WW domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZ17_LEIMU

TriTrypDb:

LmxM.27.1140

Length:

583

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZ17

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZ17

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	469	473	PF00656	0.635
CLV_NRD_NRD_1	106	108	PF00675	0.702
CLV_PCSK_KEX2_1	105	107	PF00082	0.701
CLV_PCSK_SKI1_1	425	429	PF00082	0.570
CLV_PCSK_SKI1_1	578	582	PF00082	0.500
DEG_COP1_1	430	438	PF00400	0.616
DEG_SCF_FBW7_1	275	281	PF00400	0.755
DEG_SIAH_1	527	535	PF03145	0.664
DEG_SPOP_SBC_1	279	283	PF00917	0.706
DEG_SPOP_SBC_1	514	518	PF00917	0.566
DOC_CKS1_1	275	280	PF01111	0.776
DOC_MAPK_JIP1_4	565	571	PF00069	0.544
DOC_PP1_RVXF_1	2	9	PF00149	0.675
DOC_PP2B_LxvP_1	569	572	PF13499	0.789
DOC_PP4_FxxP_1	224	227	PF00568	0.539
DOC_USP7_MATH_1	257	261	PF00917	0.706
DOC_USP7_MATH_1	279	283	PF00917	0.640
DOC_USP7_MATH_1	299	303	PF00917	0.531
DOC_USP7_MATH_1	334	338	PF00917	0.610
DOC_USP7_MATH_1	346	350	PF00917	0.628
DOC_USP7_MATH_1	378	382	PF00917	0.753
DOC_USP7_MATH_1	415	419	PF00917	0.716
DOC_USP7_MATH_1	441	445	PF00917	0.608
DOC_USP7_MATH_1	450	454	PF00917	0.544
DOC_USP7_MATH_1	476	480	PF00917	0.851
DOC_USP7_MATH_1	486	490	PF00917	0.654
DOC_USP7_MATH_1	564	568	PF00917	0.590
DOC_USP7_MATH_1	58	62	PF00917	0.777
DOC_WW_Pin1_4	227	232	PF00397	0.678
DOC_WW_Pin1_4	258	263	PF00397	0.691
DOC_WW_Pin1_4	274	279	PF00397	0.715
DOC_WW_Pin1_4	336	341	PF00397	0.813
DOC_WW_Pin1_4	366	371	PF00397	0.727
DOC_WW_Pin1_4	389	394	PF00397	0.679
DOC_WW_Pin1_4	398	403	PF00397	0.689
LIG_14-3-3_CanoR_1	156	160	PF00244	0.654
LIG_14-3-3_CanoR_1	44	50	PF00244	0.742
LIG_14-3-3_CanoR_1	90	99	PF00244	0.637
LIG_AP2alpha_2	111	113	PF02296	0.777
LIG_BIR_II_1	1	5	PF00653	0.693
LIG_BIR_III_2	457	461	PF00653	0.747
LIG_BRCT_BRCA1_1	338	342	PF00533	0.536
LIG_BRCT_BRCA1_1	436	440	PF00533	0.741
LIG_EVH1_1	274	278	PF00568	0.806
LIG_EVH1_1	571	575	PF00568	0.787
LIG_EVH1_2	573	577	PF00568	0.788
LIG_FHA_1	275	281	PF00498	0.735
LIG_FHA_1	323	329	PF00498	0.727
LIG_FHA_1	342	348	PF00498	0.533
LIG_FHA_1	46	52	PF00498	0.799
LIG_FHA_1	472	478	PF00498	0.836
LIG_FHA_2	557	563	PF00498	0.554
LIG_IBAR_NPY_1	507	509	PF08397	0.757
LIG_LIR_Apic_2	222	227	PF02991	0.674
LIG_LIR_Apic_2	292	297	PF02991	0.554
LIG_LIR_Apic_2	408	414	PF02991	0.837
LIG_LIR_Apic_2	506	512	PF02991	0.837
LIG_LIR_Gen_1	170	178	PF02991	0.699
LIG_LIR_Nem_3	144	150	PF02991	0.690
LIG_LIR_Nem_3	170	175	PF02991	0.697
LIG_LIR_Nem_3	576	580	PF02991	0.796
LIG_LIR_Nem_3	73	77	PF02991	0.676
LIG_Pex14_2	577	581	PF04695	0.506
LIG_PTAP_UEV_1	547	552	PF05743	0.659
LIG_SH2_CRK	294	298	PF00017	0.769
LIG_SH2_CRK	390	394	PF00017	0.825
LIG_SH2_CRK	411	415	PF00017	0.841
LIG_SH2_CRK	509	513	PF00017	0.835
LIG_SH2_CRK	544	548	PF00017	0.555
LIG_SH2_GRB2like	99	102	PF00017	0.665
LIG_SH2_NCK_1	218	222	PF00017	0.817
LIG_SH2_NCK_1	390	394	PF00017	0.825
LIG_SH2_NCK_1	411	415	PF00017	0.549
LIG_SH2_SRC	218	221	PF00017	0.738
LIG_SH2_SRC	314	317	PF00017	0.827
LIG_SH2_SRC	509	512	PF00017	0.838
LIG_SH2_STAP1	150	154	PF00017	0.670
LIG_SH2_STAT3	150	153	PF00017	0.670
LIG_SH2_STAT5	223	226	PF00017	0.825
LIG_SH2_STAT5	314	317	PF00017	0.827
LIG_SH2_STAT5	411	414	PF00017	0.577
LIG_SH3_1	187	193	PF00018	0.744
LIG_SH3_1	273	279	PF00018	0.697
