Polyprenol reductase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZ55_LEIMU

TriTrypDb:

LmxM.27.1510

Length:

470

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	9
GO:0016020	membrane	2	11
GO:0031090	organelle membrane	3	9
GO:0110165	cellular anatomical entity	1	11
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9AZ55

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZ55

Function

Biological processes
Term	Name	Level	Count
GO:0006066	alcohol metabolic process	3	10
GO:0006488	dolichol-linked oligosaccharide biosynthetic process	5	10
GO:0006490	oligosaccharide-lipid intermediate biosynthetic process	4	10
GO:0006629	lipid metabolic process	3	10
GO:0006720	isoprenoid metabolic process	4	10
GO:0008152	metabolic process	1	10
GO:0008300	isoprenoid catabolic process	5	10
GO:0009056	catabolic process	2	10
GO:0009058	biosynthetic process	2	10
GO:0009987	cellular process	1	10
GO:0016042	lipid catabolic process	4	10
GO:0016093	polyprenol metabolic process	4	10
GO:0016095	polyprenol catabolic process	5	10
GO:0019348	dolichol metabolic process	5	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044242	cellular lipid catabolic process	4	10
GO:0044248	cellular catabolic process	3	10
GO:0044255	cellular lipid metabolic process	3	10
GO:0044281	small molecule metabolic process	2	10
GO:0044282	small molecule catabolic process	3	10
GO:0046164	alcohol catabolic process	4	10
GO:0071704	organic substance metabolic process	2	10
GO:1901135	carbohydrate derivative metabolic process	3	10
GO:1901137	carbohydrate derivative biosynthetic process	4	10
GO:1901575	organic substance catabolic process	3	10
GO:1901576	organic substance biosynthetic process	3	10
GO:1901615	organic hydroxy compound metabolic process	3	10
GO:1901616	organic hydroxy compound catabolic process	4	10
GO:0008299	isoprenoid biosynthetic process	4	1
GO:0008610	lipid biosynthetic process	4	1
GO:0016094	polyprenol biosynthetic process	5	1
GO:0019408	dolichol biosynthetic process	6	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0046165	alcohol biosynthetic process	4	1
GO:1901617	organic hydroxy compound biosynthetic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0003865	3-oxo-5-alpha-steroid 4-dehydrogenase activity	5	10
GO:0016229	steroid dehydrogenase activity	3	10
GO:0016491	oxidoreductase activity	2	10
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	10
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	4	9
GO:0033765	steroid dehydrogenase activity, acting on the CH-CH group of donors	4	10
GO:0102389	polyprenol reductase activity	5	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	4	8	PF00656	0.342
CLV_C14_Caspase3-7	44	48	PF00656	0.533
CLV_C14_Caspase3-7	442	446	PF00656	0.561
CLV_NRD_NRD_1	244	246	PF00675	0.407
CLV_NRD_NRD_1	269	271	PF00675	0.374
CLV_NRD_NRD_1	300	302	PF00675	0.443
