Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZ00_LEIMU

TriTrypDb:

LmxM.27.0990

Length:

280

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZ00

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZ00

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	252	254	PF00675	0.685
CLV_NRD_NRD_1	35	37	PF00675	0.599
CLV_PCSK_KEX2_1	252	254	PF00082	0.685
CLV_PCSK_KEX2_1	35	37	PF00082	0.634
CLV_PCSK_SKI1_1	146	150	PF00082	0.518
CLV_PCSK_SKI1_1	36	40	PF00082	0.613
DEG_COP1_1	263	272	PF00400	0.581
DEG_MDM2_SWIB_1	159	166	PF02201	0.532
DEG_Nend_UBRbox_1	1	4	PF02207	0.656
DEG_SPOP_SBC_1	116	120	PF00917	0.681
DEG_SPOP_SBC_1	221	225	PF00917	0.548
DOC_AGCK_PIF_2	68	73	PF00069	0.630
DOC_CYCLIN_RxL_1	143	153	PF00134	0.530
DOC_MAPK_gen_1	35	45	PF00069	0.603
DOC_MAPK_MEF2A_6	39	47	PF00069	0.600
DOC_USP7_MATH_1	109	113	PF00917	0.589
DOC_USP7_MATH_1	116	120	PF00917	0.672
DOC_USP7_MATH_1	196	200	PF00917	0.747
DOC_USP7_MATH_1	221	225	PF00917	0.632
DOC_USP7_MATH_1	234	238	PF00917	0.595
DOC_USP7_MATH_1	88	92	PF00917	0.707
DOC_USP7_MATH_1	95	99	PF00917	0.604
DOC_WW_Pin1_4	141	146	PF00397	0.549
DOC_WW_Pin1_4	150	155	PF00397	0.700
DOC_WW_Pin1_4	206	211	PF00397	0.696
LIG_14-3-3_CanoR_1	214	218	PF00244	0.622
LIG_FHA_1	142	148	PF00498	0.460
LIG_FHA_1	183	189	PF00498	0.769
LIG_FHA_1	238	244	PF00498	0.757
LIG_FHA_1	53	59	PF00498	0.577
LIG_FHA_1	61	67	PF00498	0.524
LIG_FHA_2	151	157	PF00498	0.589
LIG_FHA_2	213	219	PF00498	0.666
LIG_FHA_2	245	251	PF00498	0.586
LIG_FHA_2	7	13	PF00498	0.594
LIG_FHA_2	88	94	PF00498	0.649
LIG_GBD_Chelix_1	235	243	PF00786	0.693
LIG_LIR_Gen_1	160	171	PF02991	0.592
LIG_LIR_Gen_1	263	272	PF02991	0.651
LIG_LIR_Nem_3	160	166	PF02991	0.602
LIG_LIR_Nem_3	263	267	PF02991	0.615
LIG_LIR_Nem_3	72	77	PF02991	0.697
LIG_NRP_CendR_1	278	280	PF00754	0.626
LIG_Pex14_2	159	163	PF04695	0.489
LIG_REV1ctd_RIR_1	71	79	PF16727	0.538
LIG_SH2_NCK_1	264	268	PF00017	0.601
LIG_SH3_3	131	137	PF00018	0.429
LIG_SH3_3	186	192	PF00018	0.555
LIG_SH3_3	264	270	PF00018	0.512
LIG_SH3_3	40	46	PF00018	0.579
LIG_SH3_3	63	69	PF00018	0.572
LIG_SUMO_SIM_anti_2	271	277	PF11976	0.611
LIG_TRAF2_1	248	251	PF00917	0.675
MOD_CDK_SPK_2	141	146	PF00069	0.370
MOD_CK1_1	100	106	PF00069	0.715
MOD_CK1_1	182	188	PF00069	0.740
MOD_CK1_1	201	207	PF00069	0.597
MOD_CK1_1	225	231	PF00069	0.695
MOD_CK1_1	237	243	PF00069	0.734
MOD_CK2_1	150	156	PF00069	0.592
MOD_CK2_1	212	218	PF00069	0.663
MOD_CK2_1	244	250	PF00069	0.672
MOD_CK2_1	47	53	PF00069	0.547
MOD_CK2_1	6	12	PF00069	0.590
MOD_GlcNHglycan	111	114	PF01048	0.706
MOD_GlcNHglycan	181	184	PF01048	0.677
MOD_GlcNHglycan	230	233	PF01048	0.631
MOD_GlcNHglycan	270	273	PF01048	0.639
MOD_GlcNHglycan	97	100	PF01048	0.684
MOD_GSK3_1	105	112	PF00069	0.773
MOD_GSK3_1	116	123	PF00069	0.717
MOD_GSK3_1	150	157	PF00069	0.488
MOD_GSK3_1	18	25	PF00069	0.727
MOD_GSK3_1	197	204	PF00069	0.645
MOD_GSK3_1	212	219	PF00069	0.549
MOD_GSK3_1	221	228	PF00069	0.623
MOD_N-GLC_1	197	202	PF02516	0.701
MOD_NEK2_1	105	110	PF00069	0.777
MOD_NEK2_1	197	202	PF00069	0.737
MOD_NEK2_1	212	217	PF00069	0.510
MOD_NEK2_1	239	244	PF00069	0.774
MOD_NEK2_1	47	52	PF00069	0.635
MOD_NEK2_2	154	159	PF00069	0.368
MOD_PIKK_1	222	228	PF00454	0.719
MOD_PKA_2	213	219	PF00069	0.584
MOD_PKA_2	22	28	PF00069	0.619
MOD_Plk_1	197	203	PF00069	0.592
MOD_Plk_2-3	6	12	PF00069	0.586
MOD_Plk_4	154	160	PF00069	0.368
MOD_Plk_4	198	204	PF00069	0.579
MOD_Plk_4	234	240	PF00069	0.606
MOD_Plk_4	47	53	PF00069	0.542
MOD_Plk_4	60	66	PF00069	0.489
MOD_ProDKin_1	141	147	PF00069	0.541
MOD_ProDKin_1	150	156	PF00069	0.698
MOD_ProDKin_1	206	212	PF00069	0.697
TRG_DiLeu_BaEn_2	130	136	PF01217	0.603
TRG_DiLeu_BaLyEn_6	143	148	PF01217	0.522
TRG_ENDOCYTIC_2	264	267	PF00928	0.580
TRG_ER_diArg_1	252	255	PF00400	0.659
TRG_ER_diArg_1	34	36	PF00400	0.619

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6J0	Leptomonas seymouri	46%	100%
A0A1X0P427	Trypanosomatidae	32%	100%
A0A3S7X0L8	Leishmania donovani	87%	100%
A0A422N2W4	Trypanosoma rangeli	30%	100%
A4HFM2	Leishmania braziliensis	74%	100%
A4I2Q0	Leishmania infantum	88%	100%
D0A5V2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AD76	Leishmania major	87%	100%