Putative translation initiation factor eIF2B subunit-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

translation initiation factor eIF2B delta subunit, putative

Species:

Leishmania mexicana

UniProt:

E9AZ24_LEIMU

TriTrypDb:

LmxM.27.1210

Length:

541

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AZ24

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZ24

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003743	translation initiation factor activity	4	11
GO:0005488	binding	1	11
GO:0008135	translation factor activity, RNA binding	3	11
GO:0045182	translation regulator activity	1	11
GO:0090079	translation regulator activity, nucleic acid binding	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	220	222	PF00675	0.380
CLV_NRD_NRD_1	238	240	PF00675	0.231
CLV_NRD_NRD_1	28	30	PF00675	0.443
CLV_NRD_NRD_1	400	402	PF00675	0.218
CLV_PCSK_FUR_1	220	224	PF00082	0.478
CLV_PCSK_KEX2_1	128	130	PF00082	0.477
CLV_PCSK_KEX2_1	220	222	PF00082	0.378
CLV_PCSK_KEX2_1	238	240	PF00082	0.235
CLV_PCSK_KEX2_1	24	26	PF00082	0.424
CLV_PCSK_KEX2_1	326	328	PF00082	0.298
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.477
CLV_PCSK_PC1ET2_1	222	224	PF00082	0.410
CLV_PCSK_PC1ET2_1	24	26	PF00082	0.424
CLV_PCSK_PC1ET2_1	326	328	PF00082	0.303
CLV_PCSK_SKI1_1	116	120	PF00082	0.560
CLV_PCSK_SKI1_1	19	23	PF00082	0.427
CLV_PCSK_SKI1_1	230	234	PF00082	0.357
CLV_PCSK_SKI1_1	25	29	PF00082	0.414
CLV_PCSK_SKI1_1	265	269	PF00082	0.455
CLV_PCSK_SKI1_1	402	406	PF00082	0.218
DEG_APCC_DBOX_1	24	32	PF00400	0.469
DEG_COP1_1	192	200	PF00400	0.490
DEG_COP1_1	408	417	PF00400	0.475
DEG_Nend_UBRbox_1	1	4	PF02207	0.421
DEG_SPOP_SBC_1	487	491	PF00917	0.504
DEG_SPOP_SBC_1	79	83	PF00917	0.644
DOC_CKS1_1	450	455	PF01111	0.563
DOC_CKS1_1	467	472	PF01111	0.402
DOC_MAPK_DCC_7	454	463	PF00069	0.342
DOC_MAPK_gen_1	324	331	PF00069	0.511
DOC_MAPK_gen_1	398	407	PF00069	0.418
DOC_MAPK_MEF2A_6	158	166	PF00069	0.441
DOC_MAPK_MEF2A_6	398	407	PF00069	0.418
DOC_MAPK_MEF2A_6	412	419	PF00069	0.418
DOC_MAPK_MEF2A_6	454	463	PF00069	0.342
DOC_MIT_MIM_1	234	244	PF04212	0.437
DOC_PP2B_LxvP_1	195	198	PF13499	0.450
DOC_PP2B_LxvP_1	456	459	PF13499	0.509
DOC_PP4_FxxP_1	400	403	PF00568	0.491
DOC_USP7_MATH_1	196	200	PF00917	0.529
DOC_USP7_MATH_1	293	297	PF00917	0.525
DOC_USP7_MATH_1	487	491	PF00917	0.457
DOC_USP7_MATH_1	78	82	PF00917	0.747
DOC_USP7_UBL2_3	280	284	PF12436	0.453
DOC_USP7_UBL2_3	398	402	PF12436	0.418
DOC_WW_Pin1_4	443	448	PF00397	0.436
DOC_WW_Pin1_4	449	454	PF00397	0.431
DOC_WW_Pin1_4	466	471	PF00397	0.519
DOC_WW_Pin1_4	483	488	PF00397	0.441
DOC_WW_Pin1_4	497	502	PF00397	0.413
DOC_WW_Pin1_4	81	86	PF00397	0.680
