Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

inner dynein arm I1 intermediate chain, axonemal

Species:

Leishmania mexicana

UniProt:

E9AZ66_LEIMU

TriTrypDb:

LmxM.27.1630

Length:

834

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005858	axonemal dynein complex	4	1
GO:0005875	microtubule associated complex	2	1
GO:0005930	axoneme	2	1
GO:0030286	dynein complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0036156	inner dynein arm	5	1
GO:0110165	cellular anatomical entity	1	2
GO:1902494	catalytic complex	2	1
GO:0005929	cilium	4	1
GO:0031514	motile cilium	5	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

E9AZ66

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZ66

Function

Biological processes
Term	Name	Level	Count
GO:0001539	cilium or flagellum-dependent cell motility	3	1
GO:0003341	cilium movement	4	1
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0036159	inner dynein arm assembly	7	1
GO:0043933	protein-containing complex organization	4	1
GO:0048870	cell motility	2	1
GO:0060285	cilium-dependent cell motility	4	1
GO:0060294	cilium movement involved in cell motility	5	1
GO:0065003	protein-containing complex assembly	5	1
GO:0070286	axonemal dynein complex assembly	6	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0045503	dynein light chain binding	3	1
GO:0045504	dynein heavy chain binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.518
CLV_C14_Caspase3-7	175	179	PF00656	0.571
CLV_C14_Caspase3-7	504	508	PF00656	0.532
CLV_C14_Caspase3-7	597	601	PF00656	0.482
CLV_NRD_NRD_1	152	154	PF00675	0.598
CLV_NRD_NRD_1	164	166	PF00675	0.456
CLV_NRD_NRD_1	253	255	PF00675	0.547
CLV_NRD_NRD_1	264	266	PF00675	0.548
CLV_NRD_NRD_1	289	291	PF00675	0.635
CLV_NRD_NRD_1	479	481	PF00675	0.511
CLV_NRD_NRD_1	552	554	PF00675	0.570
CLV_NRD_NRD_1	683	685	PF00675	0.600
CLV_NRD_NRD_1	727	729	PF00675	0.354
CLV_NRD_NRD_1	74	76	PF00675	0.659
CLV_NRD_NRD_1	787	789	PF00675	0.722
CLV_NRD_NRD_1	91	93	PF00675	0.474
CLV_PCSK_KEX2_1	152	154	PF00082	0.667
CLV_PCSK_KEX2_1	164	166	PF00082	0.642
CLV_PCSK_KEX2_1	266	268	PF00082	0.555
CLV_PCSK_KEX2_1	289	291	PF00082	0.549
CLV_PCSK_KEX2_1	552	554	PF00082	0.570
CLV_PCSK_KEX2_1	683	685	PF00082	0.580
CLV_PCSK_KEX2_1	727	729	PF00082	0.416
CLV_PCSK_KEX2_1	787	789	PF00082	0.722
CLV_PCSK_KEX2_1	91	93	PF00082	0.476
CLV_PCSK_PC1ET2_1	266	268	PF00082	0.517
CLV_PCSK_PC7_1	262	268	PF00082	0.532
