Putative choline/ethanolamine kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

choline/ethanolamine kinase, putative

Species:

Leishmania mexicana

UniProt:

E9AZ47_LEIMU

TriTrypDb:

LmxM.27.1420

Length:

638

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AZ47

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZ47

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0044237	cellular metabolic process	2	7
GO:0006629	lipid metabolic process	3	1
GO:0006644	phospholipid metabolic process	4	1
GO:0006646	phosphatidylethanolamine biosynthetic process	6	1
GO:0006650	glycerophospholipid metabolic process	5	1
GO:0006656	phosphatidylcholine biosynthetic process	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008610	lipid biosynthetic process	4	1
GO:0008654	phospholipid biosynthetic process	5	1
GO:0009058	biosynthetic process	2	1
GO:0019637	organophosphate metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0045017	glycerolipid biosynthetic process	4	1
GO:0046337	phosphatidylethanolamine metabolic process	6	1
GO:0046470	phosphatidylcholine metabolic process	4	1
GO:0046474	glycerophospholipid biosynthetic process	5	1
GO:0046486	glycerolipid metabolic process	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0090407	organophosphate biosynthetic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0004103	choline kinase activity	5	4
GO:0004305	ethanolamine kinase activity	5	1
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	137	141	PF00656	0.539
CLV_C14_Caspase3-7	319	323	PF00656	0.529
CLV_C14_Caspase3-7	550	554	PF00656	0.468
CLV_NRD_NRD_1	226	228	PF00675	0.534
CLV_NRD_NRD_1	478	480	PF00675	0.275
CLV_NRD_NRD_1	531	533	PF00675	0.354
CLV_PCSK_KEX2_1	226	228	PF00082	0.534
CLV_PCSK_KEX2_1	257	259	PF00082	0.426
CLV_PCSK_KEX2_1	430	432	PF00082	0.292
CLV_PCSK_KEX2_1	491	493	PF00082	0.275
CLV_PCSK_KEX2_1	531	533	PF00082	0.425
CLV_PCSK_PC1ET2_1	257	259	PF00082	0.426
CLV_PCSK_PC1ET2_1	430	432	PF00082	0.252
CLV_PCSK_PC1ET2_1	491	493	PF00082	0.275
CLV_PCSK_SKI1_1	130	134	PF00082	0.697
CLV_PCSK_SKI1_1	352	356	PF00082	0.318
CLV_PCSK_SKI1_1	492	496	PF00082	0.275
CLV_PCSK_SKI1_1	535	539	PF00082	0.370
CLV_PCSK_SKI1_1	566	570	PF00082	0.394
CLV_PCSK_SKI1_1	586	590	PF00082	0.229
DOC_AGCK_PIF_2	315	320	PF00069	0.529
DOC_CDC14_PxL_1	503	511	PF14671	0.460
DOC_CKS1_1	109	114	PF01111	0.729
DOC_CKS1_1	196	201	PF01111	0.573
