Exocyst complex component Sec6

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZ02_LEIMU

TriTrypDb:

LmxM.27.1010

Length:

934

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000145	exocyst	3	11
GO:0032991	protein-containing complex	1	11
GO:0099023	vesicle tethering complex	2	11
GO:0005737	cytoplasm	2	1
GO:0020016	ciliary pocket	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AZ02

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZ02

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0006887	exocytosis	4	11
GO:0009987	cellular process	1	11
GO:0016192	vesicle-mediated transport	4	11
GO:0032940	secretion by cell	3	11
GO:0046903	secretion	4	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0140352	export from cell	2	11
GO:0031503	protein-containing complex localization	2	1
GO:0051601	exocyst localization	3	1

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	100	102	PF00675	0.517
CLV_NRD_NRD_1	206	208	PF00675	0.523
CLV_NRD_NRD_1	516	518	PF00675	0.478
CLV_NRD_NRD_1	562	564	PF00675	0.426
CLV_NRD_NRD_1	623	625	PF00675	0.502
CLV_NRD_NRD_1	694	696	PF00675	0.327
CLV_NRD_NRD_1	900	902	PF00675	0.557
CLV_PCSK_KEX2_1	100	102	PF00082	0.534
CLV_PCSK_KEX2_1	206	208	PF00082	0.492
CLV_PCSK_KEX2_1	562	564	PF00082	0.403
CLV_PCSK_KEX2_1	835	837	PF00082	0.313
CLV_PCSK_KEX2_1	877	879	PF00082	0.531
CLV_PCSK_KEX2_1	893	895	PF00082	0.462
CLV_PCSK_KEX2_1	900	902	PF00082	0.559
CLV_PCSK_PC1ET2_1	835	837	PF00082	0.367
CLV_PCSK_PC1ET2_1	877	879	PF00082	0.483
CLV_PCSK_PC1ET2_1	893	895	PF00082	0.497
CLV_PCSK_SKI1_1	132	136	PF00082	0.482
CLV_PCSK_SKI1_1	3	7	PF00082	0.789
CLV_PCSK_SKI1_1	562	566	PF00082	0.405
CLV_PCSK_SKI1_1	695	699	PF00082	0.298
CLV_PCSK_SKI1_1	773	777	PF00082	0.302
CLV_PCSK_SKI1_1	872	876	PF00082	0.516
CLV_PCSK_SKI1_1	890	894	PF00082	0.556
CLV_PCSK_SKI1_1	909	913	PF00082	0.721
DEG_APCC_DBOX_1	819	827	PF00400	0.556
DOC_CKS1_1	619	624	PF01111	0.543
DOC_CKS1_1	910	915	PF01111	0.749
DOC_CYCLIN_RxL_1	197	208	PF00134	0.484
DOC_CYCLIN_RxL_1	767	777	PF00134	0.557
DOC_MAPK_gen_1	244	253	PF00069	0.540
DOC_MAPK_gen_1	464	473	PF00069	0.441
DOC_MAPK_gen_1	693	703	PF00069	0.562
DOC_MAPK_gen_1	817	826	PF00069	0.590
DOC_MAPK_MEF2A_6	230	237	PF00069	0.474
DOC_MAPK_MEF2A_6	247	255	PF00069	0.474
DOC_MAPK_MEF2A_6	741	749	PF00069	0.534
DOC_PP1_RVXF_1	778	785	PF00149	0.492
DOC_PP4_FxxP_1	619	622	PF00568	0.553
DOC_USP7_MATH_1	102	106	PF00917	0.507
DOC_USP7_UBL2_3	60	64	PF12436	0.638
