S1-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZ20_LEIMU

TriTrypDb:

LmxM.27.1170

Length:

246

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZ20

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZ20

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	200	204	PF00656	0.716
CLV_C14_Caspase3-7	64	68	PF00656	0.627
CLV_C14_Caspase3-7	70	74	PF00656	0.685
CLV_NRD_NRD_1	105	107	PF00675	0.449
CLV_NRD_NRD_1	5	7	PF00675	0.557
CLV_PCSK_SKI1_1	11	15	PF00082	0.476
CLV_PCSK_SKI1_1	163	167	PF00082	0.561
CLV_PCSK_SKI1_1	220	224	PF00082	0.659
CLV_PCSK_SKI1_1	45	49	PF00082	0.418
DEG_APCC_DBOX_1	162	170	PF00400	0.697
DEG_SPOP_SBC_1	176	180	PF00917	0.637
DOC_MAPK_gen_1	106	116	PF00069	0.418
DOC_MAPK_MEF2A_6	107	116	PF00069	0.425
DOC_MAPK_MEF2A_6	27	36	PF00069	0.545
DOC_PP1_RVXF_1	108	114	PF00149	0.429
DOC_PP2B_LxvP_1	48	51	PF13499	0.519
DOC_USP7_MATH_1	56	60	PF00917	0.644
DOC_USP7_MATH_1	66	70	PF00917	0.608
DOC_USP7_MATH_1	78	82	PF00917	0.717
DOC_USP7_MATH_1	83	87	PF00917	0.686
DOC_USP7_UBL2_3	7	11	PF12436	0.537
DOC_WW_Pin1_4	129	134	PF00397	0.436
DOC_WW_Pin1_4	35	40	PF00397	0.436
DOC_WW_Pin1_4	85	90	PF00397	0.640
LIG_BIR_II_1	1	5	PF00653	0.596
LIG_BIR_III_4	19	23	PF00653	0.512
LIG_FHA_1	177	183	PF00498	0.608
LIG_LIR_Apic_2	21	26	PF02991	0.465
LIG_NRBOX	43	49	PF00104	0.374
LIG_Pex14_2	228	232	PF04695	0.439
LIG_SH2_SRC	17	20	PF00017	0.559
LIG_SH2_STAT5	17	20	PF00017	0.555
LIG_SH3_3	99	105	PF00018	0.436
LIG_SUMO_SIM_anti_2	118	124	PF11976	0.391
LIG_SUMO_SIM_par_1	118	124	PF11976	0.391
LIG_TRAF2_1	236	239	PF00917	0.620
LIG_WRC_WIRS_1	136	141	PF05994	0.517
MOD_CK1_1	181	187	PF00069	0.684
MOD_CK1_1	197	203	PF00069	0.544
MOD_CK1_1	54	60	PF00069	0.602
MOD_CK1_1	69	75	PF00069	0.701
MOD_CK1_1	88	94	PF00069	0.745
MOD_CK2_1	204	210	PF00069	0.707
MOD_CK2_1	233	239	PF00069	0.619
MOD_Cter_Amidation	4	7	PF01082	0.564
MOD_GlcNHglycan	1	4	PF01048	0.593
MOD_GlcNHglycan	19	23	PF01048	0.442
MOD_GlcNHglycan	196	199	PF01048	0.696
MOD_GlcNHglycan	53	56	PF01048	0.612
MOD_GlcNHglycan	63	66	PF01048	0.677
MOD_GlcNHglycan	85	88	PF01048	0.723
MOD_GlcNHglycan	90	93	PF01048	0.498
MOD_GSK3_1	125	132	PF00069	0.532
MOD_GSK3_1	172	179	PF00069	0.598
MOD_GSK3_1	187	194	PF00069	0.604
MOD_GSK3_1	54	61	PF00069	0.602
MOD_GSK3_1	68	75	PF00069	0.488
MOD_N-GLC_2	58	60	PF02516	0.471
MOD_NEK2_1	18	23	PF00069	0.507
MOD_NEK2_2	125	130	PF00069	0.447
MOD_PIKK_1	11	17	PF00454	0.615
MOD_PKA_2	150	156	PF00069	0.398
MOD_PKA_2	192	198	PF00069	0.749
MOD_Plk_4	135	141	PF00069	0.432
MOD_Plk_4	178	184	PF00069	0.638
MOD_ProDKin_1	129	135	PF00069	0.432
MOD_ProDKin_1	35	41	PF00069	0.438
MOD_ProDKin_1	85	91	PF00069	0.639

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6I4	Leptomonas seymouri	56%	98%
A0A1X0P448	Trypanosomatidae	41%	84%
A0A3Q8IEC6	Leishmania donovani	85%	100%
A0A3R7MDN0	Trypanosoma rangeli	45%	100%
A4HFP2	Leishmania braziliensis	79%	100%
A4I2R8	Leishmania infantum	85%	100%
D0A5X3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AD95	Leishmania major	89%	100%
V5B8N2	Trypanosoma cruzi	48%	100%