Putative ATP-binding cassette protein subfamily A, member 9

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-binding cassette protein subfamily A, member 9, putative

Species:

Leishmania mexicana

UniProt:

E9AYZ9_LEIMU

TriTrypDb:

LmxM.27.0980

Length:

844

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9AYZ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYZ9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0005215	transporter activity	1	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0015399	primary active transmembrane transporter activity	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0022804	active transmembrane transporter activity	3	7
GO:0022857	transmembrane transporter activity	2	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0042626	ATPase-coupled transmembrane transporter activity	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140359	ABC-type transporter activity	3	7
GO:0140657	ATP-dependent activity	1	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	161	165	PF00656	0.217
CLV_C14_Caspase3-7	36	40	PF00656	0.563
CLV_C14_Caspase3-7	51	55	PF00656	0.487
CLV_C14_Caspase3-7	688	692	PF00656	0.474
CLV_NRD_NRD_1	469	471	PF00675	0.380
CLV_NRD_NRD_1	498	500	PF00675	0.322
CLV_NRD_NRD_1	517	519	PF00675	0.249
CLV_NRD_NRD_1	637	639	PF00675	0.325
CLV_NRD_NRD_1	649	651	PF00675	0.274
CLV_NRD_NRD_1	679	681	PF00675	0.378
CLV_NRD_NRD_1	72	74	PF00675	0.444
CLV_NRD_NRD_1	91	93	PF00675	0.313
CLV_PCSK_FUR_1	89	93	PF00082	0.279
CLV_PCSK_KEX2_1	469	471	PF00082	0.381
CLV_PCSK_KEX2_1	498	500	PF00082	0.333
CLV_PCSK_KEX2_1	637	639	PF00082	0.316
CLV_PCSK_KEX2_1	649	651	PF00082	0.300
CLV_PCSK_KEX2_1	679	681	PF00082	0.378
CLV_PCSK_KEX2_1	71	73	PF00082	0.405
CLV_PCSK_KEX2_1	82	84	PF00082	0.354
CLV_PCSK_KEX2_1	91	93	PF00082	0.313
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.361
CLV_PCSK_PC7_1	68	74	PF00082	0.287
CLV_PCSK_SKI1_1	224	228	PF00082	0.575
CLV_PCSK_SKI1_1	404	408	PF00082	0.441
CLV_PCSK_SKI1_1	499	503	PF00082	0.312
CLV_PCSK_SKI1_1	529	533	PF00082	0.348
CLV_PCSK_SKI1_1	663	667	PF00082	0.234
DEG_SCF_FBW7_1	146	152	PF00400	0.217
DEG_SPOP_SBC_1	149	153	PF00917	0.217
DEG_SPOP_SBC_1	433	437	PF00917	0.217
DOC_CKS1_1	117	122	PF01111	0.217
DOC_CKS1_1	146	151	PF01111	0.217
DOC_CYCLIN_RxL_1	507	520	PF00134	0.480
DOC_CYCLIN_yClb5_NLxxxL_5	397	403	PF00134	0.217
DOC_MAPK_gen_1	622	630	PF00069	0.443
DOC_MAPK_gen_1	649	658	PF00069	0.505
DOC_MAPK_gen_1	68	76	PF00069	0.479
DOC_MAPK_MEF2A_6	115	124	PF00069	0.217
DOC_MAPK_MEF2A_6	649	658	PF00069	0.505
DOC_PP1_RVXF_1	399	406	PF00149	0.215
DOC_PP1_RVXF_1	661	668	PF00149	0.434
DOC_PP1_RVXF_1	70	77	PF00149	0.473
DOC_PP4_FxxP_1	117	120	PF00568	0.217
DOC_PP4_FxxP_1	477	480	PF00568	0.518