CLV_PCSK_SKI1_1	204	208	PF00082	0.546
CLV_PCSK_SKI1_1	308	312	PF00082	0.398
CLV_PCSK_SKI1_1	47	51	PF00082	0.571
CLV_PCSK_SKI1_1	480	484	PF00082	0.527
CLV_PCSK_SKI1_1	516	520	PF00082	0.511
CLV_PCSK_SKI1_1	633	637	PF00082	0.196
CLV_PCSK_SKI1_1	719	723	PF00082	0.402
CLV_PCSK_SKI1_1	92	96	PF00082	0.439
CLV_Separin_Metazoa	137	141	PF03568	0.605
CLV_Separin_Metazoa	388	392	PF03568	0.725
DEG_APCC_DBOX_1	632	640	PF00400	0.458
DEG_COP1_1	551	561	PF00400	0.688
DEG_SPOP_SBC_1	247	251	PF00917	0.488
DOC_CYCLIN_RxL_1	200	210	PF00134	0.553
DOC_CYCLIN_RxL_1	305	315	PF00134	0.514
DOC_CYCLIN_RxL_1	44	54	PF00134	0.615
DOC_CYCLIN_yClb1_LxF_4	435	440	PF00134	0.395
DOC_CYCLIN_yCln2_LP_2	301	307	PF00134	0.469
DOC_MAPK_gen_1	265	273	PF00069	0.422
DOC_MAPK_gen_1	289	297	PF00069	0.472
DOC_MAPK_gen_1	552	558	PF00069	0.669
DOC_MAPK_gen_1	604	614	PF00069	0.484
DOC_MAPK_gen_1	683	691	PF00069	0.533
DOC_MAPK_gen_1	91	98	PF00069	0.421
DOC_MAPK_MEF2A_6	91	98	PF00069	0.573
DOC_PP1_RVXF_1	435	441	PF00149	0.459
DOC_PP2B_LxvP_1	184	187	PF13499	0.476
DOC_PP2B_LxvP_1	311	314	PF13499	0.406
DOC_PP2B_LxvP_1	610	613	PF13499	0.530
DOC_USP7_MATH_1	331	335	PF00917	0.518
DOC_USP7_MATH_1	533	537	PF00917	0.402
DOC_USP7_MATH_1	668	672	PF00917	0.468
DOC_USP7_MATH_1	87	91	PF00917	0.623
DOC_USP7_UBL2_3	360	364	PF12436	0.666
DOC_USP7_UBL2_3	76	80	PF12436	0.620
DOC_WW_Pin1_4	30	35	PF00397	0.575
DOC_WW_Pin1_4	627	632	PF00397	0.425
DOC_WW_Pin1_4	9	14	PF00397	0.728
LIG_14-3-3_CanoR_1	107	117	PF00244	0.579
LIG_14-3-3_CanoR_1	152	156	PF00244	0.623
LIG_14-3-3_CanoR_1	16	23	PF00244	0.442
LIG_14-3-3_CanoR_1	223	232	PF00244	0.590
LIG_14-3-3_CanoR_1	552	559	PF00244	0.701
LIG_14-3-3_CanoR_1	568	574	PF00244	0.345
LIG_14-3-3_CanoR_1	683	691	PF00244	0.476
LIG_14-3-3_CanoR_1	709	717	PF00244	0.523
LIG_14-3-3_CanoR_1	735	743	PF00244	0.510
LIG_14-3-3_CanoR_1	91	97	PF00244	0.547
LIG_Actin_WH2_2	382	399	PF00022	0.710
LIG_Actin_WH2_2	42	59	PF00022	0.551
LIG_APCC_ABBA_1	215	220	PF00400	0.453
LIG_APCC_ABBA_1	94	99	PF00400	0.700
LIG_APCC_ABBAyCdc20_2	214	220	PF00400	0.308
LIG_BIR_II_1	1	5	PF00653	0.713
LIG_BIR_III_4	81	85	PF00653	0.645
LIG_BRCT_BRCA1_1	670	674	PF00533	0.474
LIG_Clathr_ClatBox_1	238	242	PF01394	0.524
LIG_CSL_BTD_1	494	497	PF09270	0.403
LIG_CSL_BTD_1	628	631	PF09270	0.462
LIG_CtBP_PxDLS_1	41	45	PF00389	0.630
LIG_deltaCOP1_diTrp_1	430	440	PF00928	0.513
LIG_deltaCOP1_diTrp_1	733	736	PF00928	0.547
