JmjC domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

JmjC domain, hydroxylase, putative

Species:

Leishmania mexicana

UniProt:

E9AZ18_LEIMU

TriTrypDb:

LmxM.27.1150

Length:

481

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AZ18

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZ18

Function

Biological processes
Term	Name	Level	Count
GO:0006417	regulation of translation	6	1
GO:0006449	regulation of translational termination	6	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009891	positive regulation of biosynthetic process	5	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010557	positive regulation of macromolecule biosynthetic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0010628	positive regulation of gene expression	6	1
GO:0010629	negative regulation of gene expression	6	1
GO:0018126	protein hydroxylation	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0019538	protein metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031328	positive regulation of cellular biosynthetic process	6	1
GO:0034248	regulation of amide metabolic process	5	1
GO:0034250	positive regulation of amide metabolic process	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043243	positive regulation of protein-containing complex disassembly	6	1
GO:0043244	regulation of protein-containing complex disassembly	5	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0045727	positive regulation of translation	7	1
GO:0045905	positive regulation of translational termination	7	1
GO:0048518	positive regulation of biological process	3	1
GO:0048519	negative regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051128	regulation of cellular component organization	4	1
GO:0051130	positive regulation of cellular component organization	5	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0051247	positive regulation of protein metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003824	catalytic activity	1	1
GO:0005488	binding	1	1
GO:0016491	oxidoreductase activity	2	1
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	1
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	4	1
GO:0043565	sequence-specific DNA binding	5	1
GO:0051213	dioxygenase activity	3	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	174	178	PF00656	0.524
CLV_C14_Caspase3-7	189	193	PF00656	0.357
CLV_C14_Caspase3-7	403	407	PF00656	0.310
CLV_C14_Caspase3-7	442	446	PF00656	0.508
CLV_NRD_NRD_1	411	413	PF00675	0.372
CLV_NRD_NRD_1	47	49	PF00675	0.399
CLV_NRD_NRD_1	89	91	PF00675	0.601
CLV_PCSK_KEX2_1	411	413	PF00082	0.372
CLV_PCSK_KEX2_1	46	48	PF00082	0.462
CLV_PCSK_KEX2_1	479	481	PF00082	0.577
CLV_PCSK_KEX2_1	89	91	PF00082	0.601
CLV_PCSK_PC1ET2_1	46	48	PF00082	0.456
CLV_PCSK_PC1ET2_1	479	481	PF00082	0.577
CLV_PCSK_SKI1_1	377	381	PF00082	0.330
DEG_Nend_Nbox_1	1	3	PF02207	0.427
DEG_SPOP_SBC_1	117	121	PF00917	0.400
DEG_SPOP_SBC_1	153	157	PF00917	0.489
DEG_SPOP_SBC_1	68	72	PF00917	0.355
DOC_CDC14_PxL_1	307	315	PF14671	0.413
DOC_CKS1_1	283	288	PF01111	0.503
DOC_CYCLIN_RxL_1	102	110	PF00134	0.493
DOC_PP2B_PxIxI_1	286	292	PF00149	0.436
DOC_PP4_FxxP_1	283	286	PF00568	0.512
DOC_USP7_MATH_1	143	147	PF00917	0.403
DOC_USP7_MATH_1	153	157	PF00917	0.537
DOC_USP7_MATH_1	158	162	PF00917	0.465
DOC_USP7_MATH_1	237	241	PF00917	0.467
DOC_USP7_MATH_1	347	351	PF00917	0.662
DOC_USP7_MATH_1	68	72	PF00917	0.548
DOC_WW_Pin1_4	123	128	PF00397	0.620
DOC_WW_Pin1_4	206	211	PF00397	0.611
DOC_WW_Pin1_4	239	244	PF00397	0.415
DOC_WW_Pin1_4	282	287	PF00397	0.503
LIG_14-3-3_CanoR_1	387	395	PF00244	0.382
LIG_BIR_III_4	33	37	PF00653	0.344
LIG_BRCT_BRCA1_1	252	256	PF00533	0.512
LIG_CSL_BTD_1	127	130	PF09270	0.329
LIG_DCNL_PONY_1	1	4	PF03556	0.419
LIG_deltaCOP1_diTrp_1	189	194	PF00928	0.308