DOC_WW_Pin1_4	88	93	PF00397	0.730
LIG_14-3-3_CanoR_1	123	130	PF00244	0.630
LIG_14-3-3_CanoR_1	190	195	PF00244	0.481
LIG_14-3-3_CanoR_1	306	310	PF00244	0.434
LIG_Actin_WH2_2	264	282	PF00022	0.387
LIG_BRCT_BRCA1_1	409	413	PF00533	0.420
LIG_FHA_1	190	196	PF00498	0.391
LIG_FHA_1	266	272	PF00498	0.425
LIG_FHA_1	298	304	PF00498	0.441
LIG_FHA_1	352	358	PF00498	0.421
LIG_FHA_1	515	521	PF00498	0.468
LIG_FHA_1	530	536	PF00498	0.428
LIG_FHA_1	71	77	PF00498	0.644
LIG_FHA_1	95	101	PF00498	0.537
LIG_FHA_2	117	123	PF00498	0.582
LIG_FHA_2	15	21	PF00498	0.382
LIG_FHA_2	204	210	PF00498	0.432
LIG_LIR_Apic_2	464	470	PF02991	0.512
LIG_LIR_Gen_1	205	216	PF02991	0.314
LIG_LIR_Gen_1	503	512	PF02991	0.498
LIG_LIR_Nem_3	183	188	PF02991	0.360
LIG_LIR_Nem_3	205	211	PF02991	0.326
LIG_LIR_Nem_3	282	286	PF02991	0.433
LIG_LIR_Nem_3	311	315	PF02991	0.512
LIG_LIR_Nem_3	354	358	PF02991	0.420
LIG_LIR_Nem_3	408	414	PF02991	0.432
LIG_SH2_CRK	355	359	PF00017	0.418
LIG_SH2_CRK	411	415	PF00017	0.482
LIG_SH2_PTP2	312	315	PF00017	0.512
LIG_SH2_STAT5	294	297	PF00017	0.474
LIG_SH2_STAT5	312	315	PF00017	0.474
LIG_SH2_STAT5	495	498	PF00017	0.418
LIG_SH2_STAT5	504	507	PF00017	0.418
LIG_SH3_3	151	157	PF00018	0.516
LIG_SH3_3	244	250	PF00018	0.489
LIG_SUMO_SIM_anti_2	161	167	PF11976	0.328
LIG_SUMO_SIM_par_1	192	199	PF11976	0.485
LIG_SUMO_SIM_par_1	270	276	PF11976	0.320
LIG_SUMO_SIM_par_1	327	333	PF11976	0.418
LIG_TRAF2_1	119	122	PF00917	0.518
LIG_TRFH_1	497	501	PF08558	0.418
LIG_TYR_ITIM	310	315	PF00017	0.512
LIG_TYR_ITIM	353	358	PF00017	0.418
LIG_UBA3_1	271	280	PF00899	0.379
MOD_CDK_SPK_2	449	454	PF00069	0.389
MOD_CDK_SPxK_1	466	472	PF00069	0.507
MOD_CK1_1	189	195	PF00069	0.437
MOD_CK1_1	282	288	PF00069	0.337
MOD_CK1_1	297	303	PF00069	0.446
MOD_CK1_1	37	43	PF00069	0.497
MOD_CK1_1	490	496	PF00069	0.480
MOD_CK1_1	65	71	PF00069	0.583
MOD_CK1_1	81	87	PF00069	0.541
MOD_CK2_1	116	122	PF00069	0.630
MOD_CK2_1	14	20	PF00069	0.402
MOD_CK2_1	196	202	PF00069	0.509
MOD_CK2_1	203	209	PF00069	0.467
MOD_CK2_1	282	288	PF00069	0.307
MOD_CK2_1	305	311	PF00069	0.418
MOD_CK2_1	37	43	PF00069	0.531
MOD_GlcNHglycan	12	15	PF01048	0.529
MOD_GlcNHglycan	125	128	PF01048	0.493
MOD_GlcNHglycan	174	177	PF01048	0.389
MOD_GlcNHglycan	182	185	PF01048	0.349
MOD_GlcNHglycan	224	228	PF01048	0.364
MOD_GlcNHglycan	332	335	PF01048	0.267
MOD_GlcNHglycan	347	350	PF01048	0.204
MOD_GlcNHglycan	36	39	PF01048	0.425
MOD_GlcNHglycan	375	378	PF01048	0.312
MOD_GlcNHglycan	463	466	PF01048	0.287
MOD_GlcNHglycan	479	482	PF01048	0.277
MOD_GlcNHglycan	490	493	PF01048	0.219
MOD_GlcNHglycan	517	520	PF01048	0.324
MOD_GlcNHglycan	6	9	PF01048	0.530
MOD_GlcNHglycan	68	71	PF01048	0.622