LIG_eIF4E_1	685	691	PF01652	0.479
LIG_FHA_1	16	22	PF00498	0.611
LIG_FHA_1	217	223	PF00498	0.600
LIG_FHA_1	44	50	PF00498	0.568
LIG_FHA_1	461	467	PF00498	0.494
LIG_FHA_1	565	571	PF00498	0.458
LIG_FHA_1	659	665	PF00498	0.509
LIG_FHA_1	684	690	PF00498	0.301
LIG_FHA_2	173	179	PF00498	0.546
LIG_FHA_2	232	238	PF00498	0.480
LIG_FHA_2	278	284	PF00498	0.561
LIG_FHA_2	455	461	PF00498	0.463
LIG_FHA_2	502	508	PF00498	0.568
LIG_FHA_2	521	527	PF00498	0.311
LIG_FHA_2	546	552	PF00498	0.531
LIG_FHA_2	588	594	PF00498	0.397
LIG_FHA_2	595	601	PF00498	0.348
LIG_IBAR_NPY_1	801	803	PF08397	0.678
LIG_LIR_Apic_2	210	216	PF02991	0.545
LIG_LIR_Gen_1	268	278	PF02991	0.446
LIG_LIR_Gen_1	452	461	PF02991	0.431
LIG_LIR_Gen_1	540	547	PF02991	0.490
LIG_LIR_Gen_1	647	656	PF02991	0.509
LIG_LIR_Gen_1	810	820	PF02991	0.615
LIG_LIR_Nem_3	268	273	PF02991	0.454
LIG_LIR_Nem_3	380	386	PF02991	0.737
LIG_LIR_Nem_3	452	458	PF02991	0.427
LIG_LIR_Nem_3	492	498	PF02991	0.451
LIG_LIR_Nem_3	647	652	PF02991	0.480
LIG_LIR_Nem_3	671	677	PF02991	0.452
LIG_LIR_Nem_3	697	703	PF02991	0.342
LIG_MYND_1	410	414	PF01753	0.416
LIG_PCNA_yPIPBox_3	188	198	PF02747	0.619
LIG_PDZ_Class_1	829	834	PF00595	0.721
LIG_PTB_Apo_2	130	137	PF02174	0.632
LIG_PTB_Phospho_1	130	136	PF10480	0.632
LIG_SH2_CRK	213	217	PF00017	0.551
LIG_SH2_CRK	608	612	PF00017	0.520
LIG_SH2_NCK_1	615	619	PF00017	0.473
LIG_SH2_PTP2	701	704	PF00017	0.452
LIG_SH2_SRC	246	249	PF00017	0.558
LIG_SH2_STAP1	218	222	PF00017	0.565
LIG_SH2_STAP1	530	534	PF00017	0.458
LIG_SH2_STAP1	685	689	PF00017	0.491
LIG_SH2_STAP1	732	736	PF00017	0.512
LIG_SH2_STAT3	473	476	PF00017	0.545
LIG_SH2_STAT3	583	586	PF00017	0.413
LIG_SH2_STAT3	685	688	PF00017	0.499
LIG_SH2_STAT5	116	119	PF00017	0.618
LIG_SH2_STAT5	218	221	PF00017	0.560
LIG_SH2_STAT5	246	249	PF00017	0.435
LIG_SH2_STAT5	309	312	PF00017	0.493
LIG_SH2_STAT5	473	476	PF00017	0.532
LIG_SH2_STAT5	563	566	PF00017	0.657
LIG_SH2_STAT5	595	598	PF00017	0.321
LIG_SH2_STAT5	685	688	PF00017	0.320
LIG_SH2_STAT5	701	704	PF00017	0.438
LIG_SH3_1	615	621	PF00018	0.426
LIG_SH3_1	776	782	PF00018	0.573
LIG_SH3_2	86	91	PF14604	0.664
LIG_SH3_3	128	134	PF00018	0.708
LIG_SH3_3	301	307	PF00018	0.415
LIG_SH3_3	321	327	PF00018	0.232
LIG_SH3_3	387	393	PF00018	0.602
LIG_SH3_3	491	497	PF00018	0.470
LIG_SH3_3	55	61	PF00018	0.639
LIG_SH3_3	615	621	PF00018	0.514
LIG_SH3_3	628	634	PF00018	0.438
LIG_SH3_3	7	13	PF00018	0.697
