JmjC domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Cupin-like domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AZ38_LEIMU

TriTrypDb:

LmxM.27.1320

Length:

600

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AZ38

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZ38

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0016570	histone modification	5	1
GO:0016571	histone methylation	5	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018195	peptidyl-arginine modification	6	1
GO:0018216	peptidyl-arginine methylation	5	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	1
GO:0034969	histone arginine methylation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0043985	histone H4-R3 methylation	7	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000976	transcription cis-regulatory region binding	5	1
GO:0000987	cis-regulatory region sequence-specific DNA binding	6	1
GO:0001067	transcription regulatory region nucleic acid binding	4	1
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003690	double-stranded DNA binding	5	1
GO:0005488	binding	1	1
GO:0043565	sequence-specific DNA binding	5	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1
GO:1990837	sequence-specific double-stranded DNA binding	6	1
GO:0003824	catalytic activity	1	2
GO:0016740	transferase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	244	248	PF00656	0.706
CLV_C14_Caspase3-7	312	316	PF00656	0.285
CLV_NRD_NRD_1	169	171	PF00675	0.567
CLV_NRD_NRD_1	224	226	PF00675	0.713
CLV_NRD_NRD_1	388	390	PF00675	0.327
CLV_NRD_NRD_1	422	424	PF00675	0.296
CLV_NRD_NRD_1	543	545	PF00675	0.390
CLV_NRD_NRD_1	581	583	PF00675	0.491
CLV_PCSK_FUR_1	578	582	PF00082	0.532
CLV_PCSK_KEX2_1	136	138	PF00082	0.614
CLV_PCSK_KEX2_1	168	170	PF00082	0.509
CLV_PCSK_KEX2_1	20	22	PF00082	0.576
CLV_PCSK_KEX2_1	226	228	PF00082	0.725
CLV_PCSK_KEX2_1	388	390	PF00082	0.364
CLV_PCSK_KEX2_1	400	402	PF00082	0.256
CLV_PCSK_KEX2_1	424	426	PF00082	0.279
CLV_PCSK_KEX2_1	543	545	PF00082	0.417
CLV_PCSK_KEX2_1	580	582	PF00082	0.475
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.621
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.671
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.696
CLV_PCSK_PC1ET2_1	400	402	PF00082	0.355
CLV_PCSK_PC1ET2_1	424	426	PF00082	0.271
CLV_PCSK_PC1ET2_1	580	582	PF00082	0.517
CLV_PCSK_SKI1_1	169	173	PF00082	0.429
CLV_PCSK_SKI1_1	425	429	PF00082	0.271
CLV_PCSK_SKI1_1	514	518	PF00082	0.383
CLV_PCSK_SKI1_1	520	524	PF00082	0.434
DEG_APCC_DBOX_1	508	516	PF00400	0.404
DEG_Nend_UBRbox_3	1	3	PF02207	0.550
