Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZ04_LEIMU

TriTrypDb:

LmxM.27.1030

Length:

894

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZ04

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZ04

PDB structure(s): 7am2_BK

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	523	527	PF00656	0.586
CLV_C14_Caspase3-7	665	669	PF00656	0.410
CLV_NRD_NRD_1	207	209	PF00675	0.462
CLV_NRD_NRD_1	620	622	PF00675	0.507
CLV_NRD_NRD_1	661	663	PF00675	0.413
CLV_NRD_NRD_1	692	694	PF00675	0.553
CLV_NRD_NRD_1	831	833	PF00675	0.480
CLV_PCSK_FUR_1	500	504	PF00082	0.578
CLV_PCSK_KEX2_1	207	209	PF00082	0.517
CLV_PCSK_KEX2_1	502	504	PF00082	0.470
CLV_PCSK_KEX2_1	620	622	PF00082	0.468
CLV_PCSK_KEX2_1	661	663	PF00082	0.413
CLV_PCSK_KEX2_1	691	693	PF00082	0.567
CLV_PCSK_KEX2_1	831	833	PF00082	0.435
CLV_PCSK_PC1ET2_1	502	504	PF00082	0.515
CLV_PCSK_PC1ET2_1	691	693	PF00082	0.612
CLV_PCSK_PC7_1	827	833	PF00082	0.442
CLV_PCSK_SKI1_1	194	198	PF00082	0.502
CLV_PCSK_SKI1_1	237	241	PF00082	0.549
CLV_PCSK_SKI1_1	330	334	PF00082	0.501
CLV_PCSK_SKI1_1	502	506	PF00082	0.493
CLV_PCSK_SKI1_1	667	671	PF00082	0.445
CLV_PCSK_SKI1_1	692	696	PF00082	0.477
CLV_PCSK_SKI1_1	711	715	PF00082	0.200
CLV_PCSK_SKI1_1	799	803	PF00082	0.455
CLV_PCSK_SKI1_1	834	838	PF00082	0.457
CLV_PCSK_SKI1_1	84	88	PF00082	0.672
DEG_APCC_DBOX_1	329	337	PF00400	0.534
DEG_APCC_DBOX_1	710	718	PF00400	0.446
DEG_Nend_UBRbox_1	1	4	PF02207	0.666
DEG_SCF_FBW7_2	873	880	PF00400	0.587
DEG_SPOP_SBC_1	23	27	PF00917	0.754
DEG_SPOP_SBC_1	775	779	PF00917	0.634
DOC_ANK_TNKS_1	844	851	PF00023	0.444
DOC_CDC14_PxL_1	480	488	PF14671	0.391
DOC_CKS1_1	865	870	PF01111	0.465
DOC_CKS1_1	874	879	PF01111	0.461
DOC_CYCLIN_RxL_1	325	337	PF00134	0.551
DOC_CYCLIN_yClb1_LxF_4	228	234	PF00134	0.497
DOC_MAPK_gen_1	191	201	PF00069	0.509
DOC_MAPK_gen_1	428	438	PF00069	0.444
DOC_MAPK_gen_1	664	672	PF00069	0.470
DOC_MAPK_MEF2A_6	164	171	PF00069	0.593
DOC_MAPK_MEF2A_6	431	438	PF00069	0.501
DOC_MAPK_MEF2A_6	474	482	PF00069	0.621
DOC_MAPK_MEF2A_6	745	752	PF00069	0.410
DOC_MAPK_NFAT4_5	431	439	PF00069	0.498
DOC_PP1_RVXF_1	859	866	PF00149	0.587
DOC_PP2B_LxvP_1	465	468	PF13499	0.451
DOC_PP4_FxxP_1	56	59	PF00568	0.504
DOC_PP4_FxxP_1	865	868	PF00568	0.608
DOC_USP7_MATH_1	111	115	PF00917	0.465
DOC_USP7_MATH_1	131	135	PF00917	0.606
DOC_USP7_MATH_1	23	27	PF00917	0.628
DOC_USP7_MATH_1	33	37	PF00917	0.694
DOC_USP7_MATH_1	775	779	PF00917	0.631
DOC_USP7_MATH_1	855	859	PF00917	0.535
DOC_USP7_MATH_1	93	97	PF00917	0.787
DOC_USP7_MATH_2	46	52	PF00917	0.637
DOC_WW_Pin1_4	136	141	PF00397	0.713
DOC_WW_Pin1_4	274	279	PF00397	0.470
DOC_WW_Pin1_4	396	401	PF00397	0.549
