Likely part of the mitochondrial MICOS complex, based on homology.. It is possible that this protein only has a single TM segment as the first can also be a transit signal.. Localization: Mitochondrial inner membrane (by homology)
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 9 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 8 |
| NetGPI | no | yes: 0, no: 8 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0032991 | protein-containing complex | 1 | 9 |
| GO:0061617 | MICOS complex | 4 | 9 |
| GO:0098796 | membrane protein complex | 2 | 9 |
| GO:0098798 | mitochondrial protein-containing complex | 2 | 9 |
| GO:0098800 | inner mitochondrial membrane protein complex | 3 | 9 |
| GO:0005739 | mitochondrion | 5 | 1 |
| GO:0043226 | organelle | 2 | 1 |
| GO:0043227 | membrane-bounded organelle | 3 | 1 |
| GO:0043229 | intracellular organelle | 3 | 1 |
| GO:0043231 | intracellular membrane-bounded organelle | 4 | 1 |
| GO:0110165 | cellular anatomical entity | 1 | 1 |
Related structures:
AlphaFold database: E9AZ57
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_NRD_NRD_1 | 29 | 31 | PF00675 | 0.295 |
| CLV_PCSK_KEX2_1 | 84 | 86 | PF00082 | 0.513 |
| CLV_PCSK_PC1ET2_1 | 84 | 86 | PF00082 | 0.572 |
| CLV_PCSK_SKI1_1 | 73 | 77 | PF00082 | 0.339 |
| DEG_SPOP_SBC_1 | 8 | 12 | PF00917 | 0.208 |
| DOC_CKS1_1 | 2 | 7 | PF01111 | 0.604 |
| DOC_MAPK_gen_1 | 30 | 36 | PF00069 | 0.279 |
| DOC_MAPK_gen_1 | 84 | 92 | PF00069 | 0.506 |
| DOC_MAPK_MEF2A_6 | 84 | 92 | PF00069 | 0.506 |
| DOC_USP7_MATH_1 | 103 | 107 | PF00917 | 0.570 |
| DOC_USP7_MATH_1 | 51 | 55 | PF00917 | 0.335 |
| DOC_WW_Pin1_4 | 1 | 6 | PF00397 | 0.657 |
| DOC_WW_Pin1_4 | 46 | 51 | PF00397 | 0.327 |
| LIG_14-3-3_CanoR_1 | 30 | 36 | PF00244 | 0.279 |
| LIG_FHA_1 | 10 | 16 | PF00498 | 0.335 |
| LIG_SH2_STAT5 | 74 | 77 | PF00017 | 0.340 |
| LIG_SH3_3 | 2 | 8 | PF00018 | 0.633 |
| LIG_SUMO_SIM_par_1 | 54 | 61 | PF11976 | 0.355 |
| MOD_CDK_SPK_2 | 1 | 6 | PF00069 | 0.607 |
| MOD_CDK_SPxxK_3 | 46 | 53 | PF00069 | 0.323 |
| MOD_CK1_1 | 14 | 20 | PF00069 | 0.430 |
| MOD_CK1_1 | 24 | 30 | PF00069 | 0.338 |
| MOD_CK2_1 | 13 | 19 | PF00069 | 0.311 |
| MOD_GlcNHglycan | 37 | 40 | PF01048 | 0.372 |
| MOD_GlcNHglycan | 53 | 56 | PF01048 | 0.215 |
| MOD_GlcNHglycan | 64 | 67 | PF01048 | 0.345 |
| MOD_GSK3_1 | 58 | 65 | PF00069 | 0.325 |
| MOD_GSK3_1 | 7 | 14 | PF00069 | 0.308 |
| MOD_PIKK_1 | 95 | 101 | PF00454 | 0.633 |
| MOD_PKA_1 | 30 | 36 | PF00069 | 0.279 |
| MOD_PKA_2 | 29 | 35 | PF00069 | 0.287 |
| MOD_Plk_1 | 21 | 27 | PF00069 | 0.302 |
| MOD_Plk_4 | 24 | 30 | PF00069 | 0.358 |
| MOD_ProDKin_1 | 1 | 7 | PF00069 | 0.654 |
| MOD_ProDKin_1 | 46 | 52 | PF00069 | 0.327 |
| TRG_Pf-PMV_PEXEL_1 | 73 | 77 | PF00026 | 0.279 |
| TRG_Pf-PMV_PEXEL_1 | 85 | 89 | PF00026 | 0.595 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N1PD22 | Leptomonas seymouri | 81% | 100% |
| A0A3Q8IHN0 | Leishmania donovani | 92% | 100% |
| A4HFT1 | Leishmania braziliensis | 89% | 100% |
| A4I2U5 | Leishmania infantum | 93% | 100% |
| D0A621 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 61% | 100% |
| E9ADD2 | Leishmania major | 97% | 100% |
| E9AV41 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 28% | 100% |