CBF domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CBF/Mak21 family, putative

Species:

Leishmania mexicana

UniProt:

E9AZ50_LEIMU

TriTrypDb:

LmxM.27.1450

Length:

853

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0005730	nucleolus	5	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

E9AZ50

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZ50

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	642	646	PF00656	0.570
CLV_C14_Caspase3-7	723	727	PF00656	0.729
CLV_NRD_NRD_1	148	150	PF00675	0.436
CLV_NRD_NRD_1	184	186	PF00675	0.350
CLV_NRD_NRD_1	277	279	PF00675	0.417
CLV_NRD_NRD_1	314	316	PF00675	0.378
CLV_NRD_NRD_1	791	793	PF00675	0.572
CLV_PCSK_FUR_1	791	795	PF00082	0.386
CLV_PCSK_KEX2_1	132	134	PF00082	0.420
CLV_PCSK_KEX2_1	163	165	PF00082	0.356
CLV_PCSK_KEX2_1	184	186	PF00082	0.352
CLV_PCSK_KEX2_1	314	316	PF00082	0.378
CLV_PCSK_KEX2_1	679	681	PF00082	0.777
CLV_PCSK_KEX2_1	790	792	PF00082	0.541
CLV_PCSK_KEX2_1	793	795	PF00082	0.528
CLV_PCSK_KEX2_1	849	851	PF00082	0.703
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.409
CLV_PCSK_PC1ET2_1	163	165	PF00082	0.356
CLV_PCSK_PC1ET2_1	679	681	PF00082	0.768
CLV_PCSK_PC1ET2_1	790	792	PF00082	0.549
CLV_PCSK_PC1ET2_1	793	795	PF00082	0.539
CLV_PCSK_PC1ET2_1	849	851	PF00082	0.668
CLV_PCSK_PC7_1	180	186	PF00082	0.403
CLV_PCSK_SKI1_1	129	133	PF00082	0.356
CLV_PCSK_SKI1_1	249	253	PF00082	0.396
CLV_PCSK_SKI1_1	279	283	PF00082	0.394
CLV_PCSK_SKI1_1	314	318	PF00082	0.383
CLV_PCSK_SKI1_1	346	350	PF00082	0.334
CLV_PCSK_SKI1_1	421	425	PF00082	0.363
CLV_PCSK_SKI1_1	448	452	PF00082	0.391
CLV_PCSK_SKI1_1	672	676	PF00082	0.725
CLV_PCSK_SKI1_1	77	81	PF00082	0.457
DEG_MDM2_SWIB_1	366	374	PF02201	0.306
DEG_ODPH_VHL_1	324	337	PF01847	0.413
DOC_CYCLIN_RxL_1	290	298	PF00134	0.499
DOC_CYCLIN_yClb5_NLxxxL_5	639	648	PF00134	0.602
DOC_CYCLIN_yCln2_LP_2	125	128	PF00134	0.460
DOC_MAPK_gen_1	11	18	PF00069	0.527
DOC_MAPK_gen_1	184	191	PF00069	0.272
DOC_MAPK_gen_1	369	379	PF00069	0.322
DOC_MAPK_MEF2A_6	11	20	PF00069	0.529
DOC_MAPK_MEF2A_6	519	526	PF00069	0.394
DOC_PP1_RVXF_1	247	253	PF00149	0.349
DOC_PP1_RVXF_1	419	426	PF00149	0.306
DOC_PP1_RVXF_1	792	799	PF00149	0.596
DOC_PP2B_LxvP_1	125	128	PF13499	0.460
DOC_PP2B_LxvP_1	655	658	PF13499	0.457
DOC_PP4_FxxP_1	14	17	PF00568	0.532
DOC_USP7_MATH_1	217	221	PF00917	0.476
DOC_USP7_MATH_1	404	408	PF00917	0.422
DOC_USP7_MATH_1	470	474	PF00917	0.423
DOC_USP7_MATH_1	479	483	PF00917	0.419
DOC_USP7_MATH_1	585	589	PF00917	0.491
DOC_USP7_MATH_1	665	669	PF00917	0.689
DOC_USP7_MATH_1	722	726	PF00917	0.779
DOC_USP7_MATH_1	804	808	PF00917	0.755
DOC_USP7_UBL2_3	275	279	PF12436	0.433
DOC_USP7_UBL2_3	786	790	PF12436	0.570
DOC_WW_Pin1_4	378	383	PF00397	0.321
DOC_WW_Pin1_4	538	543	PF00397	0.550
