Ion_trans domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZ32_LEIMU

TriTrypDb:

LmxM.27.1275

Length:

441

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZ32

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZ32

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	186	190	PF00656	0.439
CLV_C14_Caspase3-7	331	335	PF00656	0.508
CLV_MEL_PAP_1	106	112	PF00089	0.530
CLV_NRD_NRD_1	222	224	PF00675	0.421
CLV_NRD_NRD_1	379	381	PF00675	0.569
CLV_PCSK_KEX2_1	108	110	PF00082	0.571
CLV_PCSK_KEX2_1	222	224	PF00082	0.421
CLV_PCSK_KEX2_1	226	228	PF00082	0.424
CLV_PCSK_KEX2_1	378	380	PF00082	0.586
CLV_PCSK_PC1ET2_1	108	110	PF00082	0.571
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.447
CLV_PCSK_PC7_1	222	228	PF00082	0.478
CLV_PCSK_SKI1_1	180	184	PF00082	0.454
CLV_PCSK_SKI1_1	222	226	PF00082	0.501
CLV_PCSK_SKI1_1	233	237	PF00082	0.346
DEG_SCF_FBW7_1	86	91	PF00400	0.601
DOC_MAPK_FxFP_2	6	9	PF00069	0.596
DOC_MAPK_gen_1	138	148	PF00069	0.535
DOC_MAPK_gen_1	230	238	PF00069	0.459
DOC_MAPK_gen_1	403	412	PF00069	0.580
DOC_MAPK_MEF2A_6	45	53	PF00069	0.508
DOC_PP1_RVXF_1	178	184	PF00149	0.383
DOC_PP1_RVXF_1	262	268	PF00149	0.387
DOC_PP2B_LxvP_1	410	413	PF13499	0.576
DOC_PP2B_LxvP_1	433	436	PF13499	0.550
DOC_PP4_FxxP_1	6	9	PF00568	0.596
DOC_USP7_MATH_1	190	194	PF00917	0.443
DOC_USP7_MATH_1	349	353	PF00917	0.693
DOC_USP7_MATH_1	36	40	PF00917	0.566
DOC_USP7_MATH_1	414	418	PF00917	0.559
DOC_USP7_MATH_1	436	440	PF00917	0.590
DOC_USP7_MATH_1	88	92	PF00917	0.627
DOC_WW_Pin1_4	108	113	PF00397	0.527
DOC_WW_Pin1_4	293	298	PF00397	0.573
DOC_WW_Pin1_4	30	35	PF00397	0.633
DOC_WW_Pin1_4	340	345	PF00397	0.599
DOC_WW_Pin1_4	419	424	PF00397	0.699
DOC_WW_Pin1_4	54	59	PF00397	0.544
DOC_WW_Pin1_4	65	70	PF00397	0.696
DOC_WW_Pin1_4	84	89	PF00397	0.620
DOC_WW_Pin1_4	92	97	PF00397	0.651
LIG_14-3-3_CanoR_1	125	133	PF00244	0.538
LIG_14-3-3_CanoR_1	257	266	PF00244	0.604
LIG_14-3-3_CanoR_1	273	279	PF00244	0.490
LIG_14-3-3_CanoR_1	30	34	PF00244	0.642
LIG_14-3-3_CanoR_1	304	314	PF00244	0.492
LIG_14-3-3_CanoR_1	368	375	PF00244	0.504
LIG_14-3-3_CanoR_1	388	394	PF00244	0.539
LIG_14-3-3_CanoR_1	40	44	PF00244	0.570
LIG_14-3-3_CanoR_1	415	419	PF00244	0.585
LIG_14-3-3_CanoR_1	79	84	PF00244	0.637
