Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZ61_LEIMU

TriTrypDb:

LmxM.27.1570

Length:

435

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZ61

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZ61

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	192	196	PF00656	0.488
CLV_C14_Caspase3-7	258	262	PF00656	0.604
CLV_C14_Caspase3-7	265	269	PF00656	0.625
CLV_NRD_NRD_1	107	109	PF00675	0.494
CLV_NRD_NRD_1	11	13	PF00675	0.518
CLV_NRD_NRD_1	163	165	PF00675	0.702
CLV_NRD_NRD_1	202	204	PF00675	0.510
CLV_NRD_NRD_1	3	5	PF00675	0.630
CLV_NRD_NRD_1	355	357	PF00675	0.444
CLV_NRD_NRD_1	433	435	PF00675	0.592
CLV_PCSK_FUR_1	105	109	PF00082	0.458
CLV_PCSK_KEX2_1	107	109	PF00082	0.493
CLV_PCSK_KEX2_1	11	13	PF00082	0.518
CLV_PCSK_KEX2_1	163	165	PF00082	0.692
CLV_PCSK_KEX2_1	202	204	PF00082	0.510
CLV_PCSK_KEX2_1	3	5	PF00082	0.630
CLV_PCSK_KEX2_1	354	356	PF00082	0.451
CLV_PCSK_KEX2_1	433	435	PF00082	0.592
CLV_PCSK_SKI1_1	108	112	PF00082	0.540
CLV_PCSK_SKI1_1	121	125	PF00082	0.416
CLV_PCSK_SKI1_1	133	137	PF00082	0.398
CLV_PCSK_SKI1_1	139	143	PF00082	0.311
CLV_PCSK_SKI1_1	202	206	PF00082	0.393
CLV_PCSK_SKI1_1	257	261	PF00082	0.408
DEG_APCC_DBOX_1	95	103	PF00400	0.492
DEG_Nend_Nbox_1	1	3	PF02207	0.721
DEG_SPOP_SBC_1	21	25	PF00917	0.443
DOC_CDC14_PxL_1	267	275	PF14671	0.575
DOC_CYCLIN_RxL_1	197	211	PF00134	0.502
DOC_MAPK_gen_1	202	209	PF00069	0.492
DOC_MAPK_gen_1	3	9	PF00069	0.727
DOC_MAPK_MEF2A_6	202	209	PF00069	0.409
DOC_MAPK_NFAT4_5	202	210	PF00069	0.413
DOC_PP1_RVXF_1	119	125	PF00149	0.555
DOC_PP4_FxxP_1	274	277	PF00568	0.672
DOC_USP7_MATH_1	336	340	PF00917	0.488
DOC_WW_Pin1_4	17	22	PF00397	0.549
DOC_WW_Pin1_4	332	337	PF00397	0.498
DOC_WW_Pin1_4	424	429	PF00397	0.575
LIG_14-3-3_CanoR_1	152	157	PF00244	0.439
LIG_14-3-3_CanoR_1	257	266	PF00244	0.514
LIG_14-3-3_CanoR_1	355	361	PF00244	0.487
LIG_14-3-3_CanoR_1	77	85	PF00244	0.497
LIG_Actin_WH2_2	380	398	PF00022	0.438
LIG_AP2alpha_1	149	153	PF02296	0.395
LIG_APCC_ABBA_1	63	68	PF00400	0.460
LIG_BIR_III_2	268	272	PF00653	0.669
LIG_BIR_III_2	291	295	PF00653	0.772
LIG_BIR_III_2	319	323	PF00653	0.551
LIG_BRCT_BRCA1_1	136	140	PF00533	0.536
LIG_CaM_IQ_9	150	166	PF13499	0.561
LIG_CSL_BTD_1	18	21	PF09270	0.571
LIG_CtBP_PxDLS_1	423	427	PF00389	0.671
LIG_FHA_1	130	136	PF00498	0.491
LIG_FHA_1	258	264	PF00498	0.580
LIG_FHA_1	29	35	PF00498	0.573
LIG_FHA_2	129	135	PF00498	0.484
LIG_FHA_2	232	238	PF00498	0.638
LIG_FHA_2	33	39	PF00498	0.594
LIG_FHA_2	371	377	PF00498	0.469
LIG_FHA_2	398	404	PF00498	0.464
LIG_FHA_2	427	433	PF00498	0.606
LIG_HCF-1_HBM_1	175	178	PF13415	0.519
LIG_LIR_Gen_1	151	161	PF02991	0.429
LIG_LIR_Gen_1	367	377	PF02991	0.460
LIG_LIR_Nem_3	151	156	PF02991	0.413
LIG_LIR_Nem_3	175	181	PF02991	0.530
LIG_LIR_Nem_3	198	204	PF02991	0.387
LIG_LIR_Nem_3	367	372	PF02991	0.543
LIG_LIR_Nem_3	389	395	PF02991	0.440
LIG_MYND_1	271	275	PF01753	0.667
LIG_Pex14_2	149	153	PF04695	0.395
