Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZ48_LEIMU

TriTrypDb:

LmxM.27.1430

Length:

913

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZ48

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZ48

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	15	19	PF00656	0.306
CLV_C14_Caspase3-7	725	729	PF00656	0.510
CLV_C14_Caspase3-7	819	823	PF00656	0.497
CLV_NRD_NRD_1	229	231	PF00675	0.418
CLV_NRD_NRD_1	278	280	PF00675	0.621
CLV_NRD_NRD_1	315	317	PF00675	0.599
CLV_NRD_NRD_1	376	378	PF00675	0.454
CLV_NRD_NRD_1	586	588	PF00675	0.467
CLV_NRD_NRD_1	906	908	PF00675	0.549
CLV_PCSK_FUR_1	584	588	PF00082	0.426
CLV_PCSK_KEX2_1	278	280	PF00082	0.620
CLV_PCSK_KEX2_1	315	317	PF00082	0.539
CLV_PCSK_KEX2_1	397	399	PF00082	0.718
CLV_PCSK_KEX2_1	586	588	PF00082	0.480
CLV_PCSK_KEX2_1	830	832	PF00082	0.609
CLV_PCSK_KEX2_1	906	908	PF00082	0.549
CLV_PCSK_PC1ET2_1	397	399	PF00082	0.653
CLV_PCSK_PC1ET2_1	830	832	PF00082	0.609
CLV_PCSK_PC7_1	393	399	PF00082	0.716
CLV_PCSK_SKI1_1	241	245	PF00082	0.573
CLV_PCSK_SKI1_1	278	282	PF00082	0.643
CLV_PCSK_SKI1_1	315	319	PF00082	0.573
CLV_PCSK_SKI1_1	423	427	PF00082	0.629
CLV_PCSK_SKI1_1	511	515	PF00082	0.660
CLV_PCSK_SKI1_1	86	90	PF00082	0.491
CLV_PCSK_SKI1_1	907	911	PF00082	0.553
DEG_APCC_DBOX_1	171	179	PF00400	0.573
DEG_Nend_UBRbox_2	1	3	PF02207	0.476
DEG_SCF_FBW7_2	344	351	PF00400	0.375
DEG_SCF_TRCP1_1	516	522	PF00400	0.493
DEG_SPOP_SBC_1	257	261	PF00917	0.492
DEG_SPOP_SBC_1	300	304	PF00917	0.569
DEG_SPOP_SBC_1	520	524	PF00917	0.664
DEG_SPOP_SBC_1	525	529	PF00917	0.455
DEG_SPOP_SBC_1	605	609	PF00917	0.496
DOC_CKS1_1	345	350	PF01111	0.376
DOC_CKS1_1	477	482	PF01111	0.584
DOC_CYCLIN_RxL_1	272	283	PF00134	0.623
DOC_CYCLIN_RxL_1	312	321	PF00134	0.584
DOC_CYCLIN_RxL_1	792	806	PF00134	0.365
DOC_MAPK_gen_1	54	63	PF00069	0.527
DOC_MAPK_gen_1	683	692	PF00069	0.550
DOC_MAPK_MEF2A_6	119	128	PF00069	0.527
DOC_MAPK_MEF2A_6	54	63	PF00069	0.635
DOC_MAPK_MEF2A_6	754	762	PF00069	0.447
DOC_MAPK_MEF2A_6	90	97	PF00069	0.460
DOC_PP2B_LxvP_1	297	300	PF13499	0.760
DOC_PP4_FxxP_1	281	284	PF00568	0.646
DOC_PP4_FxxP_1	346	349	PF00568	0.509
DOC_USP7_MATH_1	220	224	PF00917	0.622
DOC_USP7_MATH_1	257	261	PF00917	0.642
DOC_USP7_MATH_1	268	272	PF00917	0.682
DOC_USP7_MATH_1	29	33	PF00917	0.422
DOC_USP7_MATH_1	300	304	PF00917	0.478
