Putative cation transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cation transporter, putative

Species:

Leishmania mexicana

UniProt:

E9AZ30_LEIMU

TriTrypDb:

LmxM.27.1265

Length:

610

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9AZ30

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZ30

Function

Biological processes
Term	Name	Level	Count
GO:0006873	intracellular monoatomic ion homeostasis	4	7
GO:0006875	obsolete intracellular metal ion homeostasis	6	7
GO:0006882	intracellular zinc ion homeostasis	7	7
GO:0009987	cellular process	1	7
GO:0019725	cellular homeostasis	2	7
GO:0030003	intracellular monoatomic cation homeostasis	5	7
GO:0042592	homeostatic process	3	7
GO:0046916	obsolete intracellular transition metal ion homeostasis	7	7
GO:0048878	chemical homeostasis	4	7
GO:0050801	monoatomic ion homeostasis	5	7
GO:0055065	obsolete metal ion homeostasis	7	7
GO:0055069	obsolete zinc ion homeostasis	8	7
GO:0055076	obsolete transition metal ion homeostasis	8	7
GO:0055080	monoatomic cation homeostasis	6	7
GO:0055082	intracellular chemical homeostasis	3	7
GO:0065007	biological regulation	1	7
GO:0065008	regulation of biological quality	2	7
GO:0072503	obsolete cellular divalent inorganic cation homeostasis	6	7
GO:0072507	obsolete divalent inorganic cation homeostasis	7	7
GO:0098771	inorganic ion homeostasis	6	7
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1
GO:0030001	metal ion transport	6	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	8
GO:0005385	zinc ion transmembrane transporter activity	7	7
GO:0008324	monoatomic cation transmembrane transporter activity	4	8
GO:0015075	monoatomic ion transmembrane transporter activity	3	8
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	7
GO:0022857	transmembrane transporter activity	2	8
GO:0022890	inorganic cation transmembrane transporter activity	4	7
GO:0046873	metal ion transmembrane transporter activity	5	7
GO:0046915	transition metal ion transmembrane transporter activity	6	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	272	276	PF00656	0.637
CLV_NRD_NRD_1	108	110	PF00675	0.411
CLV_NRD_NRD_1	162	164	PF00675	0.361
CLV_NRD_NRD_1	313	315	PF00675	0.320
CLV_NRD_NRD_1	582	584	PF00675	0.322
CLV_PCSK_FUR_1	106	110	PF00082	0.398
CLV_PCSK_KEX2_1	108	110	PF00082	0.422
CLV_PCSK_SKI1_1	112	116	PF00082	0.236
CLV_PCSK_SKI1_1	269	273	PF00082	0.424
