Arginine--tRNA ligase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

arginyl-tRNA synthetase, putative

Species:

Leishmania mexicana

UniProt:

E9AZ37_LEIMU

TriTrypDb:

LmxM.27.1310

Length:

692

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 1
Forrest at al. (procyclic)	no	yes: 1
Silverman et al.	no	yes: 1
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 3

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 3

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

E9AZ37

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZ37

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006399	tRNA metabolic process	7	12
GO:0006418	tRNA aminoacylation for protein translation	6	12
GO:0006420	arginyl-tRNA aminoacylation	7	12
GO:0006520	amino acid metabolic process	3	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0019752	carboxylic acid metabolic process	5	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043038	amino acid activation	4	12
GO:0043039	tRNA aminoacylation	5	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043436	oxoacid metabolic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044281	small molecule metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004812	aminoacyl-tRNA ligase activity	4	12
GO:0004814	arginine-tRNA ligase activity	5	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016874	ligase activity	2	12
GO:0016875	ligase activity, forming carbon-oxygen bonds	3	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140101	catalytic activity, acting on a tRNA	4	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	288	292	PF00656	0.580
CLV_C14_Caspase3-7	305	309	PF00656	0.380
CLV_C14_Caspase3-7	345	349	PF00656	0.531
CLV_C14_Caspase3-7	485	489	PF00656	0.503
CLV_NRD_NRD_1	301	303	PF00675	0.585
CLV_NRD_NRD_1	588	590	PF00675	0.303
CLV_NRD_NRD_1	99	101	PF00675	0.538
CLV_PCSK_KEX2_1	185	187	PF00082	0.293
CLV_PCSK_KEX2_1	588	590	PF00082	0.306
CLV_PCSK_PC1ET2_1	185	187	PF00082	0.303
CLV_PCSK_PC1ET2_1	588	590	PF00082	0.306
CLV_PCSK_SKI1_1	109	113	PF00082	0.546
CLV_PCSK_SKI1_1	206	210	PF00082	0.304
CLV_PCSK_SKI1_1	310	314	PF00082	0.523
CLV_PCSK_SKI1_1	358	362	PF00082	0.545
CLV_PCSK_SKI1_1	490	494	PF00082	0.303
DEG_APCC_DBOX_1	368	376	PF00400	0.536
DEG_APCC_DBOX_1	665	673	PF00400	0.514
DEG_Nend_UBRbox_4	1	3	PF02207	0.667
DEG_ODPH_VHL_1	379	392	PF01847	0.475
DOC_CKS1_1	606	611	PF01111	0.514
DOC_CYCLIN_RxL_1	152	163	PF00134	0.589
DOC_CYCLIN_RxL_1	273	283	PF00134	0.527
DOC_CYCLIN_RxL_1	674	687	PF00134	0.608
DOC_MAPK_DCC_7	384	392	PF00069	0.589
DOC_MAPK_FxFP_2	411	414	PF00069	0.503
DOC_MAPK_gen_1	122	130	PF00069	0.504
DOC_MAPK_gen_1	219	226	PF00069	0.554
DOC_MAPK_gen_1	384	392	PF00069	0.589
DOC_MAPK_gen_1	493	502	PF00069	0.580
DOC_MAPK_gen_1	678	686	PF00069	0.527
DOC_MAPK_HePTP_8	382	394	PF00069	0.580
DOC_MAPK_MEF2A_6	122	130	PF00069	0.528
DOC_MAPK_MEF2A_6	365	372	PF00069	0.565
DOC_MAPK_MEF2A_6	385	394	PF00069	0.580
DOC_MAPK_MEF2A_6	92	99	PF00069	0.589
DOC_PP1_RVXF_1	153	160	PF00149	0.589
DOC_PP4_FxxP_1	130	133	PF00568	0.503
DOC_PP4_FxxP_1	269	272	PF00568	0.514
DOC_PP4_FxxP_1	411	414	PF00568	0.503
DOC_SPAK_OSR1_1	437	441	PF12202	0.608