DEG_SCF_FBW7_2	149	154	PF00400	0.446
DEG_SPOP_SBC_1	235	239	PF00917	0.636
DOC_CDC14_PxL_1	60	68	PF14671	0.553
DOC_CKS1_1	447	452	PF01111	0.286
DOC_MAPK_gen_1	280	290	PF00069	0.311
DOC_MAPK_gen_1	423	429	PF00069	0.295
DOC_MAPK_gen_1	578	588	PF00069	0.485
DOC_MAPK_MEF2A_6	280	288	PF00069	0.336
DOC_MIT_MIM_1	300	310	PF04212	0.365
DOC_PP1_RVXF_1	423	430	PF00149	0.286
DOC_PP1_RVXF_1	512	519	PF00149	0.383
DOC_PP2B_LxvP_1	428	431	PF13499	0.271
DOC_PP2B_LxvP_1	61	64	PF13499	0.550
DOC_PP4_FxxP_1	281	284	PF00568	0.306
DOC_USP7_MATH_1	124	128	PF00917	0.751
DOC_USP7_MATH_1	201	205	PF00917	0.653
DOC_USP7_MATH_1	235	239	PF00917	0.703
DOC_USP7_MATH_1	399	403	PF00917	0.415
DOC_USP7_MATH_2	198	204	PF00917	0.459
DOC_USP7_MATH_2	265	271	PF00917	0.492
DOC_USP7_UBL2_3	135	139	PF12436	0.713
DOC_WW_Pin1_4	116	121	PF00397	0.705
DOC_WW_Pin1_4	129	134	PF00397	0.642
DOC_WW_Pin1_4	147	152	PF00397	0.430
DOC_WW_Pin1_4	160	165	PF00397	0.563
DOC_WW_Pin1_4	253	258	PF00397	0.600
DOC_WW_Pin1_4	323	328	PF00397	0.371
DOC_WW_Pin1_4	431	436	PF00397	0.311
DOC_WW_Pin1_4	446	451	PF00397	0.209
DOC_WW_Pin1_4	91	96	PF00397	0.483
LIG_14-3-3_CanoR_1	268	274	PF00244	0.442
LIG_14-3-3_CanoR_1	401	407	PF00244	0.286
LIG_14-3-3_CanoR_1	585	589	PF00244	0.624
LIG_14-3-3_CanoR_1	68	78	PF00244	0.418
LIG_AP2alpha_1	277	281	PF02296	0.398
LIG_BRCT_BRCA1_1	21	25	PF00533	0.561
LIG_BRCT_BRCA1_1	592	596	PF00533	0.516
LIG_CtBP_PxDLS_1	450	454	PF00389	0.286
LIG_deltaCOP1_diTrp_1	296	300	PF00928	0.365
LIG_EVH1_2	155	159	PF00568	0.437
LIG_FHA_1	28	34	PF00498	0.573
LIG_FHA_1	323	329	PF00498	0.325
LIG_FHA_1	452	458	PF00498	0.290
LIG_FHA_2	331	337	PF00498	0.267
LIG_FHA_2	36	42	PF00498	0.644
LIG_FHA_2	382	388	PF00498	0.358
LIG_FHA_2	533	539	PF00498	0.630
LIG_FHA_2	585	591	PF00498	0.614
LIG_LIR_Apic_2	279	284	PF02991	0.331
LIG_LIR_Apic_2	3	7	PF02991	0.442
LIG_LIR_Apic_2	367	373	PF02991	0.271
LIG_LIR_Gen_1	22	33	PF02991	0.607
LIG_LIR_Gen_1	379	390	PF02991	0.359
LIG_LIR_Gen_1	47	58	PF02991	0.450
LIG_LIR_Gen_1	74	85	PF02991	0.455
LIG_LIR_Nem_3	22	28	PF02991	0.553
LIG_LIR_Nem_3	261	266	PF02991	0.429
LIG_LIR_Nem_3	295	300	PF02991	0.286
LIG_LIR_Nem_3	338	343	PF02991	0.273
LIG_LIR_Nem_3	357	363	PF02991	0.421
LIG_LIR_Nem_3	379	385	PF02991	0.286
LIG_LIR_Nem_3	47	53	PF02991	0.462
LIG_LIR_Nem_3	74	80	PF02991	0.475
LIG_LIR_Nem_3	94	100	PF02991	0.313
LIG_PDZ_Class_2	595	600	PF00595	0.515
LIG_Pex14_1	456	460	PF04695	0.331
LIG_Pex14_2	100	104	PF04695	0.401
LIG_Pex14_2	277	281	PF04695	0.286
LIG_Pex14_2	356	360	PF04695	0.271
LIG_Pex14_2	548	552	PF04695	0.351