CLV_PCSK_SKI1_1	314	318	PF00082	0.273
CLV_PCSK_SKI1_1	48	52	PF00082	0.357
CLV_PCSK_SKI1_1	519	523	PF00082	0.269
CLV_PCSK_SKI1_1	537	541	PF00082	0.307
CLV_PCSK_SKI1_1	562	566	PF00082	0.298
CLV_PCSK_SKI1_1	584	588	PF00082	0.328
DEG_SCF_FBW7_2	556	563	PF00400	0.496
DOC_CYCLIN_RxL_1	266	277	PF00134	0.521
DOC_CYCLIN_RxL_1	45	52	PF00134	0.552
DOC_CYCLIN_RxL_1	516	524	PF00134	0.469
DOC_MAPK_gen_1	312	322	PF00069	0.419
DOC_MAPK_gen_1	61	69	PF00069	0.397
DOC_MAPK_MEF2A_6	312	320	PF00069	0.423
DOC_PP1_RVXF_1	267	274	PF00149	0.489
DOC_PP2B_LxvP_1	523	526	PF13499	0.527
DOC_PP4_FxxP_1	409	412	PF00568	0.266
DOC_USP7_MATH_1	232	236	PF00917	0.322
DOC_USP7_MATH_1	274	278	PF00917	0.654
DOC_USP7_MATH_1	336	340	PF00917	0.271
DOC_USP7_MATH_1	496	500	PF00917	0.320
DOC_WW_Pin1_4	284	289	PF00397	0.649
DOC_WW_Pin1_4	548	553	PF00397	0.512
DOC_WW_Pin1_4	556	561	PF00397	0.504
DOC_WW_Pin1_4	56	61	PF00397	0.628
LIG_14-3-3_CanoR_1	106	116	PF00244	0.600
LIG_14-3-3_CanoR_1	137	141	PF00244	0.336
LIG_14-3-3_CanoR_1	65	70	PF00244	0.402
LIG_APCC_ABBA_1	605	610	PF00400	0.523
LIG_BRCT_BRCA1_1	138	142	PF00533	0.197
LIG_BRCT_BRCA1_1	343	347	PF00533	0.250
LIG_FHA_1	156	162	PF00498	0.680
LIG_FHA_1	166	172	PF00498	0.471
LIG_FHA_1	182	188	PF00498	0.219
LIG_FHA_1	26	32	PF00498	0.250
LIG_FHA_1	3	9	PF00498	0.228
LIG_FHA_1	321	327	PF00498	0.281
LIG_FHA_1	35	41	PF00498	0.340
LIG_FHA_1	352	358	PF00498	0.353
LIG_FHA_1	515	521	PF00498	0.471
LIG_FHA_1	541	547	PF00498	0.499
LIG_FHA_1	585	591	PF00498	0.532
LIG_FHA_1	78	84	PF00498	0.299
LIG_FHA_2	270	276	PF00498	0.627
LIG_FHA_2	57	63	PF00498	0.582
LIG_LIR_Gen_1	251	258	PF02991	0.266
LIG_LIR_Gen_1	34	44	PF02991	0.291
LIG_LIR_Gen_1	344	351	PF02991	0.246
LIG_LIR_Gen_1	416	426	PF02991	0.262
LIG_LIR_Gen_1	5	14	PF02991	0.201
LIG_LIR_Nem_3	139	145	PF02991	0.234
LIG_LIR_Nem_3	243	249	PF02991	0.432
LIG_LIR_Nem_3	251	255	PF02991	0.234
LIG_LIR_Nem_3	34	39	PF02991	0.291
LIG_LIR_Nem_3	383	388	PF02991	0.298
LIG_LIR_Nem_3	416	422	PF02991	0.262
LIG_LIR_Nem_3	5	10	PF02991	0.201
LIG_LIR_Nem_3	509	514	PF02991	0.289
LIG_NRBOX	469	475	PF00104	0.271
LIG_Pex14_1	32	36	PF04695	0.271
LIG_Pex14_2	3	7	PF04695	0.201
LIG_PTB_Apo_2	599	606	PF02174	0.512
LIG_SH2_PTP2	400	403	PF00017	0.271
LIG_SH2_SRC	466	469	PF00017	0.271
LIG_SH2_STAP1	361	365	PF00017	0.309
LIG_SH2_STAP1	532	536	PF00017	0.482
LIG_SH2_STAT5	400	403	PF00017	0.292