DOC_USP7_UBL2_3	835	839	PF12436	0.586
DOC_WW_Pin1_4	28	33	PF00397	0.575
DOC_WW_Pin1_4	402	407	PF00397	0.323
DOC_WW_Pin1_4	549	554	PF00397	0.525
DOC_WW_Pin1_4	618	623	PF00397	0.482
DOC_WW_Pin1_4	909	914	PF00397	0.685
LIG_14-3-3_CanoR_1	206	210	PF00244	0.413
LIG_14-3-3_CanoR_1	216	221	PF00244	0.472
LIG_14-3-3_CanoR_1	352	357	PF00244	0.291
LIG_14-3-3_CanoR_1	830	834	PF00244	0.542
LIG_Actin_RPEL_3	186	205	PF02755	0.561
LIG_Actin_WH2_2	124	139	PF00022	0.577
LIG_Actin_WH2_2	161	178	PF00022	0.449
LIG_Actin_WH2_2	574	589	PF00022	0.437
LIG_AP2alpha_2	349	351	PF02296	0.475
LIG_APCC_ABBA_1	224	229	PF00400	0.459
LIG_APCC_ABBA_1	354	359	PF00400	0.528
LIG_BIR_II_1	1	5	PF00653	0.762
LIG_BRCT_BRCA1_1	190	194	PF00533	0.528
LIG_BRCT_BRCA1_1	446	450	PF00533	0.518
LIG_BRCT_BRCA1_1	619	623	PF00533	0.553
LIG_BRCT_BRCA1_1	866	870	PF00533	0.619
LIG_BRCT_BRCA1_2	619	625	PF00533	0.591
LIG_CaM_IQ_9	199	214	PF13499	0.495
LIG_deltaCOP1_diTrp_1	557	566	PF00928	0.416
LIG_deltaCOP1_diTrp_1	650	657	PF00928	0.461
LIG_deltaCOP1_diTrp_1	730	735	PF00928	0.450
LIG_eIF4E_1	46	52	PF01652	0.552
LIG_FHA_1	11	17	PF00498	0.741
LIG_FHA_1	450	456	PF00498	0.445
LIG_FHA_1	489	495	PF00498	0.491
LIG_FHA_1	581	587	PF00498	0.443
LIG_FHA_1	640	646	PF00498	0.324
LIG_FHA_1	665	671	PF00498	0.495
LIG_FHA_1	71	77	PF00498	0.606
LIG_FHA_1	799	805	PF00498	0.499
LIG_FHA_1	906	912	PF00498	0.730
LIG_FHA_2	45	51	PF00498	0.537
LIG_FHA_2	507	513	PF00498	0.537
LIG_FHA_2	536	542	PF00498	0.261
LIG_FHA_2	573	579	PF00498	0.442
LIG_FHA_2	674	680	PF00498	0.482
LIG_FHA_2	710	716	PF00498	0.511
LIG_FHA_2	732	738	PF00498	0.526
LIG_FHA_2	77	83	PF00498	0.623
LIG_LIR_Apic_2	402	406	PF02991	0.481
LIG_LIR_Apic_2	593	597	PF02991	0.655
LIG_LIR_Apic_2	617	622	PF02991	0.595
LIG_LIR_Apic_2	843	849	PF02991	0.613
LIG_LIR_Gen_1	219	228	PF02991	0.464
LIG_LIR_Gen_1	288	298	PF02991	0.472
LIG_LIR_Gen_1	325	336	PF02991	0.517
LIG_LIR_Gen_1	439	448	PF02991	0.466
LIG_LIR_Gen_1	495	505	PF02991	0.425
LIG_LIR_Gen_1	525	533	PF02991	0.469
LIG_LIR_Gen_1	650	657	PF02991	0.491
LIG_LIR_Gen_1	682	689	PF02991	0.534
LIG_LIR_Gen_1	730	739	PF02991	0.512
LIG_LIR_Nem_3	123	128	PF02991	0.539
LIG_LIR_Nem_3	149	155	PF02991	0.493
LIG_LIR_Nem_3	177	183	PF02991	0.468
LIG_LIR_Nem_3	219	223	PF02991	0.483
LIG_LIR_Nem_3	225	231	PF02991	0.402
LIG_LIR_Nem_3	288	293	PF02991	0.555
LIG_LIR_Nem_3	325	331	PF02991	0.468
LIG_LIR_Nem_3	349	354	PF02991	0.514
LIG_LIR_Nem_3	431	437	PF02991	0.416