DOC_CKS1_1	78	83	PF01111	0.537
DOC_CYCLIN_RxL_1	583	595	PF00134	0.356
DOC_MAPK_gen_1	477	487	PF00069	0.481
DOC_MAPK_MEF2A_6	16	25	PF00069	0.365
DOC_PP1_RVXF_1	481	488	PF00149	0.475
DOC_PP1_RVXF_1	564	571	PF00149	0.390
DOC_PP2B_LxvP_1	216	219	PF13499	0.663
DOC_PP2B_LxvP_1	304	307	PF13499	0.475
DOC_PP4_FxxP_1	123	126	PF00568	0.671
DOC_USP7_MATH_1	276	280	PF00917	0.479
DOC_USP7_MATH_1	382	386	PF00917	0.452
DOC_USP7_MATH_1	521	525	PF00917	0.442
DOC_USP7_MATH_1	548	552	PF00917	0.594
DOC_USP7_MATH_1	632	636	PF00917	0.482
DOC_USP7_UBL2_3	37	41	PF12436	0.400
DOC_USP7_UBL2_3	55	59	PF12436	0.482
DOC_WW_Pin1_4	108	113	PF00397	0.652
DOC_WW_Pin1_4	191	196	PF00397	0.664
DOC_WW_Pin1_4	234	239	PF00397	0.606
DOC_WW_Pin1_4	243	248	PF00397	0.556
DOC_WW_Pin1_4	544	549	PF00397	0.545
DOC_WW_Pin1_4	66	71	PF00397	0.678
DOC_WW_Pin1_4	77	82	PF00397	0.560
LIG_14-3-3_CanoR_1	207	213	PF00244	0.600
LIG_14-3-3_CanoR_1	226	233	PF00244	0.615
LIG_14-3-3_CanoR_1	439	449	PF00244	0.529
LIG_14-3-3_CanoR_1	51	55	PF00244	0.350
LIG_14-3-3_CanoR_1	68	78	PF00244	0.541
LIG_APCC_ABBA_1	268	273	PF00400	0.393
LIG_BIR_III_2	140	144	PF00653	0.593
LIG_BRCT_BRCA1_1	199	203	PF00533	0.520
LIG_BRCT_BRCA1_1	296	300	PF00533	0.475
LIG_FHA_1	111	117	PF00498	0.734
LIG_FHA_1	196	202	PF00498	0.648
LIG_FHA_1	244	250	PF00498	0.697
LIG_FHA_1	262	268	PF00498	0.319
LIG_FHA_1	287	293	PF00498	0.480
LIG_FHA_1	409	415	PF00498	0.485
LIG_FHA_2	135	141	PF00498	0.538
LIG_FHA_2	159	165	PF00498	0.640
LIG_FHA_2	390	396	PF00498	0.495
LIG_FHA_2	548	554	PF00498	0.461
LIG_LIR_Apic_2	122	126	PF02991	0.670
LIG_LIR_Apic_2	64	70	PF02991	0.505
LIG_LIR_Gen_1	298	309	PF02991	0.475
LIG_LIR_Gen_1	322	333	PF02991	0.514
LIG_LIR_Gen_1	411	418	PF02991	0.478
LIG_LIR_Gen_1	600	609	PF02991	0.506
LIG_LIR_Nem_3	266	271	PF02991	0.565
LIG_LIR_Nem_3	298	304	PF02991	0.475
LIG_LIR_Nem_3	313	318	PF02991	0.526
LIG_LIR_Nem_3	322	328	PF02991	0.520
LIG_LIR_Nem_3	370	375	PF02991	0.475
LIG_LIR_Nem_3	387	393	PF02991	0.475
LIG_LIR_Nem_3	411	416	PF02991	0.478
LIG_LIR_Nem_3	493	497	PF02991	0.466
LIG_LIR_Nem_3	505	509	PF02991	0.493
LIG_LIR_Nem_3	510	516	PF02991	0.516
LIG_LIR_Nem_3	600	605	PF02991	0.417
LIG_LIR_Nem_3	613	619	PF02991	0.315
LIG_LYPXL_yS_3	176	179	PF13949	0.613
LIG_LYPXL_yS_3	506	509	PF13949	0.460
LIG_NRBOX	586	592	PF00104	0.348
LIG_PCNA_yPIPBox_3	16	24	PF02747	0.395
LIG_PDZ_Class_3	633	638	PF00595	0.518