DOC_PP4_FxxP_1	667	670	PF00568	0.417
DOC_USP7_MATH_1	163	167	PF00917	0.217
DOC_USP7_MATH_1	191	195	PF00917	0.217
DOC_USP7_MATH_1	242	246	PF00917	0.326
DOC_USP7_MATH_1	249	253	PF00917	0.369
DOC_USP7_UBL2_3	726	730	PF12436	0.573
DOC_WW_Pin1_4	116	121	PF00397	0.217
DOC_WW_Pin1_4	145	150	PF00397	0.217
DOC_WW_Pin1_4	159	164	PF00397	0.199
DOC_WW_Pin1_4	744	749	PF00397	0.512
LIG_14-3-3_CanoR_1	174	184	PF00244	0.236
LIG_14-3-3_CanoR_1	229	235	PF00244	0.246
LIG_14-3-3_CanoR_1	469	477	PF00244	0.543
LIG_14-3-3_CanoR_1	529	534	PF00244	0.415
LIG_14-3-3_CanoR_1	649	655	PF00244	0.489
LIG_14-3-3_CanoR_1	774	778	PF00244	0.488
LIG_14-3-3_CanoR_1	784	789	PF00244	0.486
LIG_14-3-3_CanoR_1	817	824	PF00244	0.686
LIG_14-3-3_CanoR_1	91	99	PF00244	0.417
LIG_Actin_WH2_2	377	395	PF00022	0.228
LIG_Actin_WH2_2	412	428	PF00022	0.217
LIG_Actin_WH2_2	705	723	PF00022	0.477
LIG_APCC_ABBA_1	754	759	PF00400	0.483
LIG_BRCT_BRCA1_1	358	362	PF00533	0.351
LIG_BRCT_BRCA1_1	785	789	PF00533	0.469
LIG_Clathr_ClatBox_1	599	603	PF01394	0.548
LIG_EH1_1	346	354	PF00400	0.228
LIG_EH1_1	709	717	PF00400	0.453
LIG_FHA_1	117	123	PF00498	0.274
LIG_FHA_1	130	136	PF00498	0.359
LIG_FHA_1	203	209	PF00498	0.252
LIG_FHA_1	213	219	PF00498	0.219
LIG_FHA_1	233	239	PF00498	0.191
LIG_FHA_1	313	319	PF00498	0.388
LIG_FHA_1	338	344	PF00498	0.410
LIG_FHA_1	394	400	PF00498	0.230
LIG_FHA_1	459	465	PF00498	0.224
LIG_FHA_1	530	536	PF00498	0.548
LIG_FHA_1	54	60	PF00498	0.488
LIG_FHA_1	550	556	PF00498	0.391
LIG_FHA_1	697	703	PF00498	0.555
LIG_FHA_1	774	780	PF00498	0.530
LIG_FHA_2	129	135	PF00498	0.238
LIG_FHA_2	23	29	PF00498	0.628
LIG_FHA_2	599	605	PF00498	0.505
LIG_FHA_2	686	692	PF00498	0.473
LIG_FHA_2	733	739	PF00498	0.502
LIG_FHA_2	788	794	PF00498	0.637
LIG_FHA_2	807	813	PF00498	0.543
LIG_GBD_Chelix_1	102	110	PF00786	0.393
LIG_GBD_Chelix_1	374	382	PF00786	0.394
LIG_HCF-1_HBM_1	604	607	PF13415	0.417
LIG_LIR_Apic_2	776	780	PF02991	0.465
LIG_LIR_Gen_1	196	203	PF02991	0.249
LIG_LIR_Gen_1	252	263	PF02991	0.217
LIG_LIR_Gen_1	28	38	PF02991	0.650
LIG_LIR_Gen_1	329	339	PF02991	0.300
LIG_LIR_Gen_1	340	349	PF02991	0.465
LIG_LIR_Gen_1	786	793	PF02991	0.654
LIG_LIR_Gen_1	812	822	PF02991	0.567
LIG_LIR_Gen_1	93	103	PF02991	0.228
LIG_LIR_Nem_3	182	187	PF02991	0.260
LIG_LIR_Nem_3	196	201	PF02991	0.249
LIG_LIR_Nem_3	28	34	PF02991	0.627
LIG_LIR_Nem_3	296	300	PF02991	0.548
LIG_LIR_Nem_3	329	334	PF02991	0.300
LIG_LIR_Nem_3	340	344	PF02991	0.465
LIG_LIR_Nem_3	539	544	PF02991	0.495
LIG_LIR_Nem_3	786	792	PF02991	0.551
LIG_LIR_Nem_3	812	818	PF02991	0.578
LIG_LIR_Nem_3	93	99	PF02991	0.228
LIG_NRBOX	106	112	PF00104	0.228
LIG_PCNA_yPIPBox_3	802	815	PF02747	0.507
LIG_Pex14_1	301	305	PF04695	0.351
LIG_Pex14_1	445	449	PF04695	0.410
LIG_Pex14_2	297	301	PF04695	0.505
