RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RING-H2 zinc finger, putative

Species:

Leishmania mexicana

UniProt:

E9AZ23_LEIMU

TriTrypDb:

LmxM.27.1200

Length:

406

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZ23

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZ23

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	393	395	PF00675	0.812
CLV_PCSK_KEX2_1	19	21	PF00082	0.767
CLV_PCSK_KEX2_1	288	290	PF00082	0.586
CLV_PCSK_KEX2_1	393	395	PF00082	0.820
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.529
CLV_PCSK_PC1ET2_1	288	290	PF00082	0.582
CLV_PCSK_PC7_1	284	290	PF00082	0.590
CLV_PCSK_SKI1_1	125	129	PF00082	0.740
CLV_PCSK_SKI1_1	65	69	PF00082	0.707
CLV_PCSK_SKI1_1	75	79	PF00082	0.694
DEG_APCC_DBOX_1	247	255	PF00400	0.513
DEG_Nend_Nbox_1	1	3	PF02207	0.811
DEG_SCF_FBW7_1	104	109	PF00400	0.520
DEG_SPOP_SBC_1	139	143	PF00917	0.614
DEG_SPOP_SBC_1	181	185	PF00917	0.738
DEG_SPOP_SBC_1	330	334	PF00917	0.721
DOC_MAPK_gen_1	159	167	PF00069	0.686
DOC_PP2B_LxvP_1	380	383	PF13499	0.749
DOC_PP4_FxxP_1	237	240	PF00568	0.513
DOC_USP7_MATH_1	106	110	PF00917	0.613
DOC_USP7_MATH_1	139	143	PF00917	0.702
DOC_USP7_MATH_1	152	156	PF00917	0.552
DOC_USP7_MATH_1	161	165	PF00917	0.683
DOC_USP7_MATH_1	190	194	PF00917	0.717
DOC_USP7_MATH_1	318	322	PF00917	0.526
DOC_USP7_MATH_1	324	328	PF00917	0.560
DOC_USP7_MATH_1	330	334	PF00917	0.601
DOC_WW_Pin1_4	102	107	PF00397	0.782
DOC_WW_Pin1_4	130	135	PF00397	0.546
DOC_WW_Pin1_4	147	152	PF00397	0.694
DOC_WW_Pin1_4	182	187	PF00397	0.811
DOC_WW_Pin1_4	192	197	PF00397	0.697
DOC_WW_Pin1_4	25	30	PF00397	0.470
DOC_WW_Pin1_4	326	331	PF00397	0.668
DOC_WW_Pin1_4	334	339	PF00397	0.756
DOC_WW_Pin1_4	368	373	PF00397	0.725
DOC_WW_Pin1_4	66	71	PF00397	0.772
DOC_WW_Pin1_4	7	12	PF00397	0.803
DOC_WW_Pin1_4	88	93	PF00397	0.728
LIG_14-3-3_CanoR_1	159	167	PF00244	0.755
LIG_14-3-3_CanoR_1	20	29	PF00244	0.522
LIG_14-3-3_CanoR_1	248	252	PF00244	0.411
LIG_14-3-3_CanoR_1	357	366	PF00244	0.542
LIG_14-3-3_CanoR_1	368	372	PF00244	0.554
LIG_14-3-3_CanoR_1	396	405	PF00244	0.649
LIG_14-3-3_CanoR_1	63	70	PF00244	0.764
LIG_14-3-3_CanoR_1	97	106	PF00244	0.711
LIG_Actin_WH2_2	27	42	PF00022	0.560
LIG_FHA_1	166	172	PF00498	0.521
LIG_FHA_1	21	27	PF00498	0.713
LIG_FHA_1	314	320	PF00498	0.583
LIG_FHA_1	358	364	PF00498	0.583
LIG_FHA_2	141	147	PF00498	0.612
LIG_FHA_2	77	83	PF00498	0.692
LIG_LIR_Gen_1	321	330	PF02991	0.535
LIG_LIR_Nem_3	321	325	PF02991	0.619
LIG_PTB_Apo_2	223	230	PF02174	0.513
LIG_SH2_GRB2like	222	225	PF00017	0.436
LIG_SH2_STAP1	314	318	PF00017	0.577
LIG_SH2_STAT3	301	304	PF00017	0.561
LIG_SH2_STAT3	314	317	PF00017	0.375
LIG_SH2_STAT5	222	225	PF00017	0.436
LIG_SH2_STAT5	301	304	PF00017	0.537
LIG_SH3_3	183	189	PF00018	0.708
LIG_SH3_3	23	29	PF00018	0.610
LIG_SH3_3	381	387	PF00018	0.712
LIG_SH3_3	8	14	PF00018	0.721
LIG_TRAF2_1	176	179	PF00917	0.796
LIG_TRAF2_1	388	391	PF00917	0.754
LIG_TRAF2_1	79	82	PF00917	0.714
LIG_WRC_WIRS_1	319	324	PF05994	0.607
MOD_CAAXbox	403	406	PF01239	0.688
MOD_CDC14_SPxK_1	10	13	PF00782	0.528
MOD_CDC14_SPxK_1	69	72	PF00782	0.689
MOD_CDK_SPxK_1	66	72	PF00069	0.699
MOD_CDK_SPxK_1	7	13	PF00069	0.532
MOD_CDK_SPxxK_3	12	19	PF00069	0.709
MOD_CDK_SPxxK_3	147	154	PF00069	0.694