LIG_Pex14_2	4	8	PF04695	0.450
LIG_PTB_Apo_2	262	269	PF02174	0.424
LIG_SH2_CRK	301	305	PF00017	0.475
LIG_SH2_CRK	325	329	PF00017	0.501
LIG_SH2_CRK	67	71	PF00017	0.520
LIG_SH2_NCK_1	497	501	PF00017	0.492
LIG_SH2_SRC	309	312	PF00017	0.460
LIG_SH2_SRC	320	323	PF00017	0.460
LIG_SH2_STAP1	325	329	PF00017	0.405
LIG_SH2_STAP1	513	517	PF00017	0.475
LIG_SH2_STAT5	309	312	PF00017	0.475
LIG_SH2_STAT5	320	323	PF00017	0.475
LIG_SH2_STAT5	325	328	PF00017	0.475
LIG_SH2_STAT5	405	408	PF00017	0.486
LIG_SH2_STAT5	458	461	PF00017	0.495
LIG_SH2_STAT5	489	492	PF00017	0.475
LIG_SH2_STAT5	516	519	PF00017	0.409
LIG_SH2_STAT5	627	630	PF00017	0.374
LIG_SH3_1	190	196	PF00018	0.587
LIG_SH3_2	78	83	PF14604	0.586
LIG_SH3_3	106	112	PF00018	0.693
LIG_SH3_3	171	177	PF00018	0.614
LIG_SH3_3	190	196	PF00018	0.599
LIG_SH3_3	244	250	PF00018	0.616
LIG_SH3_3	75	81	PF00018	0.581
LIG_SUMO_SIM_par_1	589	595	PF11976	0.333
LIG_TYR_ITIM	299	304	PF00017	0.475
LIG_TYR_ITIM	316	321	PF00017	0.475
LIG_UBA3_1	406	412	PF00899	0.475
LIG_UBA3_1	448	456	PF00899	0.460
LIG_WRC_WIRS_1	159	164	PF05994	0.657
MOD_CDK_SPxK_1	77	83	PF00069	0.583
MOD_CDK_SPxxK_3	77	84	PF00069	0.583
MOD_CK1_1	110	116	PF00069	0.597
MOD_CK1_1	119	125	PF00069	0.662
MOD_CK1_1	294	300	PF00069	0.475
MOD_CK1_1	385	391	PF00069	0.529
MOD_CK1_1	440	446	PF00069	0.529
MOD_CK1_1	53	59	PF00069	0.405
MOD_CK1_1	547	553	PF00069	0.627
MOD_CK1_1	595	601	PF00069	0.321
MOD_CK1_1	66	72	PF00069	0.717
MOD_CK1_1	92	98	PF00069	0.549
MOD_CK2_1	158	164	PF00069	0.639
MOD_CK2_1	39	45	PF00069	0.395
MOD_CK2_1	447	453	PF00069	0.493
MOD_CK2_1	568	574	PF00069	0.528
MOD_CMANNOS	599	602	PF00535	0.326
MOD_DYRK1A_RPxSP_1	243	247	PF00069	0.607
MOD_GlcNHglycan	148	151	PF01048	0.659
MOD_GlcNHglycan	169	172	PF01048	0.550
MOD_GlcNHglycan	259	262	PF01048	0.441
MOD_GlcNHglycan	273	279	PF01048	0.424
MOD_GlcNHglycan	41	44	PF01048	0.396
MOD_GlcNHglycan	442	445	PF01048	0.329
MOD_GlcNHglycan	469	472	PF01048	0.275
MOD_GlcNHglycan	523	526	PF01048	0.341
MOD_GlcNHglycan	609	612	PF01048	0.483
MOD_GlcNHglycan	91	94	PF01048	0.800
MOD_GSK3_1	115	122	PF00069	0.686
MOD_GSK3_1	130	137	PF00069	0.621
MOD_GSK3_1	154	161	PF00069	0.723
MOD_GSK3_1	162	169	PF00069	0.614
MOD_GSK3_1	191	198	PF00069	0.656
MOD_GSK3_1	202	209	PF00069	0.584
MOD_GSK3_1	218	225	PF00069	0.680
MOD_GSK3_1	23	30	PF00069	0.504
MOD_GSK3_1	257	264	PF00069	0.456
