Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZ56_LEIMU

TriTrypDb:

LmxM.27.1520

Length:

744

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZ56

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZ56

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	213	217	PF00656	0.697
CLV_C14_Caspase3-7	312	316	PF00656	0.522
CLV_C14_Caspase3-7	390	394	PF00656	0.488
CLV_C14_Caspase3-7	396	400	PF00656	0.432
CLV_C14_Caspase3-7	459	463	PF00656	0.698
CLV_MEL_PAP_1	116	122	PF00089	0.585
CLV_NRD_NRD_1	333	335	PF00675	0.731
CLV_NRD_NRD_1	343	345	PF00675	0.738
CLV_NRD_NRD_1	579	581	PF00675	0.681
CLV_NRD_NRD_1	622	624	PF00675	0.446
CLV_NRD_NRD_1	677	679	PF00675	0.539
CLV_PCSK_FUR_1	329	333	PF00082	0.833
CLV_PCSK_FUR_1	341	345	PF00082	0.557
CLV_PCSK_KEX2_1	331	333	PF00082	0.732
CLV_PCSK_KEX2_1	343	345	PF00082	0.715
CLV_PCSK_KEX2_1	53	55	PF00082	0.389
CLV_PCSK_KEX2_1	677	679	PF00082	0.539
CLV_PCSK_KEX2_1	714	716	PF00082	0.585
CLV_PCSK_PC1ET2_1	343	345	PF00082	0.777
CLV_PCSK_PC1ET2_1	53	55	PF00082	0.264
CLV_PCSK_PC1ET2_1	714	716	PF00082	0.585
CLV_PCSK_PC7_1	329	335	PF00082	0.586
CLV_PCSK_PC7_1	341	347	PF00082	0.675
CLV_PCSK_SKI1_1	152	156	PF00082	0.489
CLV_PCSK_SKI1_1	33	37	PF00082	0.493
CLV_PCSK_SKI1_1	45	49	PF00082	0.464
CLV_PCSK_SKI1_1	531	535	PF00082	0.455
CLV_PCSK_SKI1_1	613	617	PF00082	0.387
CLV_PCSK_SKI1_1	691	695	PF00082	0.483
CLV_PCSK_SKI1_1	725	729	PF00082	0.625
CLV_PCSK_SKI1_1	74	78	PF00082	0.439
DEG_APCC_DBOX_1	635	643	PF00400	0.615
DEG_APCC_DBOX_1	690	698	PF00400	0.478
DEG_APCC_DBOX_1	724	732	PF00400	0.619
DEG_APCC_DBOX_1	73	81	PF00400	0.462
DEG_ODPH_VHL_1	128	140	PF01847	0.482
DEG_SPOP_SBC_1	370	374	PF00917	0.707
DEG_SPOP_SBC_1	455	459	PF00917	0.589
DOC_ANK_TNKS_1	728	735	PF00023	0.443
DOC_CKS1_1	433	438	PF01111	0.496
DOC_CKS1_1	516	521	PF01111	0.356
DOC_CKS1_1	553	558	PF01111	0.600
DOC_CYCLIN_yCln2_LP_2	150	156	PF00134	0.495
DOC_CYCLIN_yCln2_LP_2	290	296	PF00134	0.616
DOC_CYCLIN_yCln2_LP_2	450	456	PF00134	0.635
DOC_CYCLIN_yCln2_LP_2	644	650	PF00134	0.609
DOC_MAPK_gen_1	132	140	PF00069	0.465
DOC_MAPK_gen_1	303	310	PF00069	0.639
DOC_MAPK_gen_1	528	538	PF00069	0.457
DOC_MAPK_MEF2A_6	531	540	PF00069	0.498
DOC_MAPK_MEF2A_6	651	659	PF00069	0.458
DOC_PP1_RVXF_1	31	37	PF00149	0.472
DOC_PP2B_LxvP_1	127	130	PF13499	0.464
DOC_PP4_MxPP_1	193	196	PF00568	0.534