DOC_WW_Pin1_4	824	829	PF00397	0.731
LIG_14-3-3_CanoR_1	133	142	PF00244	0.412
LIG_14-3-3_CanoR_1	149	154	PF00244	0.371
LIG_14-3-3_CanoR_1	203	211	PF00244	0.443
LIG_14-3-3_CanoR_1	21	26	PF00244	0.454
LIG_14-3-3_CanoR_1	346	351	PF00244	0.306
LIG_14-3-3_CanoR_1	369	375	PF00244	0.391
LIG_14-3-3_CanoR_1	511	515	PF00244	0.340
LIG_14-3-3_CanoR_1	62	69	PF00244	0.505
LIG_14-3-3_CanoR_1	625	629	PF00244	0.519
LIG_14-3-3_CanoR_1	71	78	PF00244	0.404
LIG_Actin_WH2_2	298	316	PF00022	0.401
LIG_APCC_ABBA_1	523	528	PF00400	0.394
LIG_APCC_ABBA_1	546	551	PF00400	0.468
LIG_BIR_II_1	1	5	PF00653	0.568
LIG_BIR_III_4	758	762	PF00653	0.694
LIG_BRCT_BRCA1_1	135	139	PF00533	0.443
LIG_BRCT_BRCA1_1	240	244	PF00533	0.481
LIG_BRCT_BRCA1_1	64	68	PF00533	0.609
LIG_BRCT_BRCA1_1	809	813	PF00533	0.665
LIG_FHA_1	142	148	PF00498	0.443
LIG_FHA_1	149	155	PF00498	0.347
LIG_FHA_1	20	26	PF00498	0.571
LIG_FHA_1	28	34	PF00498	0.584
LIG_FHA_1	296	302	PF00498	0.456
LIG_FHA_1	304	310	PF00498	0.322
LIG_FHA_1	347	353	PF00498	0.313
LIG_FHA_1	567	573	PF00498	0.690
LIG_FHA_1	652	658	PF00498	0.437
LIG_FHA_1	700	706	PF00498	0.715
LIG_FHA_1	78	84	PF00498	0.454
LIG_FHA_2	185	191	PF00498	0.488
LIG_FHA_2	243	249	PF00498	0.444
LIG_FHA_2	625	631	PF00498	0.547
LIG_FHA_2	640	646	PF00498	0.449
LIG_FHA_2	71	77	PF00498	0.422
LIG_FXI_DFP_1	717	721	PF00024	0.753
LIG_LIR_Gen_1	136	147	PF02991	0.419
LIG_LIR_Gen_1	165	172	PF02991	0.370
LIG_LIR_Gen_1	186	196	PF02991	0.272
LIG_LIR_Gen_1	241	252	PF02991	0.451
LIG_LIR_Gen_1	287	296	PF02991	0.364
LIG_LIR_Gen_1	392	402	PF02991	0.339
LIG_LIR_Gen_1	95	104	PF02991	0.398
LIG_LIR_Nem_3	10	16	PF02991	0.381
LIG_LIR_Nem_3	136	142	PF02991	0.350
LIG_LIR_Nem_3	152	158	PF02991	0.325
LIG_LIR_Nem_3	165	169	PF02991	0.274
LIG_LIR_Nem_3	186	191	PF02991	0.269
LIG_LIR_Nem_3	241	247	PF02991	0.446
LIG_LIR_Nem_3	287	291	PF02991	0.348
LIG_LIR_Nem_3	373	378	PF02991	0.367
LIG_LIR_Nem_3	392	398	PF02991	0.156
LIG_LIR_Nem_3	776	780	PF02991	0.605
LIG_LIR_Nem_3	87	93	PF02991	0.380
LIG_LIR_Nem_3	95	100	PF02991	0.366
LIG_MLH1_MIPbox_1	135	139	PF16413	0.443
LIG_MYND_1	123	127	PF01753	0.407
LIG_NRBOX	228	234	PF00104	0.387
LIG_NRBOX	351	357	PF00104	0.426
LIG_NRBOX	373	379	PF00104	0.322
LIG_NRBOX	519	525	PF00104	0.492
LIG_OCRL_FandH_1	394	406	PF00620	0.322
LIG_Pex14_2	366	370	PF04695	0.306
LIG_Pex14_2	545	549	PF04695	0.454
LIG_Pex14_2	97	101	PF04695	0.374
LIG_PTB_Apo_2	365	372	PF02174	0.322
LIG_PTB_Phospho_1	365	371	PF10480	0.322
LIG_SH2_CRK	371	375	PF00017	0.309
LIG_SH2_SRC	93	96	PF00017	0.496
LIG_SH2_STAP1	111	115	PF00017	0.384
LIG_SH2_STAP1	166	170	PF00017	0.369
LIG_SH2_STAP1	263	267	PF00017	0.364
LIG_SH2_STAP1	64	68	PF00017	0.609
LIG_SH2_STAP1	739	743	PF00017	0.727
LIG_SH2_STAT3	610	613	PF00017	0.395
LIG_SH2_STAT3	64	67	PF00017	0.476
