Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZ12_LEIMU

TriTrypDb:

LmxM.27.1100

Length:

647

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZ12

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZ12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	224	228	PF00656	0.705
CLV_C14_Caspase3-7	392	396	PF00656	0.729
CLV_C14_Caspase3-7	480	484	PF00656	0.762
CLV_NRD_NRD_1	190	192	PF00675	0.646
CLV_NRD_NRD_1	268	270	PF00675	0.684
CLV_NRD_NRD_1	273	275	PF00675	0.641
CLV_NRD_NRD_1	328	330	PF00675	0.682
CLV_NRD_NRD_1	470	472	PF00675	0.705
CLV_NRD_NRD_1	566	568	PF00675	0.789
CLV_NRD_NRD_1	593	595	PF00675	0.863
CLV_NRD_NRD_1	612	614	PF00675	0.533
CLV_NRD_NRD_1	615	617	PF00675	0.802
CLV_NRD_NRD_1	621	623	PF00675	0.705
CLV_NRD_NRD_1	66	68	PF00675	0.416
CLV_PCSK_KEX2_1	328	330	PF00082	0.606
CLV_PCSK_KEX2_1	469	471	PF00082	0.690
CLV_PCSK_KEX2_1	595	597	PF00082	0.841
CLV_PCSK_KEX2_1	612	614	PF00082	0.566
CLV_PCSK_KEX2_1	621	623	PF00082	0.705
CLV_PCSK_KEX2_1	66	68	PF00082	0.651
CLV_PCSK_PC1ET2_1	595	597	PF00082	0.841
CLV_PCSK_PC1ET2_1	612	614	PF00082	0.566
CLV_PCSK_PC1ET2_1	621	623	PF00082	0.705
CLV_PCSK_SKI1_1	124	128	PF00082	0.604
CLV_PCSK_SKI1_1	203	207	PF00082	0.565
CLV_PCSK_SKI1_1	274	278	PF00082	0.545
CLV_PCSK_SKI1_1	32	36	PF00082	0.648
CLV_PCSK_SKI1_1	394	398	PF00082	0.777
CLV_PCSK_SKI1_1	609	613	PF00082	0.847
CLV_PCSK_SKI1_1	623	627	PF00082	0.623
DEG_APCC_DBOX_1	75	83	PF00400	0.672
DEG_SCF_TRCP1_1	200	206	PF00400	0.531
DEG_SPOP_SBC_1	162	166	PF00917	0.799
DEG_SPOP_SBC_1	211	215	PF00917	0.642
DEG_SPOP_SBC_1	416	420	PF00917	0.791
DEG_SPOP_SBC_1	624	628	PF00917	0.737
DOC_CKS1_1	204	209	PF01111	0.536
DOC_CKS1_1	39	44	PF01111	0.454
DOC_CYCLIN_RxL_1	66	77	PF00134	0.544
DOC_CYCLIN_yCln2_LP_2	39	45	PF00134	0.627
DOC_MAPK_gen_1	151	158	PF00069	0.653
DOC_MAPK_gen_1	66	75	PF00069	0.620
DOC_MAPK_JIP1_4	67	73	PF00069	0.621
DOC_MAPK_MEF2A_6	66	75	PF00069	0.620
DOC_PP1_RVXF_1	56	62	PF00149	0.602
DOC_PP4_FxxP_1	126	129	PF00568	0.604
DOC_USP7_MATH_1	152	156	PF00917	0.502
DOC_USP7_MATH_1	198	202	PF00917	0.673
DOC_USP7_MATH_1	211	215	PF00917	0.657
DOC_USP7_MATH_1	276	280	PF00917	0.532
DOC_USP7_MATH_1	403	407	PF00917	0.820
DOC_USP7_MATH_1	409	413	PF00917	0.717
DOC_USP7_MATH_1	416	420	PF00917	0.578
DOC_USP7_MATH_1	475	479	PF00917	0.810