LIG_BRCT_BRCA1_1	2	6	PF00533	0.549
LIG_BRCT_BRCA1_1	315	319	PF00533	0.601
LIG_BRCT_BRCA1_1	420	424	PF00533	0.579
LIG_Clathr_ClatBox_1	169	173	PF01394	0.457
LIG_DLG_GKlike_1	79	86	PF00625	0.518
LIG_FHA_1	105	111	PF00498	0.715
LIG_FHA_1	143	149	PF00498	0.592
LIG_FHA_2	173	179	PF00498	0.390
LIG_FHA_2	435	441	PF00498	0.482
LIG_LIR_Apic_2	3	9	PF02991	0.591
LIG_LIR_Gen_1	151	161	PF02991	0.505
LIG_LIR_Gen_1	189	197	PF02991	0.420
LIG_LIR_Gen_1	421	432	PF02991	0.621
LIG_LIR_Gen_1	81	88	PF02991	0.504
LIG_LIR_Nem_3	151	156	PF02991	0.525
LIG_LIR_Nem_3	189	194	PF02991	0.417
LIG_LIR_Nem_3	333	339	PF02991	0.511
LIG_LIR_Nem_3	387	393	PF02991	0.464
LIG_LIR_Nem_3	421	427	PF02991	0.697
LIG_LIR_Nem_3	47	53	PF02991	0.570
LIG_LIR_Nem_3	81	86	PF02991	0.518
LIG_MYND_1	432	436	PF01753	0.584
LIG_SH2_PTP2	50	53	PF00017	0.509
LIG_SH2_SRC	244	247	PF00017	0.368
LIG_SH2_SRC	50	53	PF00017	0.618
LIG_SH2_STAP1	240	244	PF00017	0.369
LIG_SH2_STAT5	101	104	PF00017	0.577
LIG_SH2_STAT5	266	269	PF00017	0.576
LIG_SH2_STAT5	355	358	PF00017	0.650
LIG_SH2_STAT5	50	53	PF00017	0.542
LIG_SH2_STAT5	7	10	PF00017	0.603
LIG_SH3_3	348	354	PF00018	0.593
LIG_SH3_3	46	52	PF00018	0.614
LIG_SH3_3	90	96	PF00018	0.658
LIG_SUMO_SIM_anti_2	203	208	PF11976	0.379
LIG_SUMO_SIM_par_1	168	176	PF11976	0.450
LIG_SUMO_SIM_par_1	431	441	PF11976	0.490
LIG_TRAF2_1	405	408	PF00917	0.485
LIG_UBA3_1	194	202	PF00899	0.346
LIG_WRC_WIRS_1	150	155	PF05994	0.424
LIG_WRC_WIRS_1	314	319	PF05994	0.522
MOD_CDC14_SPxK_1	68	71	PF00782	0.667
MOD_CDC14_SPxK_1	95	98	PF00782	0.582
MOD_CDK_SPK_2	340	345	PF00069	0.613
MOD_CDK_SPxK_1	65	71	PF00069	0.671
MOD_CDK_SPxK_1	92	98	PF00069	0.604
MOD_CDK_SPxxK_3	293	300	PF00069	0.609
MOD_CDK_SPxxK_3	30	37	PF00069	0.635
MOD_CK1_1	260	266	PF00069	0.551
MOD_CK1_1	274	280	PF00069	0.487
MOD_CK1_1	296	302	PF00069	0.610
MOD_CK1_1	305	311	PF00069	0.594
MOD_CK1_1	369	375	PF00069	0.505
MOD_CK1_1	38	44	PF00069	0.667
MOD_CK1_1	389	395	PF00069	0.404
MOD_CK1_1	417	423	PF00069	0.570
MOD_CK1_1	81	87	PF00069	0.726
MOD_CK2_1	172	178	PF00069	0.303
MOD_CK2_1	317	323	PF00069	0.492
MOD_CK2_1	434	440	PF00069	0.481
MOD_DYRK1A_RPxSP_1	345	349	PF00069	0.606
MOD_GlcNHglycan	12	15	PF01048	0.533
MOD_GlcNHglycan	153	156	PF01048	0.668