DOC_USP7_MATH_1	355	359	PF00917	0.453
DOC_USP7_MATH_1	399	403	PF00917	0.695
DOC_USP7_MATH_1	421	425	PF00917	0.581
DOC_USP7_MATH_1	43	47	PF00917	0.602
DOC_USP7_MATH_1	52	56	PF00917	0.737
DOC_USP7_MATH_1	521	525	PF00917	0.662
DOC_USP7_MATH_1	551	555	PF00917	0.661
DOC_USP7_MATH_1	556	560	PF00917	0.588
DOC_USP7_MATH_1	605	609	PF00917	0.622
DOC_USP7_MATH_1	68	72	PF00917	0.366
DOC_USP7_MATH_1	810	814	PF00917	0.623
DOC_USP7_MATH_1	850	854	PF00917	0.682
DOC_USP7_MATH_1	858	862	PF00917	0.644
DOC_WW_Pin1_4	102	107	PF00397	0.488
DOC_WW_Pin1_4	280	285	PF00397	0.711
DOC_WW_Pin1_4	3	8	PF00397	0.457
DOC_WW_Pin1_4	344	349	PF00397	0.368
DOC_WW_Pin1_4	356	361	PF00397	0.544
DOC_WW_Pin1_4	476	481	PF00397	0.826
DOC_WW_Pin1_4	491	496	PF00397	0.614
DOC_WW_Pin1_4	541	546	PF00397	0.575
DOC_WW_Pin1_4	64	69	PF00397	0.495
DOC_WW_Pin1_4	649	654	PF00397	0.602
DOC_WW_Pin1_4	840	845	PF00397	0.654
LIG_14-3-3_CanoR_1	119	128	PF00244	0.556
LIG_14-3-3_CanoR_1	230	239	PF00244	0.597
LIG_14-3-3_CanoR_1	241	248	PF00244	0.570
LIG_14-3-3_CanoR_1	255	265	PF00244	0.665
LIG_14-3-3_CanoR_1	377	385	PF00244	0.482
LIG_14-3-3_CanoR_1	398	407	PF00244	0.696
LIG_14-3-3_CanoR_1	471	477	PF00244	0.755
LIG_14-3-3_CanoR_1	511	521	PF00244	0.683
LIG_14-3-3_CanoR_1	54	60	PF00244	0.557
LIG_14-3-3_CanoR_1	566	572	PF00244	0.651
LIG_14-3-3_CanoR_1	584	592	PF00244	0.568
LIG_14-3-3_CanoR_1	742	748	PF00244	0.556
LIG_14-3-3_CanoR_1	779	788	PF00244	0.598
LIG_14-3-3_CanoR_1	801	809	PF00244	0.570
LIG_14-3-3_CanoR_1	891	900	PF00244	0.574
LIG_Actin_WH2_2	363	379	PF00022	0.382
LIG_Actin_WH2_2	670	687	PF00022	0.599
LIG_APCC_ABBAyCdc20_2	315	321	PF00400	0.502
LIG_BRCT_BRCA1_1	104	108	PF00533	0.459
LIG_BRCT_BRCA1_1	26	30	PF00533	0.445
LIG_BRCT_BRCA1_1	481	485	PF00533	0.816
LIG_BRCT_BRCA1_1	5	9	PF00533	0.432
LIG_BRCT_BRCA1_1	677	681	PF00533	0.621
LIG_BRCT_BRCA1_2	677	683	PF00533	0.625
LIG_FHA_1	125	131	PF00498	0.386
LIG_FHA_1	192	198	PF00498	0.430
LIG_FHA_1	210	216	PF00498	0.595
LIG_FHA_1	275	281	PF00498	0.710
LIG_FHA_1	302	308	PF00498	0.611
LIG_FHA_1	495	501	PF00498	0.538
LIG_FHA_1	531	537	PF00498	0.646
LIG_FHA_1	634	640	PF00498	0.576
LIG_FHA_1	792	798	PF00498	0.544
LIG_FHA_2	13	19	PF00498	0.343
LIG_FHA_2	172	178	PF00498	0.641
LIG_FHA_2	211	217	PF00498	0.567
LIG_FHA_2	438	444	PF00498	0.650
LIG_FHA_2	568	574	PF00498	0.620
LIG_FHA_2	695	701	PF00498	0.486