LIG_REV1ctd_RIR_1	154	164	PF16727	0.488
LIG_REV1ctd_RIR_1	390	400	PF16727	0.434
LIG_SH2_NCK_1	87	91	PF00017	0.486
LIG_SH2_STAP1	55	59	PF00017	0.482
LIG_SH2_STAT5	178	181	PF00017	0.425
LIG_SH2_STAT5	327	330	PF00017	0.445
LIG_SH3_2	428	433	PF14604	0.562
LIG_SH3_3	269	275	PF00018	0.658
LIG_SH3_3	425	431	PF00018	0.525
LIG_SH3_3	43	49	PF00018	0.492
LIG_TRAF2_1	234	237	PF00917	0.544
LIG_TRAF2_1	35	38	PF00917	0.485
LIG_TYR_ITIM	85	90	PF00017	0.459
LIG_WRC_WIRS_1	153	158	PF05994	0.465
MOD_CK1_1	20	26	PF00069	0.435
MOD_CK1_1	414	420	PF00069	0.641
MOD_CK1_1	80	86	PF00069	0.530
MOD_CK2_1	111	117	PF00069	0.572
MOD_CK2_1	128	134	PF00069	0.419
MOD_CK2_1	177	183	PF00069	0.398
MOD_CK2_1	231	237	PF00069	0.541
MOD_CK2_1	32	38	PF00069	0.505
MOD_CK2_1	370	376	PF00069	0.496
MOD_CK2_1	397	403	PF00069	0.441
MOD_CK2_1	426	432	PF00069	0.660
MOD_CK2_1	85	91	PF00069	0.460
MOD_GlcNHglycan	113	116	PF01048	0.585
MOD_GlcNHglycan	136	139	PF01048	0.477
MOD_GlcNHglycan	25	28	PF01048	0.615
MOD_GlcNHglycan	257	260	PF01048	0.614
MOD_GlcNHglycan	414	417	PF01048	0.568
MOD_GlcNHglycan	81	85	PF01048	0.496
MOD_GSK3_1	17	24	PF00069	0.544
MOD_GSK3_1	28	35	PF00069	0.538
MOD_GSK3_1	332	339	PF00069	0.456
MOD_GSK3_1	69	76	PF00069	0.533
MOD_N-GLC_1	21	26	PF02516	0.661
MOD_NEK2_1	111	116	PF00069	0.630
MOD_NEK2_1	69	74	PF00069	0.533
MOD_PKA_2	231	237	PF00069	0.546
MOD_PKA_2	409	415	PF00069	0.525
MOD_PKB_1	354	362	PF00069	0.490
MOD_PKB_1	75	83	PF00069	0.583
MOD_Plk_1	340	346	PF00069	0.481
MOD_Plk_1	80	86	PF00069	0.525
MOD_Plk_2-3	208	214	PF00069	0.444
MOD_Plk_4	152	158	PF00069	0.463
MOD_ProDKin_1	17	23	PF00069	0.549
MOD_ProDKin_1	332	338	PF00069	0.494
MOD_ProDKin_1	424	430	PF00069	0.572
MOD_SUMO_rev_2	129	138	PF00179	0.564
TRG_AP2beta_CARGO_1	151	160	PF09066	0.481
TRG_DiLeu_BaEn_1	403	408	PF01217	0.500
TRG_ENDOCYTIC_2	178	181	PF00928	0.478
TRG_ENDOCYTIC_2	201	204	PF00928	0.413
TRG_ENDOCYTIC_2	369	372	PF00928	0.435
TRG_ENDOCYTIC_2	44	47	PF00928	0.480
TRG_ENDOCYTIC_2	87	90	PF00928	0.464
TRG_ER_diArg_1	146	149	PF00400	0.487
TRG_ER_diArg_1	162	164	PF00400	0.647
TRG_ER_diArg_1	2	4	PF00400	0.642
TRG_ER_diArg_1	201	203	PF00400	0.493
TRG_ER_diArg_1	219	222	PF00400	0.327
TRG_ER_diArg_1	354	356	PF00400	0.451
TRG_ER_diArg_1	433	435	PF00400	0.592
TRG_ER_diArg_1	75	78	PF00400	0.573
TRG_NES_CRM1_1	386	399	PF08389	0.440
TRG_Pf-PMV_PEXEL_1	139	144	PF00026	0.440
TRG_Pf-PMV_PEXEL_1	203	208	PF00026	0.527
TRG_Pf-PMV_PEXEL_1	358	362	PF00026	0.426
TRG_Pf-PMV_PEXEL_1	402	406	PF00026	0.486

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE13	Leptomonas seymouri	63%	90%
A0A1X0P4A4	Trypanosomatidae	48%	92%
A0A381ML35	Leishmania infantum	96%	100%
A0A3Q8IGD4	Leishmania donovani	96%	100%
A0A3Q8IQ02	Leishmania donovani	96%	100%
A0A3R7LRX2	Trypanosoma rangeli	52%	97%
A4HFT4	Leishmania braziliensis	83%	99%
D0A626	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	98%
E9ADD6	Leishmania major	96%	100%