DOC_WW_Pin1_4	474	479	PF00397	0.622
DOC_WW_Pin1_4	6	11	PF00397	0.526
DOC_WW_Pin1_4	771	776	PF00397	0.603
DOC_WW_Pin1_4	784	789	PF00397	0.568
DOC_WW_Pin1_4	864	869	PF00397	0.463
DOC_WW_Pin1_4	873	878	PF00397	0.449
LIG_14-3-3_CanoR_1	194	199	PF00244	0.509
LIG_14-3-3_CanoR_1	243	248	PF00244	0.492
LIG_14-3-3_CanoR_1	34	38	PF00244	0.634
LIG_14-3-3_CanoR_1	412	417	PF00244	0.332
LIG_14-3-3_CanoR_1	503	507	PF00244	0.446
LIG_14-3-3_CanoR_1	692	700	PF00244	0.534
LIG_14-3-3_CanoR_1	799	807	PF00244	0.496
LIG_Actin_WH2_2	227	242	PF00022	0.475
LIG_Actin_WH2_2	649	666	PF00022	0.504
LIG_Actin_WH2_2	786	801	PF00022	0.444
LIG_BRCT_BRCA1_1	220	224	PF00533	0.394
LIG_BRCT_BRCA1_1	49	53	PF00533	0.598
LIG_BRCT_BRCA1_1	63	67	PF00533	0.617
LIG_deltaCOP1_diTrp_1	225	233	PF00928	0.539
LIG_deltaCOP1_diTrp_1	408	413	PF00928	0.505
LIG_EH1_1	622	630	PF00400	0.535
LIG_eIF4E_1	218	224	PF01652	0.509
LIG_eIF4E_1	729	735	PF01652	0.385
LIG_FHA_1	123	129	PF00498	0.719
LIG_FHA_1	130	136	PF00498	0.743
LIG_FHA_1	212	218	PF00498	0.466
LIG_FHA_1	326	332	PF00498	0.529
LIG_FHA_1	462	468	PF00498	0.734
LIG_FHA_1	475	481	PF00498	0.588
LIG_FHA_1	536	542	PF00498	0.498
LIG_FHA_1	597	603	PF00498	0.532
LIG_FHA_1	716	722	PF00498	0.530
LIG_FHA_1	777	783	PF00498	0.504
LIG_FHA_1	785	791	PF00498	0.535
LIG_FHA_1	874	880	PF00498	0.458
LIG_FHA_2	195	201	PF00498	0.475
LIG_FHA_2	726	732	PF00498	0.442
LIG_GSK3_LRP6_1	11	16	PF00069	0.508
LIG_LIR_Apic_2	312	316	PF02991	0.515
LIG_LIR_Gen_1	113	122	PF02991	0.696
LIG_LIR_Gen_1	252	262	PF02991	0.406
LIG_LIR_Gen_1	430	441	PF02991	0.431
LIG_LIR_Gen_1	493	501	PF02991	0.484
LIG_LIR_Gen_1	557	567	PF02991	0.446
LIG_LIR_Nem_3	113	119	PF02991	0.696
LIG_LIR_Nem_3	252	258	PF02991	0.408
LIG_LIR_Nem_3	36	40	PF02991	0.593
LIG_LIR_Nem_3	430	436	PF02991	0.420
LIG_LIR_Nem_3	493	498	PF02991	0.453
LIG_LIR_Nem_3	50	56	PF02991	0.477
LIG_LIR_Nem_3	583	589	PF02991	0.633
LIG_LIR_Nem_3	611	616	PF02991	0.387
LIG_LIR_Nem_3	64	70	PF02991	0.487
LIG_NRBOX	401	407	PF00104	0.460
LIG_NRBOX	431	437	PF00104	0.445
LIG_NRBOX	446	452	PF00104	0.353
LIG_PCNA_yPIPBox_3	207	217	PF02747	0.545
LIG_Pex14_2	372	376	PF04695	0.591
LIG_SH2_CRK	37	41	PF00017	0.541
LIG_SH2_CRK	433	437	PF00017	0.494
LIG_SH2_CRK	875	879	PF00017	0.473
LIG_SH2_NCK_1	423	427	PF00017	0.255
LIG_SH2_PTP2	613	616	PF00017	0.524
LIG_SH2_STAP1	423	427	PF00017	0.468
LIG_SH2_STAP1	705	709	PF00017	0.477
LIG_SH2_STAT5	245	248	PF00017	0.434
LIG_SH2_STAT5	300	303	PF00017	0.540
LIG_SH2_STAT5	313	316	PF00017	0.573
LIG_SH2_STAT5	613	616	PF00017	0.486
LIG_SH2_STAT5	722	725	PF00017	0.421
LIG_SH2_STAT5	729	732	PF00017	0.356
LIG_SH2_STAT5	742	745	PF00017	0.367
LIG_SH2_STAT5	866	869	PF00017	0.482
