Charged multivesicular body protein 2a

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Snf7, putative

Species:

Leishmania mexicana

UniProt:

E9AZ49_LEIMU

TriTrypDb:

LmxM.27.1440

Length:

215

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000815	ESCRT III complex	3	1
GO:0005737	cytoplasm	2	1
GO:0005768	endosome	7	1
GO:0005770	late endosome	8	1
GO:0005771	multivesicular body	9	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0031982	vesicle	4	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0032991	protein-containing complex	1	1
GO:0036452	ESCRT complex	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0097708	intracellular vesicle	5	1
GO:0098796	membrane protein complex	2	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AZ49

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZ49

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0007034	vacuolar transport	4	11
GO:0009987	cellular process	1	11
GO:0046907	intracellular transport	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11
GO:0008104	protein localization	4	1
GO:0015031	protein transport	4	1
GO:0016192	vesicle-mediated transport	4	1
GO:0016197	endosomal transport	4	1
GO:0032509	endosome transport via multivesicular body sorting pathway	5	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0045324	late endosome to vacuole transport	5	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071985	multivesicular body sorting pathway	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	201	205	PF00656	0.656
CLV_C14_Caspase3-7	55	59	PF00656	0.303
CLV_NRD_NRD_1	41	43	PF00675	0.326
CLV_NRD_NRD_1	70	72	PF00675	0.321
CLV_NRD_NRD_1	8	10	PF00675	0.561
CLV_PCSK_KEX2_1	20	22	PF00082	0.256
CLV_PCSK_KEX2_1	8	10	PF00082	0.586
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.303
CLV_PCSK_SKI1_1	105	109	PF00082	0.352
CLV_PCSK_SKI1_1	50	54	PF00082	0.303
DOC_MIT_MIM_1	200	211	PF04212	0.529
DOC_USP7_MATH_1	110	114	PF00917	0.343
DOC_USP7_UBL2_3	105	109	PF12436	0.321
DOC_USP7_UBL2_3	211	215	PF12436	0.525
DOC_USP7_UBL2_3	49	53	PF12436	0.303
DOC_USP7_UBL2_3	72	76	PF12436	0.303
DOC_WW_Pin1_4	8	13	PF00397	0.534
LIG_14-3-3_CanoR_1	34	44	PF00244	0.408
LIG_14-3-3_CanoR_1	79	87	PF00244	0.338
LIG_14-3-3_CanoR_1	90	95	PF00244	0.298
LIG_FHA_2	160	166	PF00498	0.328
LIG_FHA_2	193	199	PF00498	0.647
LIG_FHA_2	24	30	PF00498	0.268
LIG_FHA_2	9	15	PF00498	0.494
LIG_PCNA_yPIPBox_3	140	152	PF02747	0.284
LIG_SH2_STAT3	19	22	PF00017	0.453
LIG_TRAF2_1	11	14	PF00917	0.486
LIG_TRAF2_1	162	165	PF00917	0.435
LIG_TRAF2_1	199	202	PF00917	0.701
LIG_TRAF2_1	38	41	PF00917	0.376
LIG_UBA3_1	136	140	PF00899	0.303
LIG_UBA3_1	44	53	PF00899	0.435
MOD_CDK_SPxxK_3	8	15	PF00069	0.619
MOD_CK2_1	159	165	PF00069	0.303
MOD_CK2_1	192	198	PF00069	0.649
MOD_CK2_1	35	41	PF00069	0.449
MOD_CK2_1	8	14	PF00069	0.502
MOD_GlcNHglycan	96	99	PF01048	0.462
MOD_GSK3_1	192	199	PF00069	0.705
MOD_GSK3_1	90	97	PF00069	0.344
MOD_NEK2_1	210	215	PF00069	0.577
MOD_NEK2_1	23	28	PF00069	0.288
MOD_NEK2_1	67	72	PF00069	0.303
MOD_NEK2_1	94	99	PF00069	0.307
MOD_PIKK_1	192	198	PF00454	0.649
MOD_PIKK_1	36	42	PF00454	0.370
MOD_PIKK_1	79	85	PF00454	0.331
MOD_Plk_2-3	159	165	PF00069	0.303
MOD_ProDKin_1	8	14	PF00069	0.530
MOD_SUMO_rev_2	38	45	PF00179	0.318
TRG_ER_diArg_1	15	18	PF00400	0.421
TRG_ER_diArg_1	68	71	PF00400	0.323
TRG_ER_diArg_1	7	9	PF00400	0.567
TRG_ER_diArg_1	78	81	PF00400	0.320
TRG_Pf-PMV_PEXEL_1	28	33	PF00026	0.328