MOD_GlcNHglycan	249	252	PF01048	0.314
MOD_GlcNHglycan	319	322	PF01048	0.591
MOD_GSK3_1	104	111	PF00069	0.600
MOD_GSK3_1	267	274	PF00069	0.576
MOD_GSK3_1	296	303	PF00069	0.551
MOD_GSK3_1	313	320	PF00069	0.630
MOD_GSK3_1	345	352	PF00069	0.679
MOD_GSK3_1	35	42	PF00069	0.642
MOD_GSK3_1	356	363	PF00069	0.650
MOD_GSK3_1	414	421	PF00069	0.612
MOD_GSK3_1	63	70	PF00069	0.682
MOD_GSK3_1	75	82	PF00069	0.617
MOD_GSK3_1	84	91	PF00069	0.623
MOD_N-GLC_1	293	298	PF02516	0.604
MOD_N-GLC_1	54	59	PF02516	0.528
MOD_N-GLC_1	72	77	PF02516	0.767
MOD_NEK2_1	267	272	PF00069	0.570
MOD_NEK2_1	29	34	PF00069	0.670
MOD_NEK2_1	317	322	PF00069	0.599
MOD_NEK2_1	356	361	PF00069	0.622
MOD_PIKK_1	127	133	PF00454	0.572
MOD_PIKK_1	280	286	PF00454	0.585
MOD_PIKK_1	302	308	PF00454	0.587
MOD_PIKK_1	88	94	PF00454	0.621
MOD_PKA_1	300	306	PF00069	0.526
MOD_PKA_2	133	139	PF00069	0.611
MOD_PKA_2	19	25	PF00069	0.653
MOD_PKA_2	218	224	PF00069	0.419
MOD_PKA_2	274	280	PF00069	0.521
MOD_PKA_2	29	35	PF00069	0.560
MOD_PKA_2	36	42	PF00069	0.501
MOD_PKA_2	367	373	PF00069	0.516
MOD_PKA_2	414	420	PF00069	0.563
MOD_PKA_2	75	81	PF00069	0.688
MOD_Plk_1	117	123	PF00069	0.585
MOD_Plk_1	386	392	PF00069	0.535
MOD_Plk_4	190	196	PF00069	0.601
MOD_Plk_4	313	319	PF00069	0.601
MOD_ProDKin_1	108	114	PF00069	0.527
MOD_ProDKin_1	293	299	PF00069	0.574
MOD_ProDKin_1	30	36	PF00069	0.633
MOD_ProDKin_1	340	346	PF00069	0.596
MOD_ProDKin_1	419	425	PF00069	0.698
MOD_ProDKin_1	54	60	PF00069	0.543
MOD_ProDKin_1	65	71	PF00069	0.696
MOD_ProDKin_1	84	90	PF00069	0.619
MOD_ProDKin_1	92	98	PF00069	0.650
MOD_SUMO_rev_2	260	265	PF00179	0.387
TRG_DiLeu_BaLyEn_6	160	165	PF01217	0.417
TRG_DiLeu_BaLyEn_6	361	366	PF01217	0.479
TRG_DiLeu_BaLyEn_6	429	434	PF01217	0.584
TRG_ENDOCYTIC_2	150	153	PF00928	0.434
TRG_ENDOCYTIC_2	336	339	PF00928	0.507
TRG_ENDOCYTIC_2	50	53	PF00928	0.618
TRG_ER_diArg_1	378	380	PF00400	0.573
TRG_ER_diArg_1	98	101	PF00400	0.629
TRG_Pf-PMV_PEXEL_1	223	228	PF00026	0.423
TRG_Pf-PMV_PEXEL_1	254	258	PF00026	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCB3	Leptomonas seymouri	36%	96%
A0A3S7X0N8	Leishmania donovani	82%	100%
A4HFQ4	Leishmania braziliensis	62%	100%
A4I2S9	Leishmania infantum	82%	100%
E9ADA7	Leishmania major	81%	100%