Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZ06_LEIMU

TriTrypDb:

LmxM.27.1045

Length:

146

Annotations

LeishMANIAdb annotations

This small membrane protein has a very long, basic N-terminus that might indicate a putative mitochondrial transit signal.. The protein is conserved in all KInetoplastids, but not seen outside this group.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9AZ06

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZ06

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	134	136	PF00675	0.595
CLV_NRD_NRD_1	21	23	PF00675	0.456
CLV_NRD_NRD_1	3	5	PF00675	0.448
CLV_PCSK_FUR_1	131	135	PF00082	0.626
CLV_PCSK_FUR_1	18	22	PF00082	0.424
CLV_PCSK_KEX2_1	130	132	PF00082	0.582
CLV_PCSK_KEX2_1	133	135	PF00082	0.597
CLV_PCSK_KEX2_1	20	22	PF00082	0.458
CLV_PCSK_KEX2_1	3	5	PF00082	0.448
CLV_PCSK_PC1ET2_1	130	132	PF00082	0.577
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.442
CLV_Separin_Metazoa	10	14	PF03568	0.648
DEG_Nend_Nbox_1	1	3	PF02207	0.635
DOC_MAPK_gen_1	111	120	PF00069	0.416
DOC_MAPK_gen_1	3	11	PF00069	0.643
DOC_MAPK_MEF2A_6	114	122	PF00069	0.457
DOC_MAPK_MEF2A_6	3	11	PF00069	0.640
DOC_PP2B_LxvP_1	9	12	PF13499	0.671
LIG_14-3-3_CanoR_1	68	73	PF00244	0.656
LIG_FHA_2	94	100	PF00498	0.466
LIG_Integrin_RGD_1	114	116	PF01839	0.583
LIG_LIR_Gen_1	105	113	PF02991	0.495
LIG_LIR_Nem_3	105	110	PF02991	0.469
LIG_LIR_Nem_3	119	125	PF02991	0.348
LIG_LIR_Nem_3	81	86	PF02991	0.294
LIG_REV1ctd_RIR_1	90	98	PF16727	0.576
LIG_SH2_CRK	107	111	PF00017	0.404
LIG_SH2_STAT3	50	53	PF00017	0.693
LIG_SH2_STAT5	107	110	PF00017	0.456
LIG_SH2_STAT5	50	53	PF00017	0.599
LIG_SH2_STAT5	86	89	PF00017	0.284
LIG_SH2_STAT5	95	98	PF00017	0.366
LIG_SH3_2	57	62	PF14604	0.659
LIG_SH3_3	35	41	PF00018	0.768
LIG_SH3_3	54	60	PF00018	0.578
LIG_SH3_3	8	14	PF00018	0.687
LIG_TYR_ITSM	103	110	PF00017	0.496
MOD_CK2_1	93	99	PF00069	0.390
MOD_Cter_Amidation	128	131	PF01082	0.628
MOD_Cter_Amidation	29	32	PF01082	0.357
MOD_GlcNHglycan	45	48	PF01048	0.434
MOD_PIKK_1	102	108	PF00454	0.492
MOD_PKA_2	67	73	PF00069	0.676
MOD_Plk_4	105	111	PF00069	0.417
MOD_Plk_4	79	85	PF00069	0.339
TRG_DiLeu_BaLyEn_6	135	140	PF01217	0.435
TRG_ENDOCYTIC_2	107	110	PF00928	0.326
TRG_ENDOCYTIC_2	89	92	PF00928	0.351
TRG_ER_diArg_1	131	134	PF00400	0.400
TRG_ER_diArg_1	2	4	PF00400	0.652
TRG_ER_diArg_1	21	24	PF00400	0.627
TRG_ER_diArg_1	55	58	PF00400	0.593
TRG_NLS_Bipartite_1	3	24	PF00514	0.658
TRG_NLS_MonoExtC_3	129	134	PF00514	0.415
TRG_NLS_MonoExtC_3	19	24	PF00514	0.722
TRG_NLS_MonoExtN_4	18	24	PF00514	0.654
TRG_Pf-PMV_PEXEL_1	138	143	PF00026	0.624

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZT6	Leptomonas seymouri	74%	100%
A0A0S4JFD9	Bodo saltans	53%	100%
A0A1X0P4W3	Trypanosomatidae	52%	100%
A0A3S7X0M9	Leishmania donovani	95%	100%
A0A422MWH1	Trypanosoma rangeli	55%	100%
A4HFM8	Leishmania braziliensis	86%	100%
A4I2Q6	Leishmania infantum	95%	100%
D0A5V7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9AD82	Leishmania major	92%	100%