LIG_deltaCOP1_diTrp_1	261	266	PF00928	0.421
LIG_eIF4E_1	274	280	PF01652	0.517
LIG_FHA_1	320	326	PF00498	0.576
LIG_FHA_1	358	364	PF00498	0.327
LIG_FHA_1	428	434	PF00498	0.490
LIG_FHA_1	70	76	PF00498	0.622
LIG_FHA_1	8	14	PF00498	0.463
LIG_FHA_2	172	178	PF00498	0.356
LIG_FHA_2	283	289	PF00498	0.455
LIG_FHA_2	75	81	PF00498	0.544
LIG_FHA_2	94	100	PF00498	0.639
LIG_LIR_Apic_2	177	183	PF02991	0.365
LIG_LIR_Apic_2	261	267	PF02991	0.421
LIG_LIR_Gen_1	229	238	PF02991	0.247
LIG_LIR_Gen_1	425	433	PF02991	0.445
LIG_LIR_Gen_1	470	476	PF02991	0.492
LIG_LIR_Gen_1	76	85	PF02991	0.431
LIG_LIR_Gen_1	8	19	PF02991	0.291
LIG_LIR_Nem_3	240	244	PF02991	0.432
LIG_LIR_Nem_3	247	252	PF02991	0.476
LIG_LIR_Nem_3	324	329	PF02991	0.432
LIG_LIR_Nem_3	407	413	PF02991	0.452
LIG_LIR_Nem_3	470	475	PF02991	0.490
LIG_LIR_Nem_3	8	14	PF02991	0.318
LIG_Pex14_1	190	194	PF04695	0.307
LIG_Pex14_1	369	373	PF04695	0.429
LIG_SH2_CRK	180	184	PF00017	0.354
LIG_SH2_CRK	234	238	PF00017	0.470
LIG_SH2_CRK	315	319	PF00017	0.477
LIG_SH2_STAP1	252	256	PF00017	0.421
LIG_SH2_STAP1	472	476	PF00017	0.491
LIG_SH2_STAT5	134	137	PF00017	0.291
LIG_SH2_STAT5	274	277	PF00017	0.464
LIG_SH3_3	124	130	PF00018	0.417
LIG_SH3_3	18	24	PF00018	0.317
LIG_SH3_3	298	304	PF00018	0.413
LIG_SH3_3	305	311	PF00018	0.412
LIG_SH3_3	62	68	PF00018	0.454
LIG_SUMO_SIM_anti_2	396	404	PF11976	0.409
LIG_SUMO_SIM_par_1	358	364	PF11976	0.278
LIG_TRAF2_1	85	88	PF00917	0.519
LIG_TYR_ITIM	313	318	PF00017	0.251
LIG_WRC_WIRS_1	191	196	PF05994	0.380
MOD_CK1_1	115	121	PF00069	0.460
MOD_CK1_1	157	163	PF00069	0.533
MOD_CK1_1	391	397	PF00069	0.464
MOD_CK1_1	425	431	PF00069	0.395
MOD_GlcNHglycan	120	123	PF01048	0.548
MOD_GlcNHglycan	156	159	PF01048	0.564
MOD_GlcNHglycan	171	174	PF01048	0.455
MOD_GlcNHglycan	216	220	PF01048	0.510
MOD_GlcNHglycan	33	37	PF01048	0.438
MOD_GlcNHglycan	349	352	PF01048	0.653
MOD_GlcNHglycan	357	360	PF01048	0.541
MOD_GlcNHglycan	406	409	PF01048	0.525
MOD_GlcNHglycan	441	444	PF01048	0.453
MOD_GlcNHglycan	451	457	PF01048	0.469
MOD_GlcNHglycan	82	85	PF01048	0.532
MOD_GSK3_1	112	119	PF00069	0.462
MOD_GSK3_1	143	150	PF00069	0.364
MOD_GSK3_1	153	160	PF00069	0.414
MOD_GSK3_1	248	255	PF00069	0.281
MOD_GSK3_1	355	362	PF00069	0.488
MOD_GSK3_1	387	394	PF00069	0.412
MOD_GSK3_1	69	76	PF00069	0.518
MOD_N-GLC_1	319	324	PF02516	0.353
MOD_N-GLC_1	419	424	PF02516	0.477
MOD_N-GLC_2	257	259	PF02516	0.281
MOD_N-GLC_2	29	31	PF02516	0.447
MOD_N-GLC_2	368	370	PF02516	0.282
MOD_NEK2_1	144	149	PF00069	0.436
MOD_NEK2_1	357	362	PF00069	0.496
MOD_NEK2_1	4	9	PF00069	0.471
MOD_NEK2_2	427	432	PF00069	0.309
MOD_PIKK_1	57	63	PF00454	0.427
MOD_PKA_2	169	175	PF00069	0.488
MOD_PKA_2	404	410	PF00069	0.457
MOD_Plk_1	422	428	PF00069	0.378
MOD_ProDKin_1	123	129	PF00069	0.611
MOD_ProDKin_1	206	212	PF00069	0.611
MOD_ProDKin_1	239	245	PF00069	0.253
MOD_ProDKin_1	282	288	PF00069	0.377
MOD_SUMO_rev_2	471	481	PF00179	0.350
TRG_DiLeu_BaEn_1	396	401	PF01217	0.511
TRG_DiLeu_BaEn_1	471	476	PF01217	0.374
TRG_ENDOCYTIC_2	11	14	PF00928	0.410
TRG_ENDOCYTIC_2	315	318	PF00928	0.341
TRG_ENDOCYTIC_2	472	475	PF00928	0.489
TRG_ER_diArg_1	410	412	PF00400	0.363
TRG_ER_diArg_1	47	49	PF00400	0.457
TRG_NES_CRM1_1	288	298	PF08389	0.390
TRG_Pf-PMV_PEXEL_1	184	189	PF00026	0.369
TRG_Pf-PMV_PEXEL_1	56	61	PF00026	0.351

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I519	Leptomonas seymouri	50%	92%
A0A0S4JI40	Bodo saltans	30%	98%
A0A1X0P4A9	Trypanosomatidae	38%	100%
A0A3R7LP24	Trypanosoma rangeli	40%	100%
A0A3S7X0M0	Leishmania donovani	88%	99%
A4HFP0	Leishmania braziliensis	76%	100%
A4I2R6	Leishmania infantum	88%	99%
D0A5X2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AD93	Leishmania major	90%	100%
Q08BY5	Danio rerio	27%	100%
V5BD54	Trypanosoma cruzi	40%	100%