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK30	Leptomonas seymouri	89%	100%
A0A0N1IL91	Leptomonas seymouri	32%	99%
A0A0S4JKU7	Bodo saltans	32%	82%
A0A0S4JP11	Bodo saltans	69%	98%
A0A1X0P3A0	Trypanosomatidae	35%	100%
A0A1X0P5A2	Trypanosomatidae	24%	100%
A0A1X0P5N6	Trypanosomatidae	77%	99%
A0A381ML17	Leishmania infantum	99%	100%
A0A3R7RGQ9	Trypanosoma rangeli	32%	99%
A0A3S5H7H9	Leishmania donovani	99%	100%
A0A3S5IQV4	Trypanosoma rangeli	76%	100%
A0A3S7XBB5	Leishmania donovani	31%	99%
A4HFS1	Leishmania braziliensis	90%	100%
A4HPL1	Leishmania braziliensis	30%	100%
A4ID53	Leishmania infantum	31%	99%
C9ZYM6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
D0A613	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	100%
D0A8K3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	98%
E9ADC5	Leishmania major	98%	100%
E9ATC3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
O14177	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	40%	100%
O14296	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	93%
O43633	Homo sapiens	57%	97%
O60074	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
O96552	Dictyostelium discoideum	28%	100%
P36095	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	96%
P36108	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	41%	93%
P69771	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	100%
Q0WTY4	Arabidopsis thaliana	35%	97%
Q3SX42	Bos taurus	32%	100%
Q4Q174	Leishmania major	31%	100%
Q4R574	Macaca fascicularis	29%	97%
Q54DB1	Dictyostelium discoideum	50%	100%
Q54GK9	Dictyostelium discoideum	33%	100%
Q54P63	Dictyostelium discoideum	26%	100%
Q58CS7	Bos taurus	30%	97%
Q5BKM3	Xenopus tropicalis	27%	98%
Q5E994	Bos taurus	26%	100%
Q5F3A2	Gallus gallus	33%	100%
Q5R605	Pongo abelii	25%	100%
Q5RAU5	Pongo abelii	30%	97%
Q5RAV2	Pongo abelii	32%	100%
Q5ZHN1	Gallus gallus	55%	98%
Q5ZKX1	Gallus gallus	25%	100%
Q66IV6	Xenopus laevis	33%	100%
Q6DF27	Xenopus tropicalis	26%	100%
Q6DFS6	Xenopus tropicalis	55%	98%
Q6IP52	Xenopus laevis	56%	98%
Q6NRM7	Xenopus laevis	27%	98%
Q6NUD8	Xenopus laevis	24%	100%
Q6NVL7	Xenopus tropicalis	35%	100%
Q6NXD2	Danio rerio	33%	100%
Q6NY88	Danio rerio	27%	97%
Q6PHF0	Danio rerio	24%	100%
Q7LBR1	Homo sapiens	26%	100%
Q7SYR0	Xenopus laevis	33%	100%
Q7SZB5	Xenopus laevis	26%	100%
Q7ZVB1	Danio rerio	26%	100%
Q7ZW25	Danio rerio	49%	98%
Q8BJF9	Mus musculus	32%	100%
Q8CGS4	Rattus norvegicus	29%	96%
Q8LE58	Arabidopsis thaliana	28%	100%
Q921W0	Mus musculus	26%	100%
Q941D5	Arabidopsis thaliana	33%	100%
Q99LU0	Mus musculus	26%	100%
Q9CQ10	Mus musculus	29%	96%
Q9CQD4	Mus musculus	25%	100%
Q9DB34	Mus musculus	57%	97%
Q9HD42	Homo sapiens	25%	100%
Q9SKI2	Arabidopsis thaliana	46%	96%
Q9UQN3	Homo sapiens	32%	100%
Q9Y3E7	Homo sapiens	30%	97%