	893	897	PF02991	0.712
LIG_LIR_Gen_1	11	20	PF02991	0.318
LIG_LIR_Gen_1	141	150	PF02991	0.300
LIG_LIR_Gen_1	339	350	PF02991	0.347
LIG_LIR_Gen_1	367	372	PF02991	0.422
LIG_LIR_Gen_1	419	429	PF02991	0.381
LIG_LIR_Gen_1	707	717	PF02991	0.465
LIG_LIR_Gen_1	852	859	PF02991	0.626
LIG_LIR_Nem_3	11	16	PF02991	0.368
LIG_LIR_Nem_3	141	145	PF02991	0.300
LIG_LIR_Nem_3	160	165	PF02991	0.469
LIG_LIR_Nem_3	339	345	PF02991	0.347
LIG_LIR_Nem_3	367	371	PF02991	0.304
LIG_LIR_Nem_3	377	383	PF02991	0.316
LIG_LIR_Nem_3	419	424	PF02991	0.355
LIG_LIR_Nem_3	513	519	PF02991	0.548
LIG_LIR_Nem_3	707	712	PF02991	0.465
LIG_LIR_Nem_3	852	856	PF02991	0.624
LIG_MLH1_MIPbox_1	338	342	PF16413	0.318
LIG_PCNA_yPIPBox_3	608	622	PF02747	0.395
LIG_PDZ_Class_2	895	900	PF00595	0.621
LIG_Pex14_1	112	116	PF04695	0.300
LIG_SH2_CRK	800	804	PF00017	0.655
LIG_SH2_CRK	811	815	PF00017	0.717
LIG_SH2_CRK	831	835	PF00017	0.561
LIG_SH2_CRK	853	857	PF00017	0.622
LIG_SH2_CRK	86	90	PF00017	0.318
LIG_SH2_CRK	876	880	PF00017	0.753
LIG_SH2_CRK	894	898	PF00017	0.708
LIG_SH2_GRB2like	57	60	PF00017	0.365
LIG_SH2_NCK_1	136	140	PF00017	0.300
LIG_SH2_NCK_1	172	176	PF00017	0.300
LIG_SH2_PTP2	142	145	PF00017	0.361
LIG_SH2_SRC	142	145	PF00017	0.415
LIG_SH2_SRC	238	241	PF00017	0.318
LIG_SH2_SRC	507	510	PF00017	0.560
LIG_SH2_SRC	831	834	PF00017	0.608
LIG_SH2_SRC	876	879	PF00017	0.731
LIG_SH2_STAP1	238	242	PF00017	0.318
LIG_SH2_STAT5	142	145	PF00017	0.371
LIG_SH2_STAT5	213	216	PF00017	0.347
LIG_SH2_STAT5	34	37	PF00017	0.423
LIG_SH2_STAT5	341	344	PF00017	0.302
LIG_SH2_STAT5	507	510	PF00017	0.513
LIG_SH2_STAT5	740	743	PF00017	0.619
LIG_SH2_STAT5	802	805	PF00017	0.493
LIG_SH2_STAT5	86	89	PF00017	0.300
LIG_SH3_3	305	311	PF00018	0.423
LIG_SH3_3	346	352	PF00018	0.305
LIG_SH3_3	440	446	PF00018	0.378
LIG_SH3_3	807	813	PF00018	0.574
LIG_SH3_3	845	851	PF00018	0.696
LIG_SH3_3	861	867	PF00018	0.554
LIG_SH3_3	883	889	PF00018	0.516
LIG_SxIP_EBH_1	338	347	PF03271	0.201
LIG_TRAF2_1	328	331	PF00917	0.236
LIG_TYR_ITIM	84	89	PF00017	0.433
LIG_UBA3_1	451	459	PF00899	0.560
LIG_UBA3_1	532	541	PF00899	0.441
LIG_WRC_WIRS_1	113	118	PF05994	0.337
LIG_WRC_WIRS_1	242	247	PF05994	0.365
LIG_WW_1	850	853	PF00397	0.609
MOD_CDK_SPxK_1	6	12	PF00069	0.443
MOD_CK1_1	124	130	PF00069	0.434
MOD_CK1_1	244	250	PF00069	0.371
MOD_CK1_1	29	35	PF00069	0.380
MOD_CK1_1	321	327	PF00069	0.347
MOD_CK1_1	358	364	PF00069	0.380
MOD_CK1_1	4	10	PF00069	0.491
MOD_CK1_1	41	47	PF00069	0.303
MOD_CK1_1	416	422	PF00069	0.521
MOD_CK1_1	462	468	PF00069	0.555
MOD_CK1_1	523	529	PF00069	0.462
MOD_CK1_1	637	643	PF00069	0.567
MOD_CK1_1	70	76	PF00069	0.365
MOD_CK1_1	857	863	PF00069	0.650