DOC_USP7_MATH_1	189	193	PF00917	0.556
DOC_USP7_MATH_1	203	207	PF00917	0.497
DOC_USP7_MATH_1	243	247	PF00917	0.368
DOC_USP7_MATH_1	311	315	PF00917	0.705
DOC_USP7_MATH_1	365	369	PF00917	0.771
DOC_USP7_MATH_1	370	374	PF00917	0.784
DOC_USP7_MATH_1	455	459	PF00917	0.679
DOC_USP7_MATH_1	549	553	PF00917	0.506
DOC_USP7_MATH_1	615	619	PF00917	0.550
DOC_USP7_MATH_1	67	71	PF00917	0.296
DOC_USP7_MATH_1	685	689	PF00917	0.534
DOC_USP7_MATH_2	519	525	PF00917	0.504
DOC_USP7_UBL2_3	339	343	PF12436	0.743
DOC_WW_Pin1_4	17	22	PF00397	0.488
DOC_WW_Pin1_4	218	223	PF00397	0.587
DOC_WW_Pin1_4	23	28	PF00397	0.498
DOC_WW_Pin1_4	260	265	PF00397	0.422
DOC_WW_Pin1_4	415	420	PF00397	0.556
DOC_WW_Pin1_4	432	437	PF00397	0.497
DOC_WW_Pin1_4	515	520	PF00397	0.528
DOC_WW_Pin1_4	552	557	PF00397	0.602
DOC_WW_Pin1_4	592	597	PF00397	0.544
DOC_WW_Pin1_4	662	667	PF00397	0.578
LIG_14-3-3_CanoR_1	119	128	PF00244	0.469
LIG_14-3-3_CanoR_1	132	141	PF00244	0.485
LIG_14-3-3_CanoR_1	19	29	PF00244	0.550
LIG_14-3-3_CanoR_1	245	249	PF00244	0.309
LIG_14-3-3_CanoR_1	270	278	PF00244	0.510
LIG_14-3-3_CanoR_1	333	342	PF00244	0.695
LIG_14-3-3_CanoR_1	45	51	PF00244	0.472
LIG_14-3-3_CanoR_1	597	602	PF00244	0.562
LIG_14-3-3_CanoR_1	613	622	PF00244	0.358
LIG_14-3-3_CanoR_1	623	629	PF00244	0.506
LIG_14-3-3_CanoR_1	646	655	PF00244	0.583
LIG_EH1_1	649	657	PF00400	0.472
LIG_eIF4E_1	29	35	PF01652	0.476
LIG_EVH1_2	183	187	PF00568	0.541
LIG_FHA_1	122	128	PF00498	0.464
LIG_FHA_1	196	202	PF00498	0.705
LIG_FHA_1	248	254	PF00498	0.496
LIG_FHA_1	261	267	PF00498	0.493
LIG_FHA_1	279	285	PF00498	0.599
LIG_FHA_1	305	311	PF00498	0.601
LIG_FHA_1	593	599	PF00498	0.565
LIG_FHA_1	63	69	PF00498	0.487
LIG_FHA_1	685	691	PF00498	0.502
LIG_FHA_1	90	96	PF00498	0.318
LIG_FHA_2	134	140	PF00498	0.486
LIG_FHA_2	295	301	PF00498	0.587
LIG_FHA_2	388	394	PF00498	0.492
LIG_FHA_2	516	522	PF00498	0.517
LIG_FHA_2	555	561	PF00498	0.511
LIG_FHA_2	614	620	PF00498	0.561
LIG_FHA_2	7	13	PF00498	0.493
LIG_LIR_Gen_1	298	309	PF02991	0.601
LIG_LIR_Gen_1	406	417	PF02991	0.486
LIG_LIR_Gen_1	557	567	PF02991	0.572
LIG_LIR_Gen_1	9	17	PF02991	0.475
LIG_LIR_Nem_3	298	304	PF02991	0.588
LIG_LIR_Nem_3	70	76	PF02991	0.467
LIG_LIR_Nem_3	9	13	PF02991	0.480
LIG_NRBOX	252	258	PF00104	0.481
LIG_SH2_CRK	64	68	PF00017	0.489
LIG_SH2_CRK	699	703	PF00017	0.517
LIG_SH2_CRK	73	77	PF00017	0.458
LIG_SH2_STAP1	675	679	PF00017	0.519
