Leucine-rich repeat protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

predicted leucine-rich repeat protein

Species:

Leishmania mexicana

UniProt:

E9AZ34_LEIMU

TriTrypDb:

LmxM.27.1290

Length:

396

Annotations

LeishMANIAdb annotations

Leucine-rich repeat proteins with a hydrophobic terminal helix. Unlike its distant animal relatives, this cytoplasmic sensor protein might be anchored to the membrane.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	13
GO:0042995	cell projection	2	13
GO:0043226	organelle	2	13
GO:0043227	membrane-bounded organelle	3	13
GO:0110165	cellular anatomical entity	1	13
GO:0120025	plasma membrane bounded cell projection	3	13

Expansion

Sequence features

E9AZ34

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZ34

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	378	380	PF00675	0.515
CLV_PCSK_KEX2_1	378	380	PF00082	0.515
CLV_PCSK_KEX2_1	45	47	PF00082	0.693
CLV_PCSK_PC1ET2_1	45	47	PF00082	0.605
CLV_PCSK_SKI1_1	79	83	PF00082	0.587
DEG_ODPH_VHL_1	185	196	PF01847	0.425
DEG_SPOP_SBC_1	12	16	PF00917	0.565
DEG_SPOP_SBC_1	2	6	PF00917	0.589
DOC_CKS1_1	130	135	PF01111	0.479
DOC_CYCLIN_RxL_1	189	198	PF00134	0.337
DOC_MIT_MIM_1	34	46	PF04212	0.612
DOC_PP1_RVXF_1	226	232	PF00149	0.446
DOC_USP7_MATH_1	12	16	PF00917	0.704
DOC_USP7_MATH_1	120	124	PF00917	0.492
DOC_USP7_MATH_1	326	330	PF00917	0.480
DOC_USP7_MATH_1	81	85	PF00917	0.456
DOC_USP7_MATH_1	90	94	PF00917	0.444
DOC_WW_Pin1_4	129	134	PF00397	0.365
LIG_14-3-3_CanoR_1	116	125	PF00244	0.445
LIG_14-3-3_CanoR_1	296	303	PF00244	0.457
LIG_14-3-3_CanoR_1	362	367	PF00244	0.433
LIG_Actin_WH2_2	245	260	PF00022	0.387
LIG_Actin_WH2_2	347	364	PF00022	0.513
LIG_FHA_1	116	122	PF00498	0.483
LIG_FHA_1	326	332	PF00498	0.385
LIG_FHA_1	358	364	PF00498	0.481
LIG_FHA_1	383	389	PF00498	0.474
LIG_FHA_1	80	86	PF00498	0.463
LIG_FHA_2	210	216	PF00498	0.474
LIG_FHA_2	3	9	PF00498	0.666
LIG_LIR_Gen_1	190	201	PF02991	0.459
LIG_LIR_Gen_1	223	234	PF02991	0.326
LIG_LIR_Nem_3	190	196	PF02991	0.459
LIG_LIR_Nem_3	223	229	PF02991	0.326
LIG_LIR_Nem_3	253	257	PF02991	0.311
LIG_LIR_Nem_3	97	103	PF02991	0.415
LIG_LRP6_Inhibitor_1	271	277	PF00058	0.311
LIG_LYPXL_SIV_4	64	72	PF13949	0.472
LIG_MAD2	248	256	PF02301	0.425
LIG_PDZ_Class_3	391	396	PF00595	0.542
LIG_SH2_CRK	100	104	PF00017	0.518
LIG_SH2_CRK	226	230	PF00017	0.425
LIG_SH2_CRK	47	51	PF00017	0.605
LIG_SH2_NCK_1	226	230	PF00017	0.392
LIG_SH2_PTP2	130	133	PF00017	0.501
LIG_SH2_STAP1	23	27	PF00017	0.601
LIG_SH2_STAT5	130	133	PF00017	0.501
LIG_SH2_STAT5	65	68	PF00017	0.403
LIG_SH3_1	49	55	PF00018	0.662
LIG_SH3_3	49	55	PF00018	0.565
LIG_SUMO_SIM_anti_2	123	128	PF11976	0.381
LIG_SUMO_SIM_par_1	92	99	PF11976	0.461
LIG_TRAF2_1	218	221	PF00917	0.414
LIG_TRAF2_1	22	25	PF00917	0.573
LIG_TRAF2_1	302	305	PF00917	0.376
LIG_TRAF2_1	32	35	PF00917	0.502
LIG_TYR_ITIM	224	229	PF00017	0.392
LIG_TYR_ITIM	98	103	PF00017	0.452
LIG_WRC_WIRS_1	172	177	PF05994	0.507
MOD_CK1_1	329	335	PF00069	0.399
MOD_CK1_1	357	363	PF00069	0.493
MOD_CK1_1	384	390	PF00069	0.523
MOD_CK1_1	57	63	PF00069	0.577
MOD_CK2_1	2	8	PF00069	0.649
MOD_CK2_1	209	215	PF00069	0.494
MOD_GlcNHglycan	118	121	PF01048	0.483
MOD_GlcNHglycan	133	136	PF01048	0.327
MOD_GlcNHglycan	175	178	PF01048	0.469
MOD_GlcNHglycan	328	331	PF01048	0.400
MOD_GlcNHglycan	345	348	PF01048	0.329
MOD_GlcNHglycan	354	357	PF01048	0.457
MOD_GlcNHglycan	58	62	PF01048	0.453
MOD_GSK3_1	116	123	PF00069	0.479
MOD_GSK3_1	148	155	PF00069	0.395
MOD_GSK3_1	321	328	PF00069	0.405
MOD_GSK3_1	352	359	PF00069	0.458
MOD_GSK3_1	382	389	PF00069	0.564
MOD_N-GLC_1	152	157	PF02516	0.504
MOD_N-GLC_1	215	220	PF02516	0.381
MOD_N-GLC_1	272	277	PF02516	0.311
MOD_N-GLC_1	279	284	PF02516	0.342
MOD_NEK2_1	1	6	PF00069	0.628
MOD_NEK2_1	115	120	PF00069	0.374
MOD_NEK2_1	13	18	PF00069	0.579
MOD_NEK2_1	152	157	PF00069	0.409
MOD_NEK2_1	209	214	PF00069	0.392
MOD_NEK2_1	222	227	PF00069	0.226
MOD_NEK2_1	354	359	PF00069	0.495
MOD_NEK2_1	96	101	PF00069	0.384
MOD_NEK2_2	187	192	PF00069	0.446
MOD_NEK2_2	386	391	PF00069	0.345
MOD_OFUCOSY	279	284	PF10250	0.456
MOD_PIKK_1	13	19	PF00454	0.640
MOD_PKA_2	115	121	PF00069	0.420
MOD_PKA_2	390	396	PF00069	0.480
MOD_Plk_1	215	221	PF00069	0.321
MOD_Plk_1	222	228	PF00069	0.270
MOD_Plk_1	272	278	PF00069	0.311
MOD_Plk_1	96	102	PF00069	0.394
MOD_Plk_2-3	215	221	PF00069	0.365
MOD_Plk_4	120	126	PF00069	0.368
MOD_Plk_4	330	336	PF00069	0.368
MOD_ProDKin_1	129	135	PF00069	0.362
TRG_ENDOCYTIC_2	100	103	PF00928	0.464
TRG_ENDOCYTIC_2	226	229	PF00928	0.392
TRG_ENDOCYTIC_2	65	68	PF00928	0.498
TRG_ER_diArg_1	377	379	PF00400	0.518
TRG_Pf-PMV_PEXEL_1	248	253	PF00026	0.385
TRG_Pf-PMV_PEXEL_1	296	300	PF00026	0.398

