Vesicular transport protein (CDC48 homologue),putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

vesicular transport protein (CDC48 homologue), putative

Species:

Leishmania mexicana

UniProt:

E9AZ07_LEIMU

TriTrypDb:

LmxM.27.1050

Length:

666

Annotations

LeishMANIAdb annotations

A large and likely artifical grouping of protease domain carrying proteins related to proteasomal proteases. Only a tiny subgroup (the AFG3-related mitochondrail proteins) seem to have a TM segment.. Localization: Cytoplasmic (by homology) / Mitochondrial (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0016020	membrane	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

E9AZ07

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZ07

Function

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Biological processes
Term	Name	Level	Count
GO:0009889	regulation of biosynthetic process	4	1
GO:0009891	positive regulation of biosynthetic process	5	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010557	positive regulation of macromolecule biosynthetic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0022613	ribonucleoprotein complex biogenesis	4	1

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016462	pyrophosphatase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	12
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	12
GO:0016887	ATP hydrolysis activity	7	12
GO:0017076	purine nucleotide binding	4	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	473	477	PF00656	0.300
CLV_C14_Caspase3-7	500	504	PF00656	0.300
CLV_C14_Caspase3-7	521	525	PF00656	0.369
CLV_MEL_PAP_1	398	404	PF00089	0.436
CLV_NRD_NRD_1	201	203	PF00675	0.288
CLV_NRD_NRD_1	23	25	PF00675	0.763
CLV_NRD_NRD_1	252	254	PF00675	0.300
CLV_NRD_NRD_1	318	320	PF00675	0.316
CLV_NRD_NRD_1	481	483	PF00675	0.300
CLV_NRD_NRD_1	507	509	PF00675	0.421

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2H1	Leptomonas seymouri	32%	72%
A0A0N0P3G0	Leptomonas seymouri	45%	84%
A0A0N0P640	Leptomonas seymouri	26%	90%
A0A0N0P6J4	Leptomonas seymouri	87%	100%
A0A0N1I568	Leptomonas seymouri	29%	69%
A0A0S4IKL1	Bodo saltans	32%	100%
A0A0S4IMC7	Bodo saltans	45%	100%
A0A0S4JAU3	Bodo saltans	71%	100%
A0A0S4JI00	Bodo saltans	41%	90%
A0A0S4JTC3	Bodo saltans	27%	91%

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