Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZ46_LEIMU

TriTrypDb:

LmxM.27.1410

Length:

375

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZ46

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZ46

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	136	140	PF00656	0.473
CLV_C14_Caspase3-7	15	19	PF00656	0.440
CLV_NRD_NRD_1	289	291	PF00675	0.513
CLV_NRD_NRD_1	69	71	PF00675	0.456
CLV_PCSK_KEX2_1	289	291	PF00082	0.416
CLV_PCSK_KEX2_1	69	71	PF00082	0.456
CLV_PCSK_SKI1_1	204	208	PF00082	0.384
CLV_PCSK_SKI1_1	223	227	PF00082	0.274
CLV_PCSK_SKI1_1	275	279	PF00082	0.381
CLV_PCSK_SKI1_1	289	293	PF00082	0.327
CLV_PCSK_SKI1_1	349	353	PF00082	0.426
DEG_APCC_DBOX_1	348	356	PF00400	0.321
DEG_Nend_UBRbox_2	1	3	PF02207	0.470
DEG_SPOP_SBC_1	134	138	PF00917	0.551
DOC_CKS1_1	224	229	PF01111	0.402
DOC_CYCLIN_RxL_1	284	293	PF00134	0.326
DOC_CYCLIN_yCln2_LP_2	94	100	PF00134	0.425
DOC_MAPK_MEF2A_6	342	350	PF00069	0.340
DOC_MAPK_MEF2A_6	50	58	PF00069	0.479
DOC_PP1_RVXF_1	175	182	PF00149	0.288
DOC_PP2B_LxvP_1	299	302	PF13499	0.467
DOC_PP4_FxxP_1	31	34	PF00568	0.431
DOC_USP7_MATH_1	127	131	PF00917	0.742
DOC_USP7_MATH_1	134	138	PF00917	0.536
DOC_USP7_MATH_1	285	289	PF00917	0.405
DOC_USP7_MATH_2	317	323	PF00917	0.419
DOC_USP7_UBL2_3	12	16	PF12436	0.322
DOC_WW_Pin1_4	120	125	PF00397	0.701
DOC_WW_Pin1_4	129	134	PF00397	0.630
DOC_WW_Pin1_4	223	228	PF00397	0.425
DOC_WW_Pin1_4	236	241	PF00397	0.305
DOC_WW_Pin1_4	30	35	PF00397	0.463
LIG_14-3-3_CanoR_1	109	113	PF00244	0.385
LIG_14-3-3_CanoR_1	141	147	PF00244	0.432
LIG_14-3-3_CanoR_1	162	171	PF00244	0.495
LIG_14-3-3_CanoR_1	177	182	PF00244	0.503
LIG_14-3-3_CanoR_1	204	213	PF00244	0.416
LIG_14-3-3_CanoR_1	342	346	PF00244	0.447
LIG_14-3-3_CanoR_1	50	54	PF00244	0.502
LIG_APCC_ABBA_1	274	279	PF00400	0.536
LIG_BRCT_BRCA1_1	23	27	PF00533	0.482
LIG_FHA_1	191	197	PF00498	0.419
LIG_FHA_1	236	242	PF00498	0.380
LIG_FHA_1	269	275	PF00498	0.418
LIG_FHA_1	304	310	PF00498	0.331
LIG_FHA_1	53	59	PF00498	0.629
LIG_FHA_1	60	66	PF00498	0.498
LIG_FHA_2	153	159	PF00498	0.394
LIG_FHA_2	88	94	PF00498	0.323
LIG_LIR_Apic_2	29	34	PF02991	0.427
LIG_LIR_Gen_1	111	120	PF02991	0.603
LIG_LIR_Gen_1	183	192	PF02991	0.375
LIG_LIR_Gen_1	256	267	PF02991	0.218
LIG_LIR_Gen_1	310	317	PF02991	0.406
LIG_LIR_Gen_1	43	51	PF02991	0.390
LIG_LIR_Nem_3	111	116	PF02991	0.545
LIG_LIR_Nem_3	183	188	PF02991	0.351
LIG_LIR_Nem_3	256	262	PF02991	0.284
LIG_LIR_Nem_3	310	316	PF02991	0.511
LIG_LIR_Nem_3	43	47	PF02991	0.349
LIG_NRP_CendR_1	374	375	PF00754	0.584
LIG_Pex14_2	181	185	PF04695	0.426
LIG_Pex14_2	188	192	PF04695	0.472
LIG_Pex14_2	27	31	PF04695	0.413
LIG_SH2_CRK	144	148	PF00017	0.423
LIG_SH2_CRK	313	317	PF00017	0.408
LIG_SH2_NCK_1	358	362	PF00017	0.514
LIG_SH2_SRC	358	361	PF00017	0.511
LIG_SH2_STAT3	365	368	PF00017	0.535
LIG_SH2_STAT5	13	16	PF00017	0.386
LIG_SH2_STAT5	144	147	PF00017	0.410
LIG_SH2_STAT5	266	269	PF00017	0.356
LIG_SH2_STAT5	365	368	PF00017	0.647