LIG_SH2_STAT5	419	422	PF00017	0.271
LIG_SH2_STAT5	466	469	PF00017	0.271
LIG_SH2_STAT5	487	490	PF00017	0.275
LIG_SH2_STAT5	579	582	PF00017	0.564
LIG_SH3_3	407	413	PF00018	0.197
LIG_SH3_3	546	552	PF00018	0.505
LIG_SUMO_SIM_anti_2	196	202	PF11976	0.266
LIG_SUMO_SIM_anti_2	253	260	PF11976	0.310
LIG_SUMO_SIM_anti_2	323	328	PF11976	0.238
LIG_SUMO_SIM_anti_2	476	483	PF11976	0.271
LIG_SUMO_SIM_anti_2	502	509	PF11976	0.282
LIG_SUMO_SIM_par_1	124	131	PF11976	0.273
LIG_SUMO_SIM_par_1	303	309	PF11976	0.560
LIG_SUMO_SIM_par_1	320	325	PF11976	0.266
LIG_SUMO_SIM_par_1	419	424	PF11976	0.271
LIG_SUMO_SIM_par_1	502	509	PF11976	0.287
LIG_SUMO_SIM_par_1	519	524	PF11976	0.463
LIG_Vh1_VBS_1	147	165	PF01044	0.274
LIG_WRC_WIRS_1	33	38	PF05994	0.271
LIG_WRC_WIRS_1	39	44	PF05994	0.271
LIG_WW_3	559	563	PF00397	0.503
MOD_CDK_SPK_2	548	553	PF00069	0.532
MOD_CDK_SPK_2	56	61	PF00069	0.611
MOD_CDK_SPxK_1	556	562	PF00069	0.496
MOD_CDK_SPxxK_3	56	63	PF00069	0.606
MOD_CK1_1	155	161	PF00069	0.565
MOD_CK1_1	223	229	PF00069	0.422
MOD_CK1_1	235	241	PF00069	0.296
MOD_CK1_1	26	32	PF00069	0.266
MOD_CK1_1	277	283	PF00069	0.648
MOD_CK1_1	34	40	PF00069	0.253
MOD_CK1_1	499	505	PF00069	0.271
MOD_CK1_1	530	536	PF00069	0.506
MOD_CK2_1	446	452	PF00069	0.458
MOD_GlcNHglycan	12	15	PF01048	0.244
MOD_GlcNHglycan	205	208	PF01048	0.271
MOD_GlcNHglycan	214	217	PF01048	0.271
MOD_GlcNHglycan	222	225	PF01048	0.386
MOD_GlcNHglycan	234	237	PF01048	0.271
MOD_GlcNHglycan	25	28	PF01048	0.623
MOD_GlcNHglycan	259	262	PF01048	0.311
MOD_GlcNHglycan	454	457	PF01048	0.275
MOD_GlcNHglycan	498	501	PF01048	0.271
MOD_GlcNHglycan	508	511	PF01048	0.271
MOD_GlcNHglycan	523	526	PF01048	0.357
MOD_GlcNHglycan	580	583	PF01048	0.425
MOD_GlcNHglycan	77	80	PF01048	0.250
MOD_GSK3_1	104	111	PF00069	0.653
MOD_GSK3_1	2	9	PF00069	0.589
MOD_GSK3_1	269	276	PF00069	0.654
MOD_GSK3_1	34	41	PF00069	0.239
MOD_GSK3_1	438	445	PF00069	0.491
MOD_GSK3_1	475	482	PF00069	0.271
MOD_GSK3_1	574	581	PF00069	0.569
MOD_GSK3_1	584	591	PF00069	0.582
MOD_GSK3_1	61	68	PF00069	0.611
MOD_N-GLC_1	530	535	PF02516	0.311
MOD_N-GLC_1	574	579	PF02516	0.372
MOD_N-GLC_1	601	606	PF02516	0.308
MOD_NEK2_1	10	15	PF00069	0.262
MOD_NEK2_1	116	121	PF00069	0.277
MOD_NEK2_1	182	187	PF00069	0.342
MOD_NEK2_1	203	208	PF00069	0.299
MOD_NEK2_1	220	225	PF00069	0.571
MOD_NEK2_1	25	30	PF00069	0.382
MOD_NEK2_1	257	262	PF00069	0.299
MOD_NEK2_1	273	278	PF00069	0.573
