Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania mexicana

UniProt:

E9AZ43_LEIMU

TriTrypDb:

LmxM.27.1370

Length:

1517

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZ43

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

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Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004672	protein kinase activity	3	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7
GO:0017076	purine nucleotide binding	4	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1069	1073	PF00656	0.684
CLV_C14_Caspase3-7	306	310	PF00656	0.506
CLV_C14_Caspase3-7	459	463	PF00656	0.604
CLV_C14_Caspase3-7	829	833	PF00656	0.690
CLV_C14_Caspase3-7	885	889	PF00656	0.738
CLV_NRD_NRD_1	1003	1005	PF00675	0.676
CLV_NRD_NRD_1	1010	1012	PF00675	0.676
CLV_NRD_NRD_1	1238	1240	PF00675	0.749
CLV_NRD_NRD_1	1247	1249	PF00675	0.593
CLV_NRD_NRD_1	1419	1421	PF00675	0.667

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAR4	Leptomonas seymouri	42%	98%
A0A3Q8IHL8	Leishmania donovani	86%	100%
A4HFR4	Leishmania braziliensis	66%	98%
A4I2U0	Leishmania infantum	86%	100%
E9ADB8	Leishmania major	86%	100%

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