Protein phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Protein phosphatase

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZ21_LEIMU

TriTrypDb:

LmxM.27.1180

Length:

422

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZ21

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZ21

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0004721	phosphoprotein phosphatase activity	3	8
GO:0004722	protein serine/threonine phosphatase activity	4	8
GO:0005488	binding	1	8
GO:0016787	hydrolase activity	2	8
GO:0016788	hydrolase activity, acting on ester bonds	3	8
GO:0016791	phosphatase activity	5	8
GO:0017018	myosin phosphatase activity	5	8
GO:0042578	phosphoric ester hydrolase activity	4	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0140096	catalytic activity, acting on a protein	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	182	186	PF00656	0.764
CLV_NRD_NRD_1	3	5	PF00675	0.623
CLV_PCSK_KEX2_1	3	5	PF00082	0.623
CLV_PCSK_SKI1_1	335	339	PF00082	0.489
DEG_APCC_DBOX_1	334	342	PF00400	0.592
DEG_Nend_Nbox_1	1	3	PF02207	0.688
DEG_SPOP_SBC_1	193	197	PF00917	0.399
DOC_CYCLIN_yClb5_NLxxxL_5	330	338	PF00134	0.558
DOC_CYCLIN_yCln2_LP_2	246	252	PF00134	0.533
DOC_MAPK_MEF2A_6	261	270	PF00069	0.583
DOC_MAPK_MEF2A_6	384	392	PF00069	0.481
DOC_PP2B_LxvP_1	266	269	PF13499	0.564
DOC_PP4_FxxP_1	414	417	PF00568	0.712
DOC_USP7_MATH_1	151	155	PF00917	0.752
DOC_USP7_MATH_1	179	183	PF00917	0.823
DOC_USP7_MATH_1	322	326	PF00917	0.658
DOC_USP7_MATH_1	368	372	PF00917	0.482
DOC_USP7_MATH_1	85	89	PF00917	0.491
DOC_USP7_MATH_2	403	409	PF00917	0.653
DOC_WW_Pin1_4	256	261	PF00397	0.483
DOC_WW_Pin1_4	364	369	PF00397	0.447
LIG_14-3-3_CanoR_1	205	215	PF00244	0.534
LIG_14-3-3_CanoR_1	302	310	PF00244	0.521
LIG_APCC_ABBA_1	296	301	PF00400	0.550
LIG_Clathr_ClatBox_1	267	271	PF01394	0.493
LIG_deltaCOP1_diTrp_1	294	304	PF00928	0.476
LIG_EH1_1	289	297	PF00400	0.429
LIG_eIF4E_1	75	81	PF01652	0.518
LIG_FHA_1	107	113	PF00498	0.454
LIG_FHA_1	138	144	PF00498	0.508
LIG_FHA_1	161	167	PF00498	0.704
LIG_FHA_1	194	200	PF00498	0.563
LIG_FHA_1	224	230	PF00498	0.390
LIG_FHA_1	278	284	PF00498	0.529
LIG_FHA_1	387	393	PF00498	0.466
LIG_FHA_2	112	118	PF00498	0.483
LIG_FHA_2	176	182	PF00498	0.646
LIG_FHA_2	189	195	PF00498	0.589
LIG_FHA_2	257	263	PF00498	0.514
LIG_FHA_2	334	340	PF00498	0.580
LIG_Integrin_isoDGR_2	232	234	PF01839	0.530
LIG_LIR_Apic_2	411	417	PF02991	0.628
LIG_LIR_Gen_1	126	136	PF02991	0.524
LIG_LIR_Gen_1	281	292	PF02991	0.414
LIG_LIR_Gen_1	34	45	PF02991	0.473
LIG_LIR_Nem_3	126	131	PF02991	0.528
LIG_LIR_Nem_3	281	287	PF02991	0.401
LIG_LIR_Nem_3	294	300	PF02991	0.423
LIG_LIR_Nem_3	34	40	PF02991	0.551