DOC_USP7_MATH_1	496	500	PF00917	0.752
DOC_USP7_MATH_1	569	573	PF00917	0.666
DOC_USP7_MATH_1	624	628	PF00917	0.854
DOC_USP7_MATH_1	630	634	PF00917	0.754
DOC_USP7_MATH_2	569	575	PF00917	0.754
DOC_USP7_UBL2_3	591	595	PF12436	0.858
DOC_USP7_UBL2_3	608	612	PF12436	0.565
DOC_USP7_UBL2_3	617	621	PF12436	0.698
DOC_WW_Pin1_4	203	208	PF00397	0.533
DOC_WW_Pin1_4	38	43	PF00397	0.445
DOC_WW_Pin1_4	401	406	PF00397	0.849
DOC_WW_Pin1_4	52	57	PF00397	0.433
DOC_WW_Pin1_4	6	11	PF00397	0.791
LIG_14-3-3_CanoR_1	151	157	PF00244	0.658
LIG_14-3-3_CanoR_1	191	196	PF00244	0.628
LIG_14-3-3_CanoR_1	274	284	PF00244	0.762
LIG_14-3-3_CanoR_1	291	296	PF00244	0.547
LIG_14-3-3_CanoR_1	297	305	PF00244	0.732
LIG_14-3-3_CanoR_1	312	321	PF00244	0.597
LIG_14-3-3_CanoR_1	339	344	PF00244	0.733
LIG_14-3-3_CanoR_1	485	489	PF00244	0.707
LIG_14-3-3_CanoR_1	498	504	PF00244	0.566
LIG_14-3-3_CanoR_1	622	632	PF00244	0.738
LIG_Actin_WH2_2	228	245	PF00022	0.562
LIG_BRCT_BRCA1_1	258	262	PF00533	0.627
LIG_BRCT_BRCA1_1	8	12	PF00533	0.717
LIG_Clathr_ClatBox_1	261	265	PF01394	0.665
LIG_EH1_1	129	137	PF00400	0.587
LIG_eIF4E_1	130	136	PF01652	0.583
LIG_FHA_1	105	111	PF00498	0.625
LIG_FHA_1	184	190	PF00498	0.514
LIG_FHA_1	235	241	PF00498	0.580
LIG_FHA_1	249	255	PF00498	0.365
LIG_FHA_1	343	349	PF00498	0.541
LIG_FHA_1	418	424	PF00498	0.808
LIG_FHA_1	546	552	PF00498	0.744
LIG_FHA_1	627	633	PF00498	0.778
LIG_FHA_2	213	219	PF00498	0.769
LIG_FHA_2	250	256	PF00498	0.525
LIG_FHA_2	352	358	PF00498	0.547
LIG_FHA_2	498	504	PF00498	0.635
LIG_FHA_2	513	519	PF00498	0.672
LIG_FHA_2	552	558	PF00498	0.768
LIG_KLC1_Yacidic_2	227	232	PF13176	0.709
LIG_LIR_Gen_1	373	383	PF02991	0.759
LIG_LIR_Nem_3	119	125	PF02991	0.498
LIG_LIR_Nem_3	373	379	PF02991	0.761
LIG_LIR_Nem_3	507	513	PF02991	0.758
LIG_LIR_Nem_3	88	94	PF02991	0.660
LIG_SH2_CRK	122	126	PF00017	0.478
LIG_SH2_NCK_1	130	134	PF00017	0.589
LIG_SH2_SRC	230	233	PF00017	0.703
LIG_SH2_SRC	376	379	PF00017	0.768
LIG_SH2_SRC	441	444	PF00017	0.759
LIG_SH2_STAP1	23	27	PF00017	0.720
LIG_SH2_STAP1	376	380	PF00017	0.551
LIG_SH2_STAT5	230	233	PF00017	0.703
LIG_SH2_STAT5	305	308	PF00017	0.841
LIG_SH2_STAT5	422	425	PF00017	0.810
LIG_SH3_2	589	594	PF14604	0.564
LIG_SH3_2	84	89	PF14604	0.492
LIG_SH3_3	146	152	PF00018	0.652