CLV_NRD_NRD_1	403	405	PF00675	0.349
CLV_NRD_NRD_1	413	415	PF00675	0.375
CLV_NRD_NRD_1	95	97	PF00675	0.309
CLV_PCSK_KEX2_1	243	245	PF00082	0.375
CLV_PCSK_KEX2_1	269	271	PF00082	0.456
CLV_PCSK_KEX2_1	300	302	PF00082	0.433
CLV_PCSK_KEX2_1	403	405	PF00082	0.349
CLV_PCSK_KEX2_1	413	415	PF00082	0.375
CLV_PCSK_SKI1_1	12	16	PF00082	0.371
CLV_PCSK_SKI1_1	217	221	PF00082	0.482
CLV_PCSK_SKI1_1	313	317	PF00082	0.286
CLV_PCSK_SKI1_1	421	425	PF00082	0.447
CLV_PCSK_SKI1_1	448	452	PF00082	0.241
DEG_Nend_Nbox_1	1	3	PF02207	0.311
DOC_CKS1_1	289	294	PF01111	0.611
DOC_CYCLIN_yCln2_LP_2	136	142	PF00134	0.392
DOC_MAPK_gen_1	169	178	PF00069	0.571
DOC_MAPK_gen_1	205	215	PF00069	0.278
DOC_MAPK_gen_1	269	275	PF00069	0.483
DOC_MAPK_RevD_3	228	244	PF00069	0.253
DOC_USP7_MATH_1	121	125	PF00917	0.401
DOC_USP7_MATH_1	192	196	PF00917	0.313
DOC_USP7_MATH_1	204	208	PF00917	0.336
DOC_USP7_MATH_1	372	376	PF00917	0.401
DOC_WW_Pin1_4	124	129	PF00397	0.415
DOC_WW_Pin1_4	135	140	PF00397	0.551
DOC_WW_Pin1_4	244	249	PF00397	0.613
DOC_WW_Pin1_4	250	255	PF00397	0.614
DOC_WW_Pin1_4	282	287	PF00397	0.628
DOC_WW_Pin1_4	288	293	PF00397	0.728
DOC_WW_Pin1_4	76	81	PF00397	0.539
LIG_14-3-3_CanoR_1	160	167	PF00244	0.545
LIG_14-3-3_CanoR_1	205	211	PF00244	0.411
LIG_14-3-3_CanoR_1	96	101	PF00244	0.523
LIG_Actin_WH2_2	436	454	PF00022	0.551
LIG_BRCT_BRCA1_1	18	22	PF00533	0.387
LIG_deltaCOP1_diTrp_1	262	268	PF00928	0.497
LIG_EH1_1	326	334	PF00400	0.355
LIG_eIF4E_1	327	333	PF01652	0.208
LIG_FHA_1	147	153	PF00498	0.331
LIG_FHA_1	162	168	PF00498	0.537
LIG_FHA_1	173	179	PF00498	0.475
LIG_FHA_1	184	190	PF00498	0.347
LIG_FHA_1	319	325	PF00498	0.529
LIG_FHA_1	329	335	PF00498	0.362
LIG_FHA_1	410	416	PF00498	0.616
LIG_FHA_2	289	295	PF00498	0.605
LIG_FHA_2	396	402	PF00498	0.530
LIG_FHA_2	420	426	PF00498	0.521
LIG_FHA_2	452	458	PF00498	0.440
LIG_LIR_Gen_1	177	187	PF02991	0.297
LIG_LIR_Gen_1	19	30	PF02991	0.399
LIG_LIR_Gen_1	33	40	PF02991	0.554
LIG_LIR_Gen_1	365	376	PF02991	0.396
LIG_LIR_Gen_1	99	108	PF02991	0.324
LIG_LIR_Nem_3	177	182	PF02991	0.297
LIG_LIR_Nem_3	19	25	PF02991	0.358
LIG_LIR_Nem_3	265	271	PF02991	0.615
LIG_LIR_Nem_3	33	37	PF02991	0.611
LIG_LIR_Nem_3	365	371	PF02991	0.401
LIG_LIR_Nem_3	375	381	PF02991	0.440
LIG_LIR_Nem_3	99	103	PF02991	0.355
LIG_NRBOX	331	337	PF00104	0.173
LIG_Pex14_1	18	22	PF04695	0.397
LIG_Pex14_2	115	119	PF04695	0.414
LIG_Pex14_2	30	34	PF04695	0.611
LIG_Pex14_2	466	470	PF04695	0.604
LIG_Pex14_2	88	92	PF04695	0.527
LIG_PTB_Apo_2	306	313	PF02174	0.567
LIG_SH2_CRK	302	306	PF00017	0.516
LIG_SH2_STAP1	320	324	PF00017	0.495
LIG_SH2_STAP1	64	68	PF00017	0.624
LIG_SH2_STAT5	104	107	PF00017	0.279
LIG_SH2_STAT5	188	191	PF00017	0.279
LIG_SH2_STAT5	306	309	PF00017	0.535
LIG_SH2_STAT5	320	323	PF00017	0.520
LIG_SH3_3	125	131	PF00018	0.467
LIG_SH3_3	138	144	PF00018	0.390
LIG_SH3_3	312	318	PF00018	0.491
LIG_SUMO_SIM_anti_2	331	337	PF11976	0.381