MOD_CK1_1	890	896	PF00069	0.501
MOD_CK2_1	112	118	PF00069	0.433
MOD_CK2_1	124	130	PF00069	0.409
MOD_CK2_1	151	157	PF00069	0.306
MOD_CK2_1	358	364	PF00069	0.348
MOD_CK2_1	371	377	PF00069	0.372
MOD_CK2_1	475	481	PF00069	0.483
MOD_CK2_1	534	540	PF00069	0.619
MOD_CK2_1	554	560	PF00069	0.573
MOD_CK2_1	63	69	PF00069	0.365
MOD_CK2_1	633	639	PF00069	0.478
MOD_CK2_1	642	648	PF00069	0.478
MOD_CK2_1	70	76	PF00069	0.277
MOD_GlcNHglycan	100	103	PF01048	0.433
MOD_GlcNHglycan	3	6	PF01048	0.587
MOD_GlcNHglycan	324	327	PF01048	0.365
MOD_GlcNHglycan	392	395	PF01048	0.430
MOD_GlcNHglycan	407	410	PF01048	0.327
MOD_GlcNHglycan	433	436	PF01048	0.478
MOD_GlcNHglycan	461	464	PF01048	0.396
MOD_GlcNHglycan	492	496	PF01048	0.312
MOD_GlcNHglycan	590	593	PF01048	0.360
MOD_GlcNHglycan	691	694	PF01048	0.408
MOD_GlcNHglycan	826	829	PF01048	0.657
MOD_GSK3_1	112	119	PF00069	0.269
MOD_GSK3_1	122	129	PF00069	0.351
MOD_GSK3_1	145	152	PF00069	0.474
MOD_GSK3_1	181	188	PF00069	0.281
MOD_GSK3_1	240	247	PF00069	0.302
MOD_GSK3_1	309	316	PF00069	0.365
MOD_GSK3_1	318	325	PF00069	0.337
MOD_GSK3_1	336	343	PF00069	0.410
MOD_GSK3_1	34	41	PF00069	0.355
MOD_GSK3_1	360	367	PF00069	0.292
MOD_GSK3_1	416	423	PF00069	0.524
MOD_GSK3_1	462	469	PF00069	0.515
MOD_GSK3_1	471	478	PF00069	0.467
MOD_GSK3_1	57	64	PF00069	0.327
MOD_GSK3_1	610	617	PF00069	0.443
MOD_GSK3_1	633	640	PF00069	0.495
MOD_GSK3_1	648	655	PF00069	0.430
MOD_GSK3_1	681	688	PF00069	0.560
MOD_GSK3_1	70	77	PF00069	0.316
MOD_GSK3_1	736	743	PF00069	0.480
MOD_GSK3_1	820	827	PF00069	0.564
MOD_GSK3_1	854	861	PF00069	0.745
MOD_GSK3_1	98	105	PF00069	0.397
MOD_LATS_1	623	629	PF00433	0.487
MOD_N-GLC_1	336	341	PF02516	0.334
MOD_N-GLC_1	41	46	PF02516	0.330
MOD_N-GLC_1	457	462	PF02516	0.360
MOD_N-GLC_1	74	79	PF02516	0.408
MOD_N-GLC_2	268	270	PF02516	0.295
MOD_N-GLC_2	404	406	PF02516	0.534
MOD_N-GLC_2	477	479	PF02516	0.349
MOD_N-GLC_2	704	706	PF02516	0.278
MOD_NEK2_1	1	6	PF00069	0.388
MOD_NEK2_1	116	121	PF00069	0.325
MOD_NEK2_1	138	143	PF00069	0.300
MOD_NEK2_1	174	179	PF00069	0.433
MOD_NEK2_1	245	250	PF00069	0.344
MOD_NEK2_1	371	376	PF00069	0.430
MOD_NEK2_1	447	452	PF00069	0.570
MOD_NEK2_1	633	638	PF00069	0.477
MOD_NEK2_1	67	72	PF00069	0.402
MOD_NEK2_2	216	221	PF00069	0.365
MOD_NEK2_2	336	341	PF00069	0.378
MOD_PIKK_1	145	151	PF00454	0.433
MOD_PIKK_1	309	315	PF00454	0.365
MOD_PIKK_1	414	420	PF00454	0.578
MOD_PIKK_1	457	463	PF00454	0.445
MOD_PIKK_1	638	644	PF00454	0.486
MOD_PIKK_1	792	798	PF00454	0.658
MOD_PKA_1	193	199	PF00069	0.397
MOD_PKA_1	253	259	PF00069	0.207
MOD_PKA_1	414	420	PF00069	0.590
MOD_PKA_2	193	199	PF00069	0.464