LIG_SH3_3	776	782	PF00018	0.573
LIG_SH3_3	83	89	PF00018	0.662
LIG_SUMO_SIM_anti_2	236	242	PF11976	0.509
LIG_SUMO_SIM_anti_2	292	300	PF11976	0.471
LIG_SUMO_SIM_par_1	236	242	PF11976	0.459
LIG_SUMO_SIM_par_1	40	46	PF11976	0.622
LIG_SUMO_SIM_par_1	635	641	PF11976	0.339
LIG_SUMO_SIM_par_1	644	650	PF11976	0.337
LIG_TRAF2_1	187	190	PF00917	0.647
LIG_TRAF2_1	313	316	PF00917	0.550
LIG_TRAF2_1	70	73	PF00917	0.642
LIG_TRFH_1	701	705	PF08558	0.509
LIG_UBA3_1	206	214	PF00899	0.275
LIG_WRC_WIRS_1	349	354	PF05994	0.533
LIG_WRC_WIRS_1	558	563	PF05994	0.675
LIG_WRC_WIRS_1	695	700	PF05994	0.345
MOD_CDC14_SPxK_1	630	633	PF00782	0.428
MOD_CDK_SPxK_1	627	633	PF00069	0.394
MOD_CDK_SPxxK_3	9	16	PF00069	0.441
MOD_CK1_1	122	128	PF00069	0.581
MOD_CK1_1	157	163	PF00069	0.622
MOD_CK1_1	257	263	PF00069	0.389
MOD_CK1_1	28	34	PF00069	0.654
MOD_CK1_1	293	299	PF00069	0.520
MOD_CK1_1	351	357	PF00069	0.573
MOD_CK1_1	545	551	PF00069	0.488
MOD_CK1_1	67	73	PF00069	0.532
MOD_CK1_1	708	714	PF00069	0.469
MOD_CK2_1	231	237	PF00069	0.575
MOD_CK2_1	277	283	PF00069	0.490
MOD_CK2_1	415	421	PF00069	0.435
MOD_CK2_1	454	460	PF00069	0.476
MOD_CK2_1	545	551	PF00069	0.503
MOD_CK2_1	67	73	PF00069	0.532
MOD_CK2_1	708	714	PF00069	0.502
MOD_Cter_Amidation	252	255	PF01082	0.581
MOD_Cter_Amidation	263	266	PF01082	0.382
MOD_GlcNHglycan	1	4	PF01048	0.683
MOD_GlcNHglycan	110	113	PF01048	0.690
MOD_GlcNHglycan	256	259	PF01048	0.512
MOD_GlcNHglycan	262	265	PF01048	0.525
MOD_GlcNHglycan	27	30	PF01048	0.664
MOD_GlcNHglycan	354	357	PF01048	0.587
MOD_GlcNHglycan	487	490	PF01048	0.649
MOD_GlcNHglycan	535	538	PF01048	0.402
MOD_GlcNHglycan	711	714	PF01048	0.428
MOD_GlcNHglycan	831	834	PF01048	0.674
MOD_GSK3_1	11	18	PF00069	0.511
MOD_GSK3_1	115	122	PF00069	0.590
MOD_GSK3_1	151	158	PF00069	0.662
MOD_GSK3_1	348	355	PF00069	0.476
MOD_GSK3_1	364	371	PF00069	0.598
MOD_GSK3_1	456	463	PF00069	0.497
MOD_GSK3_1	557	564	PF00069	0.659
MOD_GSK3_1	679	686	PF00069	0.504
MOD_GSK3_1	690	697	PF00069	0.281
MOD_GSK3_1	705	712	PF00069	0.405
MOD_GSK3_1	734	741	PF00069	0.545
MOD_GSK3_1	755	762	PF00069	0.595
MOD_LATS_1	550	556	PF00433	0.648
MOD_N-GLC_1	223	228	PF02516	0.591
MOD_N-GLC_1	449	454	PF02516	0.537
MOD_N-GLC_2	520	522	PF02516	0.433
MOD_NEK2_1	1	6	PF00069	0.684
MOD_NEK2_1	207	212	PF00069	0.536
MOD_NEK2_1	352	357	PF00069	0.626
MOD_NEK2_1	569	574	PF00069	0.498
MOD_NEK2_1	690	695	PF00069	0.440
MOD_NEK2_1	755	760	PF00069	0.556
