Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AZ41_LEIMU

TriTrypDb:

LmxM.27.1350

Length:

271

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 4

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZ41

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZ41

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	113	117	PF00656	0.532
CLV_C14_Caspase3-7	155	159	PF00656	0.525
CLV_C14_Caspase3-7	83	87	PF00656	0.544
CLV_NRD_NRD_1	13	15	PF00675	0.583
CLV_NRD_NRD_1	165	167	PF00675	0.593
CLV_NRD_NRD_1	186	188	PF00675	0.614
CLV_NRD_NRD_1	268	270	PF00675	0.658
CLV_PCSK_FUR_1	266	270	PF00082	0.514
CLV_PCSK_KEX2_1	13	15	PF00082	0.584
CLV_PCSK_KEX2_1	174	176	PF00082	0.604
CLV_PCSK_KEX2_1	268	270	PF00082	0.614
CLV_PCSK_PC1ET2_1	174	176	PF00082	0.624
CLV_PCSK_SKI1_1	175	179	PF00082	0.623
DEG_Nend_Nbox_1	1	3	PF02207	0.644
DEG_SPOP_SBC_1	230	234	PF00917	0.534
DOC_USP7_MATH_1	200	204	PF00917	0.633
DOC_USP7_MATH_1	230	234	PF00917	0.537
DOC_USP7_MATH_1	66	70	PF00917	0.507
DOC_USP7_MATH_1	99	103	PF00917	0.516
DOC_WW_Pin1_4	211	216	PF00397	0.605
DOC_WW_Pin1_4	226	231	PF00397	0.648
DOC_WW_Pin1_4	243	248	PF00397	0.650
DOC_WW_Pin1_4	73	78	PF00397	0.494
LIG_14-3-3_CanoR_1	166	171	PF00244	0.615
LIG_14-3-3_CanoR_1	217	227	PF00244	0.753
LIG_14-3-3_CterR_2	266	271	PF00244	0.516
LIG_Actin_RPEL_3	31	50	PF02755	0.376
LIG_Actin_WH2_2	56	73	PF00022	0.550
LIG_BRCT_BRCA1_1	96	100	PF00533	0.508
LIG_FHA_1	123	129	PF00498	0.560
LIG_FHA_1	243	249	PF00498	0.528
LIG_FHA_2	63	69	PF00498	0.462
LIG_FHA_2	88	94	PF00498	0.623
LIG_IBAR_NPY_1	180	182	PF08397	0.657
LIG_LIR_Gen_1	116	127	PF02991	0.388
LIG_LIR_Gen_1	97	108	PF02991	0.689
LIG_LIR_Nem_3	116	122	PF02991	0.387
LIG_LIR_Nem_3	97	103	PF02991	0.691
LIG_SH2_CRK	119	123	PF00017	0.505
LIG_SH2_STAT3	144	147	PF00017	0.561
LIG_SH2_STAT5	119	122	PF00017	0.398
LIG_SH2_STAT5	30	33	PF00017	0.438
LIG_SH3_2	9	14	PF14604	0.566
LIG_SH3_3	221	227	PF00018	0.679
LIG_SH3_3	254	260	PF00018	0.567
LIG_SH3_3	6	12	PF00018	0.583
LIG_SH3_3	76	82	PF00018	0.600
LIG_SxIP_EBH_1	241	252	PF03271	0.524
LIG_UBA3_1	49	53	PF00899	0.378
LIG_WW_3	10	14	PF00397	0.564
MOD_CDC14_SPxK_1	214	217	PF00782	0.639
MOD_CDK_SPxK_1	211	217	PF00069	0.638
MOD_CK1_1	203	209	PF00069	0.650
MOD_CK1_1	219	225	PF00069	0.721
MOD_CK1_1	229	235	PF00069	0.651
MOD_GlcNHglycan	221	224	PF01048	0.667
MOD_GlcNHglycan	261	264	PF01048	0.521
MOD_GlcNHglycan	39	42	PF01048	0.608
MOD_GSK3_1	189	196	PF00069	0.617
MOD_GSK3_1	200	207	PF00069	0.553
MOD_GSK3_1	211	218	PF00069	0.656
MOD_GSK3_1	222	229	PF00069	0.666
MOD_GSK3_1	239	246	PF00069	0.726
MOD_GSK3_1	62	69	PF00069	0.468
MOD_GSK3_1	82	89	PF00069	0.542
MOD_GSK3_1	99	106	PF00069	0.441
MOD_NEK2_1	1	6	PF00069	0.682
MOD_NEK2_1	122	127	PF00069	0.529
MOD_NEK2_1	152	157	PF00069	0.527
MOD_NEK2_1	37	42	PF00069	0.521
MOD_NEK2_2	66	71	PF00069	0.477
MOD_PIKK_1	111	117	PF00454	0.527
MOD_PIKK_1	133	139	PF00454	0.522
MOD_PIKK_1	191	197	PF00454	0.527
MOD_PIKK_1	43	49	PF00454	0.551
MOD_PK_1	166	172	PF00069	0.620
MOD_PKA_1	166	172	PF00069	0.620
MOD_PKA_2	216	222	PF00069	0.767
MOD_PKA_2	37	43	PF00069	0.450
MOD_Plk_1	66	72	PF00069	0.443
MOD_Plk_4	17	23	PF00069	0.473
MOD_ProDKin_1	211	217	PF00069	0.606
MOD_ProDKin_1	226	232	PF00069	0.650
MOD_ProDKin_1	243	249	PF00069	0.650
MOD_ProDKin_1	73	79	PF00069	0.495
MOD_SUMO_rev_2	54	62	PF00179	0.478
TRG_ENDOCYTIC_2	119	122	PF00928	0.503
TRG_ER_diArg_1	12	14	PF00400	0.582
TRG_ER_diArg_1	266	269	PF00400	0.748
TRG_Pf-PMV_PEXEL_1	187	191	PF00026	0.605

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIX8	Leptomonas seymouri	39%	75%
A0A3Q8IEA3	Leishmania donovani	82%	86%
A4HFR2	Leishmania braziliensis	55%	100%
A4I2T8	Leishmania infantum	82%	86%
E9ADB6	Leishmania major	79%	100%