LIG_SH3_3	185	191	PF00018	0.815
LIG_SH3_3	228	234	PF00018	0.758
LIG_SH3_3	256	262	PF00018	0.758
LIG_SH3_3	272	278	PF00018	0.649
LIG_SH3_3	303	309	PF00018	0.762
LIG_SH3_3	313	319	PF00018	0.675
LIG_SH3_3	321	327	PF00018	0.525
LIG_SH3_3	364	370	PF00018	0.650
LIG_SH3_3	377	383	PF00018	0.692
LIG_SH3_3	399	405	PF00018	0.759
LIG_SH3_3	442	448	PF00018	0.522
LIG_SH3_3	498	504	PF00018	0.738
LIG_SH3_3	525	531	PF00018	0.831
LIG_SH3_3	545	551	PF00018	0.509
LIG_SH3_3	569	575	PF00018	0.801
LIG_SH3_3	576	582	PF00018	0.679
LIG_TRFH_1	411	415	PF08558	0.549
LIG_WRC_WIRS_1	553	558	PF05994	0.846
LIG_WRPW_2	577	580	PF00400	0.796
MOD_CK1_1	260	266	PF00069	0.744
MOD_CK1_1	281	287	PF00069	0.834
MOD_CK1_1	322	328	PF00069	0.757
MOD_CK1_1	45	51	PF00069	0.745
MOD_CK1_1	478	484	PF00069	0.677
MOD_CK1_1	549	555	PF00069	0.830
MOD_CK2_1	556	562	PF00069	0.555
MOD_GlcNHglycan	21	24	PF01048	0.652
MOD_GlcNHglycan	285	288	PF01048	0.840
MOD_GlcNHglycan	31	34	PF01048	0.543
MOD_GlcNHglycan	321	324	PF01048	0.568
MOD_GlcNHglycan	336	339	PF01048	0.670
MOD_GlcNHglycan	376	379	PF01048	0.551
MOD_GlcNHglycan	424	428	PF01048	0.843
MOD_GlcNHglycan	430	433	PF01048	0.767
MOD_GlcNHglycan	452	455	PF01048	0.690
MOD_GlcNHglycan	548	551	PF01048	0.791
MOD_GlcNHglycan	566	569	PF01048	0.581
MOD_GlcNHglycan	62	65	PF01048	0.781
MOD_GlcNHglycan	68	71	PF01048	0.704
MOD_GlcNHglycan	74	77	PF01048	0.600
MOD_GSK3_1	257	264	PF00069	0.811
MOD_GSK3_1	274	281	PF00069	0.595
MOD_GSK3_1	285	292	PF00069	0.618
MOD_GSK3_1	334	341	PF00069	0.660
MOD_GSK3_1	346	353	PF00069	0.636
MOD_GSK3_1	362	369	PF00069	0.635
MOD_GSK3_1	374	381	PF00069	0.736
MOD_GSK3_1	38	45	PF00069	0.815
MOD_GSK3_1	405	412	PF00069	0.546
MOD_GSK3_1	423	430	PF00069	0.605
MOD_GSK3_1	462	469	PF00069	0.738
MOD_GSK3_1	471	478	PF00069	0.697
MOD_GSK3_1	513	520	PF00069	0.727
MOD_GSK3_1	552	559	PF00069	0.811
MOD_GSK3_1	66	73	PF00069	0.657
MOD_GSK3_1	90	97	PF00069	0.567
MOD_N-GLC_1	42	47	PF02516	0.814
MOD_NEK2_1	289	294	PF00069	0.712
MOD_NEK2_1	360	365	PF00069	0.713
MOD_NEK2_1	38	43	PF00069	0.817
MOD_NEK2_1	428	433	PF00069	0.631
MOD_NEK2_1	556	561	PF00069	0.766
MOD_PIKK_1	210	216	PF00454	0.739
MOD_PIKK_1	299	305	PF00454	0.795
MOD_PIKK_1	308	314	PF00454	0.678
MOD_PIKK_1	346	352	PF00454	0.545
MOD_PIKK_1	38	44	PF00454	0.816
MOD_PIKK_1	382	388	PF00454	0.826
MOD_PIKK_1	405	411	PF00454	0.820
MOD_PIKK_1	415	421	PF00454	0.685
MOD_PIKK_1	58	64	PF00454	0.508
MOD_PIKK_1	94	100	PF00454	0.725
MOD_PKA_1	106	112	PF00069	0.704
MOD_PKA_2	106	112	PF00069	0.704
MOD_PKA_2	155	161	PF00069	0.668
MOD_PKA_2	19	25	PF00069	0.622
MOD_PKA_2	210	216	PF00069	0.561
MOD_PKA_2	564	570	PF00069	0.840
MOD_Plk_1	42	48	PF00069	0.738
MOD_Plk_1	423	429	PF00069	0.570
MOD_ProDKin_1	227	233	PF00069	0.679
MOD_ProDKin_1	258	264	PF00069	0.690
MOD_ProDKin_1	274	280	PF00069	0.719
MOD_ProDKin_1	336	342	PF00069	0.818
MOD_ProDKin_1	366	372	PF00069	0.725
MOD_ProDKin_1	389	395	PF00069	0.679
MOD_ProDKin_1	398	404	PF00069	0.688
MOD_SUMO_for_1	537	540	PF00179	0.775
TRG_DiLeu_BaLyEn_6	199	204	PF01217	0.836
TRG_ENDOCYTIC_2	172	175	PF00928	0.706
TRG_ER_diArg_1	104	107	PF00400	0.695

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IPV7	Leishmania donovani	86%	100%
A4HFN9	Leishmania braziliensis	62%	96%
A4I2R5	Leishmania infantum	86%	100%
E9AD92	Leishmania major	85%	100%