LIG_SH2_STAT5	138	141	PF00017	0.509
LIG_SH2_STAT5	157	160	PF00017	0.171
LIG_SH2_STAT5	161	164	PF00017	0.355
LIG_SH2_STAT5	288	291	PF00017	0.375
LIG_SH2_STAT5	591	594	PF00017	0.463
LIG_SH2_STAT5	93	96	PF00017	0.496
LIG_SH3_1	124	130	PF00018	0.390
LIG_SH3_2	127	132	PF14604	0.395
LIG_SH3_3	124	130	PF00018	0.401
LIG_SH3_3	13	19	PF00018	0.524
LIG_SH3_3	455	461	PF00018	0.405
LIG_SUMO_SIM_anti_2	186	193	PF11976	0.292
LIG_SUMO_SIM_anti_2	349	354	PF11976	0.322
LIG_SUMO_SIM_anti_2	521	526	PF11976	0.494
LIG_SUMO_SIM_par_1	2	10	PF11976	0.310
LIG_SUMO_SIM_par_1	29	34	PF11976	0.322
LIG_SUMO_SIM_par_1	376	381	PF11976	0.322
LIG_SUMO_SIM_par_1	433	439	PF11976	0.306
LIG_SUMO_SIM_par_1	652	659	PF11976	0.442
LIG_TRAF2_1	274	277	PF00917	0.514
LIG_TRAF2_1	326	329	PF00917	0.467
LIG_TRAF2_1	691	694	PF00917	0.705
LIG_TYR_ITIM	153	158	PF00017	0.336
LIG_UBA3_1	243	249	PF00899	0.359
LIG_UBA3_1	250	254	PF00899	0.393
LIG_UBA3_1	352	360	PF00899	0.306
LIG_UBA3_1	377	383	PF00899	0.319
LIG_WW_3	126	130	PF00397	0.479
MOD_CDK_SPK_2	378	383	PF00069	0.306
MOD_CDK_SPxxK_3	824	831	PF00069	0.732
MOD_CK1_1	2	8	PF00069	0.528
MOD_CK1_1	234	240	PF00069	0.525
MOD_CK1_1	303	309	PF00069	0.426
MOD_CK1_1	473	479	PF00069	0.407
MOD_CK1_1	510	516	PF00069	0.358
MOD_CK1_1	583	589	PF00069	0.553
MOD_CK1_1	663	669	PF00069	0.680
MOD_CK1_1	70	76	PF00069	0.465
MOD_CK1_1	807	813	PF00069	0.581
MOD_CK2_1	195	201	PF00069	0.374
MOD_CK2_1	242	248	PF00069	0.442
MOD_CK2_1	271	277	PF00069	0.463
MOD_CK2_1	628	634	PF00069	0.565
MOD_CK2_1	689	695	PF00069	0.670
MOD_GlcNHglycan	387	390	PF01048	0.368
MOD_GlcNHglycan	477	480	PF01048	0.424
MOD_GlcNHglycan	595	598	PF01048	0.508
MOD_GlcNHglycan	630	634	PF01048	0.531
MOD_GlcNHglycan	651	654	PF01048	0.578
MOD_GlcNHglycan	662	665	PF01048	0.640
MOD_GlcNHglycan	802	805	PF01048	0.588
MOD_GlcNHglycan	806	809	PF01048	0.619
MOD_GlcNHglycan	810	813	PF01048	0.630
MOD_GSK3_1	231	238	PF00069	0.421
MOD_GSK3_1	27	34	PF00069	0.584
MOD_GSK3_1	300	307	PF00069	0.410
MOD_GSK3_1	385	392	PF00069	0.329
MOD_GSK3_1	471	478	PF00069	0.435
MOD_GSK3_1	562	569	PF00069	0.680
MOD_GSK3_1	580	587	PF00069	0.470
MOD_GSK3_1	619	626	PF00069	0.486
MOD_GSK3_1	63	70	PF00069	0.502
MOD_GSK3_1	656	663	PF00069	0.537
MOD_GSK3_1	668	675	PF00069	0.719
MOD_GSK3_1	800	807	PF00069	0.562
MOD_GSK3_1	820	827	PF00069	0.783
MOD_N-GLC_1	566	571	PF02516	0.552
MOD_N-GLC_1	593	598	PF02516	0.477
MOD_NEK2_1	1	6	PF00069	0.625
MOD_NEK2_1	100	105	PF00069	0.363
MOD_NEK2_1	162	167	PF00069	0.351
MOD_NEK2_1	172	177	PF00069	0.357
MOD_NEK2_1	195	200	PF00069	0.375
MOD_NEK2_1	233	238	PF00069	0.412
MOD_NEK2_1	295	300	PF00069	0.434
MOD_NEK2_1	337	342	PF00069	0.404
MOD_NEK2_1	639	644	PF00069	0.582
MOD_NEK2_2	257	262	PF00069	0.373
MOD_NEK2_2	370	375	PF00069	0.391