LIG_LIR_Nem_3	439	443	PF02991	0.434
LIG_LIR_Nem_3	495	500	PF02991	0.403
LIG_LIR_Nem_3	525	531	PF02991	0.465
LIG_LIR_Nem_3	620	626	PF02991	0.504
LIG_LIR_Nem_3	632	638	PF02991	0.433
LIG_LIR_Nem_3	650	656	PF02991	0.284
LIG_LIR_Nem_3	730	735	PF02991	0.494
LIG_LIR_Nem_3	783	787	PF02991	0.461
LIG_MAD2	909	917	PF02301	0.687
LIG_MLH1_MIPbox_1	866	870	PF16413	0.656
LIG_Pex14_1	653	657	PF04695	0.404
LIG_Pex14_2	220	224	PF04695	0.474
LIG_Pex14_2	566	570	PF04695	0.355
LIG_Pex14_2	588	592	PF04695	0.441
LIG_Pex14_2	619	623	PF04695	0.540
LIG_Pex14_2	802	806	PF04695	0.496
LIG_PTB_Apo_2	237	244	PF02174	0.537
LIG_PTB_Phospho_1	237	243	PF10480	0.532
LIG_REV1ctd_RIR_1	382	390	PF16727	0.330
LIG_REV1ctd_RIR_1	867	876	PF16727	0.564
LIG_RPA_C_Fungi	895	907	PF08784	0.635
LIG_SH2_CRK	125	129	PF00017	0.573
LIG_SH2_CRK	180	184	PF00017	0.547
LIG_SH2_CRK	196	200	PF00017	0.339
LIG_SH2_CRK	243	247	PF00017	0.531
LIG_SH2_CRK	328	332	PF00017	0.412
LIG_SH2_CRK	403	407	PF00017	0.428
LIG_SH2_CRK	594	598	PF00017	0.640
LIG_SH2_GRB2like	594	597	PF00017	0.627
LIG_SH2_GRB2like	709	712	PF00017	0.480
LIG_SH2_NCK_1	328	332	PF00017	0.467
LIG_SH2_NCK_1	403	407	PF00017	0.532
LIG_SH2_NCK_1	594	598	PF00017	0.672
LIG_SH2_NCK_1	663	667	PF00017	0.480
LIG_SH2_SRC	594	597	PF00017	0.498
LIG_SH2_STAP1	328	332	PF00017	0.493
LIG_SH2_STAP1	425	429	PF00017	0.410
LIG_SH2_STAP1	434	438	PF00017	0.410
LIG_SH2_STAT3	357	360	PF00017	0.443
LIG_SH2_STAT3	786	789	PF00017	0.447
LIG_SH2_STAT5	227	230	PF00017	0.410
LIG_SH2_STAT5	357	360	PF00017	0.400
LIG_SH2_STAT5	437	440	PF00017	0.379
LIG_SH2_STAT5	46	49	PF00017	0.537
LIG_SH2_STAT5	530	533	PF00017	0.358
LIG_SH2_STAT5	54	57	PF00017	0.529
LIG_SH2_STAT5	637	640	PF00017	0.365
LIG_SH2_STAT5	663	666	PF00017	0.383
LIG_SH2_STAT5	680	683	PF00017	0.480
LIG_SH2_STAT5	709	712	PF00017	0.342
LIG_SH2_STAT5	786	789	PF00017	0.428
LIG_SH3_3	220	226	PF00018	0.493
LIG_SH3_3	344	350	PF00018	0.428
LIG_SH3_3	775	781	PF00018	0.355
LIG_SH3_3	80	86	PF00018	0.514
LIG_SUMO_SIM_anti_2	229	236	PF11976	0.516
LIG_SUMO_SIM_anti_2	512	517	PF11976	0.559
LIG_SUMO_SIM_par_1	490	498	PF11976	0.551
LIG_TRAF2_1	47	50	PF00917	0.563
LIG_TRAF2_1	555	558	PF00917	0.563
LIG_TYR_ITAM	177	199	PF00017	0.541
LIG_TYR_ITIM	150	155	PF00017	0.585
LIG_TYR_ITIM	178	183	PF00017	0.550
LIG_UBA3_1	375	381	PF00899	0.505
LIG_UBA3_1	51	60	PF00899	0.646
LIG_UBA3_1	702	708	PF00899	0.402
LIG_UBA3_1	771	780	PF00899	0.244