LIG_Pex14_2	377	381	PF04695	0.351
LIG_Pex14_2	758	762	PF04695	0.485
LIG_PTB_Apo_2	301	308	PF02174	0.224
LIG_Rb_LxCxE_1	552	566	PF01857	0.415
LIG_REV1ctd_RIR_1	755	762	PF16727	0.487
LIG_SH2_CRK	184	188	PF00017	0.402
LIG_SH2_CRK	198	202	PF00017	0.217
LIG_SH2_CRK	609	613	PF00017	0.505
LIG_SH2_CRK	777	781	PF00017	0.605
LIG_SH2_GRB2like	521	524	PF00017	0.501
LIG_SH2_PTP2	331	334	PF00017	0.217
LIG_SH2_SRC	521	524	PF00017	0.501
LIG_SH2_SRC	607	610	PF00017	0.417
LIG_SH2_STAP1	20	24	PF00017	0.624
LIG_SH2_STAP1	255	259	PF00017	0.233
LIG_SH2_STAP1	356	360	PF00017	0.410
LIG_SH2_STAT3	589	592	PF00017	0.505
LIG_SH2_STAT5	298	301	PF00017	0.379
LIG_SH2_STAT5	312	315	PF00017	0.451
LIG_SH2_STAT5	331	334	PF00017	0.204
LIG_SH2_STAT5	413	416	PF00017	0.388
LIG_SH2_STAT5	570	573	PF00017	0.545
LIG_SH2_STAT5	589	592	PF00017	0.410
LIG_SH2_STAT5	607	610	PF00017	0.505
LIG_SH3_3	130	136	PF00018	0.217
LIG_SH3_3	143	149	PF00018	0.198
LIG_SUMO_SIM_anti_2	340	346	PF11976	0.320
LIG_SUMO_SIM_anti_2	552	559	PF11976	0.415
LIG_SUMO_SIM_par_1	118	127	PF11976	0.260
LIG_SUMO_SIM_par_1	141	148	PF11976	0.217
LIG_SUMO_SIM_par_1	383	388	PF11976	0.414
LIG_SUMO_SIM_par_1	460	465	PF11976	0.289
LIG_SUMO_SIM_par_1	598	604	PF11976	0.507
LIG_TRAF2_1	26	29	PF00917	0.612
LIG_TRAF2_1	48	51	PF00917	0.660
LIG_TRAF2_1	601	604	PF00917	0.505
LIG_TRAF2_1	7	10	PF00917	0.675
LIG_UBA3_1	106	115	PF00899	0.228
LIG_Vh1_VBS_1	385	403	PF01044	0.228
MOD_CK1_1	118	124	PF00069	0.272
MOD_CK1_1	166	172	PF00069	0.228
MOD_CK1_1	194	200	PF00069	0.228
MOD_CK1_1	23	29	PF00069	0.407
MOD_CK1_1	233	239	PF00069	0.232
MOD_CK1_1	293	299	PF00069	0.252
MOD_CK1_1	765	771	PF00069	0.346
MOD_CK1_1	787	793	PF00069	0.316
MOD_CK1_1	807	813	PF00069	0.426
MOD_CK1_1	836	842	PF00069	0.494
MOD_CK2_1	22	28	PF00069	0.522
MOD_CK2_1	598	604	PF00069	0.351
MOD_CK2_1	732	738	PF00069	0.454
MOD_CK2_1	787	793	PF00069	0.360
MOD_CK2_1	806	812	PF00069	0.438
MOD_Cter_Amidation	467	470	PF01082	0.378
MOD_GlcNHglycan	164	168	PF01048	0.228
MOD_GlcNHglycan	193	196	PF01048	0.254
MOD_GlcNHglycan	205	208	PF01048	0.228
MOD_GlcNHglycan	22	25	PF01048	0.419
MOD_GlcNHglycan	292	295	PF01048	0.224
MOD_GlcNHglycan	349	352	PF01048	0.296
MOD_GlcNHglycan	387	390	PF01048	0.228
MOD_GlcNHglycan	565	568	PF01048	0.343
MOD_GlcNHglycan	643	647	PF01048	0.348
MOD_GlcNHglycan	668	673	PF01048	0.351
MOD_GSK3_1	118	125	PF00069	0.391
MOD_GSK3_1	144	151	PF00069	0.277
MOD_GSK3_1	159	166	PF00069	0.200
MOD_GSK3_1	18	25	PF00069	0.656
MOD_GSK3_1	229	236	PF00069	0.286
MOD_GSK3_1	265	272	PF00069	0.285
MOD_GSK3_1	308	315	PF00069	0.332
MOD_GSK3_1	549	556	PF00069	0.351
MOD_GSK3_1	638	645	PF00069	0.362
MOD_GSK3_1	650	657	PF00069	0.395
MOD_GSK3_1	691	698	PF00069	0.409
MOD_GSK3_1	761	768	PF00069	0.374
