Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZ05_LEIMU

TriTrypDb:

LmxM.27.1040

Length:

419

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9AZ05

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZ05

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	143	145	PF00675	0.591
CLV_NRD_NRD_1	175	177	PF00675	0.427
CLV_NRD_NRD_1	210	212	PF00675	0.365
CLV_NRD_NRD_1	358	360	PF00675	0.473
CLV_NRD_NRD_1	371	373	PF00675	0.450
CLV_NRD_NRD_1	60	62	PF00675	0.646
CLV_PCSK_KEX2_1	143	145	PF00082	0.621
CLV_PCSK_KEX2_1	175	177	PF00082	0.427
CLV_PCSK_KEX2_1	200	202	PF00082	0.460
CLV_PCSK_KEX2_1	210	212	PF00082	0.423
CLV_PCSK_KEX2_1	358	360	PF00082	0.473
CLV_PCSK_KEX2_1	371	373	PF00082	0.450
CLV_PCSK_KEX2_1	60	62	PF00082	0.646
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.441
CLV_PCSK_SKI1_1	243	247	PF00082	0.376
DEG_Nend_UBRbox_3	1	3	PF02207	0.527
DOC_MAPK_gen_1	58	68	PF00069	0.449
DOC_MAPK_HePTP_8	398	410	PF00069	0.321
DOC_MAPK_MEF2A_6	401	410	PF00069	0.300
DOC_MAPK_MEF2A_6	60	69	PF00069	0.446
DOC_PP1_RVXF_1	241	247	PF00149	0.579
DOC_PP1_RVXF_1	399	406	PF00149	0.351
DOC_PP4_FxxP_1	9	12	PF00568	0.500
DOC_USP7_MATH_1	130	134	PF00917	0.490
DOC_USP7_MATH_1	318	322	PF00917	0.642
DOC_USP7_MATH_1	352	356	PF00917	0.716
DOC_USP7_MATH_1	367	371	PF00917	0.619
DOC_USP7_MATH_1	79	83	PF00917	0.501
DOC_WW_Pin1_4	295	300	PF00397	0.652
DOC_WW_Pin1_4	308	313	PF00397	0.663
DOC_WW_Pin1_4	80	85	PF00397	0.476
LIG_14-3-3_CanoR_1	144	154	PF00244	0.289
LIG_Actin_WH2_2	401	419	PF00022	0.301
LIG_BRCT_BRCA1_1	81	85	PF00533	0.422
LIG_Clathr_ClatBox_1	254	258	PF01394	0.536
LIG_EVH1_2	40	44	PF00568	0.401
LIG_FHA_1	146	152	PF00498	0.272
LIG_FHA_1	188	194	PF00498	0.582
LIG_FHA_1	214	220	PF00498	0.534
LIG_FHA_1	24	30	PF00498	0.528
LIG_FHA_1	276	282	PF00498	0.566
LIG_FHA_2	260	266	PF00498	0.614
LIG_FHA_2	32	38	PF00498	0.488
LIG_GBD_Chelix_1	403	411	PF00786	0.343
LIG_IRF3_LxIS_1	120	125	PF10401	0.455
LIG_LIR_Apic_2	344	348	PF02991	0.572
LIG_LIR_Apic_2	6	12	PF02991	0.497
LIG_PCNA_yPIPBox_3	167	178	PF02747	0.645
LIG_SH2_CRK	345	349	PF00017	0.660
LIG_SH2_NCK_1	317	321	PF00017	0.602
LIG_SH2_SRC	317	320	PF00017	0.604
LIG_SH2_STAP1	263	267	PF00017	0.586
LIG_SH2_STAT5	155	158	PF00017	0.351
LIG_SH3_1	81	87	PF00018	0.419
LIG_SH3_3	296	302	PF00018	0.681
LIG_SH3_3	43	49	PF00018	0.404
LIG_SH3_3	81	87	PF00018	0.419
LIG_SUMO_SIM_anti_2	160	165	PF11976	0.425
LIG_SUMO_SIM_anti_2	181	191	PF11976	0.574
LIG_SUMO_SIM_anti_2	382	388	PF11976	0.606
LIG_SUMO_SIM_par_1	160	165	PF11976	0.380
LIG_SUMO_SIM_par_1	181	191	PF11976	0.574