LIG_SH3_3	221	227	PF00018	0.392
LIG_SUMO_SIM_par_1	114	119	PF11976	0.454
LIG_SUMO_SIM_par_1	54	60	PF11976	0.607
LIG_SUMO_SIM_par_1	89	96	PF11976	0.484
LIG_TYR_ITIM	257	262	PF00017	0.385
LIG_WRC_WIRS_1	143	148	PF05994	0.415
LIG_WRC_WIRS_1	178	183	PF05994	0.448
MOD_CDK_SPxK_1	223	229	PF00069	0.400
MOD_CK1_1	122	128	PF00069	0.717
MOD_CK1_1	137	143	PF00069	0.529
MOD_CK1_1	180	186	PF00069	0.483
MOD_CK1_1	190	196	PF00069	0.316
MOD_CK1_1	21	27	PF00069	0.531
MOD_CK1_1	212	218	PF00069	0.560
MOD_CK1_1	59	65	PF00069	0.529
MOD_CK2_1	163	169	PF00069	0.354
MOD_CK2_1	312	318	PF00069	0.468
MOD_CK2_1	319	325	PF00069	0.435
MOD_CK2_1	341	347	PF00069	0.359
MOD_CK2_1	87	93	PF00069	0.383
MOD_DYRK1A_RPxSP_1	223	227	PF00069	0.396
MOD_GlcNHglycan	165	168	PF01048	0.458
MOD_GlcNHglycan	173	176	PF01048	0.417
MOD_GlcNHglycan	23	26	PF01048	0.620
MOD_GlcNHglycan	79	82	PF01048	0.591
MOD_GSK3_1	114	121	PF00069	0.603
MOD_GSK3_1	129	136	PF00069	0.661
MOD_GSK3_1	17	24	PF00069	0.595
MOD_GSK3_1	177	184	PF00069	0.369
MOD_GSK3_1	52	59	PF00069	0.566
MOD_N-GLC_1	370	375	PF02516	0.577
MOD_NEK2_1	116	121	PF00069	0.553
MOD_NEK2_1	171	176	PF00069	0.413
MOD_NEK2_1	181	186	PF00069	0.288
MOD_NEK2_1	195	200	PF00069	0.268
MOD_NEK2_1	253	258	PF00069	0.323
MOD_NEK2_1	312	317	PF00069	0.596
MOD_NEK2_1	370	375	PF00069	0.491
MOD_NEK2_1	42	47	PF00069	0.344
MOD_NEK2_2	152	157	PF00069	0.406
MOD_NEK2_2	64	69	PF00069	0.271
MOD_PIKK_1	283	289	PF00454	0.461
MOD_PIKK_1	49	55	PF00454	0.397
MOD_PKA_2	108	114	PF00069	0.384
MOD_PKA_2	171	177	PF00069	0.490
MOD_PKA_2	341	347	PF00069	0.453
MOD_PKA_2	49	55	PF00069	0.592
MOD_Plk_1	17	23	PF00069	0.601
MOD_Plk_1	42	48	PF00069	0.370
MOD_Plk_2-3	319	325	PF00069	0.407
MOD_Plk_4	108	114	PF00069	0.419
MOD_Plk_4	142	148	PF00069	0.568
MOD_Plk_4	177	183	PF00069	0.375
MOD_Plk_4	253	259	PF00069	0.278
MOD_Plk_4	319	325	PF00069	0.407
MOD_Plk_4	87	93	PF00069	0.381
MOD_ProDKin_1	120	126	PF00069	0.703
MOD_ProDKin_1	129	135	PF00069	0.628
MOD_ProDKin_1	223	229	PF00069	0.433
MOD_ProDKin_1	236	242	PF00069	0.313
MOD_ProDKin_1	30	36	PF00069	0.461
MOD_SUMO_rev_2	80	88	PF00179	0.477
TRG_DiLeu_BaEn_1	319	324	PF01217	0.515
TRG_DiLeu_BaLyEn_6	287	292	PF01217	0.383
TRG_ENDOCYTIC_2	144	147	PF00928	0.418
TRG_ENDOCYTIC_2	259	262	PF00928	0.364
TRG_ENDOCYTIC_2	313	316	PF00928	0.545
TRG_ENDOCYTIC_2	358	361	PF00928	0.456
TRG_ER_diArg_1	289	291	PF00400	0.331
TRG_ER_diArg_1	302	305	PF00400	0.372
TRG_ER_diArg_1	68	70	PF00400	0.441
TRG_Pf-PMV_PEXEL_1	204	208	PF00026	0.387
TRG_Pf-PMV_PEXEL_1	289	293	PF00026	0.276

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5R9	Leptomonas seymouri	59%	96%
A0A0S4JR94	Bodo saltans	28%	100%
A0A3Q8IDF7	Leishmania donovani	93%	100%
A0A422NFS8	Trypanosoma rangeli	35%	100%
A4HFR8	Leishmania braziliensis	78%	100%
A4I2U3	Leishmania infantum	93%	100%
D0A609	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9ADC2	Leishmania major	93%	100%
V5B0Z1	Trypanosoma cruzi	36%	100%