LIG_FHA_2	723	729	PF00498	0.507
LIG_GBD_Chelix_1	904	912	PF00786	0.607
LIG_LIR_Gen_1	250	258	PF02991	0.620
LIG_LIR_Gen_1	288	297	PF02991	0.626
LIG_LIR_Gen_1	335	346	PF02991	0.470
LIG_LIR_Gen_1	361	372	PF02991	0.453
LIG_LIR_Nem_3	250	256	PF02991	0.615
LIG_LIR_Nem_3	288	292	PF02991	0.624
LIG_LIR_Nem_3	335	341	PF02991	0.471
LIG_LIR_Nem_3	361	367	PF02991	0.494
LIG_LIR_Nem_3	570	574	PF02991	0.586
LIG_LIR_Nem_3	590	595	PF02991	0.644
LIG_LIR_Nem_3	6	12	PF02991	0.300
LIG_LIR_Nem_3	667	673	PF02991	0.523
LIG_LIR_Nem_3	678	684	PF02991	0.547
LIG_LIR_Nem_3	89	95	PF02991	0.456
LIG_MLH1_MIPbox_1	5	9	PF16413	0.432
LIG_PCNA_yPIPBox_3	230	243	PF02747	0.555
LIG_PDZ_Class_3	908	913	PF00595	0.595
LIG_SH2_CRK	338	342	PF00017	0.446
LIG_SH2_CRK	670	674	PF00017	0.581
LIG_SH2_PTP2	340	343	PF00017	0.407
LIG_SH2_SRC	338	341	PF00017	0.433
LIG_SH2_STAP1	191	195	PF00017	0.577
LIG_SH2_STAP1	334	338	PF00017	0.467
LIG_SH2_STAP1	496	500	PF00017	0.636
LIG_SH2_STAP1	506	510	PF00017	0.523
LIG_SH2_STAP1	596	600	PF00017	0.606
LIG_SH2_STAT3	469	472	PF00017	0.495
LIG_SH2_STAT3	506	509	PF00017	0.586
LIG_SH2_STAT3	539	542	PF00017	0.629
LIG_SH2_STAT5	100	103	PF00017	0.426
LIG_SH2_STAT5	334	337	PF00017	0.497
LIG_SH2_STAT5	340	343	PF00017	0.424
LIG_SH2_STAT5	345	348	PF00017	0.478
LIG_SH2_STAT5	463	466	PF00017	0.611
LIG_SH2_STAT5	496	499	PF00017	0.549
LIG_SH3_1	474	480	PF00018	0.671
LIG_SH3_3	216	222	PF00018	0.585
LIG_SH3_3	281	287	PF00018	0.616
LIG_SH3_3	474	480	PF00018	0.671
LIG_SH3_3	628	634	PF00018	0.499
LIG_SH3_3	636	642	PF00018	0.492
LIG_SH3_3	687	693	PF00018	0.505
LIG_SH3_3	841	847	PF00018	0.570
LIG_Sin3_3	825	832	PF02671	0.488
LIG_SUMO_SIM_anti_2	497	504	PF11976	0.584
LIG_SUMO_SIM_anti_2	573	581	PF11976	0.580
LIG_SUMO_SIM_par_1	192	198	PF11976	0.415
LIG_SUMO_SIM_par_1	864	871	PF11976	0.413
LIG_SxIP_EBH_1	363	377	PF03271	0.375
LIG_TRAF2_1	411	414	PF00917	0.696
LIG_WRC_WIRS_1	363	368	PF05994	0.549
MOD_CDC14_SPxK_1	283	286	PF00782	0.609
MOD_CDK_SPxK_1	280	286	PF00069	0.612
MOD_CK1_1	111	117	PF00069	0.466
MOD_CK1_1	210	216	PF00069	0.680
MOD_CK1_1	259	265	PF00069	0.656
MOD_CK1_1	303	309	PF00069	0.569
MOD_CK1_1	358	364	PF00069	0.528
MOD_CK1_1	365	371	PF00069	0.497
MOD_CK1_1	409	415	PF00069	0.760
MOD_CK1_1	494	500	PF00069	0.690
MOD_CK1_1	512	518	PF00069	0.599
MOD_CK1_1	523	529	PF00069	0.656