MOD_NEK2_1	291	296	PF00069	0.605
MOD_NEK2_1	320	325	PF00069	0.275
MOD_NEK2_1	351	356	PF00069	0.275
MOD_NEK2_1	402	407	PF00069	0.299
MOD_NEK2_1	421	426	PF00069	0.279
MOD_NEK2_1	438	443	PF00069	0.601
MOD_NEK2_1	473	478	PF00069	0.282
MOD_NEK2_1	514	519	PF00069	0.471
MOD_NEK2_1	521	526	PF00069	0.544
MOD_NEK2_1	540	545	PF00069	0.454
MOD_NEK2_1	77	82	PF00069	0.276
MOD_OFUCOSY	118	123	PF10250	0.274
MOD_PK_1	65	71	PF00069	0.201
MOD_PKA_1	108	114	PF00069	0.587
MOD_PKA_1	584	590	PF00069	0.520
MOD_PKA_2	107	113	PF00069	0.625
MOD_PKA_2	136	142	PF00069	0.337
MOD_PKA_2	23	29	PF00069	0.397
MOD_PKB_1	106	114	PF00069	0.604
MOD_Plk_1	165	171	PF00069	0.503
MOD_Plk_1	274	280	PF00069	0.618
MOD_Plk_1	562	568	PF00069	0.496
MOD_Plk_1	601	607	PF00069	0.504
MOD_Plk_1	61	67	PF00069	0.563
MOD_Plk_4	116	122	PF00069	0.303
MOD_Plk_4	136	142	PF00069	0.359
MOD_Plk_4	175	181	PF00069	0.323
MOD_Plk_4	182	188	PF00069	0.390
MOD_Plk_4	2	8	PF00069	0.397
MOD_Plk_4	223	229	PF00069	0.433
MOD_Plk_4	235	241	PF00069	0.362
MOD_Plk_4	26	32	PF00069	0.246
MOD_Plk_4	303	309	PF00069	0.561
MOD_Plk_4	322	328	PF00069	0.396
MOD_Plk_4	352	358	PF00069	0.341
MOD_Plk_4	364	370	PF00069	0.336
MOD_Plk_4	38	44	PF00069	0.271
MOD_Plk_4	421	427	PF00069	0.281
MOD_Plk_4	475	481	PF00069	0.285
MOD_Plk_4	541	547	PF00069	0.528
MOD_Plk_4	601	607	PF00069	0.504
MOD_ProDKin_1	284	290	PF00069	0.649
MOD_ProDKin_1	548	554	PF00069	0.509
MOD_ProDKin_1	556	562	PF00069	0.506
MOD_ProDKin_1	56	62	PF00069	0.624
MOD_SUMO_rev_2	309	317	PF00179	0.543
MOD_SUMO_rev_2	367	374	PF00179	0.446
TRG_DiLeu_BaEn_1	194	199	PF01217	0.392
TRG_DiLeu_BaEn_1	253	258	PF01217	0.271
TRG_DiLeu_BaEn_1	416	421	PF01217	0.246
TRG_DiLeu_BaEn_2	312	318	PF01217	0.446
TRG_DiLeu_BaEn_3	299	305	PF01217	0.593
TRG_DiLeu_BaLyEn_6	509	514	PF01217	0.271
TRG_DiLeu_BaLyEn_6	62	67	PF01217	0.597
TRG_ENDOCYTIC_2	382	385	PF00928	0.446
TRG_ENDOCYTIC_2	400	403	PF00928	0.271
TRG_ENDOCYTIC_2	419	422	PF00928	0.271
TRG_ENDOCYTIC_2	466	469	PF00928	0.271
TRG_ER_diArg_1	106	109	PF00400	0.606
TRG_NES_CRM1_1	599	610	PF08389	0.459
TRG_NLS_MonoExtC_3	582	588	PF00514	0.514

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB11	Leptomonas seymouri	59%	100%
A0A3Q8IDA3	Leishmania donovani	91%	100%
A4HFQ2	Leishmania braziliensis	78%	100%
A4HJM3	Leishmania braziliensis	25%	100%
A4I2S7	Leishmania infantum	90%	100%
E9ADA5	Leishmania major	89%	100%