LIG_WRC_WIRS_1	217	222	PF05994	0.581
MOD_CDK_SPxK_1	618	624	PF00069	0.529
MOD_CDK_SPxxK_3	28	35	PF00069	0.575
MOD_CDK_SPxxK_3	618	625	PF00069	0.534
MOD_CK1_1	105	111	PF00069	0.461
MOD_CK1_1	31	37	PF00069	0.666
MOD_CK1_1	402	408	PF00069	0.608
MOD_CK1_1	449	455	PF00069	0.473
MOD_CK1_1	549	555	PF00069	0.522
MOD_CK1_1	70	76	PF00069	0.603
MOD_CK1_1	731	737	PF00069	0.401
MOD_CK2_1	44	50	PF00069	0.534
MOD_CK2_1	53	59	PF00069	0.500
MOD_CK2_1	572	578	PF00069	0.375
MOD_CK2_1	673	679	PF00069	0.480
MOD_CK2_1	709	715	PF00069	0.373
MOD_CK2_1	76	82	PF00069	0.617
MOD_CK2_1	856	862	PF00069	0.547
MOD_GlcNHglycan	16	19	PF01048	0.736
MOD_GlcNHglycan	328	331	PF01048	0.538
MOD_GlcNHglycan	406	409	PF01048	0.594
MOD_GlcNHglycan	439	443	PF01048	0.450
MOD_GlcNHglycan	444	449	PF01048	0.398
MOD_GlcNHglycan	458	461	PF01048	0.453
MOD_GlcNHglycan	484	487	PF01048	0.503
MOD_GlcNHglycan	607	610	PF01048	0.766
MOD_GlcNHglycan	866	869	PF01048	0.620
MOD_GSK3_1	10	17	PF00069	0.746
MOD_GSK3_1	102	109	PF00069	0.519
MOD_GSK3_1	26	33	PF00069	0.631
MOD_GSK3_1	261	268	PF00069	0.704
MOD_GSK3_1	456	463	PF00069	0.485
MOD_GSK3_1	478	485	PF00069	0.513
MOD_GSK3_1	691	698	PF00069	0.442
MOD_GSK3_1	840	847	PF00069	0.612
MOD_GSK3_1	848	855	PF00069	0.559
MOD_GSK3_1	905	912	PF00069	0.636
MOD_N-GLC_1	163	168	PF02516	0.563
MOD_N-GLC_1	546	551	PF02516	0.539
MOD_N-GLC_1	93	98	PF02516	0.612
MOD_N-GLC_2	572	574	PF02516	0.377
MOD_NEK2_1	1	6	PF00069	0.759
MOD_NEK2_1	371	376	PF00069	0.421
MOD_NEK2_1	428	433	PF00069	0.511
MOD_NEK2_1	446	451	PF00069	0.480
MOD_NEK2_1	500	505	PF00069	0.428
MOD_NEK2_1	81	86	PF00069	0.536
MOD_NEK2_1	844	849	PF00069	0.488
MOD_NEK2_1	870	875	PF00069	0.602
MOD_NEK2_1	88	93	PF00069	0.535
MOD_PIKK_1	106	112	PF00454	0.493
MOD_PIKK_1	317	323	PF00454	0.621
MOD_PIKK_1	809	815	PF00454	0.480
MOD_PIKK_1	844	850	PF00454	0.601
MOD_PK_1	352	358	PF00069	0.283
MOD_PKA_1	695	701	PF00069	0.479
MOD_PKA_1	725	731	PF00069	0.480
MOD_PKA_1	835	841	PF00069	0.434
MOD_PKA_2	10	16	PF00069	0.743
MOD_PKA_2	205	211	PF00069	0.418
MOD_PKA_2	816	822	PF00069	0.375
MOD_PKA_2	829	835	PF00069	0.349
MOD_PKB_1	693	701	PF00069	0.447
MOD_Plk_1	163	169	PF00069	0.528
MOD_Plk_1	371	377	PF00069	0.428
MOD_Plk_1	416	422	PF00069	0.482
MOD_Plk_1	438	444	PF00069	0.474
MOD_Plk_1	511	517	PF00069	0.557
MOD_Plk_1	546	552	PF00069	0.596
MOD_Plk_1	572	578	PF00069	0.389
MOD_Plk_1	743	749	PF00069	0.432
MOD_Plk_1	81	87	PF00069	0.539
MOD_Plk_1	828	834	PF00069	0.447