DOC_USP7_MATH_1	321	325	PF00917	0.653
DOC_USP7_UBL2_3	109	113	PF12436	0.595
DOC_USP7_UBL2_3	15	19	PF12436	0.580
DOC_USP7_UBL2_3	299	303	PF12436	0.486
DOC_USP7_UBL2_3	357	361	PF12436	0.478
DOC_WW_Pin1_4	605	610	PF00397	0.509
DOC_WW_Pin1_4	63	68	PF00397	0.530
LIG_14-3-3_CanoR_1	410	414	PF00244	0.514
LIG_14-3-3_CanoR_1	674	678	PF00244	0.514
LIG_Actin_WH2_2	132	147	PF00022	0.514
LIG_Actin_WH2_2	536	554	PF00022	0.516
LIG_Actin_WH2_2	612	629	PF00022	0.543
LIG_Actin_WH2_2	663	680	PF00022	0.514
LIG_BRCT_BRCA1_1	648	652	PF00533	0.509
LIG_BRCT_BRCA1_1	90	94	PF00533	0.554
LIG_Clathr_ClatBox_1	683	687	PF01394	0.608
LIG_deltaCOP1_diTrp_1	172	177	PF00928	0.494
LIG_deltaCOP1_diTrp_1	467	476	PF00928	0.504
LIG_FAT_LD_1	372	380	PF03623	0.524
LIG_FHA_1	103	109	PF00498	0.414
LIG_FHA_1	426	432	PF00498	0.545
LIG_FHA_1	497	503	PF00498	0.514
LIG_FHA_1	5	11	PF00498	0.571
LIG_FHA_1	678	684	PF00498	0.589
LIG_FHA_2	259	265	PF00498	0.545
LIG_FHA_2	343	349	PF00498	0.533
LIG_FHA_2	462	468	PF00498	0.589
LIG_FHA_2	483	489	PF00498	0.514
LIG_FHA_2	606	612	PF00498	0.510
LIG_FHA_2	626	632	PF00498	0.486
LIG_LIR_Apic_2	129	133	PF02991	0.503
LIG_LIR_Apic_2	267	272	PF02991	0.514
LIG_LIR_Gen_1	249	258	PF02991	0.489
LIG_LIR_Gen_1	388	398	PF02991	0.580
LIG_LIR_Gen_1	432	443	PF02991	0.544
LIG_LIR_Gen_1	562	569	PF02991	0.567
LIG_LIR_Gen_1	639	648	PF02991	0.514
LIG_LIR_Gen_1	91	99	PF02991	0.574
LIG_LIR_Nem_3	175	180	PF02991	0.534
LIG_LIR_Nem_3	249	254	PF02991	0.511
LIG_LIR_Nem_3	267	273	PF02991	0.503
LIG_LIR_Nem_3	388	394	PF02991	0.511
LIG_LIR_Nem_3	432	438	PF02991	0.565
LIG_LIR_Nem_3	573	579	PF02991	0.371
LIG_LIR_Nem_3	646	651	PF02991	0.533
LIG_LIR_Nem_3	91	97	PF02991	0.574
LIG_MAD2	125	133	PF02301	0.527
LIG_MAD2	54	62	PF02301	0.552
LIG_MLH1_MIPbox_1	648	652	PF16413	0.514
LIG_PCNA_yPIPBox_3	265	278	PF02747	0.399
LIG_PDZ_Class_3	687	692	PF00595	0.514
LIG_Pex14_1	173	177	PF04695	0.493
LIG_Pex14_2	391	395	PF04695	0.527
LIG_Pex14_2	407	411	PF04695	0.527
LIG_Pex14_2	648	652	PF04695	0.514
LIG_SH2_CRK	255	259	PF00017	0.543
LIG_SH2_CRK	270	274	PF00017	0.503
LIG_SH2_CRK	581	585	PF00017	0.514
LIG_SH2_SRC	579	582	PF00017	0.503
LIG_SH2_STAP1	559	563	PF00017	0.503
LIG_SH2_STAT3	383	386	PF00017	0.514
LIG_SH2_STAT5	183	186	PF00017	0.527
LIG_SH2_STAT5	191	194	PF00017	0.527
LIG_SH2_STAT5	242	245	PF00017	0.607
LIG_SH2_STAT5	255	258	PF00017	0.454
LIG_SH2_STAT5	424	427	PF00017	0.577
LIG_SH2_STAT5	448	451	PF00017	0.520
LIG_SH2_STAT5	548	551	PF00017	0.498
LIG_SH3_1	24	30	PF00018	0.589
LIG_SH3_3	24	30	PF00018	0.547
LIG_SH3_3	83	89	PF00018	0.399
LIG_SH3_4	361	368	PF00018	0.446
LIG_SUMO_SIM_anti_2	513	519	PF11976	0.527
LIG_SUMO_SIM_anti_2	680	685	PF11976	0.589
LIG_SUMO_SIM_par_1	668	673	PF11976	0.514
LIG_SUMO_SIM_par_1	82	88	PF11976	0.570
LIG_TRAF2_1	231	234	PF00917	0.527
LIG_TRAF2_1	247	250	PF00917	0.527
LIG_TRAF2_1	261	264	PF00917	0.496
LIG_TRAF2_1	298	301	PF00917	0.638
LIG_TRAF2_1	30	33	PF00917	0.608
LIG_TRAF2_1	530	533	PF00917	0.492
LIG_TRAF2_1	608	611	PF00917	0.470
LIG_TRFH_1	26	30	PF08558	0.608
LIG_TYR_ITAM	252	273	PF00017	0.547
LIG_TYR_ITIM	546	551	PF00017	0.505
LIG_UBA3_1	179	185	PF00899	0.503
LIG_UBA3_1	334	340	PF00899	0.485
LIG_UBA3_1	35	40	PF00899	0.493