MOD_GSK3_1	10	17	PF00069	0.622
MOD_GSK3_1	186	193	PF00069	0.385
MOD_GSK3_1	293	300	PF00069	0.440
MOD_GSK3_1	356	363	PF00069	0.454
MOD_GSK3_1	437	444	PF00069	0.551
MOD_GSK3_1	483	490	PF00069	0.448
MOD_GSK3_1	62	69	PF00069	0.525
MOD_GSK3_1	80	87	PF00069	0.667
MOD_GSK3_1	96	103	PF00069	0.637
MOD_N-GLC_1	100	105	PF02516	0.567
MOD_NEK2_1	279	284	PF00069	0.344
MOD_NEK2_1	304	309	PF00069	0.433
MOD_NEK2_1	373	378	PF00069	0.487
MOD_NEK2_1	407	412	PF00069	0.433
MOD_NEK2_1	461	466	PF00069	0.549
MOD_NEK2_1	477	482	PF00069	0.355
MOD_NEK2_1	488	493	PF00069	0.493
MOD_NEK2_1	515	520	PF00069	0.466
MOD_PIKK_1	14	20	PF00454	0.324
MOD_PIKK_1	530	536	PF00454	0.560
MOD_PKA_2	189	195	PF00069	0.446
MOD_PKA_2	305	311	PF00069	0.423
MOD_PKA_2	461	467	PF00069	0.503
MOD_PKA_2	529	535	PF00069	0.564
MOD_PKB_1	221	229	PF00069	0.318
MOD_Plk_1	203	209	PF00069	0.456
MOD_Plk_1	265	271	PF00069	0.371
MOD_Plk_1	288	294	PF00069	0.271
MOD_Plk_1	530	536	PF00069	0.530
MOD_Plk_4	190	196	PF00069	0.418
MOD_Plk_4	282	288	PF00069	0.325
MOD_Plk_4	297	303	PF00069	0.485
MOD_Plk_4	305	311	PF00069	0.440
MOD_Plk_4	360	366	PF00069	0.418
MOD_Plk_4	500	506	PF00069	0.464
MOD_ProDKin_1	443	449	PF00069	0.436
MOD_ProDKin_1	454	460	PF00069	0.421
MOD_ProDKin_1	466	472	PF00069	0.485
MOD_ProDKin_1	483	489	PF00069	0.441
MOD_ProDKin_1	497	503	PF00069	0.413
MOD_ProDKin_1	81	87	PF00069	0.680
MOD_ProDKin_1	88	94	PF00069	0.730
MOD_SUMO_rev_2	103	109	PF00179	0.454
MOD_SUMO_rev_2	273	282	PF00179	0.443
TRG_DiLeu_BaEn_1	161	166	PF01217	0.384
TRG_DiLeu_BaEn_1	167	172	PF01217	0.415
TRG_DiLeu_BaEn_2	408	414	PF01217	0.418
TRG_DiLeu_BaLyEn_6	444	449	PF01217	0.342
TRG_ENDOCYTIC_2	312	315	PF00928	0.512
TRG_ENDOCYTIC_2	355	358	PF00928	0.418
TRG_ENDOCYTIC_2	411	414	PF00928	0.512
TRG_ENDOCYTIC_2	504	507	PF00928	0.457
TRG_ER_diArg_1	219	221	PF00400	0.361
TRG_ER_diArg_1	237	239	PF00400	0.237
TRG_Pf-PMV_PEXEL_1	340	344	PF00026	0.312

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1D4	Leptomonas seymouri	71%	80%
A0A1X0P4F2	Trypanosomatidae	44%	92%
A0A3Q8IE91	Leishmania donovani	95%	81%
A0A422MX80	Trypanosoma rangeli	52%	88%
A4HFP5	Leishmania braziliensis	87%	100%
A4I2S1	Leishmania infantum	95%	81%
D0A5X8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	86%
E9AD99	Leishmania major	93%	100%
P12754	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	83%
P41111	Oryctolagus cuniculus	25%	100%
Q09924	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
Q3T058	Bos taurus	24%	100%
Q54FM3	Dictyostelium discoideum	24%	87%
Q61749	Mus musculus	26%	100%
Q63186	Rattus norvegicus	26%	100%
Q9UI10	Homo sapiens	25%	100%
V5BHQ4	Trypanosoma cruzi	52%	100%