LIG_SUMO_SIM_par_1	393	399	PF11976	0.472
LIG_TYR_ITIM	153	158	PF00017	0.351
LIG_UBA3_1	192	200	PF00899	0.451
LIG_UBA3_1	394	401	PF00899	0.473
MOD_CK1_1	133	139	PF00069	0.481
MOD_CK1_1	374	380	PF00069	0.661
MOD_CK1_1	382	388	PF00069	0.571
MOD_CK1_1	53	59	PF00069	0.575
MOD_CK1_1	80	86	PF00069	0.535
MOD_CK2_1	100	106	PF00069	0.468
MOD_CK2_1	162	168	PF00069	0.631
MOD_CK2_1	259	265	PF00069	0.608
MOD_CK2_1	31	37	PF00069	0.528
MOD_CK2_1	92	98	PF00069	0.493
MOD_GlcNHglycan	15	18	PF01048	0.754
MOD_GlcNHglycan	164	167	PF01048	0.483
MOD_GlcNHglycan	320	323	PF01048	0.457
MOD_GlcNHglycan	365	368	PF01048	0.601
MOD_GlcNHglycan	373	376	PF01048	0.600
MOD_GlcNHglycan	381	384	PF01048	0.512
MOD_GlcNHglycan	412	415	PF01048	0.327
MOD_GlcNHglycan	94	97	PF01048	0.742
MOD_GSK3_1	118	125	PF00069	0.502
MOD_GSK3_1	13	20	PF00069	0.558
MOD_GSK3_1	132	139	PF00069	0.497
MOD_GSK3_1	359	366	PF00069	0.695
MOD_GSK3_1	367	374	PF00069	0.650
MOD_GSK3_1	375	382	PF00069	0.607
MOD_GSK3_1	50	57	PF00069	0.598
MOD_GSK3_1	73	80	PF00069	0.521
MOD_N-GLC_1	110	115	PF02516	0.705
MOD_N-GLC_1	233	238	PF02516	0.360
MOD_N-GLC_1	3	8	PF02516	0.614
MOD_N-GLC_1	31	36	PF02516	0.620
MOD_N-GLC_1	73	78	PF02516	0.707
MOD_N-GLC_1	92	97	PF02516	0.762
MOD_NEK2_1	122	127	PF00069	0.501
MOD_NEK2_1	187	192	PF00069	0.592
MOD_NEK2_1	275	280	PF00069	0.523
MOD_NEK2_1	351	356	PF00069	0.622
MOD_PIKK_1	205	211	PF00454	0.615
MOD_PIKK_1	302	308	PF00454	0.640
MOD_PKA_1	358	364	PF00069	0.755
MOD_PKA_1	371	377	PF00069	0.680
MOD_PKA_2	358	364	PF00069	0.713
MOD_PKA_2	371	377	PF00069	0.774
MOD_PKA_2	51	57	PF00069	0.528
MOD_Plk_1	233	239	PF00069	0.521
MOD_Plk_1	31	37	PF00069	0.466
MOD_Plk_1	50	56	PF00069	0.491
MOD_Plk_2-3	100	106	PF00069	0.526
MOD_Plk_4	118	124	PF00069	0.525
MOD_Plk_4	188	194	PF00069	0.577
MOD_Plk_4	277	283	PF00069	0.611
MOD_Plk_4	382	388	PF00069	0.665
MOD_ProDKin_1	295	301	PF00069	0.652
MOD_ProDKin_1	308	314	PF00069	0.663
MOD_ProDKin_1	80	86	PF00069	0.476
MOD_SUMO_for_1	199	202	PF00179	0.598
TRG_DiLeu_BaEn_1	181	186	PF01217	0.543
TRG_DiLeu_BaEn_2	250	256	PF01217	0.505
TRG_ENDOCYTIC_2	155	158	PF00928	0.351
TRG_ER_diArg_1	143	145	PF00400	0.417
TRG_ER_diArg_1	174	176	PF00400	0.627
TRG_ER_diArg_1	358	360	PF00400	0.683
TRG_Pf-PMV_PEXEL_1	201	205	PF00026	0.445

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCL1	Leptomonas seymouri	45%	98%
A0A3S7X0L7	Leishmania donovani	86%	100%
A4HFM7	Leishmania braziliensis	63%	100%
A4I2Q5	Leishmania infantum	86%	100%
E9AD81	Leishmania major	85%	100%
V5AT52	Trypanosoma cruzi	25%	100%