MOD_GSK3_1	779	786	PF00069	0.290
MOD_GSK3_1	802	809	PF00069	0.461
MOD_LATS_1	222	228	PF00433	0.228
MOD_N-GLC_1	172	177	PF02516	0.327
MOD_N-GLC_1	203	208	PF02516	0.351
MOD_N-GLC_1	230	235	PF02516	0.228
MOD_N-GLC_1	290	295	PF02516	0.284
MOD_N-GLC_1	363	368	PF02516	0.228
MOD_N-GLC_1	529	534	PF02516	0.224
MOD_N-GLC_1	691	696	PF02516	0.289
MOD_NEK2_1	109	114	PF00069	0.252
MOD_NEK2_1	144	149	PF00069	0.319
MOD_NEK2_1	150	155	PF00069	0.258
MOD_NEK2_1	172	177	PF00069	0.379
MOD_NEK2_1	202	207	PF00069	0.455
MOD_NEK2_1	22	27	PF00069	0.525
MOD_NEK2_1	385	390	PF00069	0.241
MOD_NEK2_1	392	397	PF00069	0.239
MOD_NEK2_1	425	430	PF00069	0.395
MOD_NEK2_1	458	463	PF00069	0.247
MOD_NEK2_1	543	548	PF00069	0.351
MOD_PIKK_1	242	248	PF00454	0.419
MOD_PIKK_1	470	476	PF00454	0.410
MOD_PIKK_1	804	810	PF00454	0.449
MOD_PIKK_1	90	96	PF00454	0.474
MOD_PK_1	650	656	PF00069	0.351
MOD_PK_1	784	790	PF00069	0.317
MOD_PK_1	802	808	PF00069	0.310
MOD_PKA_1	650	656	PF00069	0.351
MOD_PKA_2	636	642	PF00069	0.405
MOD_PKA_2	773	779	PF00069	0.300
MOD_PKA_2	783	789	PF00069	0.412
MOD_PKA_2	816	822	PF00069	0.519
MOD_PKA_2	90	96	PF00069	0.228
MOD_PKB_1	831	839	PF00069	0.400
MOD_Plk_1	163	169	PF00069	0.368
MOD_Plk_1	172	178	PF00069	0.308
MOD_Plk_1	203	209	PF00069	0.224
MOD_Plk_1	230	236	PF00069	0.228
MOD_Plk_1	250	256	PF00069	0.191
MOD_Plk_1	433	439	PF00069	0.257
MOD_Plk_1	529	535	PF00069	0.224
MOD_Plk_1	691	697	PF00069	0.285
MOD_Plk_1	724	730	PF00069	0.432
MOD_Plk_1	802	808	PF00069	0.442
MOD_Plk_2-3	434	440	PF00069	0.228
MOD_Plk_2-3	598	604	PF00069	0.351
MOD_Plk_4	109	115	PF00069	0.299
MOD_Plk_4	118	124	PF00069	0.396
MOD_Plk_4	197	203	PF00069	0.397
MOD_Plk_4	250	256	PF00069	0.253
MOD_Plk_4	270	276	PF00069	0.405
MOD_Plk_4	293	299	PF00069	0.406
MOD_Plk_4	308	314	PF00069	0.291
MOD_Plk_4	337	343	PF00069	0.406
MOD_Plk_4	654	660	PF00069	0.224
MOD_Plk_4	691	697	PF00069	0.412
MOD_Plk_4	784	790	PF00069	0.353
MOD_ProDKin_1	116	122	PF00069	0.228
MOD_ProDKin_1	145	151	PF00069	0.228
MOD_ProDKin_1	159	165	PF00069	0.202
MOD_ProDKin_1	744	750	PF00069	0.352
MOD_SUMO_rev_2	281	286	PF00179	0.224
MOD_SUMO_rev_2	45	53	PF00179	0.406
TRG_DiLeu_BaEn_2	452	458	PF01217	0.228
TRG_DiLeu_BaEn_2	538	544	PF01217	0.345
TRG_DiLeu_BaEn_4	603	609	PF01217	0.410
TRG_DiLeu_BaEn_4	703	709	PF01217	0.426
TRG_ENDOCYTIC_2	184	187	PF00928	0.486
TRG_ENDOCYTIC_2	198	201	PF00928	0.228
TRG_ENDOCYTIC_2	255	258	PF00928	0.228
TRG_ENDOCYTIC_2	331	334	PF00928	0.228
TRG_ENDOCYTIC_2	449	452	PF00928	0.410
TRG_ENDOCYTIC_2	609	612	PF00928	0.351
TRG_ER_diArg_1	469	472	PF00400	0.473
TRG_ER_diArg_1	636	638	PF00400	0.228
TRG_ER_diArg_1	71	73	PF00400	0.322
TRG_ER_diArg_1	831	834	PF00400	0.396
TRG_NES_CRM1_1	453	465	PF08389	0.331
TRG_Pf-PMV_PEXEL_1	721	725	PF00026	0.324