MOD_PIKK_1	155	161	PF00454	0.533
MOD_PIKK_1	207	213	PF00454	0.537
MOD_PIKK_1	545	551	PF00454	0.537
MOD_PIKK_1	64	70	PF00454	0.616
MOD_PIKK_1	683	689	PF00454	0.525
MOD_PK_1	552	558	PF00069	0.669
MOD_PK_1	620	626	PF00069	0.458
MOD_PKA_1	254	260	PF00069	0.514
MOD_PKA_1	552	558	PF00069	0.669
MOD_PKA_1	683	689	PF00069	0.550
MOD_PKA_2	15	21	PF00069	0.697
MOD_PKA_2	151	157	PF00069	0.666
MOD_PKA_2	551	557	PF00069	0.656
MOD_PKA_2	679	685	PF00069	0.552
MOD_PKA_2	708	714	PF00069	0.538
MOD_PKA_2	734	740	PF00069	0.388
MOD_PKA_2	755	761	PF00069	0.587
MOD_Plk_1	291	297	PF00069	0.537
MOD_Plk_2-3	127	133	PF00069	0.715
MOD_Plk_2-3	738	744	PF00069	0.560
MOD_Plk_4	172	178	PF00069	0.519
MOD_Plk_4	293	299	PF00069	0.457
MOD_Plk_4	348	354	PF00069	0.529
MOD_Plk_4	444	450	PF00069	0.565
MOD_Plk_4	460	466	PF00069	0.501
MOD_Plk_4	542	548	PF00069	0.464
MOD_Plk_4	552	558	PF00069	0.603
MOD_Plk_4	61	67	PF00069	0.615
MOD_Plk_4	620	626	PF00069	0.440
MOD_ProDKin_1	30	36	PF00069	0.575
MOD_ProDKin_1	627	633	PF00069	0.426
MOD_ProDKin_1	9	15	PF00069	0.728
MOD_SUMO_for_1	187	190	PF00179	0.588
MOD_SUMO_rev_2	439	447	PF00179	0.441
MOD_SUMO_rev_2	708	718	PF00179	0.572
TRG_DiLeu_BaEn_1	647	652	PF01217	0.482
TRG_DiLeu_BaEn_3	811	817	PF01217	0.627
TRG_DiLeu_BaEn_4	189	195	PF01217	0.627
TRG_DiLeu_BaEn_4	315	321	PF01217	0.531
TRG_DiLeu_BaLyEn_6	494	499	PF01217	0.418
TRG_DiLeu_BaLyEn_6	779	784	PF01217	0.696
TRG_ENDOCYTIC_2	136	139	PF00928	0.597
TRG_ENDOCYTIC_2	608	611	PF00928	0.518
TRG_ER_diArg_1	151	153	PF00400	0.668
TRG_ER_diArg_1	164	166	PF00400	0.642
TRG_ER_diArg_1	683	685	PF00400	0.600
TRG_ER_diArg_1	727	729	PF00400	0.410
TRG_ER_diArg_1	91	93	PF00400	0.516
TRG_NES_CRM1_1	48	62	PF08389	0.605
TRG_NLS_MonoExtN_4	478	484	PF00514	0.511
TRG_Pf-PMV_PEXEL_1	308	312	PF00026	0.440

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0G2KIZ8	Danio rerio	26%	86%
A0A0N1PF46	Leptomonas seymouri	68%	96%
A0A0S4JPP6	Bodo saltans	41%	100%
A0A1X0P495	Trypanosomatidae	48%	100%
A0A3Q8IEC3	Leishmania donovani	92%	99%
A0A422N9T1	Trypanosoma rangeli	48%	100%
A4HFT9	Leishmania braziliensis	85%	100%
A4HK88	Leishmania braziliensis	24%	100%
A4I2V5	Leishmania infantum	92%	99%
B2RY71	Mus musculus	24%	90%
D0A634	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9ADE2	Leishmania major	91%	100%
Q8IWG1	Homo sapiens	23%	94%
Q95JP0	Macaca fascicularis	23%	94%
V5BGF1	Trypanosoma cruzi	47%	100%