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUH0	Leptomonas seymouri	27%	84%
A0A0N1I317	Leptomonas seymouri	75%	99%
A0A0S4JL85	Bodo saltans	25%	93%
A0A0S4JV86	Bodo saltans	39%	100%
A0A1X0NTY3	Trypanosomatidae	28%	88%
A0A1X0P364	Trypanosomatidae	25%	92%
A0A1X0P4Z4	Trypanosomatidae	48%	100%
A0A3Q8IDE6	Leishmania donovani	95%	100%
A0A3R7L7Y9	Trypanosoma rangeli	26%	89%
A0A3R7NL91	Trypanosoma rangeli	49%	100%
A0A3S5H5G2	Leishmania donovani	27%	90%
A0A3S5H6F0	Leishmania donovani	28%	100%
A0A3S7WXH1	Leishmania donovani	26%	100%
A0A3S7WZL6	Leishmania donovani	25%	92%
A4H461	Leishmania braziliensis	28%	90%
A4H5X9	Leishmania braziliensis	27%	100%
A4HCM9	Leishmania braziliensis	24%	100%
A4HEQ6	Leishmania braziliensis	24%	100%
A4HFQ6	Leishmania braziliensis	86%	100%
A4HSD0	Leishmania infantum	27%	90%
A4HU75	Leishmania infantum	28%	100%
A4I053	Leishmania infantum	26%	100%
A4I1Y5	Leishmania infantum	25%	92%
A4I2T1	Leishmania infantum	95%	100%
C9ZPX6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	92%
C9ZS33	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	88%
D0A5Z5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	95%
E9ADA9	Leishmania major	95%	100%
E9AKB9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AN05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AW16	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AY32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	84%
P10775	Sus scrofa	28%	87%
P29315	Rattus norvegicus	26%	87%
Q0VAA2	Homo sapiens	27%	81%
Q14BP6	Mus musculus	28%	100%
Q4Q9E1	Leishmania major	27%	100%
Q4QBG0	Leishmania major	26%	100%
Q4QHM3	Leishmania major	28%	100%
Q4QJI8	Leishmania major	28%	90%
Q6ZQY2	Homo sapiens	29%	100%
Q91VI7	Mus musculus	25%	87%
Q9LE82	Arabidopsis thaliana	26%	74%
Q9M651	Arabidopsis thaliana	26%	73%
V5BPZ7	Trypanosoma cruzi	30%	88%
V5DHF2	Trypanosoma cruzi	49%	100%