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4F0	Leptomonas seymouri	52%	75%
A0A0S4KM38	Bodo saltans	57%	100%
A0A3S5H6J8	Leishmania donovani	49%	100%
A0A3S7WRU9	Leishmania donovani	49%	100%
A4HV30	Leishmania infantum	49%	100%
A4I2P9	Leishmania infantum	27%	77%
Q1PEH6	Arabidopsis thaliana	28%	91%
Q54DT1	Dictyostelium discoideum	28%	100%
Q552P3	Dictyostelium discoideum	28%	100%
Q84K47	Arabidopsis thaliana	28%	86%
Q8LPK0	Arabidopsis thaliana	25%	94%
Q8T5Z7	Dictyostelium discoideum	27%	96%
Q8T6J0	Dictyostelium discoideum	29%	100%
Q9FKF2	Arabidopsis thaliana	28%	89%
Q9FLT4	Arabidopsis thaliana	29%	93%
Q9FLT5	Arabidopsis thaliana	28%	89%
Q9FLT8	Arabidopsis thaliana	28%	92%
Q9STT5	Arabidopsis thaliana	29%	90%
Q9STT6	Arabidopsis thaliana	28%	91%
Q9STT7	Arabidopsis thaliana	28%	90%
Q9STT8	Arabidopsis thaliana	28%	90%