LIG_Pex14_2	596	600	PF04695	0.519
LIG_SH2_CRK	370	374	PF00017	0.343
LIG_SH2_CRK	90	94	PF00017	0.495
LIG_SH2_GRB2like	412	415	PF00017	0.306
LIG_SH2_NCK_1	370	374	PF00017	0.286
LIG_SH2_PTP2	112	115	PF00017	0.477
LIG_SH2_PTP2	77	80	PF00017	0.529
LIG_SH2_STAP1	412	416	PF00017	0.286
LIG_SH2_STAP1	461	465	PF00017	0.279
LIG_SH2_STAT5	112	115	PF00017	0.486
LIG_SH2_STAT5	340	343	PF00017	0.277
LIG_SH2_STAT5	370	373	PF00017	0.365
LIG_SH2_STAT5	375	378	PF00017	0.312
LIG_SH2_STAT5	412	415	PF00017	0.286
LIG_SH2_STAT5	50	53	PF00017	0.580
LIG_SH2_STAT5	506	509	PF00017	0.314
LIG_SH2_STAT5	77	80	PF00017	0.400
LIG_SH2_STAT5	90	93	PF00017	0.441
LIG_SH2_STAT5	97	100	PF00017	0.297
LIG_SH3_3	149	155	PF00018	0.447
LIG_SH3_3	246	252	PF00018	0.750
LIG_SH3_3	281	287	PF00018	0.328
LIG_SH3_3	321	327	PF00018	0.374
LIG_SH3_3	393	399	PF00018	0.398
LIG_SH3_3	444	450	PF00018	0.286
LIG_SUMO_SIM_par_1	286	292	PF11976	0.271
LIG_SUMO_SIM_par_1	29	35	PF11976	0.568
LIG_SUMO_SIM_par_1	449	455	PF11976	0.289
LIG_TRAF2_1	464	467	PF00917	0.385
LIG_TRAF2_1	536	539	PF00917	0.526
LIG_TRFH_1	189	193	PF08558	0.392
LIG_WW_1	186	189	PF00397	0.481
MOD_CDC14_SPxK_1	326	329	PF00782	0.343
MOD_CDK_SPK_2	253	258	PF00069	0.715
MOD_CDK_SPxK_1	129	135	PF00069	0.641
MOD_CDK_SPxK_1	323	329	PF00069	0.415
MOD_CDK_SPxxK_3	129	136	PF00069	0.640
MOD_CK1_1	131	137	PF00069	0.688
MOD_CK1_1	204	210	PF00069	0.728
MOD_CK1_1	238	244	PF00069	0.661
MOD_CK1_1	270	276	PF00069	0.368
MOD_CK1_1	32	38	PF00069	0.577
MOD_CK1_1	402	408	PF00069	0.343
MOD_CK2_1	100	106	PF00069	0.441
MOD_CK2_1	135	141	PF00069	0.766
MOD_CK2_1	238	244	PF00069	0.758
MOD_CK2_1	270	276	PF00069	0.369
MOD_CK2_1	449	455	PF00069	0.271
MOD_CK2_1	461	467	PF00069	0.271
MOD_CK2_1	532	538	PF00069	0.514
MOD_Cter_Amidation	421	424	PF01082	0.286
MOD_GlcNHglycan	208	211	PF01048	0.731
MOD_GlcNHglycan	213	217	PF01048	0.627
MOD_GlcNHglycan	219	222	PF01048	0.816
MOD_GlcNHglycan	241	244	PF01048	0.514
MOD_GlcNHglycan	319	322	PF01048	0.437
MOD_GlcNHglycan	401	404	PF01048	0.364
MOD_GlcNHglycan	526	529	PF01048	0.378
MOD_GlcNHglycan	592	595	PF01048	0.502
MOD_GSK3_1	100	107	PF00069	0.433
MOD_GSK3_1	124	131	PF00069	0.645
MOD_GSK3_1	135	142	PF00069	0.537
MOD_GSK3_1	200	207	PF00069	0.704
MOD_GSK3_1	212	219	PF00069	0.551
MOD_GSK3_1	234	241	PF00069	0.644
MOD_GSK3_1	288	295	PF00069	0.306
MOD_GSK3_1	313	320	PF00069	0.418
MOD_GSK3_1	32	39	PF00069	0.622
MOD_GSK3_1	496	503	PF00069	0.271
MOD_GSK3_1	534	541	PF00069	0.609
MOD_GSK3_1	590	597	PF00069	0.566
MOD_GSK3_1	67	74	PF00069	0.406
MOD_N-GLC_1	129	134	PF02516	0.662
MOD_N-GLC_1	410	415	PF02516	0.271