MOD_GSK3_1	382	389	PF00069	0.481
MOD_GSK3_1	430	437	PF00069	0.486
MOD_GSK3_1	512	519	PF00069	0.475
MOD_GSK3_1	544	551	PF00069	0.582
MOD_GSK3_1	62	69	PF00069	0.737
MOD_GSK3_1	92	99	PF00069	0.570
MOD_N-GLC_1	544	549	PF02516	0.548
MOD_NEK2_1	162	167	PF00069	0.732
MOD_NEK2_1	202	207	PF00069	0.647
MOD_NEK2_1	300	305	PF00069	0.503
MOD_NEK2_1	363	368	PF00069	0.475
MOD_NEK2_1	406	411	PF00069	0.478
MOD_NEK2_1	434	439	PF00069	0.486
MOD_NEK2_1	487	492	PF00069	0.539
MOD_NEK2_1	50	55	PF00069	0.440
MOD_PIKK_1	116	122	PF00454	0.692
MOD_PIKK_1	363	369	PF00454	0.475
MOD_PIKK_1	416	422	PF00454	0.499
MOD_PIKK_1	72	78	PF00454	0.712
MOD_PKA_1	257	263	PF00069	0.458
MOD_PKA_1	430	436	PF00069	0.486
MOD_PKA_2	186	192	PF00069	0.547
MOD_PKA_2	206	212	PF00069	0.585
MOD_PKA_2	225	231	PF00069	0.614
MOD_PKA_2	233	239	PF00069	0.549
MOD_PKA_2	257	263	PF00069	0.458
MOD_PKA_2	294	300	PF00069	0.496
MOD_PKA_2	348	354	PF00069	0.475
MOD_PKA_2	363	369	PF00069	0.475
MOD_PKA_2	400	406	PF00069	0.510
MOD_PKA_2	430	436	PF00069	0.529
MOD_PKA_2	50	56	PF00069	0.411
MOD_Plk_1	394	400	PF00069	0.495
MOD_Plk_1	63	69	PF00069	0.502
MOD_Plk_4	197	203	PF00069	0.522
MOD_Plk_4	27	33	PF00069	0.359
MOD_Plk_4	276	282	PF00069	0.312
MOD_Plk_4	300	306	PF00069	0.482
MOD_Plk_4	323	329	PF00069	0.456
MOD_Plk_4	430	436	PF00069	0.596
MOD_Plk_4	447	453	PF00069	0.440
MOD_Plk_4	512	518	PF00069	0.475
MOD_Plk_4	92	98	PF00069	0.607
MOD_ProDKin_1	108	114	PF00069	0.653
MOD_ProDKin_1	191	197	PF00069	0.663
MOD_ProDKin_1	234	240	PF00069	0.605
MOD_ProDKin_1	243	249	PF00069	0.544
MOD_ProDKin_1	544	550	PF00069	0.550
MOD_ProDKin_1	66	72	PF00069	0.678
MOD_ProDKin_1	77	83	PF00069	0.561
MOD_SUMO_rev_2	92	102	PF00179	0.668
TRG_DiLeu_BaEn_1	402	407	PF01217	0.475
TRG_DiLeu_BaLyEn_6	10	15	PF01217	0.449
TRG_DiLeu_BaLyEn_6	358	363	PF01217	0.475
TRG_ENDOCYTIC_2	176	179	PF00928	0.662
TRG_ENDOCYTIC_2	301	304	PF00928	0.475
TRG_ENDOCYTIC_2	318	321	PF00928	0.475
TRG_ENDOCYTIC_2	324	327	PF00928	0.475
TRG_ENDOCYTIC_2	329	332	PF00928	0.475
TRG_ENDOCYTIC_2	371	374	PF00928	0.495
TRG_ENDOCYTIC_2	506	509	PF00928	0.503
TRG_ENDOCYTIC_2	627	630	PF00928	0.404
TRG_ER_diArg_1	530	532	PF00400	0.426

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5C8	Leptomonas seymouri	57%	100%
A0A3Q8IPY5	Leishmania donovani	87%	100%
A4HFS0	Leishmania braziliensis	72%	100%
A4I2U4	Leishmania infantum	87%	100%
E9ADC3	Leishmania major	87%	100%