MOD_PIKK_1	133	139	PF00454	0.418
MOD_PIKK_1	438	444	PF00454	0.453
MOD_PIKK_1	619	625	PF00454	0.505
MOD_PIKK_1	63	69	PF00454	0.529
MOD_PKA_1	149	155	PF00069	0.467
MOD_PKA_1	184	190	PF00069	0.493
MOD_PKA_1	672	678	PF00069	0.703
MOD_PKA_2	148	154	PF00069	0.414
MOD_PKA_2	184	190	PF00069	0.507
MOD_PKA_2	202	208	PF00069	0.326
MOD_PKA_2	510	516	PF00069	0.356
MOD_PKA_2	624	630	PF00069	0.526
MOD_PKA_2	639	645	PF00069	0.487
MOD_PKA_2	668	674	PF00069	0.595
MOD_PKA_2	70	76	PF00069	0.430
MOD_PKB_1	60	68	PF00069	0.540
MOD_Plk_1	301	307	PF00069	0.400
MOD_Plk_2-3	44	50	PF00069	0.472
MOD_Plk_2-3	689	695	PF00069	0.690
MOD_Plk_2-3	710	716	PF00069	0.633
MOD_Plk_4	149	155	PF00069	0.390
MOD_Plk_4	172	178	PF00069	0.484
MOD_Plk_4	184	190	PF00069	0.466
MOD_Plk_4	2	8	PF00069	0.515
MOD_Plk_4	238	244	PF00069	0.477
MOD_Plk_4	284	290	PF00069	0.354
MOD_Plk_4	348	354	PF00069	0.320
MOD_Plk_4	362	368	PF00069	0.306
MOD_Plk_4	37	43	PF00069	0.547
MOD_Plk_4	44	50	PF00069	0.557
MOD_Plk_4	513	519	PF00069	0.366
MOD_ProDKin_1	378	384	PF00069	0.321
MOD_ProDKin_1	538	544	PF00069	0.551
MOD_ProDKin_1	824	830	PF00069	0.729
MOD_SUMO_rev_2	274	281	PF00179	0.415
MOD_SUMO_rev_2	4	14	PF00179	0.388
MOD_SUMO_rev_2	47	56	PF00179	0.548
MOD_SUMO_rev_2	482	490	PF00179	0.412
MOD_SUMO_rev_2	558	565	PF00179	0.722
TRG_DiLeu_BaEn_1	776	781	PF01217	0.594
TRG_DiLeu_BaEn_2	247	253	PF01217	0.388
TRG_DiLeu_BaLyEn_6	414	419	PF01217	0.306
TRG_ENDOCYTIC_2	155	158	PF00928	0.336
TRG_ENDOCYTIC_2	166	169	PF00928	0.358
TRG_ENDOCYTIC_2	226	229	PF00928	0.360
TRG_ENDOCYTIC_2	288	291	PF00928	0.350
TRG_ENDOCYTIC_2	319	322	PF00928	0.513
TRG_ENDOCYTIC_2	371	374	PF00928	0.309
TRG_ENDOCYTIC_2	375	378	PF00928	0.302
TRG_ER_diArg_1	313	315	PF00400	0.379
TRG_ER_diArg_1	60	63	PF00400	0.589
TRG_ER_diArg_1	614	617	PF00400	0.428
TRG_ER_diArg_1	791	794	PF00400	0.536
TRG_ER_diArg_1	831	834	PF00400	0.662
TRG_ER_diArg_1	850	853	PF00400	0.462
TRG_NES_CRM1_1	538	551	PF08389	0.540
TRG_NES_CRM1_1	89	102	PF08389	0.368
TRG_NLS_MonoCore_2	789	794	PF00514	0.585
TRG_NLS_MonoExtC_3	789	794	PF00514	0.528
TRG_Pf-PMV_PEXEL_1	231	235	PF00026	0.512

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKJ4	Leptomonas seymouri	80%	100%
A0A0S4JS41	Bodo saltans	52%	100%
A0A1X0P4I0	Trypanosomatidae	61%	100%
A0A3R7MHJ2	Trypanosoma rangeli	59%	100%
A0A3S7X0Q5	Leishmania donovani	94%	100%
A4HFS2	Leishmania braziliensis	84%	100%
A4I371	Leishmania infantum	94%	100%
D0A614	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9ADC6	Leishmania major	94%	100%
G0SEQ5	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	28%	82%
O36021	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	99%
Q12176	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	83%
V5DHD7	Trypanosoma cruzi	59%	100%