MOD_N-GLC_1	418	423	PF02516	0.271
MOD_NEK2_1	100	105	PF00069	0.413
MOD_NEK2_1	128	133	PF00069	0.472
MOD_NEK2_1	205	210	PF00069	0.725
MOD_NEK2_1	317	322	PF00069	0.429
MOD_NEK2_1	381	386	PF00069	0.349
MOD_NEK2_1	496	501	PF00069	0.271
MOD_NEK2_1	522	527	PF00069	0.369
MOD_NEK2_1	552	557	PF00069	0.358
MOD_NEK2_1	69	74	PF00069	0.453
MOD_NEK2_2	29	34	PF00069	0.627
MOD_OFUCOSY	67	73	PF10250	0.439
MOD_PIKK_1	500	506	PF00454	0.271
MOD_PKA_1	135	141	PF00069	0.698
MOD_PKA_1	313	319	PF00069	0.343
MOD_PKA_2	100	106	PF00069	0.435
MOD_PKA_2	267	273	PF00069	0.382
MOD_PKA_2	584	590	PF00069	0.647
MOD_PKA_2	67	73	PF00069	0.405
MOD_Plk_1	330	336	PF00069	0.232
MOD_Plk_1	461	467	PF00069	0.252
MOD_Plk_1	496	502	PF00069	0.310
MOD_Plk_1	552	558	PF00069	0.478
MOD_Plk_2-3	331	337	PF00069	0.227
MOD_Plk_2-3	534	540	PF00069	0.535
MOD_Plk_4	180	186	PF00069	0.337
MOD_Plk_4	201	207	PF00069	0.472
MOD_Plk_4	29	35	PF00069	0.483
MOD_Plk_4	313	319	PF00069	0.343
MOD_Plk_4	584	590	PF00069	0.616
MOD_Plk_4	93	99	PF00069	0.525
MOD_ProDKin_1	116	122	PF00069	0.711
MOD_ProDKin_1	129	135	PF00069	0.641
MOD_ProDKin_1	147	153	PF00069	0.426
MOD_ProDKin_1	160	166	PF00069	0.558
MOD_ProDKin_1	253	259	PF00069	0.584
MOD_ProDKin_1	323	329	PF00069	0.371
MOD_ProDKin_1	431	437	PF00069	0.311
MOD_ProDKin_1	446	452	PF00069	0.209
MOD_ProDKin_1	91	97	PF00069	0.483
MOD_SUMO_rev_2	138	145	PF00179	0.753
TRG_AP2beta_CARGO_1	379	389	PF09066	0.306
TRG_ENDOCYTIC_2	112	115	PF00928	0.486
TRG_ENDOCYTIC_2	188	191	PF00928	0.393
TRG_ENDOCYTIC_2	473	476	PF00928	0.281
TRG_ENDOCYTIC_2	50	53	PF00928	0.580
TRG_ENDOCYTIC_2	77	80	PF00928	0.385
TRG_ENDOCYTIC_2	90	93	PF00928	0.426
TRG_ENDOCYTIC_2	97	100	PF00928	0.297
TRG_ER_diArg_1	167	170	PF00400	0.604
TRG_ER_diArg_1	388	390	PF00400	0.322
TRG_ER_diArg_1	423	426	PF00400	0.296
TRG_ER_diArg_1	543	546	PF00400	0.480
TRG_ER_diArg_1	581	583	PF00400	0.567
TRG_NES_CRM1_1	52	65	PF08389	0.483
TRG_NLS_MonoExtC_3	134	139	PF00514	0.620
TRG_NLS_MonoExtC_3	224	230	PF00514	0.571
TRG_NLS_MonoExtN_4	133	140	PF00514	0.685
TRG_NLS_MonoExtN_4	223	229	PF00514	0.691
TRG_Pf-PMV_PEXEL_1	569	573	PF00026	0.473

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4D1	Leptomonas seymouri	74%	100%
A0A0S4JT19	Bodo saltans	45%	100%
A0A1X0P469	Trypanosomatidae	51%	100%
A0A3Q8IE56	Leishmania donovani	94%	100%
A0A422NFR7	Trypanosoma rangeli	51%	100%
A4HFQ9	Leishmania braziliensis	85%	99%
A4I2T5	Leishmania infantum	94%	100%
D0A601	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9ADB3	Leishmania major	94%	100%
V5BL30	Trypanosoma cruzi	50%	100%