LIG_SH2_STAT3	63	66	PF00017	0.492
LIG_SH2_STAT3	695	698	PF00017	0.477
LIG_SH2_STAT5	252	255	PF00017	0.476
LIG_SH2_STAT5	64	67	PF00017	0.501
LIG_SH2_STAT5	695	698	PF00017	0.477
LIG_SH2_STAT5	8	11	PF00017	0.485
LIG_SH3_3	305	311	PF00018	0.732
LIG_SH3_3	34	40	PF00018	0.501
LIG_SH3_3	349	355	PF00018	0.740
LIG_SH3_3	513	519	PF00018	0.389
LIG_SUMO_SIM_anti_2	136	142	PF11976	0.486
LIG_SUMO_SIM_par_1	306	312	PF11976	0.576
LIG_SUMO_SIM_par_1	46	51	PF11976	0.450
LIG_SUMO_SIM_par_1	637	643	PF11976	0.640
LIG_UBA3_1	425	432	PF00899	0.481
LIG_UBA3_1	727	735	PF00899	0.530
LIG_WRC_WIRS_1	377	382	PF05994	0.516
MOD_CDK_SPK_2	592	597	PF00069	0.544
MOD_CDK_SPxxK_3	260	267	PF00069	0.503
MOD_CK1_1	115	121	PF00069	0.493
MOD_CK1_1	20	26	PF00069	0.535
MOD_CK1_1	247	253	PF00069	0.482
MOD_CK1_1	288	294	PF00069	0.604
MOD_CK1_1	3	9	PF00069	0.559
MOD_CK1_1	372	378	PF00069	0.788
MOD_CK1_1	379	385	PF00069	0.718
MOD_CK1_1	387	393	PF00069	0.579
MOD_CK1_1	418	424	PF00069	0.509
MOD_CK1_1	552	558	PF00069	0.495
MOD_CK1_1	589	595	PF00069	0.665
MOD_CK1_1	605	611	PF00069	0.522
MOD_CK2_1	294	300	PF00069	0.703
MOD_CK2_1	515	521	PF00069	0.530
MOD_CK2_1	554	560	PF00069	0.511
MOD_CK2_1	613	619	PF00069	0.556
MOD_GlcNHglycan	164	167	PF01048	0.492
MOD_GlcNHglycan	205	208	PF01048	0.613
MOD_GlcNHglycan	322	325	PF01048	0.730
MOD_GlcNHglycan	336	339	PF01048	0.687
MOD_GlcNHglycan	349	352	PF01048	0.661
MOD_GlcNHglycan	367	370	PF01048	0.611
MOD_GlcNHglycan	383	386	PF01048	0.621
MOD_GlcNHglycan	403	406	PF01048	0.357
MOD_GlcNHglycan	458	461	PF01048	0.771
MOD_GlcNHglycan	5	8	PF01048	0.657
MOD_GlcNHglycan	511	514	PF01048	0.576
MOD_GlcNHglycan	549	552	PF01048	0.480
MOD_GlcNHglycan	587	591	PF01048	0.548
MOD_GlcNHglycan	604	607	PF01048	0.531
MOD_GSK3_1	111	118	PF00069	0.522
MOD_GSK3_1	195	202	PF00069	0.594
MOD_GSK3_1	226	233	PF00069	0.483
MOD_GSK3_1	243	250	PF00069	0.507
MOD_GSK3_1	256	263	PF00069	0.473
MOD_GSK3_1	365	372	PF00069	0.613
MOD_GSK3_1	393	400	PF00069	0.651
MOD_GSK3_1	403	410	PF00069	0.674
MOD_GSK3_1	470	477	PF00069	0.729
MOD_GSK3_1	582	589	PF00069	0.756
MOD_GSK3_1	592	599	PF00069	0.580
MOD_GSK3_1	605	612	PF00069	0.544
MOD_GSK3_1	85	92	PF00069	0.327
MOD_LATS_1	83	89	PF00433	0.612
MOD_N-GLC_1	679	684	PF02516	0.625
MOD_N-GLC_2	658	660	PF02516	0.454
MOD_NEK2_1	248	253	PF00069	0.474
MOD_NEK2_1	256	261	PF00069	0.503