MOD_CK1_1	55	61	PF00069	0.532
MOD_CK1_1	626	632	PF00069	0.641
MOD_CK1_1	817	823	PF00069	0.535
MOD_CK1_1	840	846	PF00069	0.587
MOD_CK2_1	205	211	PF00069	0.576
MOD_CK2_1	384	390	PF00069	0.571
MOD_CK2_1	409	415	PF00069	0.723
MOD_CK2_1	437	443	PF00069	0.649
MOD_GlcNHglycan	112	116	PF01048	0.644
MOD_GlcNHglycan	132	135	PF01048	0.301
MOD_GlcNHglycan	203	206	PF01048	0.732
MOD_GlcNHglycan	207	210	PF01048	0.700
MOD_GlcNHglycan	266	269	PF01048	0.700
MOD_GlcNHglycan	297	300	PF01048	0.629
MOD_GlcNHglycan	31	34	PF01048	0.516
MOD_GlcNHglycan	310	313	PF01048	0.738
MOD_GlcNHglycan	378	381	PF01048	0.530
MOD_GlcNHglycan	401	404	PF01048	0.731
MOD_GlcNHglycan	413	419	PF01048	0.566
MOD_GlcNHglycan	511	514	PF01048	0.672
MOD_GlcNHglycan	516	519	PF01048	0.639
MOD_GlcNHglycan	523	526	PF01048	0.774
MOD_GlcNHglycan	553	556	PF01048	0.626
MOD_GlcNHglycan	611	614	PF01048	0.581
MOD_GlcNHglycan	783	786	PF01048	0.583
MOD_GlcNHglycan	803	806	PF01048	0.405
MOD_GlcNHglycan	816	819	PF01048	0.577
MOD_GlcNHglycan	825	828	PF01048	0.745
MOD_GlcNHglycan	839	842	PF01048	0.550
MOD_GlcNHglycan	852	855	PF01048	0.697
MOD_GlcNHglycan	860	863	PF01048	0.743
MOD_GSK3_1	12	19	PF00069	0.359
MOD_GSK3_1	126	133	PF00069	0.328
MOD_GSK3_1	201	208	PF00069	0.754
MOD_GSK3_1	264	271	PF00069	0.615
MOD_GSK3_1	295	302	PF00069	0.716
MOD_GSK3_1	358	365	PF00069	0.428
MOD_GSK3_1	409	416	PF00069	0.592
MOD_GSK3_1	472	479	PF00069	0.712
MOD_GSK3_1	519	526	PF00069	0.783
MOD_GSK3_1	556	563	PF00069	0.576
MOD_GSK3_1	605	612	PF00069	0.646
MOD_GSK3_1	619	626	PF00069	0.492
MOD_GSK3_1	64	71	PF00069	0.471
MOD_GSK3_1	647	654	PF00069	0.597
MOD_GSK3_1	671	678	PF00069	0.529
MOD_GSK3_1	717	724	PF00069	0.622
MOD_GSK3_1	810	817	PF00069	0.523
MOD_N-GLC_1	560	565	PF02516	0.651
MOD_N-GLC_1	720	725	PF02516	0.642
MOD_N-GLC_2	35	37	PF02516	0.475
MOD_NEK2_1	124	129	PF00069	0.475
MOD_NEK2_1	16	21	PF00069	0.491
MOD_NEK2_1	171	176	PF00069	0.641
MOD_NEK2_1	24	29	PF00069	0.372
MOD_NEK2_1	332	337	PF00069	0.435
MOD_NEK2_1	376	381	PF00069	0.578
MOD_NEK2_1	514	519	PF00069	0.620
MOD_NEK2_1	673	678	PF00069	0.589
MOD_NEK2_1	704	709	PF00069	0.389
MOD_NEK2_1	743	748	PF00069	0.452
MOD_NEK2_1	781	786	PF00069	0.524
MOD_NEK2_1	803	808	PF00069	0.583
MOD_NEK2_1	879	884	PF00069	0.583
MOD_NEK2_2	453	458	PF00069	0.436
MOD_PIKK_1	220	226	PF00454	0.501