LIG_SH3_3	192	198	PF00018	0.451
LIG_SH3_3	201	207	PF00018	0.513
LIG_SH3_3	586	592	PF00018	0.567
LIG_SH3_3	629	635	PF00018	0.771
LIG_SH3_3	72	78	PF00018	0.613
LIG_SH3_3	81	87	PF00018	0.620
LIG_SH3_4	591	598	PF00018	0.760
LIG_SUMO_SIM_anti_2	246	252	PF11976	0.546
LIG_SUMO_SIM_par_1	106	111	PF11976	0.611
LIG_SUMO_SIM_par_1	246	252	PF11976	0.546
LIG_SUMO_SIM_par_1	548	554	PF11976	0.746
LIG_SxIP_EBH_1	527	537	PF03271	0.716
LIG_TRAF2_1	354	357	PF00917	0.547
MOD_CDC14_SPxK_1	55	58	PF00782	0.435
MOD_CDK_SPK_2	6	11	PF00069	0.714
MOD_CDK_SPxK_1	52	58	PF00069	0.461
MOD_CK1_1	154	160	PF00069	0.595
MOD_CK1_1	164	170	PF00069	0.710
MOD_CK1_1	256	262	PF00069	0.618
MOD_CK1_1	279	285	PF00069	0.783
MOD_CK1_1	327	333	PF00069	0.598
MOD_CK1_1	342	348	PF00069	0.648
MOD_CK1_1	401	407	PF00069	0.793
MOD_CK1_1	412	418	PF00069	0.679
MOD_CK1_1	421	427	PF00069	0.533
MOD_CK1_1	484	490	PF00069	0.715
MOD_CK1_1	514	520	PF00069	0.786
MOD_CK1_1	521	527	PF00069	0.711
MOD_CK1_1	545	551	PF00069	0.714
MOD_CK2_1	162	168	PF00069	0.732
MOD_CK2_1	249	255	PF00069	0.528
MOD_CK2_1	350	356	PF00069	0.661
MOD_CK2_1	452	458	PF00069	0.735
MOD_CK2_1	497	503	PF00069	0.635
MOD_CK2_1	512	518	PF00069	0.669
MOD_CK2_1	551	557	PF00069	0.768
MOD_CK2_1	92	98	PF00069	0.756
MOD_Cter_Amidation	605	608	PF01082	0.843
MOD_DYRK1A_RPxSP_1	203	207	PF00069	0.534
MOD_GlcNHglycan	101	105	PF01048	0.552
MOD_GlcNHglycan	158	161	PF01048	0.555
MOD_GlcNHglycan	174	177	PF01048	0.549
MOD_GlcNHglycan	200	203	PF01048	0.699
MOD_GlcNHglycan	298	301	PF01048	0.826
MOD_GlcNHglycan	335	338	PF01048	0.561
MOD_GlcNHglycan	400	403	PF01048	0.802
MOD_GlcNHglycan	411	414	PF01048	0.683
MOD_GlcNHglycan	436	439	PF01048	0.717
MOD_GlcNHglycan	500	503	PF01048	0.776
MOD_GlcNHglycan	520	523	PF01048	0.554
MOD_GlcNHglycan	560	563	PF01048	0.848
MOD_GlcNHglycan	598	601	PF01048	0.599
MOD_GlcNHglycan	632	635	PF01048	0.776
MOD_GlcNHglycan	94	97	PF01048	0.631
MOD_GSK3_1	100	107	PF00069	0.552
MOD_GSK3_1	152	159	PF00069	0.545
MOD_GSK3_1	183	190	PF00069	0.606
MOD_GSK3_1	249	256	PF00069	0.529
MOD_GSK3_1	275	282	PF00069	0.612
MOD_GSK3_1	291	298	PF00069	0.728
MOD_GSK3_1	327	334	PF00069	0.733
MOD_GSK3_1	335	342	PF00069	0.777
MOD_GSK3_1	37	44	PF00069	0.573
MOD_GSK3_1	394	401	PF00069	0.843
MOD_GSK3_1	412	419	PF00069	0.543
MOD_GSK3_1	448	455	PF00069	0.754