MOD_PKA_2	413	419	PF00069	0.545
MOD_PKA_2	447	453	PF00069	0.549
MOD_PKA_2	500	506	PF00069	0.420
MOD_PKA_2	642	648	PF00069	0.445
MOD_Plk_1	216	222	PF00069	0.349
MOD_Plk_1	26	32	PF00069	0.378
MOD_Plk_1	336	342	PF00069	0.300
MOD_Plk_1	42	48	PF00069	0.178
MOD_Plk_1	730	736	PF00069	0.560
MOD_Plk_1	74	80	PF00069	0.336
MOD_Plk_2-3	614	620	PF00069	0.395
MOD_Plk_4	138	144	PF00069	0.330
MOD_Plk_4	174	180	PF00069	0.433
MOD_Plk_4	245	251	PF00069	0.374
MOD_Plk_4	313	319	PF00069	0.440
MOD_Plk_4	336	342	PF00069	0.404
MOD_Plk_4	364	370	PF00069	0.360
MOD_Plk_4	447	453	PF00069	0.535
MOD_Plk_4	528	534	PF00069	0.441
MOD_Plk_4	57	63	PF00069	0.349
MOD_Plk_4	642	648	PF00069	0.534
MOD_Plk_4	704	710	PF00069	0.478
MOD_Plk_4	715	721	PF00069	0.478
MOD_Plk_4	74	80	PF00069	0.300
MOD_ProDKin_1	358	364	PF00069	0.203
MOD_ProDKin_1	523	529	PF00069	0.560
MOD_ProDKin_1	6	12	PF00069	0.511
MOD_ProDKin_1	70	76	PF00069	0.405
MOD_ProDKin_1	802	808	PF00069	0.547
MOD_ProDKin_1	885	891	PF00069	0.510
MOD_SUMO_for_1	214	217	PF00179	0.300
MOD_SUMO_for_1	673	676	PF00179	0.487
MOD_SUMO_rev_2	154	161	PF00179	0.352
MOD_SUMO_rev_2	325	333	PF00179	0.493
MOD_SUMO_rev_2	456	460	PF00179	0.512
MOD_SUMO_rev_2	481	490	PF00179	0.568
MOD_SUMO_rev_2	603	609	PF00179	0.500
TRG_DiLeu_BaEn_2	363	369	PF01217	0.418
TRG_ENDOCYTIC_2	142	145	PF00928	0.378
TRG_ENDOCYTIC_2	162	165	PF00928	0.178
TRG_ENDOCYTIC_2	171	174	PF00928	0.264
TRG_ENDOCYTIC_2	238	241	PF00928	0.318
TRG_ENDOCYTIC_2	709	712	PF00928	0.465
TRG_ENDOCYTIC_2	800	803	PF00928	0.496
TRG_ENDOCYTIC_2	811	814	PF00928	0.704
TRG_ENDOCYTIC_2	853	856	PF00928	0.604
TRG_ENDOCYTIC_2	86	89	PF00928	0.300
TRG_ER_diArg_1	440	443	PF00400	0.554
TRG_ER_diArg_1	505	507	PF00400	0.542
TRG_ER_diArg_1	777	779	PF00400	0.589
TRG_NES_CRM1_1	195	207	PF08389	0.405
TRG_NES_CRM1_1	854	866	PF08389	0.593
TRG_Pf-PMV_PEXEL_1	556	560	PF00026	0.311
TRG_Pf-PMV_PEXEL_1	602	606	PF00026	0.335
TRG_Pf-PMV_PEXEL_1	744	749	PF00026	0.354

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2T8	Leptomonas seymouri	74%	100%
A0A1X0P4J9	Trypanosomatidae	51%	100%
A0A3S7X0S6	Leishmania donovani	90%	98%
A0A422N9P5	Trypanosoma rangeli	46%	100%
A4HFU0	Leishmania braziliensis	85%	100%
A4I2V6	Leishmania infantum	90%	98%
D0A635	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9ADE3	Leishmania major	89%	100%
P79020	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	22%	100%
Q6BLT2	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	21%	100%
Q8T7K0	Dictyostelium discoideum	21%	100%
Q8WUM4	Homo sapiens	25%	100%
Q9QZA2	Rattus norvegicus	22%	100%
Q9WU78	Mus musculus	25%	100%
V5BQH3	Trypanosoma cruzi	49%	100%