LIG_SH2_STAT5	875	878	PF00017	0.464
LIG_SH3_1	5	11	PF00018	0.504
LIG_SH3_1	884	890	PF00018	0.458
LIG_SH3_3	301	307	PF00018	0.557
LIG_SH3_3	359	365	PF00018	0.713
LIG_SH3_3	5	11	PF00018	0.770
LIG_SH3_3	582	588	PF00018	0.664
LIG_SH3_3	804	810	PF00018	0.618
LIG_SH3_3	865	871	PF00018	0.479
LIG_SH3_3	884	890	PF00018	0.497
LIG_Sin3_3	287	294	PF02671	0.467
LIG_SUMO_SIM_anti_2	377	386	PF11976	0.475
LIG_SUMO_SIM_par_1	167	173	PF11976	0.536
LIG_SUMO_SIM_par_1	462	469	PF11976	0.441
LIG_TRFH_1	300	304	PF08558	0.573
LIG_TYR_ITIM	35	40	PF00017	0.554
LIG_TYR_ITIM	873	878	PF00017	0.459
LIG_UBA3_1	540	547	PF00899	0.416
LIG_UBA3_1	789	796	PF00899	0.411
LIG_UBA3_1	878	882	PF00899	0.361
LIG_Vh1_VBS_1	642	660	PF01044	0.385
LIG_WW_2	362	365	PF00397	0.433
LIG_WW_3	91	95	PF00397	0.774
MOD_CK1_1	120	126	PF00069	0.761
MOD_CK1_1	24	30	PF00069	0.750
MOD_CK1_1	249	255	PF00069	0.434
MOD_CK1_1	36	42	PF00069	0.593
MOD_CK1_1	463	469	PF00069	0.712
MOD_CK1_1	496	502	PF00069	0.530
MOD_CK1_1	543	549	PF00069	0.570
MOD_CK1_1	647	653	PF00069	0.418
MOD_CK1_1	757	763	PF00069	0.465
MOD_CK1_1	774	780	PF00069	0.495
MOD_CK1_1	792	798	PF00069	0.467
MOD_CK1_1	96	102	PF00069	0.810
MOD_CK2_1	206	212	PF00069	0.416
MOD_CK2_1	219	225	PF00069	0.383
MOD_CK2_1	418	424	PF00069	0.524
MOD_CK2_1	533	539	PF00069	0.439
MOD_CK2_1	605	611	PF00069	0.439
MOD_CMANNOS	410	413	PF00535	0.511
MOD_Cter_Amidation	618	621	PF01082	0.596
MOD_GlcNHglycan	118	122	PF01048	0.731
MOD_GlcNHglycan	29	32	PF01048	0.765
MOD_GlcNHglycan	322	325	PF01048	0.497
MOD_GlcNHglycan	388	391	PF01048	0.450
MOD_GlcNHglycan	495	498	PF01048	0.491
MOD_GlcNHglycan	535	538	PF01048	0.430
MOD_GlcNHglycan	547	550	PF01048	0.401
MOD_GlcNHglycan	591	594	PF01048	0.590
MOD_GlcNHglycan	646	649	PF01048	0.427
MOD_GlcNHglycan	664	667	PF01048	0.311
MOD_GlcNHglycan	95	98	PF01048	0.741
MOD_GSK3_1	106	113	PF00069	0.700
MOD_GSK3_1	11	18	PF00069	0.745
MOD_GSK3_1	117	124	PF00069	0.682
MOD_GSK3_1	19	26	PF00069	0.790
MOD_GSK3_1	241	248	PF00069	0.483
MOD_GSK3_1	320	327	PF00069	0.424
MOD_GSK3_1	36	43	PF00069	0.656
MOD_GSK3_1	366	373	PF00069	0.646
MOD_GSK3_1	457	464	PF00069	0.696
MOD_GSK3_1	482	489	PF00069	0.483
MOD_GSK3_1	545	552	PF00069	0.564
MOD_GSK3_1	643	650	PF00069	0.356
MOD_GSK3_1	751	758	PF00069	0.426
MOD_GSK3_1	771	778	PF00069	0.334
MOD_N-GLC_1	344	349	PF02516	0.626
MOD_N-GLC_1	783	788	PF02516	0.607
MOD_NEK2_1	130	135	PF00069	0.761
MOD_NEK2_1	17	22	PF00069	0.518
MOD_NEK2_1	201	206	PF00069	0.402
MOD_NEK2_1	411	416	PF00069	0.550
MOD_NEK2_1	486	491	PF00069	0.540
MOD_NEK2_1	514	519	PF00069	0.496
MOD_NEK2_1	533	538	PF00069	0.228
MOD_NEK2_1	540	545	PF00069	0.407