MOD_NEK2_1	403	408	PF00069	0.413
MOD_NEK2_1	442	447	PF00069	0.530
MOD_NEK2_1	48	53	PF00069	0.271
MOD_NEK2_1	509	514	PF00069	0.557
MOD_NEK2_1	522	527	PF00069	0.486
MOD_NEK2_2	189	194	PF00069	0.609
MOD_PIKK_1	20	26	PF00454	0.525
MOD_PIKK_1	379	385	PF00454	0.627
MOD_PIKK_1	62	68	PF00454	0.482
MOD_PIKK_1	627	633	PF00454	0.720
MOD_PIKK_1	685	691	PF00454	0.527
MOD_PK_1	597	603	PF00069	0.554
MOD_PKA_2	118	124	PF00069	0.477
MOD_PKA_2	244	250	PF00069	0.320
MOD_PKA_2	269	275	PF00069	0.509
MOD_PKA_2	304	310	PF00069	0.523
MOD_PKA_2	579	585	PF00069	0.570
MOD_PKA_2	596	602	PF00069	0.552
MOD_PKA_2	622	628	PF00069	0.453
MOD_PKB_1	332	340	PF00069	0.800
MOD_PKB_1	344	352	PF00069	0.532
MOD_Plk_1	196	202	PF00069	0.414
MOD_Plk_1	299	305	PF00069	0.686
MOD_Plk_1	471	477	PF00069	0.433
MOD_Plk_2-3	640	646	PF00069	0.357
MOD_Plk_4	226	232	PF00069	0.500
MOD_Plk_4	248	254	PF00069	0.583
MOD_Plk_4	304	310	PF00069	0.642
MOD_Plk_4	376	382	PF00069	0.514
MOD_Plk_4	384	390	PF00069	0.489
MOD_Plk_4	397	403	PF00069	0.452
MOD_Plk_4	522	528	PF00069	0.491
MOD_Plk_4	549	555	PF00069	0.578
MOD_Plk_4	605	611	PF00069	0.426
MOD_Plk_4	651	657	PF00069	0.459
MOD_ProDKin_1	17	23	PF00069	0.495
MOD_ProDKin_1	218	224	PF00069	0.579
MOD_ProDKin_1	260	266	PF00069	0.421
MOD_ProDKin_1	415	421	PF00069	0.550
MOD_ProDKin_1	432	438	PF00069	0.495
MOD_ProDKin_1	515	521	PF00069	0.530
MOD_ProDKin_1	552	558	PF00069	0.597
MOD_ProDKin_1	592	598	PF00069	0.528
MOD_ProDKin_1	662	668	PF00069	0.573
MOD_SUMO_for_1	713	716	PF00179	0.523
MOD_SUMO_rev_2	259	268	PF00179	0.524
TRG_DiLeu_BaLyEn_6	123	128	PF01217	0.463
TRG_DiLeu_BaLyEn_6	181	186	PF01217	0.612
TRG_DiLeu_BaLyEn_6	30	35	PF01217	0.472
TRG_DiLeu_BaLyEn_6	538	543	PF01217	0.473
TRG_DiLeu_BaLyEn_6	726	731	PF01217	0.614
TRG_ENDOCYTIC_2	73	76	PF00928	0.460
TRG_ER_diArg_1	329	332	PF00400	0.831
TRG_ER_diArg_1	333	335	PF00400	0.750
TRG_ER_diArg_1	573	576	PF00400	0.478
TRG_ER_diArg_1	677	679	PF00400	0.539
TRG_Pf-PMV_PEXEL_1	528	532	PF00026	0.561
TRG_Pf-PMV_PEXEL_1	541	545	PF00026	0.399
TRG_Pf-PMV_PEXEL_1	729	733	PF00026	0.633
TRG_Pf-PMV_PEXEL_1	74	79	PF00026	0.277

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5D1	Leptomonas seymouri	64%	100%
A0A3S7X0R8	Leishmania donovani	91%	100%
A4HFT0	Leishmania braziliensis	80%	100%
A4I368	Leishmania infantum	91%	100%
E9ADD1	Leishmania major	89%	100%