LIG_UBA3_1	375	384	PF00899	0.474
LIG_UBA3_1	540	547	PF00899	0.543
MOD_CDK_SPxxK_3	605	612	PF00069	0.514
MOD_CK1_1	199	205	PF00069	0.563
MOD_CK1_1	496	502	PF00069	0.503
MOD_CK1_1	570	576	PF00069	0.408
MOD_CK1_1	605	611	PF00069	0.589
MOD_CK2_1	244	250	PF00069	0.511
MOD_CK2_1	258	264	PF00069	0.503
MOD_CK2_1	295	301	PF00069	0.572
MOD_CK2_1	353	359	PF00069	0.473
MOD_CK2_1	527	533	PF00069	0.492
MOD_CK2_1	605	611	PF00069	0.540
MOD_Cter_Amidation	488	491	PF01082	0.303
MOD_GlcNHglycan	129	133	PF01048	0.412
MOD_GlcNHglycan	495	498	PF01048	0.313
MOD_GlcNHglycan	568	572	PF01048	0.439
MOD_GSK3_1	310	317	PF00069	0.531
MOD_GSK3_1	349	356	PF00069	0.474
MOD_GSK3_1	422	429	PF00069	0.503
MOD_GSK3_1	523	530	PF00069	0.537
MOD_GSK3_1	673	680	PF00069	0.589
MOD_N-GLC_1	646	651	PF02516	0.408
MOD_N-GLC_1	95	100	PF02516	0.327
MOD_NEK2_1	144	149	PF00069	0.514
MOD_NEK2_1	551	556	PF00069	0.511
MOD_NEK2_1	567	572	PF00069	0.373
MOD_NEK2_1	662	667	PF00069	0.527
MOD_PIKK_1	314	320	PF00454	0.544
MOD_PIKK_1	523	529	PF00454	0.543
MOD_PIKK_1	54	60	PF00454	0.589
MOD_PK_1	402	408	PF00069	0.580
MOD_PK_1	583	589	PF00069	0.503
MOD_PKA_2	144	150	PF00069	0.514
MOD_PKA_2	409	415	PF00069	0.514
MOD_PKA_2	673	679	PF00069	0.514
MOD_Plk_1	199	205	PF00069	0.558
MOD_Plk_1	233	239	PF00069	0.503
MOD_Plk_1	349	355	PF00069	0.503
MOD_Plk_1	510	516	PF00069	0.514
MOD_Plk_1	602	608	PF00069	0.573
MOD_Plk_1	610	616	PF00069	0.550
MOD_Plk_1	670	676	PF00069	0.514
MOD_Plk_1	95	101	PF00069	0.527
MOD_Plk_2-3	472	478	PF00069	0.563
MOD_Plk_4	103	109	PF00069	0.377
MOD_Plk_4	144	150	PF00069	0.513
MOD_Plk_4	265	271	PF00069	0.502
MOD_Plk_4	402	408	PF00069	0.580
MOD_ProDKin_1	605	611	PF00069	0.509
MOD_ProDKin_1	63	69	PF00069	0.530
MOD_SUMO_rev_2	298	304	PF00179	0.546
MOD_SUMO_rev_2	356	362	PF00179	0.468
TRG_DiLeu_BaEn_4	350	356	PF01217	0.562
TRG_DiLeu_BaEn_4	532	538	PF01217	0.492
TRG_DiLeu_BaLyEn_6	152	157	PF01217	0.589
TRG_DiLeu_BaLyEn_6	269	274	PF01217	0.543
TRG_DiLeu_BaLyEn_6	31	36	PF01217	0.589
TRG_ENDOCYTIC_2	255	258	PF00928	0.503
TRG_ENDOCYTIC_2	270	273	PF00928	0.503
TRG_ENDOCYTIC_2	435	438	PF00928	0.503
TRG_ENDOCYTIC_2	455	458	PF00928	0.518
TRG_ENDOCYTIC_2	548	551	PF00928	0.505
TRG_ENDOCYTIC_2	563	566	PF00928	0.451
TRG_ENDOCYTIC_2	581	584	PF00928	0.503
TRG_ENDOCYTIC_2	642	645	PF00928	0.514
TRG_NES_CRM1_1	504	519	PF08389	0.527
TRG_NLS_MonoExtN_4	119	126	PF00514	0.574
TRG_Pf-PMV_PEXEL_1	125	129	PF00026	0.389
TRG_Pf-PMV_PEXEL_1	656	660	PF00026	0.351

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4S4	Leptomonas seymouri	85%	100%
A0A0S4JSY3	Bodo saltans	59%	100%
A0A1X0P461	Trypanosomatidae	69%	100%
A0A3Q8IED7	Leishmania donovani	97%	100%
A0A3R7MEE6	Trypanosoma rangeli	70%	100%
A1RS32	Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)	24%	100%
A4HFQ8	Leishmania braziliensis	91%	100%
A4I2T4	Leishmania infantum	97%	100%
D0A5Z9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
E9ADB2	Leishmania major	97%	100%
Q0I6R7	Synechococcus sp. (strain CC9311)	35%	100%
Q7URC7	Rhodopirellula baltica (strain DSM 10527 / NCIMB 13988 / SH1)	31%	100%
Q971X1	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	23%	100%
V5BQK5	Trypanosoma cruzi	68%	100%