LIG_SUMO_SIM_par_1	132	138	PF11976	0.394
LIG_SUMO_SIM_par_1	148	154	PF11976	0.215
LIG_WRC_WIRS_1	275	280	PF05994	0.308
MOD_CDC14_SPxK_1	247	250	PF00782	0.441
MOD_CDC14_SPxK_1	253	256	PF00782	0.441
MOD_CDK_SPxK_1	244	250	PF00069	0.402
MOD_CDK_SPxK_1	255	261	PF00069	0.394
MOD_CK1_1	124	130	PF00069	0.535
MOD_CK1_1	199	205	PF00069	0.448
MOD_CK2_1	288	294	PF00069	0.518
MOD_CK2_1	395	401	PF00069	0.395
MOD_CK2_1	451	457	PF00069	0.294
MOD_GlcNHglycan	123	126	PF01048	0.611
MOD_GlcNHglycan	194	197	PF01048	0.411
MOD_GlcNHglycan	362	365	PF01048	0.606
MOD_GlcNHglycan	398	401	PF01048	0.476
MOD_GlcNHglycan	417	420	PF01048	0.555
MOD_GlcNHglycan	43	46	PF01048	0.587
MOD_GlcNHglycan	63	67	PF01048	0.470
MOD_GSK3_1	103	110	PF00069	0.287
MOD_GSK3_1	192	199	PF00069	0.486
MOD_GSK3_1	244	251	PF00069	0.620
MOD_GSK3_1	340	347	PF00069	0.623
MOD_GSK3_1	356	363	PF00069	0.683
MOD_GSK3_1	377	384	PF00069	0.424
MOD_GSK3_1	415	422	PF00069	0.511
MOD_GSK3_1	92	99	PF00069	0.394
MOD_N-GLC_1	121	126	PF02516	0.626
MOD_N-GLC_1	409	414	PF02516	0.428
MOD_N-GLC_2	309	311	PF02516	0.400
MOD_NEK2_1	103	108	PF00069	0.345
MOD_NEK2_1	146	151	PF00069	0.292
MOD_NEK2_1	161	166	PF00069	0.433
MOD_NEK2_1	395	400	PF00069	0.368
MOD_NEK2_1	415	420	PF00069	0.519
MOD_NEK2_1	451	456	PF00069	0.277
MOD_NEK2_1	84	89	PF00069	0.400
MOD_NEK2_2	183	188	PF00069	0.297
MOD_NEK2_2	206	211	PF00069	0.326
MOD_NEK2_2	356	361	PF00069	0.396
MOD_PIKK_1	340	346	PF00454	0.372
MOD_PKA_1	96	102	PF00069	0.302
MOD_PKA_2	159	165	PF00069	0.407
MOD_PKA_2	204	210	PF00069	0.523
MOD_PKA_2	451	457	PF00069	0.278
MOD_PKA_2	92	98	PF00069	0.405
MOD_Plk_1	35	41	PF00069	0.354
MOD_Plk_4	129	135	PF00069	0.556
MOD_Plk_4	146	152	PF00069	0.265
MOD_Plk_4	174	180	PF00069	0.286
MOD_Plk_4	183	189	PF00069	0.267
MOD_Plk_4	236	242	PF00069	0.484
MOD_Plk_4	328	334	PF00069	0.362
MOD_Plk_4	377	383	PF00069	0.468
MOD_Plk_4	385	391	PF00069	0.422
MOD_Plk_4	451	457	PF00069	0.278
MOD_Plk_4	84	90	PF00069	0.385
MOD_ProDKin_1	124	130	PF00069	0.529
MOD_ProDKin_1	135	141	PF00069	0.706
MOD_ProDKin_1	244	250	PF00069	0.525
MOD_ProDKin_1	255	261	PF00069	0.443
MOD_ProDKin_1	282	288	PF00069	0.543
MOD_ProDKin_1	76	82	PF00069	0.416
TRG_ENDOCYTIC_2	304	307	PF00928	0.457
TRG_ER_diArg_1	243	245	PF00400	0.524
TRG_ER_diArg_1	268	270	PF00400	0.472
TRG_ER_diArg_1	299	301	PF00400	0.469
TRG_ER_diArg_1	403	405	PF00400	0.428
TRG_ER_diArg_1	413	415	PF00400	0.464
TRG_Pf-PMV_PEXEL_1	421	425	PF00026	0.416

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXY2	Leptomonas seymouri	43%	100%
A0A0S4JTN4	Bodo saltans	26%	100%
A0A1X0P483	Trypanosomatidae	30%	100%
A0A3Q8ICQ8	Leishmania donovani	88%	100%
A0A3R7NH72	Trypanosoma rangeli	33%	100%
A4HFS9	Leishmania braziliensis	70%	100%
A4I367	Leishmania infantum	88%	100%
D0A619	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9ADD0	Leishmania major	87%	100%