MOD_Plk_1	856	862	PF00069	0.478
MOD_Plk_1	924	930	PF00069	0.425
MOD_Plk_2-3	261	267	PF00069	0.720
MOD_Plk_2-3	573	579	PF00069	0.407
MOD_Plk_2-3	925	931	PF00069	0.685
MOD_Plk_4	164	170	PF00069	0.465
MOD_Plk_4	233	239	PF00069	0.399
MOD_Plk_4	371	377	PF00069	0.505
MOD_Plk_4	416	422	PF00069	0.509
MOD_Plk_4	446	452	PF00069	0.509
MOD_Plk_4	478	484	PF00069	0.559
MOD_Plk_4	511	517	PF00069	0.548
MOD_Plk_4	684	690	PF00069	0.447
MOD_Plk_4	709	715	PF00069	0.368
MOD_Plk_4	728	734	PF00069	0.319
MOD_Plk_4	798	804	PF00069	0.331
MOD_Plk_4	848	854	PF00069	0.447
MOD_ProDKin_1	28	34	PF00069	0.573
MOD_ProDKin_1	402	408	PF00069	0.322
MOD_ProDKin_1	549	555	PF00069	0.522
MOD_ProDKin_1	618	624	PF00069	0.481
MOD_ProDKin_1	909	915	PF00069	0.686
MOD_SUMO_for_1	63	66	PF00179	0.649
MOD_SUMO_rev_2	582	589	PF00179	0.452
TRG_DiLeu_BaEn_1	411	416	PF01217	0.475
TRG_DiLeu_BaEn_2	416	422	PF01217	0.389
TRG_DiLeu_BaEn_3	683	689	PF01217	0.447
TRG_DiLeu_BaLyEn_6	363	368	PF01217	0.438
TRG_DiLeu_BaLyEn_6	84	89	PF01217	0.501
TRG_ENDOCYTIC_2	125	128	PF00928	0.574
TRG_ENDOCYTIC_2	152	155	PF00928	0.467
TRG_ENDOCYTIC_2	180	183	PF00928	0.471
TRG_ENDOCYTIC_2	184	187	PF00928	0.441
TRG_ENDOCYTIC_2	196	199	PF00928	0.346
TRG_ENDOCYTIC_2	217	220	PF00928	0.547
TRG_ENDOCYTIC_2	243	246	PF00928	0.422
TRG_ENDOCYTIC_2	290	293	PF00928	0.367
TRG_ENDOCYTIC_2	328	331	PF00928	0.472
TRG_ENDOCYTIC_2	425	428	PF00928	0.409
TRG_ENDOCYTIC_2	437	440	PF00928	0.370
TRG_ENDOCYTIC_2	528	531	PF00928	0.442
TRG_ER_diArg_1	205	207	PF00400	0.498
TRG_ER_diArg_1	562	564	PF00400	0.428
TRG_ER_diArg_1	99	101	PF00400	0.536
TRG_ER_FFAT_2	43	50	PF00635	0.612
TRG_NES_CRM1_1	229	241	PF08389	0.474
TRG_NES_CRM1_1	66	80	PF08389	0.613
TRG_NLS_MonoCore_2	874	879	PF00514	0.502
TRG_NLS_MonoExtC_3	875	881	PF00514	0.478
TRG_NLS_MonoExtN_4	872	879	PF00514	0.485
TRG_Pf-PMV_PEXEL_1	244	248	PF00026	0.439
TRG_Pf-PMV_PEXEL_1	257	261	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	624	628	PF00026	0.489
TRG_Pf-PMV_PEXEL_1	695	700	PF00026	0.402
TRG_Pf-PMV_PEXEL_1	858	862	PF00026	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY82	Leptomonas seymouri	71%	97%
A0A0S4JGX2	Bodo saltans	35%	100%
A0A1X0P4D3	Trypanosomatidae	53%	100%
A0A3Q8IE79	Leishmania donovani	93%	100%
A0A3R7M5J1	Trypanosoma rangeli	50%	100%
A4HFM4	Leishmania braziliensis	84%	100%
A4I2Q2	Leishmania infantum	93%	100%
D0A5V4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AD78	Leishmania major	93%	100%