MOD_PIKK_1	230	236	PF00454	0.483
MOD_PIKK_1	301	307	PF00454	0.576
MOD_PIKK_1	654	660	PF00454	0.552
MOD_PIKK_1	70	76	PF00454	0.485
MOD_PKA_1	230	236	PF00069	0.416
MOD_PKA_2	171	177	PF00069	0.577
MOD_PKA_2	285	291	PF00069	0.681
MOD_PKA_2	376	382	PF00069	0.475
MOD_PKA_2	399	405	PF00069	0.823
MOD_PKA_2	55	61	PF00069	0.532
MOD_PKA_2	578	584	PF00069	0.541
MOD_PKA_2	585	591	PF00069	0.528
MOD_PKA_2	717	723	PF00069	0.609
MOD_PKA_2	743	749	PF00069	0.480
MOD_PKA_2	781	787	PF00069	0.514
MOD_Plk_1	191	197	PF00069	0.580
MOD_Plk_1	210	216	PF00069	0.639
MOD_Plk_1	560	566	PF00069	0.654
MOD_Plk_2-3	173	179	PF00069	0.573
MOD_Plk_2-3	211	217	PF00069	0.522
MOD_Plk_4	12	18	PF00069	0.318
MOD_Plk_4	136	142	PF00069	0.548
MOD_Plk_4	496	502	PF00069	0.560
MOD_Plk_4	531	537	PF00069	0.556
MOD_Plk_4	573	579	PF00069	0.597
MOD_Plk_4	894	900	PF00069	0.619
MOD_ProDKin_1	102	108	PF00069	0.483
MOD_ProDKin_1	280	286	PF00069	0.711
MOD_ProDKin_1	3	9	PF00069	0.455
MOD_ProDKin_1	344	350	PF00069	0.372
MOD_ProDKin_1	356	362	PF00069	0.540
MOD_ProDKin_1	476	482	PF00069	0.823
MOD_ProDKin_1	491	497	PF00069	0.610
MOD_ProDKin_1	541	547	PF00069	0.576
MOD_ProDKin_1	64	70	PF00069	0.503
MOD_ProDKin_1	649	655	PF00069	0.596
MOD_ProDKin_1	840	846	PF00069	0.655
MOD_SUMO_rev_2	223	233	PF00179	0.556
MOD_SUMO_rev_2	705	714	PF00179	0.466
TRG_DiLeu_BaEn_1	326	331	PF01217	0.444
TRG_DiLeu_BaLyEn_6	313	318	PF01217	0.598
TRG_DiLeu_BaLyEn_6	658	663	PF01217	0.570
TRG_DiLeu_BaLyEn_6	798	803	PF01217	0.343
TRG_ENDOCYTIC_2	338	341	PF00928	0.449
TRG_ENDOCYTIC_2	670	673	PF00928	0.581
TRG_ER_diArg_1	278	280	PF00400	0.626
TRG_ER_diArg_1	314	316	PF00400	0.629
TRG_ER_diArg_1	54	57	PF00400	0.444
TRG_ER_diArg_1	585	587	PF00400	0.477
TRG_ER_diArg_1	906	908	PF00400	0.549
TRG_NES_CRM1_1	238	250	PF08389	0.582
TRG_NLS_MonoCore_2	396	401	PF00514	0.764
TRG_NLS_MonoExtN_4	395	401	PF00514	0.776
TRG_Pf-PMV_PEXEL_1	241	245	PF00026	0.573
TRG_Pf-PMV_PEXEL_1	278	282	PF00026	0.665
TRG_Pf-PMV_PEXEL_1	316	321	PF00026	0.496
TRG_Pf-PMV_PEXEL_1	661	665	PF00026	0.649

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWA8	Leptomonas seymouri	49%	98%
A0A381ML15	Leishmania infantum	86%	100%
A0A3S7X0S0	Leishmania donovani	86%	100%
A4HFR9	Leishmania braziliensis	72%	100%
D0A612	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9ADC4	Leishmania major	85%	99%