MOD_NEK2_1	589	594	PF00069	0.569
MOD_NEK2_1	644	649	PF00069	0.356
MOD_NEK2_1	670	675	PF00069	0.349
MOD_NEK2_1	735	740	PF00069	0.380
MOD_NEK2_1	789	794	PF00069	0.458
MOD_NEK2_2	765	770	PF00069	0.530
MOD_PIKK_1	484	490	PF00454	0.603
MOD_PIKK_1	849	855	PF00454	0.562
MOD_PKA_1	502	508	PF00069	0.273
MOD_PKA_1	692	698	PF00069	0.565
MOD_PKA_2	206	212	PF00069	0.563
MOD_PKA_2	320	326	PF00069	0.486
MOD_PKA_2	33	39	PF00069	0.664
MOD_PKA_2	411	417	PF00069	0.565
MOD_PKA_2	502	508	PF00069	0.314
MOD_PKA_2	692	698	PF00069	0.506
MOD_PKA_2	93	99	PF00069	0.735
MOD_Plk_1	174	180	PF00069	0.434
MOD_Plk_1	211	217	PF00069	0.514
MOD_Plk_1	218	224	PF00069	0.509
MOD_Plk_1	61	67	PF00069	0.574
MOD_Plk_2-3	219	225	PF00069	0.530
MOD_Plk_2-3	374	380	PF00069	0.504
MOD_Plk_2-3	725	731	PF00069	0.430
MOD_Plk_4	111	117	PF00069	0.608
MOD_Plk_4	194	200	PF00069	0.509
MOD_Plk_4	219	225	PF00069	0.465
MOD_Plk_4	260	266	PF00069	0.375
MOD_Plk_4	40	46	PF00069	0.611
MOD_Plk_4	466	472	PF00069	0.667
MOD_Plk_4	751	757	PF00069	0.432
MOD_Plk_4	814	820	PF00069	0.570
MOD_ProDKin_1	136	142	PF00069	0.717
MOD_ProDKin_1	274	280	PF00069	0.462
MOD_ProDKin_1	396	402	PF00069	0.543
MOD_ProDKin_1	474	480	PF00069	0.607
MOD_ProDKin_1	6	12	PF00069	0.525
MOD_ProDKin_1	771	777	PF00069	0.596
MOD_ProDKin_1	784	790	PF00069	0.562
MOD_ProDKin_1	864	870	PF00069	0.464
MOD_ProDKin_1	873	879	PF00069	0.459
MOD_SUMO_for_1	769	772	PF00179	0.479
MOD_SUMO_rev_2	389	398	PF00179	0.568
TRG_DiLeu_BaEn_1	276	281	PF01217	0.530
TRG_DiLeu_BaLyEn_6	164	169	PF01217	0.509
TRG_DiLeu_BaLyEn_6	509	514	PF01217	0.530
TRG_DiLeu_BaLyEn_6	785	790	PF01217	0.430
TRG_DiLeu_BaLyEn_6	874	879	PF01217	0.316
TRG_ENDOCYTIC_2	37	40	PF00928	0.546
TRG_ENDOCYTIC_2	433	436	PF00928	0.439
TRG_ENDOCYTIC_2	613	616	PF00928	0.574
TRG_ENDOCYTIC_2	875	878	PF00928	0.459
TRG_ER_diArg_1	620	622	PF00400	0.498
TRG_ER_diArg_1	661	664	PF00400	0.426
TRG_ER_diArg_1	70	73	PF00400	0.560
TRG_ER_diArg_1	82	85	PF00400	0.540
TRG_ER_diArg_1	824	827	PF00400	0.455
TRG_ER_diArg_1	830	832	PF00400	0.444
TRG_NES_CRM1_1	257	269	PF08389	0.241
TRG_NES_CRM1_1	283	295	PF08389	0.469
TRG_NES_CRM1_1	430	444	PF08389	0.520
TRG_Pf-PMV_PEXEL_1	215	219	PF00026	0.541
TRG_Pf-PMV_PEXEL_1	330	334	PF00026	0.514

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I525	Leptomonas seymouri	67%	95%
A0A0S4JJP4	Bodo saltans	28%	100%
A0A1X0P5I8	Trypanosomatidae	41%	100%
A0A3S7X0L4	Leishmania donovani	93%	100%
A0A422N2Z0	Trypanosoma rangeli	42%	100%
A4HFM6	Leishmania braziliensis	85%	100%
A4I2Q4	Leishmania infantum	93%	100%
D0A5V6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AD80	Leishmania major	93%	100%
V5B8L6	Trypanosoma cruzi	42%	100%