MOD_GSK3_1	48	55	PF00069	0.531
MOD_GSK3_1	484	491	PF00069	0.795
MOD_GSK3_1	498	505	PF00069	0.536
MOD_GSK3_1	513	520	PF00069	0.613
MOD_GSK3_1	547	554	PF00069	0.823
MOD_GSK3_1	624	631	PF00069	0.792
MOD_N-GLC_1	48	53	PF02516	0.517
MOD_NEK2_1	156	161	PF00069	0.654
MOD_NEK2_1	249	254	PF00069	0.525
MOD_NEK2_1	27	32	PF00069	0.444
MOD_NEK2_1	295	300	PF00069	0.828
MOD_NEK2_1	497	502	PF00069	0.584
MOD_NEK2_1	5	10	PF00069	0.629
MOD_NEK2_1	641	646	PF00069	0.834
MOD_PIKK_1	276	282	PF00454	0.675
MOD_PIKK_1	404	410	PF00454	0.765
MOD_PK_1	448	454	PF00069	0.819
MOD_PKA_1	191	197	PF00069	0.643
MOD_PKA_1	469	475	PF00069	0.716
MOD_PKA_1	607	613	PF00069	0.817
MOD_PKA_2	152	158	PF00069	0.542
MOD_PKA_2	187	193	PF00069	0.649
MOD_PKA_2	282	288	PF00069	0.735
MOD_PKA_2	296	302	PF00069	0.628
MOD_PKA_2	311	317	PF00069	0.525
MOD_PKA_2	327	333	PF00069	0.533
MOD_PKA_2	469	475	PF00069	0.716
MOD_PKA_2	484	490	PF00069	0.525
MOD_PKA_2	497	503	PF00069	0.567
MOD_PKA_2	511	517	PF00069	0.652
MOD_PKA_2	612	618	PF00069	0.848
MOD_PKB_1	594	602	PF00069	0.856
MOD_Plk_1	100	106	PF00069	0.489
MOD_Plk_1	233	239	PF00069	0.567
MOD_Plk_1	431	437	PF00069	0.595
MOD_Plk_1	48	54	PF00069	0.723
MOD_Plk_1	551	557	PF00069	0.846
MOD_Plk_4	134	140	PF00069	0.477
MOD_Plk_4	253	259	PF00069	0.602
MOD_Plk_4	418	424	PF00069	0.808
MOD_ProDKin_1	203	209	PF00069	0.536
MOD_ProDKin_1	38	44	PF00069	0.452
MOD_ProDKin_1	401	407	PF00069	0.847
MOD_ProDKin_1	52	58	PF00069	0.425
MOD_ProDKin_1	6	12	PF00069	0.792
MOD_SUMO_rev_2	387	396	PF00179	0.682
MOD_SUMO_rev_2	561	569	PF00179	0.838
TRG_DiLeu_BaLyEn_6	55	60	PF01217	0.617
TRG_ENDOCYTIC_2	122	125	PF00928	0.474
TRG_ENDOCYTIC_2	376	379	PF00928	0.768
TRG_ENDOCYTIC_2	510	513	PF00928	0.778
TRG_ER_diArg_1	178	181	PF00400	0.507
TRG_ER_diArg_1	468	471	PF00400	0.682
TRG_ER_diArg_1	66	69	PF00400	0.375
TRG_NLS_Bipartite_1	594	616	PF00514	0.777
TRG_NLS_MonoExtC_3	611	616	PF00514	0.848
TRG_NLS_MonoExtN_4	591	598	PF00514	0.857
TRG_NLS_MonoExtN_4	609	616	PF00514	0.551
TRG_NLS_MonoExtN_4	619	625	PF00514	0.671
TRG_Pf-PMV_PEXEL_1	58	62	PF00026	0.589

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X0L5	Leishmania donovani	86%	100%
A4HFN4	Leishmania braziliensis	67%	100%
A4I2R1	Leishmania infantum	86%	100%
E9AD88	Leishmania major	84%	100%