MOD_CDK_SPxxK_3	88	95	PF00069	0.746
MOD_CK1_1	108	114	PF00069	0.747
MOD_CK1_1	144	150	PF00069	0.659
MOD_CK1_1	15	21	PF00069	0.695
MOD_CK1_1	155	161	PF00069	0.714
MOD_CK1_1	163	169	PF00069	0.784
MOD_CK1_1	170	176	PF00069	0.621
MOD_CK1_1	184	190	PF00069	0.605
MOD_CK1_1	195	201	PF00069	0.592
MOD_CK1_1	329	335	PF00069	0.721
MOD_CK1_1	378	384	PF00069	0.724
MOD_CK1_1	392	398	PF00069	0.553
MOD_CK1_1	55	61	PF00069	0.712
MOD_CK1_1	66	72	PF00069	0.745
MOD_CK1_1	7	13	PF00069	0.793
MOD_CK1_1	76	82	PF00069	0.651
MOD_CK2_1	197	203	PF00069	0.776
MOD_CK2_1	385	391	PF00069	0.739
MOD_CK2_1	76	82	PF00069	0.719
MOD_GlcNHglycan	108	111	PF01048	0.672
MOD_GlcNHglycan	326	329	PF01048	0.661
MOD_GlcNHglycan	43	46	PF01048	0.754
MOD_GlcNHglycan	59	62	PF01048	0.635
MOD_GlcNHglycan	65	68	PF01048	0.735
MOD_GlcNHglycan	7	10	PF01048	0.700
MOD_GSK3_1	1	8	PF00069	0.712
MOD_GSK3_1	102	109	PF00069	0.790
MOD_GSK3_1	117	124	PF00069	0.653
MOD_GSK3_1	140	147	PF00069	0.751
MOD_GSK3_1	15	22	PF00069	0.660
MOD_GSK3_1	161	168	PF00069	0.707
MOD_GSK3_1	170	177	PF00069	0.656
MOD_GSK3_1	180	187	PF00069	0.585
MOD_GSK3_1	190	197	PF00069	0.712
MOD_GSK3_1	198	205	PF00069	0.696
MOD_GSK3_1	324	331	PF00069	0.730
MOD_GSK3_1	385	392	PF00069	0.760
MOD_GSK3_1	48	55	PF00069	0.689
MOD_GSK3_1	93	100	PF00069	0.751
MOD_LATS_1	355	361	PF00433	0.525
MOD_N-GLC_1	5	10	PF02516	0.524
MOD_N-GLC_1	63	68	PF02516	0.654
MOD_N-GLC_2	356	358	PF02516	0.740
MOD_NEK2_1	1	6	PF00069	0.605
MOD_NEK2_1	167	172	PF00069	0.731
MOD_NEK2_1	266	271	PF00069	0.703
MOD_NEK2_1	389	394	PF00069	0.658
MOD_NEK2_1	39	44	PF00069	0.648
MOD_NEK2_1	48	53	PF00069	0.698
MOD_NEK2_1	56	61	PF00069	0.799
MOD_NEK2_1	73	78	PF00069	0.531
MOD_NEK2_2	256	261	PF00069	0.557
MOD_PIKK_1	112	118	PF00454	0.748
MOD_PIKK_1	313	319	PF00454	0.579
MOD_PIKK_1	357	363	PF00454	0.602
MOD_PIKK_1	375	381	PF00454	0.756
MOD_PIKK_1	396	402	PF00454	0.630
MOD_PIKK_1	48	54	PF00454	0.697
MOD_PK_1	202	208	PF00069	0.663
MOD_PKA_1	19	25	PF00069	0.510
MOD_PKA_2	112	118	PF00069	0.607
MOD_PKA_2	161	167	PF00069	0.782
MOD_PKA_2	174	180	PF00069	0.582
MOD_PKA_2	19	25	PF00069	0.537
MOD_PKA_2	247	253	PF00069	0.513
MOD_PKA_2	367	373	PF00069	0.578
MOD_PKA_2	39	45	PF00069	0.537
MOD_PKA_2	392	398	PF00069	0.719
MOD_PKB_1	394	402	PF00069	0.635
MOD_PKB_1	95	103	PF00069	0.820
MOD_Plk_1	202	208	PF00069	0.759
MOD_Plk_1	48	54	PF00069	0.503
MOD_Plk_1	63	69	PF00069	0.528
MOD_Plk_4	167	173	PF00069	0.713
MOD_Plk_4	73	79	PF00069	0.699
MOD_ProDKin_1	102	108	PF00069	0.763
MOD_ProDKin_1	130	136	PF00069	0.544
MOD_ProDKin_1	147	153	PF00069	0.695
MOD_ProDKin_1	182	188	PF00069	0.812
MOD_ProDKin_1	192	198	PF00069	0.694
MOD_ProDKin_1	25	31	PF00069	0.468
MOD_ProDKin_1	326	332	PF00069	0.672
MOD_ProDKin_1	334	340	PF00069	0.757
MOD_ProDKin_1	368	374	PF00069	0.724
MOD_ProDKin_1	66	72	PF00069	0.773
MOD_ProDKin_1	7	13	PF00069	0.805
MOD_ProDKin_1	88	94	PF00069	0.729
TRG_ER_diArg_1	307	310	PF00400	0.519
TRG_ER_diArg_1	393	396	PF00400	0.820
TRG_Pf-PMV_PEXEL_1	261	265	PF00026	0.663

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZY3	Leptomonas seymouri	32%	87%
A0A3S7X0M5	Leishmania donovani	80%	98%
A4HFP6	Leishmania braziliensis	49%	100%
E9AD98	Leishmania major	79%	100%
E9AHF8	Leishmania infantum	81%	98%