Eukaryotic translation initiation factor eIF-4E,putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Eukaryotic translation initiation factor 4E-1

Species:

Leishmania mexicana

UniProt:

E9AZ65_LEIMU

TriTrypDb:

LmxM.27.1620

Length:

213

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0000932	P-body	5	1
GO:0005737	cytoplasm	2	1
GO:0010494	cytoplasmic stress granule	5	1
GO:0016281	eukaryotic translation initiation factor 4F complex	2	1
GO:0032991	protein-containing complex	1	1
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1

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Expansion

Sequence features

E9AZ65

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZ65

PDB structure(s): 5wb5_A , 6h7b_B , 6h7b_D

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0000339	RNA cap binding	5	1
GO:0000340	RNA 7-methylguanosine cap binding	6	1
GO:0000342	RNA cap 4 binding	6	1
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0003743	translation initiation factor activity	4	11
GO:0005488	binding	1	11
GO:0008135	translation factor activity, RNA binding	3	11
GO:0045182	translation regulator activity	1	11
GO:0090079	translation regulator activity, nucleic acid binding	2	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	165	167	PF00675	0.270
CLV_PCSK_KEX2_1	165	167	PF00082	0.270
CLV_PCSK_PC1ET2_1	165	167	PF00082	0.283
CLV_PCSK_SKI1_1	190	194	PF00082	0.335
CLV_PCSK_SKI1_1	58	62	PF00082	0.364
DOC_MAPK_gen_1	165	174	PF00069	0.470
DOC_MAPK_gen_1	89	100	PF00069	0.529
DOC_MAPK_MEF2A_6	167	176	PF00069	0.470
DOC_MAPK_MEF2A_6	89	98	PF00069	0.483
DOC_USP7_MATH_1	117	121	PF00917	0.608

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A075QQ08	Nicotiana tabacum	26%	96%
A0A0N0P8F2	Leptomonas seymouri	81%	100%
A0A0S4KG92	Bodo saltans	24%	73%
A0A1D8EJF9	Solanum pimpinellifolium	24%	92%
A0A1U8F5V2	Capsicum annuum	30%	100%
A0A1U8GR65	Capsicum annuum	23%	93%
A0A1X0P494	Trypanosomatidae	47%	83%
A0A2J6L8Y7	Lactuca sativa	26%	91%
A0A3Q7FGP1	Solanum lycopersicum	25%	96%
A0A3Q7I7R4	Solanum lycopersicum	30%	100%

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