LIG_LIR_Nem_3	87	92	PF02991	0.454
LIG_NRBOX	333	339	PF00104	0.541
LIG_PCNA_yPIPBox_3	330	338	PF02747	0.558
LIG_REV1ctd_RIR_1	13	22	PF16727	0.452
LIG_SH2_SRC	73	76	PF00017	0.467
LIG_SH2_STAP1	128	132	PF00017	0.487
LIG_SH2_STAP1	64	68	PF00017	0.420
LIG_SH2_STAT3	248	251	PF00017	0.527
LIG_SH2_STAT5	215	218	PF00017	0.490
LIG_SH2_STAT5	221	224	PF00017	0.419
LIG_SH2_STAT5	237	240	PF00017	0.571
LIG_SH2_STAT5	309	312	PF00017	0.593
LIG_SH2_STAT5	75	78	PF00017	0.504
LIG_SH3_3	133	139	PF00018	0.664
LIG_SUMO_SIM_anti_2	129	134	PF11976	0.497
LIG_SUMO_SIM_anti_2	274	281	PF11976	0.403
LIG_SUMO_SIM_par_1	386	393	PF11976	0.546
LIG_TRAF2_1	114	117	PF00917	0.495
LIG_TRAF2_1	118	121	PF00917	0.617
MOD_CDK_SPK_2	256	261	PF00069	0.513
MOD_CK1_1	137	143	PF00069	0.502
MOD_CK1_1	154	160	PF00069	0.583
MOD_CK1_1	175	181	PF00069	0.776
MOD_CK1_1	256	262	PF00069	0.486
MOD_CK2_1	111	117	PF00069	0.420
MOD_CK2_1	171	177	PF00069	0.802
MOD_CK2_1	188	194	PF00069	0.404
MOD_CK2_1	405	411	PF00069	0.655
MOD_Cter_Amidation	9	12	PF01082	0.558
MOD_GlcNHglycan	153	156	PF01048	0.702
MOD_GlcNHglycan	174	177	PF01048	0.812
MOD_GlcNHglycan	181	184	PF01048	0.609
MOD_GlcNHglycan	346	350	PF01048	0.509
MOD_GlcNHglycan	407	410	PF01048	0.623
MOD_GlcNHglycan	64	67	PF01048	0.402
MOD_GSK3_1	137	144	PF00069	0.549
MOD_GSK3_1	150	157	PF00069	0.753
MOD_GSK3_1	171	178	PF00069	0.721
MOD_GSK3_1	179	186	PF00069	0.669
MOD_GSK3_1	188	195	PF00069	0.492
MOD_GSK3_1	364	371	PF00069	0.442
MOD_GSK3_1	386	393	PF00069	0.465
MOD_GSK3_1	401	408	PF00069	0.499
MOD_GSK3_1	95	102	PF00069	0.576
MOD_N-GLC_1	256	261	PF02516	0.526
MOD_NEK2_1	111	116	PF00069	0.422
MOD_NEK2_1	150	155	PF00069	0.786
MOD_NEK2_1	345	350	PF00069	0.374
MOD_NEK2_1	38	43	PF00069	0.487
MOD_NEK2_1	390	395	PF00069	0.482
MOD_NEK2_2	85	90	PF00069	0.497
MOD_NEK2_2	95	100	PF00069	0.493
MOD_PIKK_1	302	308	PF00454	0.389
MOD_PKA_1	11	17	PF00069	0.441
MOD_Plk_1	169	175	PF00069	0.794
MOD_Plk_1	223	229	PF00069	0.389
MOD_Plk_1	386	392	PF00069	0.419
MOD_Plk_2-3	181	187	PF00069	0.733
MOD_Plk_4	223	229	PF00069	0.442
MOD_Plk_4	386	392	PF00069	0.419
MOD_Plk_4	48	54	PF00069	0.468
MOD_ProDKin_1	256	262	PF00069	0.486
MOD_ProDKin_1	364	370	PF00069	0.442
TRG_DiLeu_BaLyEn_6	262	267	PF01217	0.516
TRG_DiLeu_BaLyEn_6	87	92	PF01217	0.481
TRG_ENDOCYTIC_2	128	131	PF00928	0.503
TRG_ENDOCYTIC_2	73	76	PF00928	0.409
TRG_ER_diArg_1	2	4	PF00400	0.595
TRG_Pf-PMV_PEXEL_1	335	339	PF00026	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC93	Leptomonas seymouri	61%	100%
A0A0S4JF75	Bodo saltans	29%	80%
A0A3S7X0P0	Leishmania donovani	94%	100%
A4HFP3	Leishmania braziliensis	79%	100%
A4I2R9	Leishmania infantum	94%	100%
E9AD96	Leishmania major	92%	100%